Folia Medica

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  1. Cognitive Impairment in Schizophrenia, Neurotransmitters and the New Atypical Antipsychotic Aripiprazole.

    Folia Medica 58(1):12 (2016) PMID 27383873

    Cognition is a group of mental processes that includes the capacity to perceive, think, learn and to study, and the capacity of the brain to analyze information and program adaptive behaviour. Although there has been an appreciable evolution in the therapy of psychoses in the last twenty-five ye...
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  2. Lack of ERG-antibody in Benign Mimickers of Prostate Cancer.

    Folia Medica 58(1):48 (2016) PMID 27383878

    Prostate carcinoma (PC) is the second most diagnosed cancer in men worldwide. Prostate tissue in needle biopsy expresses a wide variety of architectural patterns some of which are difficult to interpret. Immunohistochemical markers, such as AMACR, p63 and 34βE12 that are currently used in diagno...
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  3. A Prospectus of Tenomodulin.

    Folia Medica 58(1):19 (2016) PMID 27383874

    Tenomodulin is a type II transmembrane glycoprotein that can regulate growth of tendon. The human tenomodulin encoding gene is mapped to Х chromosome and encodes a polypeptide consisting of 317 alpha amino acids. The protein is located on the cell surface as N-glycosylated or non-N-glycosylated ...
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  4. Eyelid Reconstruction with Full Thickness Skin Grafts After Carcinoma Excision.

    Folia Medica 58(1):42 (2016) PMID 27383877

    Various techniques have been proposed for reconstruction of the eyelid anterior lamella after carcinoma excision: among these are the transposition of skin flaps, and full-thickness skin grafts or combination of these two. To present our experience in eyelid reconstruction with full-thickness sk...
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  5. Scanning Еlectron Мicroscopy of Еnamel and Dentin of Тeeth with Hypocalcified Аmelogenesis Imperfecta.

    Folia Medica 58(1):54 (2016) PMID 27383879

    The histological features of teeth with hypocalcified amelogenesis imperfecta (AI) have been poorly studied, which calls into question the effectiveness of modern adhesive techniques used in the treatment of these noncarious defects. The aim of this study was to investigate the morphological fea...
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  6. Homozygous Carrier of Prothrombin G20210A Mutation with Massive Pulmonary Embolism and His Family: Gender Differences of Susceptibility to Mutation.

    Folia Medica 58(1):64 (2016) PMID 27383881

    Prothrombin 20210 G>A mutation is the second most frequent inherited factor increasing the risk for developing venous thromboembolism (VTE). The risk for VTE in homozygous carriers of this mutation is not well studied because of their rarity are rare. We report a case of a homozygous carrier of ...
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  7. Medical and Social Aspects of Syphilis in the Balkans from the mid-19th Century to the Interwar.

    Folia Medica 58(1):5 (2016) PMID 27383872

    The current study presents some aspects of syphilis in the Balkan Peninsula from the 19th century until the Interwar. Ever since the birth of modern Balkan States (Greece, Bulgaria, Turkey and Serbia), urbanization, poverty and the frequent wars have been considered the major factors conducive t...
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  8. Diabetes Mellitus Type 2 in Hospitalized COPD Patients: Impact on Quality of Life and Lung Function.

    Folia Medica 58(1):36 (2016) PMID 27383876

    Diabetes mellitus (DM) is estimated to affect 2-37% of COPD patients, results varying widely between studies. DM may also correlate with quality of life and lung function. To examine correlations between DM and quality of life and lung function in COPD patients admitted to hospital with exacerba...
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  9. Symptomatic Os Subtibiale Associated with Chronic Pain Around the Medial Malleolus in a Young Athlete.

    Folia Medica 58(1):60 (2016) PMID 27383880

    An os subtibiale is a rare accessory bone located below or behind the medial malleolus. Herein we present a rare case of a painful os subtibiale in a young triathlete who presented with pain, redness and swelling below his left medial malleolus. Plain radiographs and three-dimensional computed t...
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  10. Immunophenotypic Modulation of the Blast Cells in Childhood Acute Lymphoblastic Leukemia Minimal Residual Disease Detection.

    Folia Medica 58(1):28 (2016) PMID 27383875

    Early clearance of leukemic cells during induction therapy of childhood acute lymphoblastic leukemia (ALL) is a basis for treatment optimization. Currently, the most widely used methods for the detection of minute residual malignant cells in the bone marrow and/or peripheral blood, minimal resid...
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  11. Economic Burden And Health-Related Quality Of Life Of Patients With Cystic Fibrosis In Bulgaria.

