Folia Medica

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  1. 25 Hydroxyvitamin D and Cytokines in Multiple Sclerosis.

    Folia Medica 57(3):200 (2016) PMID 27180346

    Clinical trials of patients with multiple sclerosis (MS) have produced inconsistent results for the profile of cytokine secretion in serum and cerebrospinal fluid in patients with multiple sclerosis during periods of relapse and remission. Epidemiological and clinical observations data reveal an...
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  2. Burden of Sleep Disturbance Due to Traffic Noise in Bulgaria.

    Folia Medica 57(3):264 (2016) PMID 27180356

    Sleep disturbance is a risk factor for somatic, psycho-social and spiritual dysfunction. It is also arguably the most deleterious effect of traffic noise pollution. Quantification of its burden is an anchor element of environmental policy making but no data are currently available for Bulgaria w...
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  3. Epidermal Growth Factor Receptor Activating Mutations in Squamous Histology of Lung Cancer Patients of Southern Bulgaria.

    Folia Medica 57(3):191 (2016) PMID 27180345

    There is only limited data on the prevalence of epidermal growth factor receptor (EGFR) activating mutations in squamous cell carcinomas and adenosquamous carcinomas of the lung in patients of the Southern Bulgarian region and the efficacy of EGFR tyrosine kinase inhibitors. Previous reports for...
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  4. Polypharmacy May Be the Cause of Acute Lithium Intoxication at the Second Day of Treatment.

    Folia Medica 57(3):261 (2016) PMID 27180355

    Lithium is frequently used as a mood stabilizer in patients with mood disorders. Lithium has a narrow therapeutic index and high toxicity. Predisposing factors for intoxication are advanced age, diet disturbances, comorbid medical conditions affecting heart, kidneys or central nervous system and...
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  5. Heart Rate Variability as a Method for Assessment of the Autonomic Nervous System and the Adaptations to Different Physiological and Pathological Conditions.

    Folia Medica 57(3):173 (2016) PMID 27180343

    The autonomic nervous system controls the smooth muscles of the internal organs, the cardiovascular system and the secretory function of the glands and plays a major role in the processes of adaptation. Heart rate variability is a non-invasive and easily applicable method for the assessment of i...
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  6. Physical Improvement and Biological Maturity of Young Athletes (11-12 Years) with Systematic Training.

    Folia Medica 57(3):223 (2016) PMID 27180349

    The aim of this study was to investigate the infl uence of systematic training in physical growth and biological maturity in prepubertal males and estimate how this affects the physical growth and skeletal maturity. 177 primary school students of the fifth and sixth grade, from schools in Alexan...
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  7. Clinical Effect of Dental Adhesive on Marginal Integrity in Class I And Class II Resin-Composite Restorations.

    Folia Medica 57(3):250 (2016) PMID 27180353

    Dental adhesives are believed to influence marginal adaptation and marginal discoloration when used under posterior resin-based composite restorations. Studies on the latest adhesive systems reveal that the group of the three-step etch-and-rinse adhesive (3-E&RA) and the one-step self-etch adhes...
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  8. Osteoporosis: Therapeutic Options.

    Folia Medica 57(3):181 (2016) PMID 27180344

    The definition of osteoporosis was originally formulated at a conference of the World Health Organization (WHO) in 1993 as 'a systemic skeletal disease characterized by decreased bone mass and altered micro-architecture of bone tissue, leading to enhanced bone fragility and risk of fractures'. O...
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  9. Circulating microRNAs as a Novel Class of Potential Diagnostic Biomarkers in Neuropsychiatric Disorders.

    Folia Medica 57(3):159 (2016) PMID 27180342

    Neuropsychiatric diseases, such as schizophrenia, bipolar disorder (BD), major depressive disorder (MDD) and autism spectrum disorder (ASD), are a huge burden on society, impairing the health of those affected, as well as their ability to learn and work. Biomarkers that reflect the dysregulation...
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  10. Evaluation of Acute Exogenous Hypoxia Impact on the Fraction of Exhaled Nitric Oxide in Healthy Males.

    Folia Medica 57(3):230 (2016) PMID 27180350

    Exogenous hypoxia increases ventilation and contracts the pulmonary vessels. Whether those factors change the values of nitric oxide in exhaled air has not yet been evaluated. To examine the effect of exogenous normobaric hypoxia on the values of the fraction of nitric oxide in exhaled breath (F...
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  11. Clinical Impact of Dental Adhesives on Postoperative Sensitivity in Class I and Class II Resin-Composite Restorations.

