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Hereditas (Beijing)

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  1. Preparation and immunogenicity-evaluation of typhoid O-specific polysaccharides bio-conjugate vaccines.

    Hereditas (Beijing) 37(5):473 (2015) PMID 25998436

    Typhoid fever caused by Salmonella Typhi is still a major public health problem in developing countries. In this study, we constructed a genetically modified Salmonella Typhi strain expressing O-specific polysaccharides (OPS) antigen conjugated to a carrier, recombinant Pseudomonas aeruginosa ex...
  2. Genetic variance in the HIV-1 founder virus Vpr affects its ability to induce cell cycle G2 arrest and cell apoptosis.

    Hereditas (Beijing) 37(5):480 (2015) PMID 25998437

    In the event of acute infection, only a few HIV-1 viral variants can establish the initial productive clinical infection, and these viral variants are known as transmitted/founder viruses (T/F viruses). As one of the accessory proteins of HIV-1, viral protein R (Vpr) plays an important role in v...
  3. The function of PlcR in Bacillus anthracis vaccine strain A16R.

    Hereditas (Beijing) 37(5):494 (2015) PMID 25998439

    Bacillus anthracis, B. thuringiensis and B. cereus are members of the B. cereus group. They share high genetic similarity. Whereas plcR (Phospholipase C regulator) usually encodes a functional pleiotropic activator protein in B. cereus and B. thuringiensis isolates, a characteristic nonsense mut...
  4. Distinct quasispecies characteristics and positive selection within the core gene in chronic hepatitis B virus infected child and adult patients.

    Hereditas (Beijing) 37(5):465 (2015) PMID 25998435

    There are significant differences in clinical characteristics between chronic hepatitis B virus infected (CHB) child and adult patients. Viral quasispecies characteristics are associated with its pathogenic properties. For hepatitis B virus (HBV), its core region is the main immune recognition r...
  5. Adaptation strategies: how environmental fungi become fatal?

    Hereditas (Beijing) 37(5):436 (2015) PMID 25998431

    Most fungi contributing to systemic human infections are environmental pathogens, whose fatal pathogenicity is largely derived from their survival strategies developed to adapt to a plethora of natural stressors. A well-studied example of such pathogens is Cryptococcus neoformans. C. neoformans ...
  6. Identification and characterization of HIV-1 transmitted /founder viruses.

    Hereditas (Beijing) 37(5):419 (2015) PMID 25998429

    During the spread of human immunodeficiency virus type 1 (HIV-1) in the mucosa, the entire genetic diversity of the viruses is significantly reduced. The vast majority of HIV-1 mucosal infections are established by one or a few viruses and ultimately develop into systemic infections, thus the in...
  7. The effect of quorum sensing system for growth competitiveness on Shigella flexneri.

    Hereditas (Beijing) 37(5):487 (2015) PMID 25998438

    Quorum sensing (QS) regulates the onset of bacterial social responses related to cell density. Comparison between the gene sequences of all components of QS system of Escherichia coli and Shigella strains, shows that the QS system is generally lost or mutated in Shigella. Since AI-2 is produced ...
  8. Update on antimicrobial resistance in Clostridium difficile.

    Hereditas (Beijing) 37(5):458 (2015) PMID 25998434

    Clostridium difficile is the leading cause of healthcare-associated diarrhea. Since 2002, the morbidity and mortality rates of C. difficile infection have increased dramatically in Europe and North America. The emergence of C. difficile strains that are resistant to multiple antimicrobial agents...
  9. Genetic characteristics of vancomycin resistance gene cluster in Enterococcus spp.

    Hereditas (Beijing) 37(5):452 (2015) PMID 25998433

    Vancomycin resistant enterococci has become an important nosocomial pathogen since it is discovered in late 1980s. The products, encoded by vancomycin resistant gene cluster in enterococci, catalyze the synthesis of peptidoglycan precursors with low affinity with glycopeptide antibiotics includi...
  10. [In Process Citation].
    Author(s) unavailable

    Hereditas (Beijing) 37(5):409 (2015) PMID 25998427