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- Ovid from 2005, CSA, Wiley from 1984, Proquest, and Gale
Cracking the ANP32 whips: Important functions, unequal requirement, and hints at disease implications.
We present a concept of the ANP32s as having a whip-like structure. We also present hypotheses that ANP32C and other intronless sequences should not currently be considered bona fide family members, that their disparate necessity in development may be due to compensatory mechanisms, that their contr...
Defining 'medical necessity' in an age of personalised medicine: A view from Canada.
The concept of medical necessity plays a central role in many healthcare systems, including Canada's, by helping determine which healthcare services will receive funding. Despite its significance in health policy frameworks, medical necessity has proven to be notoriously difficult to define and oper...
BioEssays - Next Issue.
MicroRNA binding sites in the coding region of mRNAs: extending the repertoire of post-transcriptional gene regulation.
We propose that these domain-dependent effects serve to diversify the functional repertoire of post-transcriptional gene expression control. Possible regulatory benefits may include tuning the time-scale and magnitude of post-transcriptional regulation, regulating protein abundance depending on or i...
BioEssays - Next Issue.
Integrating DNA methylation dynamics into a framework for understanding epigenetic codes.
We discuss paradigms associated with the various components of DNA methylation/demethylation and recent advances in the understanding of its dynamic regulation in the genome, integrating these mechanisms into a framework to explain how DNA methylation could contribute to epigenetic codes. © 2014 WI...
Connecting the dots between G proteins, G protein coupled receptors, and neuronal nicotinic acetylcholine receptors (Comment on DOI 10.1002/...
Phenotypes from ancient DNA: approaches, insights and prospects.
The great majority of phenotypic characteristics are complex traits, complicating the identification of the genes underlying their expression. However, both methodological and theoretical progress in genome-wide association studies have resulted in a much better understanding of the underlying genet...
BiotecVisions 2013, June (pages A1-A8).
Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.
We found that lipid mixing often occurs seconds prior to content mixing, or without any content mixing at all, during a 50-seconds observation period, for Ca(2+) -triggered fusion with SNAREs, full-length synaptotagmin-1, and complexin. Our results illustrate the caveats of commonly used bulk lipid-...