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- Ovid from 2005, CSA, Wiley from 1984, Proquest, and Gale
Did the fire ant supergene evolve selfishly or socially?
The genetic basis for animal social organization is poorly understood. Fire ants provide one of the rare cases where variation in social organization has been demonstrated to be under genetic control, which amazingly, segregates as a single Mendelian locus. A recent genetic, genomic, and cytological...
Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.
We first discuss the general characteristics of insulator elements and their associated protein factors. A growing collection of insulator proteins have been identified including a family of proteins whose expression is developmentally regulated. We next consider several unexpected discoveries that...
3'UTRs take a long shot in the brain.
We review recent progress in the characterization of mRNA 3'UTRs and discuss their implications in the understanding of 3'UTR-mediated gene regulation. © 2014 WILEY Periodicals, Inc....
Horizontal gene acquisitions by eukaryotes as drivers of adaptive evolution.
We raise the hypothesis that horizontally acquired genes may have contributed more to adaptive evolution of eukaryotes than previously assumed. Current candidate sets of horizontally acquired eukaryotic genes may just be the tip of an iceberg. We have recently shown that adaptation of the thermoacid...
Exploiting CRISPR/Cas systems for biotechnology.
We review the development of Cas9 as an important tool to not only edit the genomes of a number of different prokaryotic and eukaryotic species, but also as an efficient system for site-specific transcriptional repression or activation. Additionally, a specific Cas9 protein has been observed to targ...
Major depressive disorder: a loss of circadian synchrony?
Circadian rhythms in the sleep/wake cycle, along with a range of physiological measures, are severely disrupted in individuals with major depressive disorder (MDD). Moreover, several central circadian genes have been implicated as potential genetic factors underlying the illness through candidate ge...
Retroviruses facilitate the rapid evolution of the mammalian placenta.
I propose that ERV-mediated regulatory evolution was, and continues to be, an important mechanism underlying the evolution of placental development. Many recent studies have focused on the co-option of ERV-derived genes for specific functional adaptations in the placenta. However, the co-option of E...
Phenotypes from ancient DNA: approaches, insights and prospects.
The great majority of phenotypic characteristics are complex traits, complicating the identification of the genes underlying their expression. However, both methodological and theoretical progress in genome-wide association studies have resulted in a much better understanding of the underlying genet...
BiotecVisions 2013, June (pages A1-A8).
Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.
We found that lipid mixing often occurs seconds prior to content mixing, or without any content mixing at all, during a 50-seconds observation period, for Ca(2+) -triggered fusion with SNAREs, full-length synaptotagmin-1, and complexin. Our results illustrate the caveats of commonly used bulk lipid-...