Trends in Biotechnology
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Emerging microengineered tools for functional analysis and phenotyping of blood cells
What place for polyacrylamide in proteomics?
Trends in Biotechnology 19:3 (2001)We describe the progress made towards establishing 2D-PAGE as the optimal separation tool for proteomics research....
Novel vaccine technologies.
Superglue from bacteria: unbreakable bridges for protein nanotechnology.
We suggest that an ideal interaction between proteins would be covalent, specific, require addition of only a peptide tag to the protein of interest, and form under a wide range of conditions. Here we summarize peptide tags that are able to form spontaneous amide bonds, based on harnessing reactions...
Global strategic partnerships in regenerative medicine.
We explore the co-development partnership landscape in the field of regenerative medicine, focusing on agreements involving one or more private entities. A majority of the largest biopharmaceutical companies have announced strategic partnerships with a specific regenerative medicine focus, signifyin...
Immunotherapy applications of carbon nanotubes: from design to safe applications.
Carbon nanotubes (CNTs) have the potential to overcome significant challenges related to vaccine development and immunotherapy. Central to these applications is an improved understanding of CNT interactions with the immune system. Unique properties such as high aspect ratio, flexible surface chemist...
Combating medical device fouling.
When interfaced with the biological environment, biomedical devices are prone to surface biofouling due to adhesion of microbial or thrombotic agents as a result of the foreign body response. Surface biofouling of medical devices occurs as a result of nonspecific adhesion of noxious substrates to th...
Lignocellulosic ethanol production at high-gravity: challenges and perspectives.
In brewing and ethanol-based biofuel industries, high-gravity fermentation produces 10-15% (v/v) ethanol, resulting in improved overall productivity, reduced capital cost, and reduced energy input compared to processing at normal gravity. High-gravity technology ensures a successful implementation o...
Modeling of cell sorting and rare cell capture with microfabricated biodevices.
We review different aspects of computer modeling and simulation of lab-on-a-chip type bioanalytical devices, with special emphasis on cell sorting and rare cell capture, such as circulating tumor cells (CTCs). We critically review important fundamental concepts and innovative applications in additio...
Synthetic biology at all scales.