    Folia Medica 57(3):243 (2016) PMID 27180352

    Self-etch adhesives are believed to prevent postoperative sensitivity when used under posterior resin-based composite restorations. A hypothesis that a one-step self-etch adhesive (1-SEA) would result in less postoperative sensitivity than a three-step etch-and-rinse adhesive (3-E&RA) was tested...
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  12. Hearing Loss in Patients with Shunt-Treated Hydrocephalus.

    Folia Medica 57(3):216 (2016) PMID 27180348

    Hearing loss is a common manifestation of the long-term complications in patients with shunt treated hydrocephalus along with motor development disturbance, cognitive and visual impairment, epilepsy and endocrine disorders. The aim of the present study was to investigate the alterations of heari...
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  13. Discrepancies between Spectral Domain Optical Coherence Tomography and Fluorescein Angiography in Detecting Uveitic Macular Edema.

    Folia Medica 57(3):207 (2016) PMID 27180347

    To compare spectral-domain optical coherence tomography (SD-OCT) with fluorescein angiography (FA) in detecting macular edema in patients with uveitis and analyse discrepancies in the findings obtained by the two methods. The study included 133 eyes from 117 patients with uveitis that had SD-OCT...
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  14. The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats.

    Folia Medica 57(3):235 (2016) PMID 27180351

    The AIM of this experimental study was to evaluate the effect of the antioxidant drug "U-74389G" in a rat model of hypoxia reoxygenation (HR) using the previously established protocol. Effects of treatment were evaluated by mean red blood cell distribution width (RDW) levels. 40 rats of a mean w...
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  15. Application of Ultrasonic Devices in Management of Periodontal Lesions - Bone Response in a Case of a Tooth with Poor Treatment Prognosis.

    Folia Medica 57(3):257 (2016) PMID 27180354

    Surgical treatment of odontogenic jaw cysts may include one of the following four basic methods: enucleation, marsupialization, staged combination of marsupialization and enucleation, or enucleation with curettage. Enucleation/cystectomy, alone or combined with other procedures, is the preferred...
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  16. Economic Burden And Health-Related Quality Of Life Of Patients With Cystic Fibrosis In Bulgaria.

    Folia Medica 57(1):56 (2015) PMID 26431096

    The aim of this study was to determine the economic burden from a societal perspective and health-related quality of life (HRQOL) of patients with cystic fibrosis (CF) in Bulgaria. We conducted a cross-sectional study of 33 patients with CF and 17 caregivers from Bulgaria. Data on socio-demograp...
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  17. NLRs Challenge Impacts Tight Junction Claudins In Sertoli Cells.

    Folia Medica 57(1):43 (2015) PMID 26431094

    The present study aims to investigate the NALP3 system and its effect on claudins in Sertoli cells using a mouse adult Sertoli cell line as a model. We focus on the Sertoli cell biology looking for the possible implications for male reproductive functions. Adult Sertoli cells were transfected wi...
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  18. Autism Spectrum Disorder - A Complex Genetic Disorder.

    Folia Medica 57(1):19 (2015) PMID 26431091

    Autism spectrum disorder is an entity that reflects a scientific consensus that several previously separated disorders are actually a single spectrum disorder with different levels of symptom severity in two core domains - deficits in social communication and interaction, and restricted repetiti...
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  19. Urothelial Carcinoma Concomitant With Malakoplakia In Non-Functioning Nephrolithic Kidneys.

    Folia Medica 57(1):78 (2015) PMID 26431100

    Nephrolithic non-functioning kidney and malakoplakia are major health problems. Kidney function cannot be fulfilled and also this leads to a high risk of development of urothelial neoplasm. We report herein a case of urothelial carcinoma concomitant with malakoplakia in non-functioning nephrolit...
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  20. Sexual Fears and Avoidant Sexual Behavior in Medical Students.

    Folia Medica 57(2):144 (2015) PMID 26933786

    Sexual fears, sometimes in the form of phobias, lead to aversive or sexually avoidant behavior blocking sexual closeness and resulting in deep personal and interpersonal distress. To determine the types of sexual fears and aversive behavior in young people of reproductive age (students) and thei...
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