Trends in Biotechnology
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Bioremediation, an environmental remediation technology for the bioeconomy.
Bioremediation differs from other industrial biotechnologies in that, although bioremediation contractors must profit from the activity, the primary driver is regulatory compliance rather than manufacturing profit. It is an attractive technology in the context of a bioeconomy but currently has limit...
Endogenous morphogens and fibrin bioscaffolds for stem cell therapeutics.
Clinical translation of mesenchymal stem cells (MSCs) is leading to optimization of procedures for ex vivo expansion. Endogenous growth factors and fibrin scaffolds can be used to support MSC expansion and transplantation. Cell growth on a fibrin scaffold mimics the 3D environment of tissue and faci...
Plant biotechnology: research behind fences.
The government of Switzerland has responded to vandalism of field experiments with genetically modified (GM) crops by establishing a protected field site. This site will enable research groups to conduct experiments without having to install and pay for security measures. This could be a model for o...
Stem cell metabolic and spectroscopic profiling.
Stem cells offer great potential for regenerative medicine because they regenerate damaged tissue by cell replacement and/or by stimulating endogenous repair mechanisms. Although stem cells are defined by their functional properties, such as the potential to proliferate, to self-renew, and to differ...
Genetic approaches to interfere with malaria transmission by vector mosquitoes.
Malaria remains one of the most devastating diseases worldwide, causing over 1 million deaths every year. The most vulnerable stages of Plasmodium development in the vector mosquito occur in the midgut lumen, making the midgut a prime target for intervention. Mosquito transgenesis and paratransgenes...
Mimicking natural bio-mineralization processes: a new tool for osteochondral scaffold development.
In recent years, the concept of regenerative medicine has gained great importance, particularly in the field of orthopaedics, in which current solutions are based mainly on the replacement of damaged tissues with devices that function only as structural replacements with limited rege...
Systems metabolic engineering for chemicals and materials.
Metabolic engineering has contributed significantly to the enhanced production of various value-added and commodity chemicals and materials from renewable resources in the past two decades. Recently, metabolic engineering has been upgraded to the systems level (thus, systems metabolic engineering) b...
Point-of-care nucleic acid testing for infectious diseases.
Nucleic acid testing for infectious diseases at the point of care is beginning to enter clinical practice in developed and developing countries; especially for applications requiring fast turnaround times, and in settings where a centralized laboratory approach faces limitations. Current systems for...
Mining high-throughput experimental data to link gene and function.
Nearly 2200 genomes that encode around 6 million proteins have now been sequenced. Around 40% of these proteins are of unknown function, even when function is loosely and minimally defined as 'belonging to a superfamily'. In addition to in silico methods, the swelling stream of high-throughput exper...
Organizing protein-DNA hybrids as nanostructures with programmed functionalities
The structural and functional information encoded in the base sequence of nucleic acids provides a means to organize hybrid protein-DNA nanostructures with pre-designed, programmed functionality. This review discusses the activation of enzyme cascades in supramolecular DNA-protein hy...