- Print ISSN
- Electronic ISSN
- Impact factor
- Usage rank
- Article count
- Free count
- Free percentage
- PDFs via platforms
- Ovid from 2005, CSA, Wiley from 1984, Proquest, and Gale
Forces shaping the antibiotic resistome.
Antibiotic resistance has become a problem of global scale. Resistance arises through mutation or through the acquisition of resistance gene(s) from other bacteria in a process called horizontal gene transfer (HGT). While HGT is recognized as an important factor in the dissemination of resistance ge...
Oxygen and animal evolution: did a rise of atmospheric oxygen "trigger" the origin of animals?
Recent studies challenge the classical view that the origin of animal life was primarily controlled by atmospheric oxygen levels. For example, some modern sponges, representing early-branching animals, can live under 200 times less oxygen than currently present in the atmosphere - levels commonly th...
Pre-birth world and the development of the immune system: mum's diet affects our adult health: new insight on how the diet during pregnancy ...
We highlight evidence showing how the maternal diet influences the establishment of the immune system, and we also discuss how unbalanced maternal diets may set the response to infection and vaccination in the progeny. © 2014 WILEY Periodicals, Inc....
How does oncogene transformation render tumor cells hypersensitive to nutrient deprivation?
Oncogene activation leads to cellular transformation by deregulation of biological processes such as proliferation and metabolism. Paradoxically, this can also sensitize cells to nutrient deprivation, potentially representing an Achilles' heel in early stage tumors. The mechanisms underlying this ph...
Do sex chromosomes affect speciation rate? (Retrospective on DOI 10.1002/bies.201100164).
Stress-induced cellular adaptive strategies: ancient evolutionarily conserved programs as new anticancer therapeutic targets.
We hypothesize that evolutionarily conserved programs rheostatically regulate mutability in fluctuating environments, and contribute to drug resistance in cancer cells. Elucidating the conserved genetic and molecular mechanisms may present novel opportunities to increase the effectiveness of cancer...
Evolution of adaptive immunity: implications of a third lymphocyte lineage in lampreys.
An alternative antigen receptor, named the variable lymphocyte receptor (VLR), was first identified in lampreys in 2004. Since then, the mechanism of VLR diversification via somatic gene assembly and the function of VLR-expressing lymphocytes have been the subject of much research. VLRs comprise leu...
FOXO in aging: did evolutionary diversification of FOXO function distract it from prolonging life?
We contrast the simple role of FOXO in the seemingly non-aging Hydra with its more diversified function in multicellular eukaryotes that manifest aging and limited life spans. From this comparison we develop the concept that, whilst once devoted to life-prolonging cell-renewal (in Hydra), evolutiona...
The--YENPTY--domain of the amyloid precursor protein: much more than just endocytosis?