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Trends in Genetics

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  1. Epigenome Editing: State of the Art, Concepts, and Perspectives.

    Trends in Genetics 32(2):101 (2016) PMID 26732754

    Epigenome editing refers to the directed alteration of chromatin marks at specific genomic loci by using targeted EpiEffectors which comprise designed DNA recognition domains (zinc finger, TAL effector, or modified CRISPR/Cas9 complex) and catalytic domains from a chromatin-modifying enzyme. Epig...
  2. Genomics and the Contrasting Dynamics of Annual and Perennial Domestication.

    Trends in Genetics 31(12):709 (2015) PMID 26603610

    Plant domestication modifies a wild species genetically for human use. Among thousands of domesticated plants, a major distinction is the difference between annual and perennial life cycles. The domestication of perennials is expected to follow different processes than annuals, with distinct gen...
  3. Short-Circuiting Gene Regulatory Networks: Origins of B Cell Lymphoma.

    Trends in Genetics 31(12):720 (2015) PMID 26604030

    B cell lymphomas (BCLs) are characterized by widespread deregulation of gene expression compared with their normal B cell counterparts. Recent epigenomic studies defined cis-regulatory elements (REs) whose activities are altered in BCL to drive some of these pathogenic expression changes. During...
  4. Metagenome Analysis Exploiting High-Throughput Chromosome Conformation Capture (3C) Data.

    Trends in Genetics 31(12):673 (2015) PMID 26608779

    Microbial communities are complex and constitute important parts of our environment. Genomic analysis of these populations is a dynamic research area but remains limited by the difficulty in assembling full genomes of individual species. Recently, a new method for metagenome assembly/analysis ba...
  5. Drosophila Chemoreceptors: A Molecular Interface Between the Chemical World and the Brain.

    Trends in Genetics 31(12):683 (2015) PMID 26477743

    Chemoreception is essential for survival. Feeding, mating, and avoidance of predators depend on detection of sensory cues. Drosophila contains diverse families of chemoreceptors that detect odors, tastants, pheromones, and noxious stimuli, including receptors of the odor receptor (Or), gustatory...
  6. The Hierarchy of Transcriptional Activation: From Enhancer to Promoter.

    Trends in Genetics 31(12):696 (2015) PMID 26599498

    Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promot...
  7. Buried Treasure: Evolutionary Perspectives on Microbial Iron Piracy.

    Trends in Genetics 31(11):627 (2015) PMID 26431675 PMCID PMC4639441

    Host-pathogen interactions provide valuable systems for the study of evolutionary genetics and natural selection. The sequestration of essential iron has emerged as a crucial innate defense system termed nutritional immunity, leading pathogens to evolve mechanisms of 'iron piracy' to scavenge th...
  8. Genetic Tailors: CTCF and Cohesin Shape the Genome During Evolution.

    Trends in Genetics 31(11):651 (2015) PMID 26439501

    Research into chromosome structure and organization is an old field that has seen some fascinating progress in recent years. Modern molecular methods that can describe the shape of chromosomes have begun to revolutionize our understanding of genome organization and the mechanisms that regulate g...
  9. Switching between Epigenetic States at Pericentromeric Heterochromatin.

    Trends in Genetics 31(11):661 (2015) PMID 26431676

    Pericentromeric DNA represents a large fraction of the mammalian genome that is usually assembled into heterochromatin. Recent advances have revealed that the composition of pericentromeric heterochromatin is surprisingly dynamic. Indeed, high levels of histone H3 trimethylation on lysine 9 (H3K...
  10. miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants.

    Trends in Genetics 31(11):613 (2015) PMID 26453491 PMCID PMC4639415

    High-throughput sequencing of miRNAs has revealed the diversity and variability of mature and functional short noncoding RNAs, including their genomic origins, biogenesis pathways, sequence variability, and newly identified products such as miRNA-offset RNAs (moRs). Here we review known cases of...