Hereditas (Beijing)

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  1. The application of CRISPR/Cas9 in genome editing of filamentous fungi.

    Hereditas (Beijing) 39(5):355 (2017) PMID 28487268

    Filamentous fungi usually refer to the eukaryotic microorganisms with developed mycelia and without large fruiting bodies. Filamentous fungi not only play an important role in material cycle in nature, but also are closely related to human health, industry and agriculture. However, the difficulti...
  2. Applications of genome editing tools in precision medicine research.

    Hereditas (Beijing) 39(3):177 (2017) PMID 28420614

    The emergence of genome editing tools, such as the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system, has enabled researchers to achieve somatic and germline genomic manipulations in cell lines and model organisms. Within a couple of years, genom...
  3. The diversity of DNA fragment editing by CRISPR/Cas9 in highly homologous or repetitive sequences.

    Hereditas (Beijing) 39(4):313 (2017) PMID 28420610

    In complex genomes, there are a large number of duplicated genes in the coding regions and many more repetitive sequences in the non-coding regions. Repetitive sequences can exert great impacts on the heredity and evolution of the organisms, as well as their genome 3D architecture and transcripti...
  4. Improving gene targeting efficiency on the porcine BMP15 gene mediated by CRISPR/Cas9 by using the RGS surrogate reporter system.

    Hereditas (Beijing) 39(1):48 (2017) PMID 28115305

    As Chinese have raised most pigs and consumed most pig products in the world, improving the fertility of sow is of economic benefits to the pig industry in China. The sheep BMP15 (bone morphogenetic protein 15) gene has been identified as a major gene for controlling ovulation rates and prolific ...
  5. Establishment of porcine Xist knockout model using CRISPR/Cas9 system.

    Hereditas (Beijing) 38(12):1081 (2016) PMID 28034840

    Somatic cell nuclear transfer technique has great applications in livestock breeding, production of genetically modified animals, rescue of endangered species and treatment of human diseases. However, the currently low efficiency in animals cloning, an average of less than 5%, greatly hindered th...
  6. Application of CRISPR/Cas9 system in breeding of new antiviral plant germplasm.

    Hereditas (Beijing) 38(9):811 (2016) PMID 27644742

    With the development and improvement of CRISPR/Cas9 system in genomic editing technology, the system has been applied to the prevention and control of animal viral infectious diseases, which has made considerable achievements. It has also been applied to the study of highly efficient gene targeti...
  7. Peptidylprolyl cis/trans isomerase activity and molecular evolution of vertebrate Cyclophilin A.

    Hereditas (Beijing) 38(8):736 (2016) PMID 27531612

    Peptidylprolyl isomerases (PPIase) cyclophilin A (CypA, encoded by PPIA) is a typical member of the Cyclophilin family and is involved in protein folding/translocation, signal transduction, inflammation, immune system regulation, apoptosis and virus replication. In the present study, we investig...
  8. Research progress on mechanisms of male sterility in plants based on high-throughput RNA sequencing.

    Hereditas (Beijing) 38(8):677 (2016) PMID 27531606

    Male sterility is defined as failing to produce functional pollen during stamen development in plants, and it plays a crucial role in plant reproductive research and hybrid seed production in utilization of crop heterosis. High throughput RNA sequencing (RNA-seq) has been used widely in the stud...
  9. Muted protein is involved in the targeting of CD63 to large dense-core vesicles of chromaffin cells.

    Hereditas (Beijing) 38(8):718 (2016) PMID 27531610

    Large dense-core vesicles (LDCVs) are characterized as a class of lysosome-related organelles (LROs), which undergo regulated release and play important roles in development, metabolism and homeostasis. The Muted protein is a subunit of the biogenesis of lysosome-related organelles complex-1 (BL...
  10. Characteristic and inheritance analysis of targeted mutagenesis mediated by genome editing in rice.

