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Trends in Genetics

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  1. Unraveling the 3D genome: genomics tools for multiscale exploration.

    Trends in Genetics 31(7):357 (2015) PMID 25887733 PMCID PMC4490074

    A decade of rapid method development has begun to yield exciting insights into the 3D architecture of the metazoan genome and the roles it may play in regulating transcription. Here we review core methods and new tools in the modern genomicist's toolbox at three length scales, ranging from singl...
  2. Where to cross? New insights into the location of meiotic crossovers.

    Trends in Genetics 31(7):393 (2015) PMID 25907025

    During meiosis, the repair of induced DNA double-strand breaks (DSBs) produces crossovers (COs). COs are essential for the proper segregation of homologous chromosomes at the first meiotic division. In addition, COs generate new combinations of genetic markers in the progeny. CO localization is ...
  3. Mitochondrial epigenetics: an overlooked layer of regulation?

    Trends in Genetics 31(7):353 (2015) PMID 25891224

    Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and...
  4. The origins of mutational robustness.

    Trends in Genetics 31(7):373 (2015) PMID 26013677

    Biological systems are resistant to genetic changes; a property known as mutational robustness, the origin of which remains an open question. In recent years, researchers have explored emergent properties of biological systems and mechanisms of genetic redundancy to reveal how mutational robustn...
  5. It's more than stamp collecting: how genome sequencing can unify biological research.

    Trends in Genetics 31(7):411 (2015) PMID 26003218 PMCID PMC4490122

    The availability of reference genome sequences, especially the human reference, has revolutionized the study of biology. However, while the genomes of some species have been fully sequenced, a wide range of biological problems still cannot be effectively studied for lack of genome sequence infor...
  6. Somatic mosaicism: implications for disease and transmission genetics.

    Trends in Genetics 31(7):382 (2015) PMID 25910407 PMCID PMC4490042

    Nearly all of the genetic material among cells within an organism is identical. However, single-nucleotide variants (SNVs), small insertions/deletions (indels), copy-number variants (CNVs), and other structural variants (SVs) continually accumulate as cells divide during development. This proces...
  7. Cell signaling and transcription factors regulating cell fate during formation of the mouse blastocyst.

    Trends in Genetics 31(7):402 (2015) PMID 25999217 PMCID PMC4490046

    The first cell fate decisions during mammalian development establish tissues essential for healthy pregnancy. The mouse has served as a valuable model for discovering pathways regulating the first cell fate decisions because of the ease with which early embryos can be recovered and the availabil...
  8. Organogenesis: variations on a theme.

    Trends in Genetics 31(6):281 (2015) PMID 25960205

  9. The alternative role of DNA methylation in splicing regulation.

    Trends in Genetics 31(5):274 (2015) PMID 25837375

    Although DNA methylation was originally thought to only affect transcription, emerging evidence shows that it also regulates alternative splicing. Exons, and especially splice sites, have higher levels of DNA methylation than flanking introns, and the splicing of about 22% of alternative exons i...
  10. The laboratory domestication of Caenorhabditis elegans.

    Trends in Genetics 31(5):224 (2015) PMID 25804345 PMCID PMC4417040

    Model organisms are of great importance to our understanding of basic biology and to making advances in biomedical research. However, the influence of laboratory cultivation on these organisms is underappreciated, and especially how that environment can affect research outcomes. Recent experimen...