Trends in Genetics
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Many G-protein-coupled receptors are encoded by retrogenes.
Limbs are moving: where are they going?
We have progressed from merely watching and playing with our toys to the more exciting activity of taking them apart. This progression is mainly due to the application of a number of new techniques that allow us not only to ablate gene function, but also to induce gene activity inappropriately in ti...
Studies of populations and genetic diseases: mixing it up. Inherited disorders and their genes in different European populations, Acquafredd...
An improved method to make sequential deletion mutants for DNA sequencing.
Neocentromeres: a place for everything and everything in its place.
Centromeres are essential for chromosome inheritance and genome stability. Centromeric proteins, including the centromeric histone centromere protein A (CENP-A), define the site of centromeric chromatin and kinetochore assembly. In many organisms, centromeres are located in or near regions of repeti...
Finding the lost treasures in exome sequencing data.
Exome sequencing is one of the most cost-efficient sequencing approaches for conducting genome research on coding regions. However, significant portions of the reads obtained in exome sequencing come from outside of the designed target regions. These additional reads are generally ignored, potential...
Long noncoding RNAs in development and disease of the central nervous system.
The central nervous system (CNS) is a complex biological system composed of numerous cell types working in concert. The intricate development and functioning of this highly ordered structure depends upon exquisite spatial and temporal control of gene expression in the cells comprising the CNS. Thus,...
RNA-binding proteins in Mendelian disease.
We focus here on two recent studies that uncovered the in vivo mRNA interactomes of human cells, jointly implicating over 1100 proteins in RNA binding. Surprisingly, over 350 of these RBPs had no prior RNA binding-related annotation or domain homology. The datasets also contain many proteins that, w...
Horizontal gene transfer between bacteria and animals
Horizontal gene transfer is increasingly described between bacteria and animals. Such transfers that are vertically inherited have the potential to influence the evolution of animals. One classic example is the transfer of DNA from mitochondria and chloroplasts to the nucleus after the acquisit...