Natural Product Reports
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Bioactive natural products derived from the Central African flora against neglected tropical diseases and HIV.
Covering: 1971 to 2013This review discusses the medicinal potential of bioactive metabolites isolated from medicinal plants in Central Africa for the treatment of neglected tropical diseases and HIV. A correlation is established between the biological activities of the isolated compounds and the use...
Recent advances in the heterologous expression of microbial natural product biosynthetic pathways.
Covering: up to 2013The heterologous expression of microbial natural product biosynthetic pathways coupled with advanced DNA engineering enables optimisation of product yields, functional elucidation of cryptic gene clusters, and generation of novel derivatives. This review summarises the recent adv...
Using NMR to identify and characterize natural products.
Over the past 28 years there have been several thousand publications describing the use of 2D NMR to identify and characterize natural products. During this time period, the amount of sample needed for this purpose has decreased from the 20-50 mg range to under 1 mg. This has been due to both improv...
Investigations of the marine flora and fauna of the Fiji Islands.
Over the past 30 years, approximately 140 papers have been published on marine natural products chemistry and related research from the Fiji Islands. These came about from studies starting in the early 1980s by the research groups of Crews at the University of California Santa Cruz, Ireland at the U...
This review covers the isolation, structural determination, synthesis and chemical and microbiological transformations of natural sesquiterpenoids. The literature is reviewed, and 435 references are cited.
Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery.
Structural biology has provided significant insights into the complex chemistry and macromolecular organization of nonribosomal peptide synthetases. In addition, novel pathways are continually described, expanding the knowledge of known biosynthetic chemistry.
Structural biology of plant sulfur metabolism: from assimilation to biosynthesis.
Covering: 1966 to 2012Sulfur is an essential element that must be assimilated by all organisms; however, the metabolic pathways for this task vary significantly, even among individual genera of bacteria, and especially so among eukaryotes. While all organisms require sulfurous amino...