Advanced search×

Trends in Genetics

Print ISSN
Impact factor
Usage rank
Article count
Free count
Free percentage
PDFs via platforms
Proquest, Sciencedirect from 1985, Gale, Rcgp, Ingenta, and CSA

  1. Organogenesis: Variations on a theme

    Trends in Genetics (2015)

  2. Evolution and population genomics of the Lyme borreliosis pathogen, Borrelia burgdorferi.

    Trends in Genetics 31(4):201 (2015) PMID 25765920 PMCID PMC4380588

    Population genomic studies have the potential to address many unresolved questions about microbial pathogens by facilitating the identification of genes underlying ecologically important traits, such as novel virulence factors and adaptations to humans or other host species. Additionally, this f...
  3. Genes from scratch--the evolutionary fate of de novo genes.

    Trends in Genetics 31(4):215 (2015) PMID 25773713 PMCID PMC4383367

    Although considered an extremely unlikely event, many genes emerge from previously noncoding genomic regions. This review covers the entire life cycle of such de novo genes. Two competing hypotheses about the process of de novo gene birth are discussed as well as the high death rate of de novo g...
  4. Concepts in solid tumor evolution.

    Trends in Genetics 31(4):208 (2015) PMID 25733351 PMCID PMC4380537

    Evolutionary mechanisms in cancer progression give tumors their individuality. Cancer evolution is different from organismal evolution, however, and we discuss where concepts from evolutionary genetics are useful or limited in facilitating an understanding of cancer. Based on these concepts we c...
  5. Putting my money where my mouth is: the Useful Genetics project.

    Trends in Genetics 31(4):195 (2015) PMID 25769728

    The personal and societal importance of genetics has increased dramatically since the 1950s, but most introductory courses still focus on teaching students how to think like geneticists, training them in Mendelian and molecular analysis. This article is a personal account of a new course with a ...
  6. Programmed translational bypassing elements in mitochondria: structure, mobility, and evolutionary origin.

    Trends in Genetics 31(4):187 (2015) PMID 25795412

    Programmed translational bypassing enables ribosomes to 'ignore' a precise mRNA interval of several dozen nucleotides. Well-characterized bypassed sequences include hop and byp elements, present in bacteriophage T4 and mitochondria of the yeast Magnusiomyces capitatus, respectively. The bypassin...
  7. Shortening trinucleotide repeats using highly specific endonucleases: a possible approach to gene therapy?

    Trends in Genetics 31(4):177 (2015) PMID 25743488

    Trinucleotide repeat expansions are involved in more than two dozen neurological and developmental disorders. Conventional therapeutic approaches aimed at regulating the expression level of affected genes, which rely on drugs, oligonucleotides, and/or transgenes, have met with only limited succe...
  8. Editorial Board and Contents
    Author(s) unavailable

    Trends in Genetics 31(4):i (2015)

  9. ITS so much more.

    Trends in Genetics 31(4):175 (2015) PMID 25765919

  10. Progress in unraveling the genetic etiology of Parkinson disease in a genomic era

    Trends in Genetics 31(3):140 (2015)

    • MPS accelerated the identification of genes for PD. • The use of MPS of gene panels has revolutionized genetic testing for PD. ...