    Hereditas (Beijing) 38(8):746 (2016) PMID 27531613

    The transcription activator-like effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) systems are two current genome editing technologies. Here, we compare and analyze the characteristics of the targeted mutations medi...
  11. Rapid construction of multiple sgRNA vectors and knockout of the Arabidopsis IAA2 gene using the CRISPR/Cas9 genomic editing technology.

    Hereditas (Beijing) 38(8):756 (2016) PMID 27531614

    IAA2 is a member of the Aux/IAA auxin responsive gene family in Arabidopsis thaliana. No iaa2 mutant has been reported until now, thus hindering its further mechanistic investigations. The normal genomic editing technology of CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats...
  12. Research progress of plant population genomics based on high-throughput sequencing.

    Hereditas (Beijing) 38(8):688 (2016) PMID 27531607

    Population genomics, a new paradigm for population genetics, combine the concepts and techniques of genomics with the theoretical system of population genetics and improve our understanding of microevolution through identification of site-specific effect and genome-wide effects using genome-wide...
  13. Advances on plant miR169/NF-YA regulation modules.

    Hereditas (Beijing) 38(8):700 (2016) PMID 27531608

    Plant microRNAs (miRNAs) are a class of small non-coding RNAs which target and regulate the expression of genes involved in several growth, development, and metabolism processes. The miR169 family is the largest and most conserved miRNA family in plants. Recent researches have shown involvement ...
  14. Application of computer simulators in population genetics.

    Hereditas (Beijing) 38(8):707 (2016) PMID 27531609

    The genomes of more and more organisms have been sequenced due to the advances in next-generation sequencing technologies. As a powerful tool, computer simulators play a critical role in studying the genome-wide DNA polymorphism pattern. Simulations can be performed both forwards-in-time and bac...
  15. Functional analysis of the upstream regulatory region of chicken miR-17-92 cluster.

    Hereditas (Beijing) 38(8):724 (2016) PMID 27531611

    miR-17-92 cluster plays important roles in cell proliferation, differentiation, apoptosis, animal development and tumorigenesis. The transcriptional regulation of miR-17-92 cluster has been extensively studied in mammals, but not in birds. To date, avian miR-17-92 cluster genomic structure has n...
  16. [Teaching design and practice of human blood type traits in genetics comprehensive laboratory course].

    Hereditas (Beijing) 38(5):461 (2016) PMID 27232494

    Comprehensive laboratory courses, which enable students to aptly apply theoretic knowledge and master experiment skills, play an important role in the present educational reform of laboratory courses. We utilized human ABO blood type as the experimental subject, and designed the experiment--"Mol...
  17. [The anti-tumor mechanisms in long-lived rodents].

    Hereditas (Beijing) 38(5):411 (2016) PMID 27232489

    Rodents, including the nude mice with congenital aplasia of the thymus, cancer-resistant naked mole rat (Heterocephalus glaber) and blind mole rat (Spalax galili), are important model organisms that are widely used in biomedical research. The aging process is closely related to cancer incidence ...
  18. [Placental developmental defects in cloned mammalian animals].

    Hereditas (Beijing) 38(5):402 (2016) PMID 27232488

    The cloning technique, also called somatic cell nuclear transfer (SCNT), has been successfully established and gradually applied to various mammalian species. However, the developmental rate of SCNT mammalian embryos is very low, usually at 1% to 5%, which limits the application of SCNT. Placent...
  19. [Expression and functional analyses of the Arabidopsis QUA1 gene in light signal transduction].

    Hereditas (Beijing) 38(5):436 (2016) PMID 27232492

    Plants not only use light as an energy source for photosynthesis, but also have to monitor the light quality and quantity input to execute appropriate physiological and developmental responses, such as cell differentiation, structural and functional changes, as well as the formation of tissues a...
  20. [Genome-wide identification, phylogenetic analysis and expression profiling of the WOX family genes in Solanum lycopersicum].

    Hereditas (Beijing) 38(5):444 (2016) PMID 27232493

    Members of the plant-specific WOX transcription factor family have been reported to play important roles in cell to cell communication as well as other physiological and developmental processes. In this study, ten members of the WOX transcription factor family were identified in Solanum lycopers...