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  1. Annexin 2 is a host protein binding to classical swine fever virus E2 glycoprotein and promoting viral growth in PK-15 cells

    Virus Research 201:16 (2015)

    We showed by proteomic analysis that cellular membrane protein annexin 2 (Anx2) was up-regulated in PK-15 cells following CSFV infection, but its function in CSFV replication remains unknown. In the present study we observed the interaction of Anx2 with CSFV E2 following infection of PK-15 cells by...
  2. Lack of antiviral antibody response in koalas infected with koala retroviruses (KoRV).

    Virus Research 198:30 (2015) PMID 25596496

    These results have implications for koala vaccination, as they suggest that therapeutic immunisation of animals carrying and expressing endogenous KoRV-A will not be successful. However, it remains unclear whether these animals can be immunised against KoRV-B and immunisation of uninfected koalas co...
  3. Long-term follow up of feline leukemia virus infection and characterization of viral RNA loads using molecular methods in tissues of cats wi...

    Virus Research 197:137 (2015) PMID 25553598

    We hypothesized, that differences in the infection outcome might be causally linked to the viral RNA and provirus loads within the host and these loads therefore may give additional insight into the pathogenesis of the virus. Thus, the goals of the present study were to follow-up on experimentally i...
  4. A novel inactivated gE/gI deleted pseudorabies virus (PRV) vaccine completely protects pigs from an emerged variant PRV challenge.

    Virus Research 195:57 (2015) PMID 25240533

    A highly virulent and antigenic variant of pseudorabies virus (PRV) broke out in China at the end of 2011 and caused great economic loss in the pig industry. In this study, an infectious bacterial artificial chromosome (BAC) clone containing the full-length genome of the emerged variant PRV ZJ01 str...
  5. The DEAD-box RNA helicase 5 positively regulates the replication of porcine reproductive and respiratory syndrome virus by interacting with ...

    Virus Research 195:217 (2015) PMID 25449571

    The nonstructural protein 9 (Nsp9) of porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized to play important roles in viral replication. The present study first screened that the DEAD-box RNA helicase 5 (DDX5) was a cellular protein interacting with the Nsp9 of PRRSV by a...
  6. New evidence of replication of hepatitis C virus in short-term peripheral blood mononuclear cell cultures.

    Virus Research 191:1 (2014) PMID 25087877

    We have previously developed an innovative system where HCV-RNA can be recovered during PBMC culture from HCV infected patients. Thus, the aim of this work was to use this novel approach in order to observe the evolution and replication of HCV genotype 1b in the PBMC of an HIV-HCV coinfected patient...
  7. Gallic acid-based small-molecule inhibitors of JC and BK polyomaviral infection.

    Virus Research 189:280 (2014) PMID 24960120 PMCID PMC4144447

    We screened several compounds that possessed similar chemical space as sialic acid for their ability to bind the virus. Positive hits in the assay were restricted to gallic acid based compounds that mimic the viruses known cellular glycan receptors. Pre-treatment of virions with these inhibitors red...
  8. Infection route of rice grassy stunt virus, a tenuivirus, in the body of its brown planthopper vector, Nilaparvata lugens (Hemiptera: Delpha...

    Virus Research 188:170 (2014) PMID 24768845

    Rice grassy stunt virus (RGSV), a tenuivirus, is transmitted by the brown planthopper (BPH), Nilaparvata lugens (Hemiptera, Delphacidae), in a persistent-propagative manner. In this study, immunofluorescence microscopy was used to investigate the infection route of RGSV in the internal organs of BPH...
  9. Grass carp reovirus induces apoptosis and oxidative stress in grass carp (Ctenopharyngodon idellus) kidney cell line.

    Virus Research 185:77 (2014) PMID 24680657

    Grass carp hemorrhage is an acute contagious disease caused by grass carp reovirus (GCRV). The pathogenesis of GCRV and the relationship between GCRV and the host cells remain unclear. The aim of the present study was to investigate the relations among apoptosis, intracellular oxidative stress and v...
  10. Changes in antiviral susceptibility to entry inhibitors and endocytic uptake of dengue-2 virus serially passaged in Vero or C6/36 cells.

    Virus Research 184:39 (2014) PMID 24583230

    The aim of the present study was to analyze the influence of virus origin, mammalian or mosquito cell-derived, on antiviral susceptibility of DENV-2 to entry inhibitors and the association of this effect with any alteration in the mode of entry into the cell. To this end, ten serial passages of DENV...