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Trends in Biotechnology

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  1. Quantum Cascade Lasers in Biomedical Infrared Imaging

    Trends in Biotechnology 33(10):557 (2015) PMID 26409774

    Technological advances, namely the integration of quantum cascade lasers (QCLs) within an infrared (IR) microscope, are enabling the development of valuable label-free biomedical-imaging tools capable of targeting and detecting salient chemical species within practical clinical timefra...
  2. DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices

    Trends in Biotechnology 33(10):586 (2015) PMID 26409777

    DNA molecules can be assembled into custom predesigned shapes via hybridization of sequence-complementary domains. The folded structures have high spatial addressability and a tremendous potential to serve as platforms and active components in a plethora of bionanotechnological applica...
  3. The ‘PHAome’

    Trends in Biotechnology 33(10):559 (2015) PMID 26409775

    Polyhydroxyalkanoates (PHAs) are a family of polyesters synthesized by bacteria. Similarly to the genome, transcriptome, and proteome (the entire array of nucleic acids and proteins present in a cell or population of cells at a given time), the PHA spectrum exhibits diverse and dynamic...
  4. Haploid Strategies for Functional Validation of Plant Genes

    Trends in Biotechnology 33(10):611 (2015) PMID 26409779

    Increasing knowledge of plant genome sequences requires the development of more reliable and efficient genetic approaches for genotype–phenotype validation. Functional identification of plant genes is generally achieved by a combination of creating genetic modifications and observing t...
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    Trends in Biotechnology 33(10):i (2015)

  6. Reductive Dehalogenases Come of Age in Biological Destruction of Organohalides

    Trends in Biotechnology 33(10):595 (2015) PMID 26409778

    Halogenated organic compounds (organohalides) are globally prevalent, recalcitrant toxic, and carcinogenic environmental pollutants. Select microorganisms encode enzymes known as reductive dehalogenases (EC that catalyze reductive dehalogenation reactions resulting in the gen...
  7. Engineering Biosynthesis Mechanisms for Diversifying Polyhydroxyalkanoates

    Trends in Biotechnology 33(10):565 (2015) PMID 26409776

    Polyhydroxyalkanoates (PHA) are a family of diverse biopolyesters synthesized by bacteria. PHA diversity, as reflected by its monomers, homopolymers, random and block copolymers, as well as functional polymers, can now be generated by engineering the three basic synthesis pathways incl...
  8. Trends Form Follows Function: New Ways to Inform and Inspire

    Trends in Biotechnology 33(10):555 (2015) PMID 26409773

  9. Materials Advances for Next-Generation Ingestible Electronic Medical Devices

    Trends in Biotechnology 33(10):575 (2015) PMID 26403162

    Electronic medical implants have collectively transformed the diagnosis and treatment of many diseases, but have many inherent limitations. Electronic implants require invasive surgeries, operate in challenging microenvironments, and are susceptible to bacterial infection and persisten...
  10. Hair coloration by gene regulation: fact or fiction

    Trends in Biotechnology (2015)

    The unravelling of hair pigmentation genetics and robust delivery systems to the hair follicle will allow the development of a new class of colouring products. The challenge will be changing hair colour from inside out by safely regulating the activity of target genes through the speci...