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Hereditas (Beijing)

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  1. Identification of C(2)M interacting proteins by yeast two-hybrid screening.

    Hereditas (Beijing) 37(11):1160 (2015) PMID 26582530

    The synaptonemal complex (SC) is a huge structure which assembles between the homologous chromosomes during meiotic prophase I. Drosophila germ cell-specific nucleoprotein C(2)M clustering at chromosomes can induce SC formation. To further study the molecular function and mechanism of C(2)M in m...
  2. sgRNA design for the CRISPR/Cas9 system and evaluation of its off-target effects.

    Hereditas (Beijing) 37(11):1125 (2015) PMID 26582526

    The third generation of CRISPR/Cas9-mediated genome editing technology has been successfully applied to genome modification of various species including animals, plants and microorganisms. How to improve the efficiency of CRISPR/Cas9 genome editing and reduce its off-target effects has been exte...
  3. Efficient genome editing in human pluripotent stem cells through CRISPR/Cas9.

    Hereditas (Beijing) 37(11):1167 (2015) PMID 26582531

    The RNA-guided CRISPR (clustered regularly interspaced short palindromic repeat)-associated Cas9 nuclease has offered a new platform for genome editing with high efficiency. Here, we report the use of CRISPR/Cas9 technology to target a specific genomic region in human pluripotent stem cells. We ...
  4. Effect of autophagy on liver regeneration.

    Hereditas (Beijing) 37(11):1116 (2015) PMID 26582525

    Autophagy is a lysosome-mediated degradation pathway, which plays an important role in hepatic physiological and pathological processes, in eukaryotic cells. The liver has a remarkable regenerative capacity. After acute or chronic injury, the residual hepatic cells can be activated to enter the ...
  5. Recent advances in transmissible tumors.

    Hereditas (Beijing) 37(11):1086 (2015) PMID 26582522

    Transmissible tumors are a class of tumor that can be transmitted between individuals through living cells. So far, four types of transmissible tumors including canine transmissible venereal tumor (CTVT),Tasmanian devil facial tumor disease (DFTD), soft-shell clams leukemia (SSCL), and hamsters ...
  6. The role of long non-coding RNAs in hematologic malignancies.

    Hereditas (Beijing) 37(11):1095 (2015) PMID 26582523

    With the rapid development of molecular biology technology, researchers have got much deeper understanding of the role of long non-coding RNA (lncRNA). It is not only indispensable for biological processes, but also plays an important role in human diseases especially in tumor. Previous studies ...
  7. Association study of telomere length with idiopathic male infertility.

    Hereditas (Beijing) 37(11):1137 (2015) PMID 26582527

    Telomeres are evolutionary conserved, multifunctional DNA-protein complexes located at the ends of eukaryotic chromosomes. Telomeres maintain chromosome stability and genome integrity and also play an important role in meiosis which aid in synapsis, homologous recombination, and segregation. Spe...
  8. [In Process Citation].
    Author(s) unavailable

    Hereditas (Beijing) 37(11):1075 (2015) PMID 26582521

  9. Genetic basis of immune response of lymphocyte-like cells in the mucosal immune system of Lampetra japonica.

    Hereditas (Beijing) 37(11):1149 (2015) PMID 26582529

    In recent years, the antigen recognition mechanism based on variable lymphocyte receptors (VLRs) was found in agnathan lamprey. To illuminate the genetic basis of immune response of lymphocyte-like cells in the mucosal immune system of lamprey and explore the evolutionary relationship of adaptiv...
  10. A quick and efficient method to generate hemophilia B mouse models by the CRISPR/Cas system.

    Hereditas (Beijing) 37(11):1143 (2015) PMID 26582528

    Hemophilia B, or the Christmas disease, is a common human disease caused by coagulation factor Ⅸ (FⅨ) deficiency. It is an X-linked recessive hereditary disease. Here we obtained FⅨ-knockout mouse strains with phenotype of hemophilia B with the CRISPR/Cas system efficient...