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  1. Did the fire ant supergene evolve selfishly or socially?

    Bioessays 36(2):200 (2014) PMID 24272711

    The genetic basis for animal social organization is poorly understood. Fire ants provide one of the rare cases where variation in social organization has been demonstrated to be under genetic control, which amazingly, segregates as a single Mendelian locus. A recent genetic, genomic, and cytological...
  2. Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.

    Bioessays 36(2):163 (2014) PMID 24277632

    We first discuss the general characteristics of insulator elements and their associated protein factors. A growing collection of insulator proteins have been identified including a family of proteins whose expression is developmentally regulated. We next consider several unexpected discoveries that...
  3. 3'UTRs take a long shot in the brain.

    Bioessays 36(1):39 (2014) PMID 24115048

    We review recent progress in the characterization of mRNA 3'UTRs and discuss their implications in the understanding of 3'UTR-mediated gene regulation. © 2014 WILEY Periodicals, Inc....
  4. Horizontal gene acquisitions by eukaryotes as drivers of adaptive evolution.

    Bioessays 36(1):9 (2014) PMID 24323918

    We raise the hypothesis that horizontally acquired genes may have contributed more to adaptive evolution of eukaryotes than previously assumed. Current candidate sets of horizontally acquired eukaryotic genes may just be the tip of an iceberg. We have recently shown that adaptation of the thermoacid...
  5. Exploiting CRISPR/Cas systems for biotechnology.

    Bioessays 36(1):34 (2014) PMID 24323919

    We review the development of Cas9 as an important tool to not only edit the genomes of a number of different prokaryotic and eukaryotic species, but also as an efficient system for site-specific transcriptional repression or activation. Additionally, a specific Cas9 protein has been observed to targ...
  6. Major depressive disorder: a loss of circadian synchrony?

    Bioessays 35(11):940 (2013) PMID 24003004

    Circadian rhythms in the sleep/wake cycle, along with a range of physiological measures, are severely disrupted in individuals with major depressive disorder (MDD). Moreover, several central circadian genes have been implicated as potential genetic factors underlying the illness through candidate ge...
  7. Retroviruses facilitate the rapid evolution of the mammalian placenta.

    Bioessays 35(10):853 (2013) PMID 23873343

    I propose that ERV-mediated regulatory evolution was, and continues to be, an important mechanism underlying the evolution of placental development. Many recent studies have focused on the co-option of ERV-derived genes for specific functional adaptations in the placenta. However, the co-option of E...
  8. Phenotypes from ancient DNA: approaches, insights and prospects.

    Bioessays 35(8):690 (2013) PMID 23703035

    The great majority of phenotypic characteristics are complex traits, complicating the identification of the genes underlying their expression. However, both methodological and theoretical progress in genome-wide association studies have resulted in a much better understanding of the underlying genet...
  9. BiotecVisions 2013, June (pages A1-A8).
    Author(s) unavailable

    Bioessays 35(7) (2013) PMID 23765580

  10. Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.

    Bioessays 35(7):658 (2013) PMID 23625805

    We found that lipid mixing often occurs seconds prior to content mixing, or without any content mixing at all, during a 50-seconds observation period, for Ca(2+) -triggered fusion with SNAREs, full-length synaptotagmin-1, and complexin. Our results illustrate the caveats of commonly used bulk lipid-...