Behavioural Brain Research
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Corticomotor excitability changes during mirrored or asynergistic wrist movements.
The current study used transcranial magnetic stimulation (TMS) of the right primary motor cortex (M1) during bimanual contractions to examine facilitatory and inhibitory influences on the contralateral, target extensor carpi radialis muscle (ECR) during changes in the task demands of the ipsilateral...
Abnormal functional connectivity density in Parkinson's disease
• Voxel-wise contrasts of FCD were performed between PD patients and controls. • PD showed decreased FCD mainly in the ventral stream and frontal regions....
Neural activity related to cognitive and emotional empathy in post-traumatic stress disorder
Behavioural Brain Research 282:37 (2015)We assessed the brain correlates of cognitive and emotional empathy in PTSD patients. • PTSD patients showed impairments in emotional empathy, but not in cognitive empathy. • I...
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis.
The brain-gut axis is a bidirectional communication system between the central nervous system and the gastrointestinal tract. Serotonin functions as a key neurotransmitter at both terminals of this network. Accumulating evidence points to a critical role for the gut microbiome in regulating normal f...
The role of serotonin in adult hippocampal neurogenesis.
We will take a broad view of serotonin from development to its physiological role as a neurotransmitter and its contribution to homeostasis of the adult rodent hippocampus. This chapter reflects the most significant findings on cellular and molecular mechanisms from neuroscientists in the field over...
Integrating actions into object location memory: A benefit for active versus passive reaching movements.
We tested whether learning the mapping between objects and their locations is better when actively moving the hand to these locations, to reveal the object, compared to when the hand is passively moved by a robotic manipulandum. Recall of object locations was more accurate in the active compared to...
Astrocyte morphology after ischemic and hemorrhagic experimental stroke has no influence on the different recovery patterns
Behavioural Brain Research 278:257 (2015)• Long-term astrocyte morphology has no influence on the different recovery patterns of stroke. • Ischemic and hemorrhagic stroke subtypes have similar long-term astro...
Growth restriction, leptin, and the programming of adult behavior in mice.
We have shown that isolated neonatal leptin deficiency leads to adult hyperactivity while neonatal leptin supplementation normalizes the brain morphology of GR mice. We hypothesized that neonatal leptin would prevent the development of GR-associated behavioral abnormalities. From postnatal day 4-14,...
Activation of GABAA and GABAB receptors in the lateral septum increases sucrose intake by differential stimulation of sucrose licking activi...
The present study was aimed to determine how direct injections into the lateral septum (LS) of muscimol and baclofen, GABAA and GABAB receptor agonists, respectively, affect intake of 10% sucrose and sucrose licking activity in rats. The effects of muscimol and baclofen on the 1-h intake of sucrose...
Asenapine sensitization from adolescence to adulthood and its potential molecular basis.
Asenapine is a new antipsychotic drug that induces a long-lasting behavioral sensitization in adult rats. The present study investigated the developmental impacts of adolescent asenapine treatment on drug sensitivity and on 3 proteins implicated in the action of antipsychotic drugs (i.e. brain-deriv...