Trends in Genetics
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The four dimensions of noncoding RNA conservation.
Evolutionary conservation is widely used as an indicator of the functional significance of newly discovered genes. Although the simple search for homology at the nucleotide or amino acid sequence level has proven to be valuable for protein-coding genes, these criteria are too narrow to describe full...
Many G-protein-coupled receptors are encoded by retrogenes.
Limbs are moving: where are they going?
We have progressed from merely watching and playing with our toys to the more exciting activity of taking them apart. This progression is mainly due to the application of a number of new techniques that allow us not only to ablate gene function, but also to induce gene activity inappropriately in ti...
Studies of populations and genetic diseases: mixing it up. Inherited disorders and their genes in different European populations, Acquafredd...
An improved method to make sequential deletion mutants for DNA sequencing.
A rationale to target the SWI/SNF complex for cancer therapy.
SWI/SNF is a multisubunit chromatin-remodeling complex that performs fundamental roles in gene regulation, cell lineage specification, and organismal development. Mutations that inactivate SWI/SNF subunits are found in nearly 20% of human cancers, which indicates that the proper functioning of this...
The role of microhomology in genomic structural variation.
Genomic structural variation, which can be defined as differences in the copy number, orientation, or location of relatively large DNA segments, is not only crucial in evolution, but also gives rise to genomic disorders. Whereas the major mechanisms that generate structural variation have been well...
How old is my gene?
We introduce a framework that can be used to compare current strategies for quantifying gene age, discuss key differences between these methods, and highlight several common problems. We argue that genes with complex evolutionary histories do not have a single well-defined age. As a result, care mus...
CENP-A and the CENP nomenclature: response to Talbert and Henikoff.
On the definition and measurement of pleiotropy.