Trends in Genetics
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Epigenetic modifications and long noncoding RNAs influence pancreas development and function
Trends in Genetics (1972)• Epigenetic modifications are required for the appropriate specification of β cells. • A global epigenome snapshot of the islet has been generated....
mRNA transport meets membrane traffic.
We focus on new findings obtained in fungal model systems. Important highlights are that RNA-binding proteins recognize cargo mRNA synergistically and that mRNAs are co-transported with membranous compartments such as the endoplasmic reticulum (ER) and endosomes. We further discuss a novel concept o...
The embryo as a laboratory: quantifying transcription in Drosophila.
We review some of these advances in early Drosophila development, which bring the embryo on par with its single celled counterparts. In particular, we discuss progress in methods to measure mRNA and protein distributions in fixed and living embryos, and we highlight some initial applications that le...
Roles of cilia, fluid flow, and Ca2+ signaling in breaking of left-right symmetry.
The emergence of left-right (L-R) asymmetry during embryogenesis is a classic problem in developmental biology. It is only since the 1990s, however, that substantial insight into this problem has been achieved by molecular and genetic approaches. Various genes required for L-R asymmetric morphogenes...
Genome sequencing for healthy individuals.
Genome sequencing of healthy individuals has the potential to lead to improved well-being and disease prevention, but numerous challenges remain that must be addressed to realize these benefits and, importantly, these benefits must be equitable across society. Copyright © 2013 Elsevier Ltd. All rig...
Synthetic lethality and cancer: cohesin and PARP at the replication fork.
Cohesins are mutated in a significant number of tumors of various types making them attractive targets for chemotherapeutic intervention. However, cohesins have a spectrum of cellular roles including sister chromatid cohesion, transcription, replication, and repair. Which of these roles are central...
Horizontal gene transfer and the evolution of bacterial and archaeal population structure.
We synthesize recent literature demonstrating the importance of habitat and niche in structuring horizontal gene transfer. This leads to a model of ecological speciation via gradual genetic isolation triggered by differential habitat-association of nascent populations. Further, we hypothesize that s...
Bridging the transgenerational gap with epigenetic memory.
We survey some of the most recent examples of transgenerational epigenetic inheritance in animals, ranging from Caenorhabditis elegans to humans, and describe approaches and limitations to studying this phenomenon. We also review the current body of evidence implicating chromatin modifications and R...
Our fragile intellect: response to Dr Mitchell.
The genetics of politics: discovery, challenges, and progress.
We review the 'genetics of politics', focusing on the topics that have received the most attention: attitudes, ideologies, and pro-social political traits, including voting behavior and participation. The emergence of this research has sparked a broad paradigm shift in the study of political behavio...