Lasers in Surgery and Medicine

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  1. Histological and modeling study of skin thermal injury to 2.0 microm laser irradiation.

    Lasers in Surgery and Medicine 40(5):358 (2008) PMID 18563778

    Qualitative and quantitative gross histopathologic studies of skin damage were performed at 48 hours after irradiation with a 2.0 microm thulium CW laser to determine the mechanisms of laser effects in the skin under various exposure conditions. Pig skin lesions were created at, below and beyond...
  2. Fractional photothermolysis for the treatment of granuloma annulare: a case report.

    Lasers in Surgery and Medicine 40(5):319 (2008) PMID 18563743

    To date, reports on the safe and effective laser treatment of disseminated granuloma annulare (GA) are still limited. A 58-year-old Caucasian female with disseminated GA was treated with fractional photothermolysis (FP) using a 1,440-nm Nd:YAG laser. Four lesions on the patient's left upper arm ...
  3. In vivo real time monitoring of vasoconstriction and vasodilation by a combined diffuse reflectance spectroscopy and Doppler optical coherence tomography approach.

    Lasers in Surgery and Medicine 40(5):323 (2008) PMID 18563744

    A combined diffuse reflectance (DR) spectroscopy and doppler optical coherence tomography (DOCT) approach may offer a powerful means for assessment of tissue function, and potentially provide a way for earlier cancer detection through non-invasive local blood supply measurements. The goal of the...
  4. Biochemical and morphological analysis of dentin following selective caries removal with a fluorescence-controlled Er:YAG laser.

    Lasers in Surgery and Medicine 40(5):350 (2008) PMID 18563782

    We evaluated the endpoint of caries removal with a novel fluorescence-controlled Er:YAG laser by biochemical analysis of dentin collagen and electron microscopy. For the biochemical analysis 210 carious and 60 caries-free teeth were treated by a fluorescence controlled Er:YAG laser (n=240) or by...
  5. Optimization of treatment parameters for Foscan-PDT of basal cell carcinomas.

    Lasers in Surgery and Medicine 40(5):300 (2008) PMID 18563776

    Basal cell carcinomas (BCCs) are the most common form of skin cancers with high and increasing incidence rates. Photodynamic therapy (PDT) with mTHPC (Foscan) has shown to be a promising treatment alternative with good cosmetic results. The current study was aimed to determine optimal treatment ...
  6. Long-pulsed dye laser versus intense pulsed light for photodamaged skin: a randomized split-face trial with blinded response evaluation.

    Lasers in Surgery and Medicine 40(5):293 (2008) PMID 18563775

    In a randomized controlled split-face trial to evaluate efficacy and adverse effects from rejuvenation with long-pulsed dye laser (LPDL) versus intense pulsed light (IPL). Twenty female volunteers with Fitzpatrick skin types I-III, classes I-II rhytids, and symmetrical split-face photodamage wer...
  7. Protoporphyrin IX fluorescence photobleaching is a useful tool to predict the response of rat ovarian cancer following hexaminolevulinate photodynamic therapy.

    Lasers in Surgery and Medicine 40(5):332 (2008) PMID 18563777

    Accurate dosimetry was shown to be critical to achieve effective photodynamic therapy (PDT). This study aimed to assess the reliability of in vivo protoporphyrin IX (PpIX) fluorescence photobleaching as a predictive tool of the hexaminolevulinate PDT (HAL-PDT) response in a rat model of advanced...
  8. Harvesting of intraoral autogenous block grafts from the chin and ramus region: preliminary results with a variable square pulse Er:YAG laser.

    Lasers in Surgery and Medicine 40(5):312 (2008) PMID 18563779

    It was the aim of this pilot study to evaluate the feasibility, benefits and limitations of a variable square pulse (VSP) Er:YAG laser for harvesting intraoral bone grafts from either the chin or ramus region. In 12 patients (5 female, 7 male) a VSP Er:YAG laser was used to harvest bone grafts e...
  9. Non-destructive assessment of inhibition of demineralization in dental enamel irradiated by a lambda=9.3-microm CO2 laser at ablative irradiation intensities with PS-OCT.

    Lasers in Surgery and Medicine 40(5):342 (2008) PMID 18563781

    Polarization sensitive optical coherence tomography (PS-OCT) has great promise for the non-destructive assessment of the efficacy of anti-caries agents such as fluoride and thermal laser treatments on enamel surfaces. The purpose of this study was to demonstrate that PS-OCT can be used to measur...
  10. Irradiation with 780 nm diode laser attenuates inflammatory cytokines but upregulates nitric oxide in lipopolysaccharide-stimulated macrophages: implications for the prevention of aneurysm progression.

