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Trends in Genetics

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  1. Buried Treasure: Evolutionary Perspectives on Microbial Iron Piracy.

    Trends in Genetics 31(11):627 (2015) PMID 26431675 PMCID PMC4639441

    Host-pathogen interactions provide valuable systems for the study of evolutionary genetics and natural selection. The sequestration of essential iron has emerged as a crucial innate defense system termed nutritional immunity, leading pathogens to evolve mechanisms of 'iron piracy' to scavenge th...
  2. Genetic Tailors: CTCF and Cohesin Shape the Genome During Evolution.

    Trends in Genetics 31(11):651 (2015) PMID 26439501

    Research into chromosome structure and organization is an old field that has seen some fascinating progress in recent years. Modern molecular methods that can describe the shape of chromosomes have begun to revolutionize our understanding of genome organization and the mechanisms that regulate g...
  3. Switching between Epigenetic States at Pericentromeric Heterochromatin.

    Trends in Genetics 31(11):661 (2015) PMID 26431676

    Pericentromeric DNA represents a large fraction of the mammalian genome that is usually assembled into heterochromatin. Recent advances have revealed that the composition of pericentromeric heterochromatin is surprisingly dynamic. Indeed, high levels of histone H3 trimethylation on lysine 9 (H3K...
  4. Dating Tips for Divergence-Time Estimation.

    Trends in Genetics 31(11):637 (2015) PMID 26439502

    The molecular clock is the only viable means of establishing an accurate timescale for Life on Earth, but it remains reliant on a capricious fossil record for calibration. 'Tip-dating' promises a conceptual advance, integrating fossil species among their living relatives using molecular/morpholo...
  5. miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants.

    Trends in Genetics 31(11):613 (2015) PMID 26453491 PMCID PMC4639415

    High-throughput sequencing of miRNAs has revealed the diversity and variability of mature and functional short noncoding RNAs, including their genomic origins, biogenesis pathways, sequence variability, and newly identified products such as miRNA-offset RNAs (moRs). Here we review known cases of...
  6. Accessing Genetic Information with Liquid Biopsies

    Trends in Genetics 31(10):564 (2015) PMID 26450339

    Recent scientific advances in understanding circulating tumor cells, cell-free DNA/RNA, and exosomes in blood have laid a solid foundation for the development of routine molecular ‘liquid biopsies’. This approach provides non-invasive access to genetic information – somatic mutations, ...
  7. Single-Cell Analysis in Cancer Genomics

    Trends in Genetics 31(10):576 (2015) PMID 26450340

    Genetic changes and environmental differences result in cellular heterogeneity among cancer cells within the same tumor, thereby complicating treatment outcomes. Recent advances in single-cell technologies have opened new avenues to characterize the intra-tumor cellular heterogeneity, ...
  8. Strategies for Imputing and Analyzing Rare Variants in Association Studies.

    Trends in Genetics 31(10):556 (2015) PMID 26450338 PMCID PMC4600126

    Rare genetic variants may be responsible for a significant amount of the uncharacterized genetic risk underlying many diseases. An efficient approach to characterizing the disease burden of rare variants may be to impute them into existing large datasets. It is well known that the ability to imp...
  9. Trends Form Follows Function: New Ways to Inform and Inspire

    Trends in Genetics 31(10):537 (2015) PMID 26450336

  10. Human Structural Variation: Mechanisms of Chromosome Rearrangements.

    Trends in Genetics 31(10):587 (2015) PMID 26209074 PMCID PMC4600437

    Chromosome structural variation (SV) is a normal part of variation in the human genome, but some classes of SV can cause neurodevelopmental disorders. Analysis of the DNA sequence at SV breakpoints can reveal mutational mechanisms and risk factors for chromosome rearrangement. Large-scale SV bre...