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Trends in Genetics

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  1. The four dimensions of noncoding RNA conservation.

    Trends in Genetics 30(4):121 (2014) PMID 24613441

    Evolutionary conservation is widely used as an indicator of the functional significance of newly discovered genes. Although the simple search for homology at the nucleotide or amino acid sequence level has proven to be valuable for protein-coding genes, these criteria are too narrow to describe full...
  2. Many G-protein-coupled receptors are encoded by retrogenes.

    Trends in Genetics 15(8):304 (1999) PMID 10431191

  3. Limbs are moving: where are they going?

    Trends in Genetics 14(6):229 (1998) PMID 9635406

    We have progressed from merely watching and playing with our toys to the more exciting activity of taking them apart. This progression is mainly due to the application of a number of new techniques that allow us not only to ablate gene function, but also to induce gene activity inappropriately in ti...
  4. Studies of populations and genetic diseases: mixing it up. Inherited disorders and their genes in different European populations, Acquafredd...

    Trends in Genetics 14(6):218 (1998) PMID 9635402

  5. An improved method to make sequential deletion mutants for DNA sequencing.

    Trends in Genetics 5(10):325 (1989) PMID 2609388

  6. A rationale to target the SWI/SNF complex for cancer therapy.

    Trends in Genetics 30(8):356 (2014) PMID 24932742 PMCID PMC4112150

    SWI/SNF is a multisubunit chromatin-remodeling complex that performs fundamental roles in gene regulation, cell lineage specification, and organismal development. Mutations that inactivate SWI/SNF subunits are found in nearly 20% of human cancers, which indicates that the proper functioning of this...
  7. The role of microhomology in genomic structural variation.

    Trends in Genetics 30(3):85 (2014) PMID 24503142

    Genomic structural variation, which can be defined as differences in the copy number, orientation, or location of relatively large DNA segments, is not only crucial in evolution, but also gives rise to genomic disorders. Whereas the major mechanisms that generate structural variation have been well...
  8. CENP-A and the CENP nomenclature: response to Talbert and Henikoff.

    Trends in Genetics 29(9):500 (2013) PMID 23910159

  9. On the definition and measurement of pleiotropy.

    Trends in Genetics 29(7):383 (2013) PMID 23727272

  10. Mining methylome databases.

    Trends in Genetics 29(2):63 (2013) PMID 23182652