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Ovid from 2005, CSA, Wiley from 1984, Proquest, and Gale

  1. Exaptive origins of regulated mRNA decay in eukaryotes.

    Bioessays (2016) PMID 27438915

    Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. We propose that two such mechanisms, nonsense-mediated decay (NMD) and motif-specific transcript...
  2. Vitamin D discovery outpaces FDA decision making.

    Bioessays 30(2):173 (2008) PMID 18200565

    The US FDA currently encourages the addition of vitamin D to milk and cereals, with the aim of reducing rickets in children and osteoporosis in adults. However, vitamin D not only regulates the expression of genes associated with calcium homeostasis, but also genes associated with cancers, autoi...
  3. cAMP-dependent protein kinase A and the dynamics of epithelial cell surface domains: moving membranes to keep in shape.

    Bioessays 30(2):146 (2008) PMID 18200529

    Cyclic adenosine monophosphate (cAMP) and cAMP-dependent protein kinase A (PKA) are evolutionary conserved molecules with a well-established position in the complex network of signal transduction pathways. cAMP/PKA-mediated signaling pathways are implicated in many biological processes that coop...
  4. The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes?

    Bioessays 30(2):156 (2008) PMID 18197594

    Obesity and type 2 diabetes arise from a set of complex gene-environment interactions. Explanations for the heritability of these syndromes and the environmental contribution to disease susceptibility are addressed by the "thrifty genotype" and the "thrifty phenotype" hypotheses. Here, the merit...
  5. Paleogenomics in vertebrates, or the recovery of lost genomes from the mist of time.

    Bioessays 30(2):122 (2008) PMID 18200550

    Knowledge of the structure of ancestral genomes provides the basis of a new framework to better represent and interpret results from genomic and evolutionary studies. Because these ancestors lived tens of hundreds of million years ago, this knowledge will inevitably take the form of abstract rep...
  6. How does noncoding transcription regulate Hox genes?

    Bioessays 30(2):110 (2008) PMID 18200528

    Noncoding RNA has arrived at centre stage in recent years with the discovery of "hidden transcriptomes" in many higher organisms. Over two decades ago, noncoding transcripts were discovered in Drosophila Hox complexes, but their function has remained elusive. Recent studies1-3 have examined the ...
  7. Neurogenesis in adult CNS: from denial to opportunities and challenges for therapy.

    Bioessays 30(2):135 (2008) PMID 18200551

    The discovery of neurogenesis and neural stem cells (NSC) in the adult CNS has overturned a long-standing and deep-routed "dogma" in neuroscience, established at the beginning of the 20(th) century. This dogma lasted for almost 90 years and died hard when NSC were finally isolated from the adult...
  8. Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging.

    Bioessays 30(2):102 (2008) PMID 18200563

    Critical cellular functions, including stem cell maintenance, fate determination, and cellular behavior, are governed by canonical Wnt signaling, an evolutionarily conserved pathway whose intracellular signal is transduced by beta-catentin. Emerging evidence suggests that canonical Wnt signaling...
  9. The gene-centric concept: a new liability?

    Bioessays 30(2):196 (2008) PMID 18200561

  10. Differential pharmacological regulation of drug efflux and pharmacoresistant schizophrenia.

    Bioessays 30(2):183 (2008) PMID 18200566

    Pharmacoresistant schizophrenia is a significant impediment to the successful management of the disease. The expression and function of P-glycoprotein (P-gp) has recently been implicated in this phenomenon. P-gp is a multidrug efflux transporter that prevents drug substrates from crossing the bl...
  11. Hagfish (cyclostomata, vertebrata): searching for the ancestral developmental plan of vertebrates.

    Bioessays 30(2):167 (2008) PMID 18197595

    The phylogenetic position of the hagfish remains enigmatic. In contrast to molecular data that suggest monophyly of the cyclostomes, several morphological features imply a more ancestral state of this animal compared with the lampreys. To resolve this question requires an understanding of the em...
  12. Another notch in stem cell biology: Drosophila intestinal stem cells and the specification of cell fates.

    Bioessays 30(2):107 (2008) PMID 18200564

    Previous work has suggested that many stem cells can be found in microanatomic niches, where adjacent somatic cells of the niche control the differentiation and proliferation states of their resident stem cells. Recently published work examining intestinal stem cells (ISCs) in the adult Drosophi...
  13. Dr Watson's woeful words--and two missed opportunities.

    Bioessays 30(2):99 (2008) PMID 18200562

  14. From priming to plasticity: the changing fate of rhizodermic cells.

    Bioessays 30(1):75 (2008) PMID 18081017

    The fate of root epidermal cells is controlled by a complex interplay of transcriptional regulators, generating a genetically determined, position-biased arrangement of root hair cells. This pattern is altered during postembryonic development and in response to environmental signals to confer de...
  15. DNA barcoding of animal species-response to DeSalle.

    Bioessays 30(1):92 (2008) PMID 18081021

  16. Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization.

    Bioessays 30(1):82 (2008) PMID 18081019

    Since most of the functions in cells are mediated by multimeric protein complexes, the determination of protein-protein interactions is an important step in the study of cellular mechanisms. Traditionally, after screening for possible target interactors by means of a yeast two-hybrid screen, sev...
  17. Asymmetric nuclear reprogramming in somatic cell nuclear transfer?

    Bioessays 30(1):66 (2008) PMID 18081016

    Despite the progress achieved over the last decade after the birth of the first cloned mammal, the efficiency of reproductive cloning remains invariably low. However, research aiming at the use of nuclear transfer for the production of patient-tailored stem cells for cell/tissue therapy is progr...
  18. Knowledge-making distinctions in synthetic biology.

    Bioessays 30(1):57 (2008) PMID 18081015

    Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each approach is characterized by differ...
  19. Drosophila telomeres: an exception providing new insights.

    Bioessays 30(1):25 (2008) PMID 18081009 PMCID PMC2804870

    Drosophila telomeres comprise DNA sequences that differ dramatically from those of other eukaryotes. Telomere functions, however, are similar to those found in telomerase-based telomeres, even though the underlying mechanisms may differ. Drosophila telomeres use arrays of retrotransposons to mai...
  20. A shifting paradigm: histone deacetylases and transcriptional activation.

    Bioessays 30(1):15 (2008) PMID 18081007

    Transcriptional repression and silencing have been strongly associated with hypoacetylation of histones. Accordingly, histone deacetylases, which remove acetyl groups from histones, have been shown to participate in mechanisms of transcriptional repression. Therefore, current models of the role ...