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Veterinary Immunology and Immunopathology

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  1. The effect of estrogen on the early cytotoxic response to IB virus infection in hen oviduct

    Veterinary Immunology and Immunopathology 164(1-2):56 (2015) PMID 25593044

    The aim of this study was to determine whether the egg-laying phase and estrogen affect the induction of cytotoxic cells in response to avian infectious bronchitis (IB) virus at early stage of infection in the oviduct. Attenuated IB virus (aIBV group) or its vehicle (control group) was...
  2. Effects of dexamethasone and Mycoplasma bovis on bovine neutrophil function in vitro

    Veterinary Immunology and Immunopathology 164(1-2):67 (2015) PMID 25593042

    It is well established that exposure either to elevated levels of glucocorticoids, or to Mycoplasma bovis (M. bovis), has a negative effect on bovine neutrophil function. The objective of this research was to determine whether in vitro treatment of bovine neutrophils by M. bovis strain...
  3. Transcriptome changes upon in vitro challenge with Mycobacterium bovis in monocyte-derived macrophages from bovine tuberculosis-infected and healthy cows

    Veterinary Immunology and Immunopathology 163(3-4):146 (2015) PMID 25550244

    As innate immune cells, macrophages are expected to respond to mycobacterial infection equally in both Mycobacterium bovis-infected cows and healthy cows. We previously found that monocyte-derived macrophages (MDMs) from M. bovis-infected cows respond differently than MDMs from healthy...
  4. Bovine leukemia virus: A major silent threat to proper immune responses in cattle

    Veterinary Immunology and Immunopathology 163(3-4):103 (2015) PMID 25554478

    Bovine leukemia virus (BLV) infection is widespread in the US dairy industry and the majority of producers do not actively try to manage or reduce BLV incidence within their herds. However, BLV is estimated to cost the dairy industry hundreds of millions of dollars annually and this is...
  5. The impact of weight loss on circulating cytokines in Beagle dogs

    Veterinary Immunology and Immunopathology 163(3-4):174 (2015) PMID 25576490

    Chronic low-grade inflammation in obesity is characterized by an increased production of pro-inflammatory and chemotactic cytokines that are contributing to insulin resistance and related co-morbidities. Cytokines act in networks and exhibit pleiotropic effects so we investigated the c...
  6. Assessment of plasma anti-elastin antibodies for use as a diagnostic aid for chronic progressive lymphoedema in Belgian Draught Horses

    Veterinary Immunology and Immunopathology 163(1-2):16 (2015) PMID 25500056

    Diagnosis of chronic progressive lymphoedema (CPL) in draught horses, including the Belgian Draught Horse, is mainly based on clinical evaluation of typical lower limb lesions. A deficient perilymphatic elastic support, caused by a pathological elastin degradation in skin and subcutis,...
  7. Mycoplasma ovipneumoniae induces inflammatory response in sheep airway epithelial cells via a MyD88-dependent TLR signaling pathway

    Veterinary Immunology and Immunopathology 163(1-2):57 (2015) PMID 25440083

    Mycoplasma ovipneumoniae (M. ovipneumoniae) is a bacterium that specifically infects sheep and goat and causes ovine infectious pleuropneumonia. In an effort to understand the pathogen–host interaction between the M. ovipneumoniae and airway epithelial cells, we investigated the host i...
  8. Transcription of innate immunity genes and cytokine secretion by canine macrophages resistant or susceptible to intracellular survival of Leishmania infantum

    Veterinary Immunology and Immunopathology 163(1-2):67 (2015) PMID 25466388

    In this study we assessed the basal transcription of genes associated with innate immunity (i.e. Nramp1, NOD1, NOD2, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, and TLR9) in canine monocyte-derived macrophages from Leishmania-free dogs. Additionally, secretion of cytokines (IL-10, IL-12,...
  9. Local pulmonary immune responses in domestic cats naturally infected with Cytauxzoon felis

    Veterinary Immunology and Immunopathology 163(1-2):1 (2015) PMID 25467887

    Cytauxzoonosis is a hemoprotozoal disease of cats and wild felids in the South and Southeastern United States caused by Cytauxzoon felis. Although the causative agent has been recognized since the seventies, no study has examined the local immune response in affected organs, such as th...
  10. Sub-isotypic differences in the immunoglobulin G response to Lawsonia intracellularis in vaccinated, seropositive, and equine proliferative enteropathy-affected horses

    Veterinary Immunology and Immunopathology 162(3-4):162 (2014) PMID 25446848

    In the horse, Lawsonia intracellularis infection results in equine proliferative enteropathy (EPE). While upwards of 100% of weanlings on an endemic farm may seroconvert, only a small percentage (approximately 5%) will develop clinical disease. Cell-mediated immune mechanisms likely pl...