Hereditas (Beijing)

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  1. Research progress in the genetics of hyperuricaemia and gout.

    Hereditas (Beijing) 38(4):300 (2016) PMID 27103454

    Gout is one of the most common inflammatory arthritis caused by hyperuricaemia, which is affected by both genetic factors and environmental factors. Early researches show that a few of rare monogenic mutations, such as PRPS1 and HPRT1 mutations, lead to abnormal purine anabolism and then cause h...
  2. The roles of auxin in seed dormancy and germination.

    Hereditas (Beijing) 38(4):314 (2016) PMID 27103455

    Seed dormancy and germination are attractive topics in the fields of plant molecular biology as they are key stages during plant growth and development. Seed dormancy is intricately regulated by complex networks of phytohormones and numerous key genes, combined with diverse environmental cues. T...
  3. Genome-wide identification and expression profiling of the C2H2-type zinc finger protein transcription factor family in tobacco.

    Hereditas (Beijing) 38(4):337 (2016) PMID 27103457

    C2H2 zinc finger protein transcription factor family members have important biological functions in eukaryotes. They not only bind DNA and RNA, but also interact with proteins. In this study, 118 members of the tobacco C2H2 zinc finger protein transcription factor family were identified from the...
  4. Locked nucleic acid couples with FokⅠnucleases to target and cleave hepatitis B virus’s gene in vitro.

    Hereditas (Beijing) 38(4):350 (2016) PMID 27103458

    Hepatitis B virus (HBV) is a dented double-stranded DNA virus. After infecting human hepatic cells, it forms cccDNA that replicates persistently and integrates randomly into the host’s genome during the process of reserve transcription. On average, in each cell with chronic HBV infection...
  5. RNA epigenetic modification: N(6)-methyladenosine.

    Hereditas (Beijing) 38(4):275 (2016) PMID 27103452

    N(6)-methyladenosine (m(6)A) is one of the most prevalent internal modifications in eukaryotic messenger RNA. The dynamic and reversible modification is installed by methyltransferase complex charactered three subunits: METTL3 (Methyltransferase-like protein 3), METTL14 (Methyltransferase-like p...
  6. Advances on the regulation of telomerase.

    Hereditas (Beijing) 38(4):289 (2016) PMID 27103453

    Telomerase is composed of the catalytic subunit TERT (Telomerase reverse transcriptase),RNA subunit TERC (Telomerase RNA component) and other telomerase associated proteins. These two compartments with other telomerase subunits can assemble a holoenzyme, which maintain the length of telomeres. T...
  7. Characterization of a cluster of CTCF-binding sites in a protocadherin regulatory region.

    Hereditas (Beijing) 38(4):323 (2016) PMID 27103456

    The mammalian clustered protocadherin (Pcdh) locus contains more than 50 highly-similar genes arrayed in tandem. These Pcdh genes are organized into three closely-linked clusters (Pcdhα, Pcdhβ, and Pcdhγ). The encoded PCDH proteins play critical roles in neuronal diversit...
  8. [The application of genome editing in identification of plant gene function and crop breeding].

    Hereditas (Beijing) 38(3):227 (2016) PMID 27001477

    Plant genome can be modified via current biotechnology with high specificity and excellent efficiency. Zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system are...
  9. [Advances on the profiling of 5-hydroxymethylcytosine].

    Hereditas (Beijing) 38(3):206 (2016) PMID 27001475

    5-hydroxymethylcytosine (5hmC) is a naturally existing component in mammalian genomic DNA and is regarded as the sixth DNA base. Accumulating studies have revealed the essential role of 5hmC in embryonic development, brain function and cancer research. Compared to another well-known cytosine met...
  10. [Application of CRISPR/Cas9 mediated genome editing in farm animals].

    Hereditas (Beijing) 38(3):217 (2016) PMID 27001476

    CRISPR (Clustered regularly interspaced short palindromic repeats)/Cas (CRISPR associated proteins) is an acquired immune system found in bacteria and archaea that fight against invasion of viruses or plasmids. CRISPR/Cas systems are currently classified into three main types: I, II and III, of ...
  11. [Genome-wide identification and expression analysis of the WRKY gene family in peach].

