Trends in Genetics
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From trans to cis: transcriptional regulatory networks in neocortical development
• Recent advances have facilitated the study of neural cis-regulatory elements. • This new work is reshaping our understanding of transcriptional regulatory networks....
Identification of loci that cause phenotypic variation in diverse species with the reciprocal hemizygosity test.
The reciprocal hemizygosity test is a straightforward genetic test that can positively identify genes that have evolved to contribute to a phenotypic difference between strains or between species. The test involves a comparison between hybrids that are genetically identical throughout the genome exc...
Worms, bacteria, and micronutrients: an elegant model of our diet.
Micronutrients are required in small proportions in a diet to carry out key metabolic roles for biomass and energy production. Humans receive micronutrients either directly from their diet or from gut microbiota that metabolize other nutrients. The nematode Caenorhabditis elegans and its bacterial d...
Systemic DNA damage responses: organismal adaptations to genome instability.
DNA damage checkpoints are important tumor-suppressor mechanisms that halt cell cycle progression to allow time for DNA repair, or induce senescence and apoptosis to remove damaged cells permanently. Non-cell-autonomous DNA damage responses activate the innate immune system in multiple metazoan spec...
Properties and rates of germline mutations in humans.
All genetic variation arises via new mutations; therefore, determining the rate and biases for different classes of mutation is essential for understanding the genetics of human disease and evolution. Decades of mutation rate analyses have focused on a relatively small number of loci because of tech...
Genetic challenges of flavor improvement in tomato.
We describe challenges associated with quality improvement, emphasizing tomato fruit flavor. Flavor improvement is particularly problematic because of the difficulty of assessing the phenotype as well as a lack of fundamental knowledge about the chemicals driving consumer preferences, the pathways f...
Genetic entropy and the human intellect.
Our fragile intellect. Part I.
New developments in genetics, anthropology, and neurobiology predict that a very large number of genes underlie our intellectual and emotional abilities, making these abilities genetically surprisingly fragile. Copyright © 2012 Elsevier Ltd. All rights reserved.
DNA methylation: a promising landscape for immune system-related diseases.
We describe how the DNA methylation patterns are modified during hematopoietic differentiation and what their role is in cell plasticity and immune function. An in-depth knowledge of these epigenetic mechanisms will help clarify how cell type-specific gene programs are established, and how they can...
Subcellular localization of RNA and proteins in prokaryotes.
The field of bacterial cell biology has been revolutionized in the last decade by improvements in imaging capabilities which have revealed that bacterial cells, previously thought to be non-compartmentalized, possess an intricate higher-order organization. Many bacterial proteins localize to specifi...