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Ovid from 2005, CSA, Wiley from 1984, Proquest, and Gale

  1. Vitamin D discovery outpaces FDA decision making.

    Bioessays 30(2):173 (2008) PMID 18200565

    The US FDA currently encourages the addition of vitamin D to milk and cereals, with the aim of reducing rickets in children and osteoporosis in adults. However, vitamin D not only regulates the expression of genes associated with calcium homeostasis, but also genes associated with cancers, autoi...
  2. cAMP-dependent protein kinase A and the dynamics of epithelial cell surface domains: moving membranes to keep in shape.

    Bioessays 30(2):146 (2008) PMID 18200529

    Cyclic adenosine monophosphate (cAMP) and cAMP-dependent protein kinase A (PKA) are evolutionary conserved molecules with a well-established position in the complex network of signal transduction pathways. cAMP/PKA-mediated signaling pathways are implicated in many biological processes that coop...
  3. The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes?

    Bioessays 30(2):156 (2008) PMID 18197594

    Obesity and type 2 diabetes arise from a set of complex gene-environment interactions. Explanations for the heritability of these syndromes and the environmental contribution to disease susceptibility are addressed by the "thrifty genotype" and the "thrifty phenotype" hypotheses. Here, the merit...
  4. Paleogenomics in vertebrates, or the recovery of lost genomes from the mist of time.

    Bioessays 30(2):122 (2008) PMID 18200550

    Knowledge of the structure of ancestral genomes provides the basis of a new framework to better represent and interpret results from genomic and evolutionary studies. Because these ancestors lived tens of hundreds of million years ago, this knowledge will inevitably take the form of abstract rep...
  5. How does noncoding transcription regulate Hox genes?

    Bioessays 30(2):110 (2008) PMID 18200528

    Noncoding RNA has arrived at centre stage in recent years with the discovery of "hidden transcriptomes" in many higher organisms. Over two decades ago, noncoding transcripts were discovered in Drosophila Hox complexes, but their function has remained elusive. Recent studies1-3 have examined the ...
  6. Neurogenesis in adult CNS: from denial to opportunities and challenges for therapy.

    Bioessays 30(2):135 (2008) PMID 18200551

    The discovery of neurogenesis and neural stem cells (NSC) in the adult CNS has overturned a long-standing and deep-routed "dogma" in neuroscience, established at the beginning of the 20(th) century. This dogma lasted for almost 90 years and died hard when NSC were finally isolated from the adult...
  7. Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging.

    Bioessays 30(2):102 (2008) PMID 18200563

    Critical cellular functions, including stem cell maintenance, fate determination, and cellular behavior, are governed by canonical Wnt signaling, an evolutionarily conserved pathway whose intracellular signal is transduced by beta-catentin. Emerging evidence suggests that canonical Wnt signaling...
  8. The gene-centric concept: a new liability?

    Bioessays 30(2):196 (2008) PMID 18200561

  9. Differential pharmacological regulation of drug efflux and pharmacoresistant schizophrenia.

    Bioessays 30(2):183 (2008) PMID 18200566

    Pharmacoresistant schizophrenia is a significant impediment to the successful management of the disease. The expression and function of P-glycoprotein (P-gp) has recently been implicated in this phenomenon. P-gp is a multidrug efflux transporter that prevents drug substrates from crossing the bl...
  10. Hagfish (cyclostomata, vertebrata): searching for the ancestral developmental plan of vertebrates.

    Bioessays 30(2):167 (2008) PMID 18197595

    The phylogenetic position of the hagfish remains enigmatic. In contrast to molecular data that suggest monophyly of the cyclostomes, several morphological features imply a more ancestral state of this animal compared with the lampreys. To resolve this question requires an understanding of the em...