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Trends in Neurosciences

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  1. Adult neural stem cells stake their ground.

    Trends in Neurosciences 37(10):563 (2014) PMID 25223700 PMCID PMC4203324

    We discuss recent findings regarding the unique organization of the V-SVZ NSC niche, the multiple regulatory controls of neuronal production, the distinct regional identities of adult NSCs, and the epigenetic mechanisms that maintain adult neurogenesis. Understanding how V-SVZ NSCs establish and mai...
  2. Exercise, APOE genotype, and the evolution of the human lifespan.

    Trends in Neurosciences 37(5):247 (2014) PMID 24690272 PMCID PMC4066890

    We propose the hypothesis that the evolution of increased physical activity approximately 2 million years ago served to reduce the amyloid plaque and vascular burden of APOE ɛ4, relaxing genetic constraints on aging. This multidisciplinary approach links human evolution with health and provides a co...
  3. Opening paths to novel analgesics: the role of potassium channels in chronic pain.

    Trends in Neurosciences 37(3):146 (2014) PMID 24461875 PMCID PMC3945816

    We review salient findings from expression, pharmacological, and genetic studies that have untangled a hitherto undervalued contribution of K⁺ channels in maladaptive pain signaling. These emerging data provide a framework to explain enigmatic pain syndromes and to design novel pharmacological treat...
  4. A de novo convergence of autism genetics and molecular neuroscience.

    Trends in Neurosciences 37(2):95 (2014) PMID 24387789 PMCID PMC4077788

    We review recent studies and suggest that they have led to a convergence on three functional pathways: (i) chromatin remodeling; (ii) wnt signaling during development; and (iii) synaptic function. These pathways and genes significantly expand the neurobiological targets for study, and suggest a path...
  5. Blurring the boundaries: developmental and activity-dependent determinants of neural circuits.

    Trends in Neurosciences 36(10):610 (2013) PMID 23876426 PMCID PMC3794160

    The human brain comprises approximately 100 billion neurons that express a diverse, and often subtype-specific, set of neurotransmitters and voltage-gated ion channels. Given this enormous complexity, a fundamental question is how is this achieved? The acquisition of neurotransmitter phenotype was v...
  6. Neuronal circuits that regulate feeding behavior and metabolism.

    Trends in Neurosciences 36(9):504 (2013) PMID 23790727 PMCID PMC3769497

    Neurons within the central nervous system receive humoral and central (neurotransmitter or neuropeptide) signals that ultimately regulate ingestive behavior and metabolism. Recent advances in mouse genetics combined with neuroanatomical and electrophysiological techniques have contributed to a bette...
  7. Interview with Edward S. Boyden.

    Trends in Neurosciences 36(1):1 (2013) PMID 23397606

  8. Pain-related changes in the brain: diagnostic and therapeutic potentials.

    Trends in Neurosciences 35(10):629 (2012) PMID 22763295

    Emerging evidence suggests that chronic pain is a disease that can alter brain function. Imaging studies have demonstrated structural remapping and functional reorganization of brain circuits under various pain conditions. In parallel, preclinical models have demonstrated that chronic pain causes lo...
  9. Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression.

    Trends in Neurosciences 35(7):395 (2012) PMID 22301434

    We draw on recent discoveries in the functional neuroanatomy of the serotonergic dorsal raphe nucleus (DR) to propose such a mechanistic account. We argue that genetically produced variability in serotonin reuptake during stressor-induced raphe-raphe interactions alters the balance in the amygdala-v...
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    Trends in Neurosciences 34(1):i (2011)