Diabetes Research and Clinical Practice
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Alcohol and type 1 diabetes: Patient knowledge of alcohol-induced sustained hypoglycaemia.
Tumor necrosis factor-α (TNF-α) -863C/A promoter polymorphism is associated with type 2 diabetes in Tunisian population.
Tumor necrosis factor α (TNFα) plays a key role in orchestrating the complex events involved in inflammation and immunity. Accordingly, TNF α has been implicated in a wide range of autoimmune and infectious diseases, but also in conditions such as obesity and insulin resistance. The aim of the prese...
Treatment of depression in type 2 diabetic patients: Effects on depressive symptoms, quality of life and metabolic control.
Type 2 diabetes (T2DM) almost doubles the risk of comorbid depression, with lifetime prevalence up to 29%. Recognition and treatment of depression in T2DM are important because of its association with hyperglycemia, diabetic complications and poor quality of life (QoL). However, although currently a...
Are recommended standards for diabetes care met in Central and South America? A systematic review.
We evaluated quality of diabetes care in low- and middle-income countries (LMIC) of Central and South America by documenting the ability to meet the guideline-recommended targets. We also identified barriers to achieving goals of treatment and characteristics of successful programs. We searched the...
Multilayer nanoencapsulation: A nanomedicine technology for diabetes research and management.
We have fabricated microvesicles containing a fluorescence lifetime-based glucose sensing system, with bacterial glucose-binding protein as the glucose receptor. Such sensors are suitable for impregnation in the dermis as a 'smart tattoo' type of non-invasive glucose monitoring technology. Nanoencap...
Brief report: Use of the Mini-Cog as a screening tool for cognitive impairment in diabetes in primary care.
The Mini-Cog was shown to be a brief, acceptable and practical cognitive screen for older people with diabetes when administered by a primary care nurse. It could be integrated easily into the annual diabetes review and help to identify those who may benefit from extra help with their management. Co...
Where does plasma methylglyoxal originate from?
The elevation of plasma methylglyoxal levels in diabetic humans is widely observed, but it is unknown to what extent different sources of methylglyoxal contribute to its plasma concentration. A retrospective analysis of clinical findings has been undertaken. There is controversy about the correlatio...
Trends in utilization and outcomes of bariatric surgery in obese people with and without type 2 diabetes in Spain (2001-2010).
We examine trends in the use of bariatric surgery in patients with and without type 2 diabetes between 2001 and 2010 in Spain. We identified patients who underwent bariatric surgery using national hospital discharge data. Discharges were grouped by diabetes status. Incidence of discharges due to bar...
Intraepidermal nerve fiber density and nerve conduction study parameters correlate with clinical staging of diabetic polyneuropathy.
We examined clinical features, intraepidermal nerve fiber densities (IENFD) and nerve conduction studies (NCS) and coefficient of variation of the R-R intervals (CVR-R) in 44 patients with diabetes. The patients were classified into stage I (n=20), II (n=6), III+IV (n=12), and V (n=6) according to t...
Clinical evaluation of a novel test strip technology for blood glucose monitoring: accuracy at hypoglycaemic glucose levels.
To evaluate OneTouch(®) Verio™ test strip performance at hypoglycaemic blood glucose (BG) levels (<70 mg/dL]) at seven clinical studies. Trained clinical staff performed duplicate capillary BG monitoring system tests on 700 individuals with type 1 and type 2 diabetes using blood from a...