Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR
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[Criteria of antibacterials choice for prophylaxis and therapy of implant-associated infections in prosthetic joints].
Prosthetic joints infection is a serious medical, social and financial problem. Significant achievements in prophylaxis of such infections are well known. In cases of primary endoprosthetics of large joints, the frequency of infection in the leading world clinics is 0.5-2%. However,...
[Remaxol hepatoprotective therapy of patients with tuberculosis and HIV infection in day unit of tuberculosis dispensary].
To improve the treatment of hepatotoxic responses to antituberculosis polychemotherapy, the impact of remaxol on the biochemical indices and parameters of the antioxidant system in patients with tuberculosis and HIV infection was estimated. The use of remaxol having cytoprotective, anticholestatic,...
[Estimation of possible use of interferon inductors for prevention of postvaccional reactions to TEOVac in animal models].
The experiments on guinea pigs showed that arbidol administered orally in a single dose 24 hours prior vaccination with TEOVAC and ridostin administered in a single dose intranasally on the 4th day after the vaccination lowered the vaccine virus accumulation in the animal organs and tissue without an...
[Clinicoimmunological monitoring of therapy in patients with associated forms of yersiniosis].
Characteristics of the clinical process and immunological profile in children with yersiniosis as a monoinfection or in association with acute intenstinal infections and virus hepatitis A are presented. The efficacy of the immunotropic therapy with cycloferon, an interferon inductor,...
[Antiinfective, antitoxic and antiparasitic effects of exogenic DNA].
[Screening of potential antibiotics, inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis--2-C-methyl-D-erythritol-2,4-cyclodi...
The recently discovered nonmevalonate pathway of isoprenoid biosynthesis is a prospective target in screening of new antibiotics. Because of the absence of the pathway in the animal cells, the specific inhibitors of the pathway will be a new class of antibiotics against many pathogen...
[Pharmacogenetics of community-acquired pneumonia].
The rate of acetylation of xenobiotics affects the course and prognosis of infectious diseases. The efficacy of antibiotic therapy of community-acquired pneumonia in RA-patients is lower than that in LA-ones. In order to ensure the best antimicrobial effect on the onset of the disease it is required...
[Ribavirin prophylaxis and therapy of experimental West Nile fever].
Investigation of the efficacy of ribavirin against the West Nile virus in standard cell cultures showed that in high concentrations it inhibited the virus reproduction (the inhibition coefficient of 100%). In the experiments on albino mice infected with the West Nile virus in a dose of 10 LD50 ribav...
[In vitro Ingavirin efficacy against adenoviral infection pathogen].
The experimental investigation of the Ingavirin antiviral effect showed that in concentrations of 200 and 100 mcg/ml it totally protected the cells from the cytopathic action of the virus, when added before the inoculation of the HeLa cell culture. After a tenfold decrease of the infective dose (up...
[Immunomodulators in the "gold standard" of the chronic viral hepatitis C therapy].
The best therapeutic effect in the treatment of patients with chronic virus hepatitis C was observed with the use of cycloferon included into the standard antiviral therapy with alpha-interferon and ribavirine. The 18-month observation revealed an increase of the biochemical and antiviral responses...