Trends in Biotechnology
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What place for polyacrylamide in proteomics?
Trends in Biotechnology 19:3 (2001)We describe the progress made towards establishing 2D-PAGE as the optimal separation tool for proteomics research....
Novel vaccine technologies.
Towards XNA nanotechnology: new materials from synthetic genetic polymers.
Nucleic acids display remarkable properties beyond information storage and propagation. The well-understood base pairing rules have enabled nucleic acids to be assembled into nanostructures of ever increasing complexity. Although nanostructures can be constructed using other building blocks, includi...
Lab-on-a-chip technologies for stem cell analysis.
We address recent lab-on-a-chip developments for stem cell analysis. We highlight in particular the tangible advantages of microfluidic devices to overcome most of the challenges associated with stem cell identification, expansion and differentiation, with the greatest advantage being that lab-on-a-...
Blood substitutes: why haven't we been more successful?
Persistent safety concerns have stalled the development of viable hemoglobin (Hb)-based oxygen carriers (HBOCs). HBOCs have several advantages over human blood, including availability, long-term storage, and lack of infectious risk. The basis of HBOC toxicity is poorly understood, however, several m...
Delivery of intrahemocoelic peptides for insect pest management.
The extensive use of chemical insecticides for insect pest management has resulted in insecticide resistance now being recorded in >500 species of insects and mites. Although gut-active toxins such as those derived from Bacillus thuringiensis (Bt) have been successfully used for insect pest manageme...
Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics.
General trends in synthetic bone grafting materials are shifting towards approaches that can illicit osteoinductive properties. Pharmacologics and biologics have been used in combination with calcium phosphate (CaP) ceramics, however, they have recently become the target of scrutiny over safety. The...
Laccase-mediated oxidation of small organics: bifunctional roles for versatile applications.
Laccases have been widely used in several biotechnological areas, including organic synthesis, bioremediation, and pulp/textile bleaching. In most applications, the enzymatic actions start with single-electron oxidation of small organics followed by formation of the corresponding radicals. These rad...
Soft robotics: a bioinspired evolution in robotics.
We review emerging soft-bodied robotic systems, and in particular recent developments inspired by soft-bodied animals. Incorporating soft technologies can potentially reduce the mechanical and algorithmic complexity involved in robot design. Incorporating soft technologies will also expedite the evo...
The greener synthesis of nanoparticles.
We examine 'greener' routes to nanoparticles of zerovalent metals, metal oxides, and salts with an emphasis on recent developments. Products from nature or those derived from natural products, such as extracts of various plants or parts of plants, tea, coffee, banana, simple amino acids, as well as...