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- Ovid from 2005, CSA, Wiley from 1984, Proquest, and Gale
MicroRNA binding sites in the coding region of mRNAs: extending the repertoire of post-transcriptional gene regulation.
We propose that these domain-dependent effects serve to diversify the functional repertoire of post-transcriptional gene expression control. Possible regulatory benefits may include tuning the time-scale and magnitude of post-transcriptional regulation, regulating protein abundance depending on or i...
BioEssays - Next Issue.
Integrating DNA methylation dynamics into a framework for understanding epigenetic codes.
We discuss paradigms associated with the various components of DNA methylation/demethylation and recent advances in the understanding of its dynamic regulation in the genome, integrating these mechanisms into a framework to explain how DNA methylation could contribute to epigenetic codes. © 2014 WI...
Phenotypes from ancient DNA: approaches, insights and prospects.
The great majority of phenotypic characteristics are complex traits, complicating the identification of the genes underlying their expression. However, both methodological and theoretical progress in genome-wide association studies have resulted in a much better understanding of the underlying genet...
BiotecVisions 2013, June (pages A1-A8).
Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.
We found that lipid mixing often occurs seconds prior to content mixing, or without any content mixing at all, during a 50-seconds observation period, for Ca(2+) -triggered fusion with SNAREs, full-length synaptotagmin-1, and complexin. Our results illustrate the caveats of commonly used bulk lipid-...
Back to the beginning: The initiation of cancer.
The roots of cancer: stem cells and the basis for tumor heterogeneity.
Recent studies of prostate cancer and other tumor types have revealed significant support, as well as unexpected complexities, for the application of concepts from normal stem cell biology to cancer. In particular, the cell of origin and cancer stem cell models have been proposed to explain the hete...
Blood stem cell products: toward sustainable benchmarks for clinical translation.
Robust ex vivo expansion of umbilical cord blood (UCB) derived hematopoietic stem and progenitor cells (HSPCs) should enable the widespread use of UCB as a source of cells to treat hematologic and immune diseases. Novel approaches for HSPC expansion have recently been developed, setting the stage fo...
Mitochondria, maternal inheritance, and asymmetric fitness: Why males die younger.
We discuss this new work and identify some areas of future research that might now be encouraged to explore what may be the underpinning cause of the strong sexual dimorphism in aging. Editor's suggested further reading in BioEssays: Mitonuclear match: Optimizing fitness and fertility over generatio...