Trends in Neurosciences
- Print ISSN
- Electronic ISSN
- Impact factor
- Usage rank
- Article count
- Free count
- Free percentage
- PDFs via platforms
- Rcgp, Sciencedirect from 1978, Proquest, CSA, Gale, and Ingenta
Exercise, APOE genotype, and the evolution of the human lifespan.
We propose the hypothesis that the evolution of increased physical activity approximately 2 million years ago served to reduce the amyloid plaque and vascular burden of APOE ɛ4, relaxing genetic constraints on aging. This multidisciplinary approach links human evolution with health and provides a co...
Kaleidoscopic protein-protein interactions in the life and death of ataxin-1: new strategies against protein aggregation.
We discuss the paradigmatic example of ataxin-1 (Atx1), the protein responsible for neurodegenerative spinocerebellar ataxia type 1 (SCA1). This disease is part of the increasing family of pathologies caused by protein aggregation and misfolding. We discuss the importance of protein-protein interact...
The human side of microglia.
Despite increasing evidence of major differences between rodent and human immune and neurological function, relatively few biomedical studies are performed with human cells. This review takes the example of neuroimmunology research and the microglia cell type to illustrate the emerging differences b...
Blurring the boundaries: developmental and activity-dependent determinants of neural circuits.
The human brain comprises approximately 100 billion neurons that express a diverse, and often subtype-specific, set of neurotransmitters and voltage-gated ion channels. Given this enormous complexity, a fundamental question is how is this achieved? The acquisition of neurotransmitter phenotype was v...
Interview with Edward S. Boyden.
Pain-related changes in the brain: diagnostic and therapeutic potentials.
Emerging evidence suggests that chronic pain is a disease that can alter brain function. Imaging studies have demonstrated structural remapping and functional reorganization of brain circuits under various pain conditions. In parallel, preclinical models have demonstrated that chronic pain causes lo...
Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression.
We draw on recent discoveries in the functional neuroanatomy of the serotonergic dorsal raphe nucleus (DR) to propose such a mechanistic account. We argue that genetically produced variability in serotonin reuptake during stressor-induced raphe-raphe interactions alters the balance in the amygdala-v...
Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder
We review how the neural circuitry implicated in PTSD in humans is related to the neural circuitry of fear. We then discuss how fear conditioning is a suitable model for studying the molecular mechanisms of the fear components that underlie PTSD, and the biology of fear conditioning with a particula...
Regulation of transmitter release by Ca2+and synaptotagmin: insights from a large CNS synapse
Transmitter release at synapses is driven by elevated intracellular Ca 2+ concentration ([Ca 2+] i) near the sites of vesicle fusion. [Ca 2+] i signals of profoundly different amplitude and kinetics drive the phasic release component during a presynaptic action pot...