    Folia Medica 57(1):56 (2015) PMID 26431096

    The aim of this study was to determine the economic burden from a societal perspective and health-related quality of life (HRQOL) of patients with cystic fibrosis (CF) in Bulgaria. We conducted a cross-sectional study of 33 patients with CF and 17 caregivers from Bulgaria. Data on socio-demograp...
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  12. NLRs Challenge Impacts Tight Junction Claudins In Sertoli Cells.

    Folia Medica 57(1):43 (2015) PMID 26431094

    The present study aims to investigate the NALP3 system and its effect on claudins in Sertoli cells using a mouse adult Sertoli cell line as a model. We focus on the Sertoli cell biology looking for the possible implications for male reproductive functions. Adult Sertoli cells were transfected wi...
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  13. Autism Spectrum Disorder - A Complex Genetic Disorder.

    Folia Medica 57(1):19 (2015) PMID 26431091

    Autism spectrum disorder is an entity that reflects a scientific consensus that several previously separated disorders are actually a single spectrum disorder with different levels of symptom severity in two core domains - deficits in social communication and interaction, and restricted repetiti...
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  14. Urothelial Carcinoma Concomitant With Malakoplakia In Non-Functioning Nephrolithic Kidneys.

    Folia Medica 57(1):78 (2015) PMID 26431100

    Nephrolithic non-functioning kidney and malakoplakia are major health problems. Kidney function cannot be fulfilled and also this leads to a high risk of development of urothelial neoplasm. We report herein a case of urothelial carcinoma concomitant with malakoplakia in non-functioning nephrolit...
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  15. Sexual Fears and Avoidant Sexual Behavior in Medical Students.

    Folia Medica 57(2):144 (2015) PMID 26933786

    Sexual fears, sometimes in the form of phobias, lead to aversive or sexually avoidant behavior blocking sexual closeness and resulting in deep personal and interpersonal distress. To determine the types of sexual fears and aversive behavior in young people of reproductive age (students) and thei...
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  16. Comparison of Directigen Flu A+B with Real Time PCR in the Diagnosis of Influenza.

    Folia Medica 57(2):104 (2015) PMID 26933779

    Early diagnosis and treatment of patients with influenza is the reason why physicians need rapid high-sensitivity influenza diagnostic tests that require no complex lab equipment and can be performed and interpreted within 15 min. The Aim of this study was to compare the rapid Directigen Flu A+B...
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  17. Acute Poisoning with Dapsone and Olanzapine: Severe Methemoglobinemia and Coma with a Favourable Outcome.

    Folia Medica 57(2):122 (2015) PMID 26933782

    Dapsone is a drug commonly used in the treatment of leprosy. In Europe it is rarely prescribed, mostly for the treatment of skin diseases such as dermatitis herpetiformis. Poisoning with dapsone is rare and reports of such cases are of interest for toxicological practice. We describe the only ac...
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  18. Evaluation of Acute Exogenous Hypoxia Impact on the Fraction of Exhaled Nitric Oxide in Healthy Males.

    Folia Medica 57(3-4):230 (2015) PMID 27180350

    Exogenous hypoxia increases ventilation and contracts the pulmonary vessels. Whether those factors change the values of nitric oxide in exhaled air has not yet been evaluated. To examine the effect of exogenous normobaric hypoxia on the values of the fraction of nitric oxide in exhaled breath (F...
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  19. Selection Of The Optimal Level Of Distal Fixation For Correction Of Scheuermann's Hyperkyphosis.

    Folia Medica 57(1):29 (2015) PMID 26431092

    To analyze the efficacy of the method for selecting the distal level of fusion in treatment of thoracic hyperkyphosis in patients with Scheuermann's disease. The fusion area needs to include all the kyphotic deformity in Scheuermann patients; however, precise levels of the distal fixation have n...
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  20. Role Of Vitamin D And Adipose Tissue Hormones In Women With Reproductive Disorders.

    Folia Medica 57(1):5 (2015) PMID 26431089

    The role of vitamin D beyond that it plays in bone metabolism and calcium homeostasis has been lately quite emphasized. In this respect, vitamin D deficiency has been associated with higher risk of cardiovascular disease, metabolic syndrome, and reproductive disorders. Growing evidence has sugge...
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