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Bioessays

Print ISSN
0265-9247
Electronic ISSN
1521-1878
Impact factor
4.479
Publisher
wiley
URL
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-1878
Usage rank
145
Article count
4918
Free count
237
Free percentage
0.0481903
PDFs via platforms
Ovid from 2005, CSA, Wiley from 1984, Proquest, and Gale

  1. Another notch in stem cell biology: Drosophila intestinal stem cells and the specification of cell fates.

    Bioessays 30(2):107 (2008) PMID 18200564

    Previous work has suggested that many stem cells can be found in microanatomic niches, where adjacent somatic cells of the niche control the differentiation and proliferation states of their resident stem cells. Recently published work examining intestinal stem cells (ISCs) in the adult Drosophi...
  2. The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes?

    Bioessays 30(2):156 (2008) PMID 18197594

    Obesity and type 2 diabetes arise from a set of complex gene-environment interactions. Explanations for the heritability of these syndromes and the environmental contribution to disease susceptibility are addressed by the "thrifty genotype" and the "thrifty phenotype" hypotheses. Here, the merit...
  3. Vitamin D discovery outpaces FDA decision making.

    Bioessays 30(2):173 (2008) PMID 18200565

    The US FDA currently encourages the addition of vitamin D to milk and cereals, with the aim of reducing rickets in children and osteoporosis in adults. However, vitamin D not only regulates the expression of genes associated with calcium homeostasis, but also genes associated with cancers, autoi...
  4. