Hereditas (Beijing)

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  1. [Placental developmental defects in cloned mammalian animals].

    Hereditas (Beijing) 38(5):402 (2016) PMID 27232488

    The cloning technique, also called somatic cell nuclear transfer (SCNT), has been successfully established and gradually applied to various mammalian species. However, the developmental rate of SCNT mammalian embryos is very low, usually at 1% to 5%, which limits the application of SCNT. Placent...
  2. [The regulatory roles of small RNAs in phytohormone signaling pathways].

    Hereditas (Beijing) 38(5):418 (2016) PMID 27232490

    Phytohormones are signaling molecules that control plant growth and development. Recent studies revealed that non-coding small RNAs play critical roles in plant development and stress responses via phytohormone signaling pathways. In this review, we summarize the present knowledge on the microRN...
  3. [The anti-tumor mechanisms in long-lived rodents].

    Hereditas (Beijing) 38(5):411 (2016) PMID 27232489

    Rodents, including the nude mice with congenital aplasia of the thymus, cancer-resistant naked mole rat (Heterocephalus glaber) and blind mole rat (Spalax galili), are important model organisms that are widely used in biomedical research. The aging process is closely related to cancer incidence ...
  4. [High-throughput functional screening using CRISPR/Cas9 system].

    Hereditas (Beijing) 38(5):391 (2016) PMID 27232487

    High-throughput screening, a powerful tool for the discovery of functionally important genes responsible for certain phenotypes, is performed according to loss-of-function or gain-of-function strategies. RNAi technology or knockout approaches have been widely used in high throughput screening du...
  5. [Teaching design and practice of human blood type traits in genetics comprehensive laboratory course].

    Hereditas (Beijing) 38(5):461 (2016) PMID 27232494

    Comprehensive laboratory courses, which enable students to aptly apply theoretic knowledge and master experiment skills, play an important role in the present educational reform of laboratory courses. We utilized human ABO blood type as the experimental subject, and designed the experiment--"Mol...
  6. [Expression and functional analyses of the Arabidopsis QUA1 gene in light signal transduction].

    Hereditas (Beijing) 38(5):436 (2016) PMID 27232492

    Plants not only use light as an energy source for photosynthesis, but also have to monitor the light quality and quantity input to execute appropriate physiological and developmental responses, such as cell differentiation, structural and functional changes, as well as the formation of tissues a...
  7. [Research advances on medical genetics in China in 2015].

    Hereditas (Beijing) 38(5):363 (2016) PMID 27232486

    Steady progress has been achieved in the medical genetics in China in 2015, as numerous original researches were published in the world's leading journals. Chinese scientists have made significant contributions to various fields of medical genetics, such as pathogenicity of rare diseases, predis...
  8. [Establishment and identification of the near-infrared fluorescence labeled exosomes in breast cancer cell lines].

    Hereditas (Beijing) 38(5):427 (2016) PMID 27232491

    Exosomes, a population of extracellular membrane vesicles of 30-100 nm in diameter, play important roles in cell biological functions, intercellular signal transduction and especially in cancer diagnosis and therapy. To better apply exosomes in mechanistic study of breast cancer signal transduct...
  9. [Genome-wide identification, phylogenetic analysis and expression profiling of the WOX family genes in Solanum lycopersicum].

    Hereditas (Beijing) 38(5):444 (2016) PMID 27232493

    Members of the plant-specific WOX transcription factor family have been reported to play important roles in cell to cell communication as well as other physiological and developmental processes. In this study, ten members of the WOX transcription factor family were identified in Solanum lycopers...
  10. Research progress in the genetics of hyperuricaemia and gout.

    Hereditas (Beijing) 38(4):300 (2016) PMID 27103454

    Gout is one of the most common inflammatory arthritis caused by hyperuricaemia, which is affected by both genetic factors and environmental factors. Early researches show that a few of rare monogenic mutations, such as PRPS1 and HPRT1 mutations, lead to abnormal purine anabolism and then cause h...
  11. Characterization of a cluster of CTCF-binding sites in a protocadherin regulatory region.

    Hereditas (Beijing) 38(4):323 (2016) PMID 27103456

    The mammalian clustered protocadherin (Pcdh) locus contains more than 50 highly-similar genes arrayed in tandem. These Pcdh genes are organized into three closely-linked clusters (Pcdhα, Pcdhβ, and Pcdhγ). The encoded PCDH proteins play critical roles in neuronal diversity, single cell identity,...
  12. RNA epigenetic modification: N6-methyladenosine.

    Hereditas (Beijing) 38(4):275 (2016) PMID 27103452

    N(6)-methyladenosine (m(6)A) is one of the most prevalent internal modifications in eukaryotic messenger RNA. The dynamic and reversible modification is installed by methyltransferase complex charactered three subunits: METTL3 (Methyltransferase-like protein 3), METTL14 (Methyltransferase-like p...
  13. Locked nucleic acid couples with Fok I nucleases to target and cleave hepatitis B virus's gene in vitro.

    Hereditas (Beijing) 38(4):350 (2016) PMID 27103458

    Hepatitis B virus (HBV) is a dented double-stranded DNA virus. After infecting human hepatic cells, it forms cccDNA that replicates persistently and integrates randomly into the host’s genome during the process of reserve transcription. On average, in each cell with chronic HBV infection, there ...
  14. Genome-wide identification and expression profiling of the C2H2-type zinc finger protein transcription factor family in tobacco.

    Hereditas (Beijing) 38(4):337 (2016) PMID 27103457

    C2H2 zinc finger protein transcription factor family members have important biological functions in eukaryotes. They not only bind DNA and RNA, but also interact with proteins. In this study, 118 members of the tobacco C2H2 zinc finger protein transcription factor family were identified from the...
  15. The roles of auxin in seed dormancy and germination.

    Hereditas (Beijing) 38(4):314 (2016) PMID 27103455

    Seed dormancy and germination are attractive topics in the fields of plant molecular biology as they are key stages during plant growth and development. Seed dormancy is intricately regulated by complex networks of phytohormones and numerous key genes, combined with diverse environmental cues. T...
  16. Advances on the regulation of telomerase.

    Hereditas (Beijing) 38(4):289 (2016) PMID 27103453

    Telomerase is composed of the catalytic subunit TERT (Telomerase reverse transcriptase),RNA subunit TERC (Telomerase RNA component) and other telomerase associated proteins. These two compartments with other telomerase subunits can assemble a holoenzyme, which maintain the length of telomeres. T...
  17. [Genome-wide identification and expression analysis of the WRKY gene family in peach].

    Hereditas (Beijing) 38(3):254 (2016) PMID 27001479

    The WRKY transcription factors are one of the largest families of transcriptional regulators and play diverse regulatory roles in biotic and abiotic stresses, plant growth and development processes. In this study, the WRKY DNA-binding domain (Pfam Database number: PF03106) downloaded from Pfam p...
  18. [Advances on the profiling of 5-hydroxymethylcytosine].

    Hereditas (Beijing) 38(3):206 (2016) PMID 27001475

    5-hydroxymethylcytosine (5hmC) is a naturally existing component in mammalian genomic DNA and is regarded as the sixth DNA base. Accumulating studies have revealed the essential role of 5hmC in embryonic development, brain function and cancer research. Compared to another well-known cytosine met...
  19. [The application of genome editing in identification of plant gene function and crop breeding].

    Hereditas (Beijing) 38(3):227 (2016) PMID 27001477

    Plant genome can be modified via current biotechnology with high specificity and excellent efficiency. Zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system are...
  20. [Application of CRISPR/Cas9 mediated genome editing in farm animals].

    Hereditas (Beijing) 38(3):217 (2016) PMID 27001476

    CRISPR (Clustered regularly interspaced short palindromic repeats)/Cas (CRISPR associated proteins) is an acquired immune system found in bacteria and archaea that fight against invasion of viruses or plasmids. CRISPR/Cas systems are currently classified into three main types: I, II and III, of ...