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Virus Research

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  1. Genome sequence heterogeneity of Lake Sinai Virus found in honey bees and Orf1/RdRP-based polymorphisms in a single host

    Virus Research (2006)

  2. Lack of antiviral antibody response in koalas infected with koala retroviruses (KoRV).

    Virus Research 198:30 (2015) PMID 25596496

    These results have implications for koala vaccination, as they suggest that therapeutic immunisation of animals carrying and expressing endogenous KoRV-A will not be successful. However, it remains unclear whether these animals can be immunised against KoRV-B and immunisation of uninfected koalas co...
  3. Protection of pigs against pandemic swine origin H1N1 influenza A virus infection by hemagglutinin- or neuraminidase-expressing attenuated p...

    Virus Research 199:20 (2015)

    • Vaccination of pigs with HA- or NA-expressing PrV induces specific serum antibodies. • Vaccination protects pigs against pandemic H1N1 SoIV challenge....
  4. Long-term follow up of feline leukemia virus infection and characterization of viral RNA loads using molecular methods in tissues of cats wi...

    Virus Research 197:137 (2015) PMID 25553598

    We hypothesized, that differences in the infection outcome might be causally linked to the viral RNA and provirus loads within the host and these loads therefore may give additional insight into the pathogenesis of the virus. Thus, the goals of the present study were to follow-up on experimentally i...
  5. Interaction between phage BFK20 helicase gp41 and its host Brevibacterium flavum primase DnaG.

    Virus Research 196:150 (2015) PMID 25463056

    We tested the interactions between phage proteins gp40, gp41, gp42, gp43 and gp44 and between these phage proteins and host replication proteins DnaZX, DnaN, Dnaδ, DnaG, DnaA, RecF, TrxC, TrxB1 and SSB using a bacterial two-hybrid system. Phage proteins gp41, gp42 and gp43 self-associated, demonstra...
  6. A novel inactivated gE/gI deleted pseudorabies virus (PRV) vaccine completely protects pigs from an emerged variant PRV challenge.

    Virus Research 195:57 (2015) PMID 25240533

    A highly virulent and antigenic variant of pseudorabies virus (PRV) broke out in China at the end of 2011 and caused great economic loss in the pig industry. In this study, an infectious bacterial artificial chromosome (BAC) clone containing the full-length genome of the emerged variant PRV ZJ01 str...
  7. The DEAD-box RNA helicase 5 positively regulates the replication of porcine reproductive and respiratory syndrome virus by interacting with ...

    Virus Research 195:217 (2015) PMID 25449571

    The nonstructural protein 9 (Nsp9) of porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized to play important roles in viral replication. The present study first screened that the DEAD-box RNA helicase 5 (DDX5) was a cellular protein interacting with the Nsp9 of PRRSV by a...
  8. Advances in targeting nucleocapsid-nucleic acid interactions in HIV-1 therapy.

    Virus Research 193:135 (2014) PMID 25026536 PMCID PMC4252855

    The continuing challenge of HIV-1 treatment resistance in patients creates a need for the development of new antiretroviral inhibitors. The HIV nucleocapsid (NC) protein is a potential therapeutic target. NC is necessary for viral RNA packaging and in the early stages of viral infection. The high le...
  9. New evidence of replication of hepatitis C virus in short-term peripheral blood mononuclear cell cultures.

    Virus Research 191:1 (2014) PMID 25087877

    We have previously developed an innovative system where HCV-RNA can be recovered during PBMC culture from HCV infected patients. Thus, the aim of this work was to use this novel approach in order to observe the evolution and replication of HCV genotype 1b in the PBMC of an HIV-HCV coinfected patient...
  10. Gallic acid-based small-molecule inhibitors of JC and BK polyomaviral infection.

    Virus Research 189:280 (2014) PMID 24960120 PMCID PMC4144447

    We screened several compounds that possessed similar chemical space as sialic acid for their ability to bind the virus. Positive hits in the assay were restricted to gallic acid based compounds that mimic the viruses known cellular glycan receptors. Pre-treatment of virions with these inhibitors red...