American Journal of Physiology - Gastrointestinal and Liver Physiology
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- Nephrology, Ebscoatoz, Rupress, Ebsconet, Ama, Highwire from 1977, Endocrine, Aacr, American Physiological Society, Proquest, Aaas, Ebsco, and Csh
Intestinal fructose transport and malabsorption in humans.
We show here by analysis of past studies on healthy adults that there is a significant relationship between fructose malabsorption and fructose dose (r=0.86, p<0.001). Thus, there is a dose-dependent and limited absorption capacity even in healthy individuals. Changes in fructose malabsorption with...
Lysyl oxidase in colorectal cancer.
We discuss the rapidly expanding body of knowledge concerning lysyl oxidase in solid tumor progression, highlighting recent advancements in the field of colorectal cancer....
Cellular mechanism of mechanotranscription in colonic smooth muscle cells.
Mechanical stretch in obstruction induces expression of cyclooxygenase-2 (COX-2) in gut smooth muscle cells (SMCs). The stretch-induced COX-2 plays a critical role in motility dysfunction in obstructive bowel disorders (OBDs). The aims of the present study were to investigate the intracellular mecha...
Simultaneous detection of gastric acid and histamine release to unravel the regulation of acid secretion from the guinea pig stomach.
We utilised a novel dual sensing approach, where an iridium oxide sensor was used to monitor pH and a boron-doped diamond (BBD) electrode was used for the detection of histamine from in vitro guinea pig stomach mucosal sections. Under basal conditions, gastrin was shown to be the main regulatory com...
Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa.
Signaling through cGMP has emerged as an important regulator of tissue homeostasis in the gastrointestinal tract but the mechanism is not known. Type 2 cGMP-dependent protein kinase (PKG2) is a major cGMP effector in the gut epithelium and the present studies have tested its importan...
Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epit...
We hypothesized that PAR(2) drives COX-2 expression in intestinal epithelial cells. Treatment of Caco-2 colon cancer cells with the PAR(2)-activating peptide 2-furoyl-LIGRLO-NH(2) (2fLI) but not by its reverse-sequence PAR(2)-inactive peptide for 3 hr led to an increase in intracellular COX-2 protei...
Diabetic KK-A(y) mice are highly susceptible to oxidative hepatocellular damage induced by acetaminophen.
We investigated acetaminophen-induced liver injury in KK-A(y) mice, an animal model of metabolic syndrome. Twelve-week-old male KK-A(y) and C57Bl/6 mice were injected intraperitoneally with 300 or 600 mg/kg acetaminophen, and euthanized 6 h later. Liver histology was assessed, and hepatic expression...
Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans.
We hypothesized that muscarinic M(3)-specific but not nonspecific receptor antagonists would delay gastrointestinal and colonic transit in humans. In this parallel-group study, gastric emptying, small intestinal transit, and colonic transit were assessed by scintigraphy on days 4-6 in 72 healthy sub...
Differential adipokine response in genetically predisposed lean and obese rats during inflammation: a role in modulating experimental coliti...
Our aim was to characterize the adipokine response and the extent of colitis in diet-induced obese (DIO) rats. DIO and control, diet-resistant (DR) animals were administered either saline or trinitrobenzene sulfonic acid (TNBS) to induce colitis. Macroscopic damage scores and myeloperoxidase (MPO) a...
GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, ...
We found that a hydrolysate prepared from zein, a major corn protein (ZeinH), strongly stimulates GLP-1 secretion in enteroendocrine GLUTag cells. Stimulatory mechanisms of GLP-1 secretion induced by ZeinH were investigated in the rat small intestine under anesthesia. Blood was collected through a p...