    Lasers in Surgery and Medicine 40(5):371 (2008) PMID 18563774

    Low level laser irradiation (LLLI) has been shown to reduce inflammation in a variety of clinical situations. We have shown that LLLI (780 nm) increases aortic smooth muscle cell proliferation and matrix protein secretion and modulates activity and expression of matrix metalloproteinases. Inflam...
  11. High-resolution two-photon excitation microscopy of ocular tissues in porcine eye.

    Lasers in Surgery and Medicine 40(4):247 (2008) PMID 18412222

    Two-photon excitation laser scanning microscopy (TPM), based on nonlinear optical (NLO) response under high irradiance, is currently being extensively employed for diagnostic purposes in biomedical fields and becomes more and more an interesting imaging technique in the intact bulk tissue examin...
  12. Photodynamic treatment as a novel approach in the therapy of arthritic joints.

    Lasers in Surgery and Medicine 40(4):265 (2008) PMID 18412224

    Minimal invasive local treatment of joints is a desirable option in the therapy of rheumatoid arthritis (RA). Aim of this study was to evaluate the effects of photodynamic treatment (PDT) with different doses of the photosensitizer meta-tetra(hydroxyphenyl)chlorin (m-THPC; or temoporfin) in a mu...
  13. Laser induced fragmentation of salivary stones: an in vitro comparison of two different, clinically approved laser systems.

    Lasers in Surgery and Medicine 40(4):257 (2008) PMID 18412223

    Clinical laser lithotripsy in urology promises a good fragmentation combined with a minimal risk of soft tissue damage and low medical complications. This in vitro study investigates the fragmentation of salivary stones by means of two clinically used laser systems. The effects induced by the FR...
  14. Scattered UV irradiation during VISX excimer laser keratorefractive surgery.

    Lasers in Surgery and Medicine 40(4):243 (2008) PMID 18412228

    To evaluate the potential occupational health hazards associated with scattered ultraviolet (UV) radiation during photorefractive keratectomy (PRK) using the VISX Star S3 excimer laser. The Laser Vision Center, National Naval Medical Center, Bethesda, Maryland, USA. Intraoperative radiometric me...
  15. Accidental Nd:YAG laser-induced choroidal neovascularization.

    Lasers in Surgery and Medicine 40(4):240 (2008) PMID 18412221

    There are few reports in the literature to describe the natural history of an occupational Nd:YAG laser-induced retinal injury. The chronological response to a Nd:YAG laser-induced injury was studied in a 48-year-old male using the techniques of color fundus photography, fluorescein angiography ...
  16. Transient immunoreactivity after laser tattoo removal: report of two cases.

    Lasers in Surgery and Medicine 40(4):231 (2008) PMID 18412226

    Laser tattoo removal is one of most commonly used indications for medical lasers. Professional tattoos contain a multitude of potentially immunogenic chemicals that are released or modified by laser treatment. We studied potential immunologic reactions following laser tattoo removal. Case report...
  17. In vitro resistance of articular chondrocytes to 5-Aminolevulinic acid based photodynamic therapy.

    Lasers in Surgery and Medicine 40(4):282 (2008) PMID 18412230

    5-Aminolevulinic acid based photodynamic therapy (5-ALA-PDT) has revealed promising results in the treatment of inflammatory joint diseases due to the sensitivity of inflamed synovial tissue. For 5-ALA-PDT to be safe and beneficial for intra-articular applications, resistance of chondrocytes is ...
  18. Multiphoton excitation fluorescence microscopy of 5-aminolevulinic acid induced fluorescence in experimental gliomas.

    Lasers in Surgery and Medicine 40(4):273 (2008) PMID 18412229

    The clinical usefulness of 5-ALA guided detection of tumor tissue has been demonstrated for a number of malignancies. However, current techniques of intraoperative detection of protoporphyrin IX fluorescence in situ do not offer subcellular resolution. Therefore, discrimination of non-specific 5...
  19. Rosacea treatment using the new-generation, high-energy, 595 nm, long pulse-duration pulsed-dye laser.

    Lasers in Surgery and Medicine 40(4):233 (2008) PMID 18412227

    Rosacea results from sun-induced hyper-vascularity of exposed facial skin, often accompanied by acneiform papules and pustules. The pulsed-dye laser has an unparalleled safety record and emits an ideal wavelength for treating the abnormal vessels that occur in rosacea patients. In this study we ...
  20. Pneumatic skin flattening reduces pain during laser hair reduction.

    Lasers in Surgery and Medicine 40(3):183 (2008) PMID 18366084

    Laser hair reduction targets melanin pigment within hair shafts, causing heating and an inflammatory response that sends hair into a prolonged telogen phase. Pain may be a limiting factor for patients seeking laser hair reduction. We investigate the affect of pneumatic skin flattening (PSF) as c...