Trends in Biotechnology
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Novel vaccine technologies.
Rapid FTIR chemical imaging: highlighting FPA detectors.
Fourier transform infrared (FTIR) spectroscopy is an established analytical technique that measures molecular bond vibrations via infrared absorption. The technique traditionally obtains single spectra from a sample, averaging the absorption information over a pre-determined aperture size. However,...
Relevance and challenges in modeling human gastric and small intestinal digestion.
Gastric and small intestinal (GSI) models are increasingly used as an alternative to in vivo assays to answer many questions raised by industry and researchers. A broad range of in vitro systems is available, from static monocompartmental to dynamic multicompartmental models. However, these models r...
Cultivation of unculturable soil bacteria.
Despite the abundance of bacterial species in soil, more than 99% of these species cannot be cultured by traditional techniques. In addition, the less than 1% of bacteria that can be cultured are not representative of the total phylogenetic diversity. Hence, identifying novel species and their new f...
Response to P.K. et al.: Bacterial laccases still have a case.
From maturity to value-added innovation: lessons from the pharmaceutical and agro-biotechnology industries
We comment on the response of these industries to the life science trajectory, in the context of maturing conventional small-molecule product pipelines and routes to market. The challenges of managing transition from maturity to new high-value-added innovation models are addressed. Furthermore, we a...
Immunochemical binding assays for detection and quantification of trace impurities in biotechnological production
New, highly sensitive, biosensor concepts make it possible to assay biomacromolecules at concentrations that previously were far below the limit of detection. The previous generation of assays used in quality control situations during biotechnological production was designed primarily for monit...
Nanofiber micelles from the self-assembly of block copolymers
Micelles are formed when block copolymers are dissolved in solvents selective for one of the blocks. In contrast to micelles formed by surfactants, block copolymer micelles are generally more robust, and this opens the door to many applications. This article examines the formation and structure...
Fungal polyketide azaphilone pigments as future natural food colorants?
We review the potential of polyketide pigments produced from chemotaxonomically selected non-toxigenic fungal strains (e.g. Penicillium and Epicoccum spp.) to serve as food colorants. We argue that the production of polyketide azaphilone pigments from such potentially safe hosts is adv...
Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development
We therefore propose structural synthetic biotechnology as a new field in biotechnology, specifically for application to the development of industrial microbial strains....