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Hereditas (Beijing)

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  1. Progress in multiplex loop-mediated isothermal amplification technology.

    Hereditas (Beijing) 37(9):899 (2015) PMID 26399529

    Loop-mediated isothermal amplification (LAMP) has been widely applied in nucleic acid diagnostics due to its high sensitivity and specificity, high speed and low requirement of equipment. In order to fully leverage these merits, achieve high efficiency and reliability in diagnostics, and expand ...
  2. Research progress in linear ubiquitin modification.

    Hereditas (Beijing) 37(9):911 (2015) PMID 26399530

    Protein ubiquitination plays vital roles in regulating various cytobiological processes such as cell cycle progression, DNA damage repair, signal transduction and membrane localization of various proteins. Moreover, proteins can be modified by single ubiquitin molecules (monoubiquitination) or u...
  3. Gene expression profiling of flag leaves at the booting stage in the japonica hybrid rice Huayou14 and its parental lines by microarray.

    Hereditas (Beijing) 37(9):932 (2015) PMID 26399533

    Gene expression profiling using microarray has contributed significantly to heterosis studies. Using the Affymetrix rice genome array, we investigated gene expression profiles in the flag leaves of the japonica hybrid rice Huayou14 and its parental cultivars Shen9A and Fan14 at the booting stage...
  4. Transcriptome screening and verification of genes related to metabolism affected by histone deacetylase inhibitors.

    Hereditas (Beijing) 37(9):918 (2015) PMID 26399531

    Histone deacetylases (HDACs) are responsible for catalyzing the deacetylation of histones, which closely related to many biological processes such as cell proliferation, differentiation and apoptosis. In recent years, HDAC inhibitors (HADCIs), with the anti-tumor potential, have been hot-spots o...
  5. Cloning and identification of splice variants of the porcine PILRA gene.

    Hereditas (Beijing) 37(9):926 (2015) PMID 26399532

    Paired immunoglobulin-like type 2 receptors (PILRs) are members of the immunoglobulin superfamily and composed of two subtypes, α and β. PILRα plays an important role in the immune response against invading pathogens, but so far there is no report on porcine PILRα. In order to analyze the potent...
  6. Bioinformatic analysis of cancer-related microRNAs and their target genes.

    Hereditas (Beijing) 37(9):855 (2015) PMID 26399525

    MicroRNAs (miRNAs) are a class of ~22 nucleotide endogenous noncoding RNAs which regulate gene expression by targeting complementary transcripts. Recent studies have found that miRNAs are closely related to tumorigenesis and can act as oncogenes or tumor suppressor genes to influence the occurre...
  7. The method of estimating bisulfite conversion rate in DNA methylation analysis.

    Hereditas (Beijing) 37(9):939 (2015) PMID 26399534

    To establish an effective method to estimate the conversion rate of bisulfite-treated genomic DNA, TaqMan qPCR assay was performed using probes and primers that are specific for bisulfite-converted or -unconverted DNA standard samples separately. Then two linear standard curves were generated by...
  8. The application of the high throughput sequencing technology in the transposable elements.

    Hereditas (Beijing) 37(9):885 (2015) PMID 26399528

    High throughput sequencing technology has dramatically improved the efficiency of DNA sequencing, and decreased the costs to a great extent. Meanwhile, this technology usually has advantages of better specificity, higher sensitivity and accuracy. Therefore, it has been applied to the research on...
  9. Research progress in physicochemical characteristics of lactoferrin and its recombinant expression systems.

    Hereditas (Beijing) 37(9):873 (2015) PMID 26399527

    Lactoferrin is an iron-binding glycoprotein with a molecular weight of about 80 kDa that belongs to the transferrin family. Due to its unique physical and chemical properties, lactoferrin has a variety of biological functions including antibacterial, antiviral, anticancer, immunomodulatory activ...
  10. Recent progresses in molecular genetics of autism spectrum disorders.

    Hereditas (Beijing) 37(9):845 (2015) PMID 26399524

    Autism spectrum disorders (ASDs) are common neurodevelopmental disorders characterized by impaired social communication, restricted and repetitive behavior or interests. Over the past 40 years, the reported prevalence for ASDs has been steadily rising world-wide. Due to the application of large-...