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Trends in Biotechnology

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  1. Microbial lipid-based lignocellulosic biorefinery: feasibility and challenges.

    Trends in Biotechnology 33(1):43 (2015) PMID 25483049

    Although single-cell oil (SCO) has been studied for decades, lipid production from lignocellulosic biomass has received substantial attention only in recent years as biofuel research moves toward producing drop-in fuels. This review gives an overview of the feasibility and challenges that exist in r...
  2. What place for polyacrylamide in proteomics?

    Trends in Biotechnology 19:3 (2001)

    We describe the progress made towards establishing 2D-PAGE as the optimal separation tool for proteomics research....
  3. Quantifying on- and off-target genome editing.

    Trends in Biotechnology 33(2):132 (2015) PMID 25595557 PMCID PMC4308725

    We still lack a comprehensive and standardized battery of assays for measuring the different genome editing outcomes created at endogenous genomic loci. Here we review the existing assays for quantifying on- and off-target genome editing and describe their utility in advancing the technology. We als...
  4. Drug target miRNAs: chances and challenges.

    Trends in Biotechnology 32(11):578 (2014) PMID 25304465

    miRNAs, short ribonucleic acid gene regulators, are increasingly popular drug targets. Traditionally 'undruggable' proteins can be targeted via their miRNA gene regulators, enabling the treatment of diseases that, at present, seem impossible to cure. However, addressing miRNAs requires innovation at...
  5. Engineering redox balance through cofactor systems.

    Trends in Biotechnology 32(6):337 (2014) PMID 24794722

    Redox balance plays an important role in the production of enzymes, pharmaceuticals, and chemicals. To meet the demands of industrial production, it is desirable that microbes maintain a maximal carbon flux towards target metabolites with no fluctuations in redox. This requires functional cofactor s...
  6. Delivery of intrahemocoelic peptides for insect pest management.

    Trends in Biotechnology 32(2):91 (2014) PMID 24331760

    The extensive use of chemical insecticides for insect pest management has resulted in insecticide resistance now being recorded in >500 species of insects and mites. Although gut-active toxins such as those derived from Bacillus thuringiensis (Bt) have been successfully used for insect pest manageme...
  7. Towards storage of cells and gametes in dry form.

    Trends in Biotechnology 31(12):688 (2013) PMID 24169600

    We review published data on cell/gamete lyophilization. Most studies have utilized the same established protocols for cryopreservation (storage in liquid nitrogen) as for cell lyophilization (dehydration of frozen samples by water sublimation). Surveying natural lyoprotectants, we suggest trehalose...
  8. Potential of proton-pumping rhodopsins: engineering photosystems into microorganisms.

    Trends in Biotechnology 31(11):633 (2013) PMID 24120288

    A wide range of proton-pumping rhodopsins (PPRs) have been discovered in recent years. Using a synthetic biology approach, PPR photosystems with different features can be easily introduced in nonphotosynthetic microbial hosts. PPRs can provide hosts with the ability to harvest light and drive the su...
  9. Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding.

    Trends in Biotechnology 31(6):375 (2013) PMID 23601269

    We discuss how the recent evolution of targeted mutagenesis and DNA insertion techniques based on tailor-made site-directed nucleases (SDNs) provides opportunities to overcome such limitations. Plant breeding companies are exploiting SDNs to develop a new generation of crops with new and improved tr...
  10. Invoking ideology in the promotion of ecological risk assessment for GM crops.

    Trends in Biotechnology 31(4):217 (2013) PMID 23375944