Advanced search×

Trends in Neurosciences

Print ISSN
Electronic ISSN
Impact factor
Usage rank
Article count
Free count
Free percentage
PDFs via platforms
Rcgp, Sciencedirect from 1978, Proquest, CSA, Gale, and Ingenta

  1. Dopaminergic basis of salience dysregulation in psychosis.

    Trends in Neurosciences 37(2):85 (2014) PMID 24388426

    Disrupted salience processing is proposed as central in linking dysregulated dopamine function with psychotic symptoms. Several strands of evidence are now converging in support of this model. Animal studies show that midbrain dopamine neurons are activated by unexpected salient events. In psychotic...
  2. Exercise, APOE genotype, and the evolution of the human lifespan.

    Trends in Neurosciences 37(5):247 (2014) PMID 24690272 PMCID PMC4066890

    We propose the hypothesis that the evolution of increased physical activity approximately 2 million years ago served to reduce the amyloid plaque and vascular burden of APOE ɛ4, relaxing genetic constraints on aging. This multidisciplinary approach links human evolution with health and provides a co...
  3. Kaleidoscopic protein-protein interactions in the life and death of ataxin-1: new strategies against protein aggregation.

    Trends in Neurosciences 37(4):211 (2014) PMID 24636457 PMCID PMC3988977

    We discuss the paradigmatic example of ataxin-1 (Atx1), the protein responsible for neurodegenerative spinocerebellar ataxia type 1 (SCA1). This disease is part of the increasing family of pathologies caused by protein aggregation and misfolding. We discuss the importance of protein-protein interact...
  4. The human side of microglia.

    Trends in Neurosciences 37(3):125 (2014) PMID 24388427

    Despite increasing evidence of major differences between rodent and human immune and neurological function, relatively few biomedical studies are performed with human cells. This review takes the example of neuroimmunology research and the microglia cell type to illustrate the emerging differences b...
  5. Blurring the boundaries: developmental and activity-dependent determinants of neural circuits.

    Trends in Neurosciences 36(10):610 (2013) PMID 23876426 PMCID PMC3794160

    The human brain comprises approximately 100 billion neurons that express a diverse, and often subtype-specific, set of neurotransmitters and voltage-gated ion channels. Given this enormous complexity, a fundamental question is how is this achieved? The acquisition of neurotransmitter phenotype was v...
  6. Interview with Edward S. Boyden.

    Trends in Neurosciences 36(1):1 (2013) PMID 23397606

  7. Pain-related changes in the brain: diagnostic and therapeutic potentials.

    Trends in Neurosciences 35(10):629 (2012) PMID 22763295

    Emerging evidence suggests that chronic pain is a disease that can alter brain function. Imaging studies have demonstrated structural remapping and functional reorganization of brain circuits under various pain conditions. In parallel, preclinical models have demonstrated that chronic pain causes lo...
  8. Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression.

    Trends in Neurosciences 35(7):395 (2012) PMID 22301434

    We draw on recent discoveries in the functional neuroanatomy of the serotonergic dorsal raphe nucleus (DR) to propose such a mechanistic account. We argue that genetically produced variability in serotonin reuptake during stressor-induced raphe-raphe interactions alters the balance in the amygdala-v...
  9. Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder

    Trends in Neurosciences 35(1):24 (2012) PMID 21798604 PMCID PMC3206195

    We review how the neural circuitry implicated in PTSD in humans is related to the neural circuitry of fear. We then discuss how fear conditioning is a suitable model for studying the molecular mechanisms of the fear components that underlie PTSD, and the biology of fear conditioning with a particula...