Trends in Genetics
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Many G-protein-coupled receptors are encoded by retrogenes.
Limbs are moving: where are they going?
We have progressed from merely watching and playing with our toys to the more exciting activity of taking them apart. This progression is mainly due to the application of a number of new techniques that allow us not only to ablate gene function, but also to induce gene activity inappropriately in ti...
Studies of populations and genetic diseases: mixing it up. Inherited disorders and their genes in different European populations, Acquafredd...
An improved method to make sequential deletion mutants for DNA sequencing.
Balancing the welfare: the use of non-human primates in research.
Until now, there have been no ideal alternatives to replace non-human primates (NHPs) in biomedical research, yet the debate on whether it is appropriate to sacrifice NHPs for research never stops. With recent advances in genomics and the appearance of new technologies, the time is right to return t...
Systemic DNA damage responses: organismal adaptations to genome instability.
DNA damage checkpoints are important tumor-suppressor mechanisms that halt cell cycle progression to allow time for DNA repair, or induce senescence and apoptosis to remove damaged cells permanently. Non-cell-autonomous DNA damage responses activate the innate immune system in multiple metazoan spec...
Properties and rates of germline mutations in humans.
All genetic variation arises via new mutations; therefore, determining the rate and biases for different classes of mutation is essential for understanding the genetics of human disease and evolution. Decades of mutation rate analyses have focused on a relatively small number of loci because of tech...
Mining methylome databases.
Is 'forward' the same as 'plus'?…and other adventures in SNP allele nomenclature.
Mechanisms of transcriptional precision in animal development.
We review recently identified mechanisms of transcriptional control that ensure reliable and reproducible patterns of gene expression in natural populations of developing embryos, despite inherent fluctuations in gene regulatory processes, variations in genetic backgrounds and exposure to diverse en...