Trends in Genetics
- Print ISSN
- Impact factor
- Usage rank
- Article count
- Free count
- Free percentage
- PDFs via platforms
- Proquest, Sciencedirect from 1985, Gale, Rcgp, Ingenta, and CSA
Many G-protein-coupled receptors are encoded by retrogenes.
Limbs are moving: where are they going?
We have progressed from merely watching and playing with our toys to the more exciting activity of taking them apart. This progression is mainly due to the application of a number of new techniques that allow us not only to ablate gene function, but also to induce gene activity inappropriately in ti...
Studies of populations and genetic diseases: mixing it up. Inherited disorders and their genes in different European populations, Acquafredd...
An improved method to make sequential deletion mutants for DNA sequencing.
Long noncoding RNAs in development and disease of the central nervous system.
The central nervous system (CNS) is a complex biological system composed of numerous cell types working in concert. The intricate development and functioning of this highly ordered structure depends upon exquisite spatial and temporal control of gene expression in the cells comprising the CNS. Thus,...
RNA-binding proteins in Mendelian disease.
We focus here on two recent studies that uncovered the in vivo mRNA interactomes of human cells, jointly implicating over 1100 proteins in RNA binding. Surprisingly, over 350 of these RBPs had no prior RNA binding-related annotation or domain homology. The datasets also contain many proteins that, w...
MicroRegulators come of age in senescence
We review recent reports that miRNAs are key modulators of cellular senescence, and we examine their influence upon specific senescence-regulatory proteins. We discuss evidence that dysregulation of miRNA-governed senescence programs underlies age-associated diseases, including cancer....
The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects
We attempt to place these findings in the context of current and future AD genetics research. CLU, CR1 and PICALM support existing hypotheses about the amyloid, lipid, chaperone and chronic inflammatory pathways in AD pathogenesis. We discuss how these and future findings can be...
Molecular diversity through RNA editing: a balancing act
RNA editing by adenosine deamination fuels the generation of RNA and protein diversity in eukaryotes, particularly in higher organisms. This includes the recoding of translated exons, widespread editing of retrotransposon-derived repeat elements and sequence modification of microRNA (miRNA) tra...