    Hereditas (Beijing) 38(3):254 (2016) PMID 27001479

    The WRKY transcription factors are one of the largest families of transcriptional regulators and play diverse regulatory roles in biotic and abiotic stresses, plant growth and development processes. In this study, the WRKY DNA-binding domain (Pfam Database number: PF03106) downloaded from Pfam p...
  12. [Identification and analysis of the NAC transcription factor family in Triticum urartu].

    Hereditas (Beijing) 38(3):243 (2016) PMID 27001478

    NAC transcription factors are one of plant-specific gene families with diverse functions, and they regulate plant development, organ formation and stress responses. Currently, the researches about NAC transcription factors mainly focus on model plants, Arabidopsis and rice, whereas such studies ...
  13. [The pathogenicity of somatic mutation to common tumors and developmental malformation of the nervous system].

    Hereditas (Beijing) 38(3):196 (2016) PMID 27001474

    In the course of development, both endogenous and exogenous factors can cause DNA damage, which resulted in somatic mutations. It is recongnized that somatic mutations are the causation of many nervous cancers, the pathogenicity of somatic mutation in developmental malformation of nervous system...
  14. [CRISPR/Cas9-based genome editing systems and the analysis of targeted genome mutations in plants].

    Hereditas (Beijing) 38(2):118 (2016) PMID 26907775

    Targeted genomic editing technologies use programmable DNA nucleases to cleave genomic target sites, thus inducing targeted mutations in the genomes. The newly prevailed clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system that consists of th...
  15. [A comparison of the knockout efficiencies of two codon-optimized Cas9 coding sequences in zebrafish embryos].

    Hereditas (Beijing) 38(2):144 (2016) PMID 26907778

    Recent years have witnessed the rapid development of the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein(CRISPR/Cas9)system. In order to realize gene knockout with high efficiency and specificity in zebrafish, several labs have synthesized distinct Cas9 cDNA s...
  16. [The connection between LINE-1 retrotransposition and human tumorigenesis].

    Hereditas (Beijing) 38(2):93 (2016) PMID 26907772

    LINE-1 is the only currently known active autonomous transposon in humans with an estimated 500 000 copies representing 17% of the human genome. LINE-1 propagates itself through a process called retrotransposition, which includes transcription and reverstranscription, to produce new DNA copies. ...
  17. [The applications of thermostable ligase chain reaction in facilitating DNA recombination].

    Hereditas (Beijing) 38(2):163 (2016) PMID 26907780

    The traditional Type Ⅱ restriction enzyme-based method is restricted by the purification steps, and therefore, cannot be applied to specific DNA assembly in chaotic system. To solve this problem, Thermostable Ligase Chain Reaction (TLCR) was introduced in the process of DNA assembly and capture....
  18. [Research progress in lampbrush chromosomes and some suggestions for their use in genetics teaching].

    Hereditas (Beijing) 38(2):170 (2016) PMID 26907781

    Lampbrush chromosomes (LBCs) are transient giant transcripts that exist at the diplotene stage of the first meiotic division in female gametocytes of almost all animals except mammals. LBCs are named for their lampbrush-like structure, however, they received the lowest research attention in stud...
  19. [Homologous recombination among bacterial genomes: the measurement and identification].

    Hereditas (Beijing) 38(2):137 (2016) PMID 26907777

    Homologous recombination is one of important sources in shaping the bacterial population diversity, which disrupts the clonal relationship among different lineages through horizontal transferring of DNA-segments. As consequence of blurring the vertical inheritance signals, the homologous recombi...
  20. [A mechanistic review of how hypoxic mircroenvironment regulates mammalian ovulation].

    Hereditas (Beijing) 38(2):109 (2016) PMID 26907774

    Mammalian ovulation is a complicated process that includes development of follicles, ovulation, formation of corpus luteum and luteolysis. The three different stages of the ovulation activity are affected by hypoxic microenvironment and hypoxia-induced factors (HIF), which play a crucial role in...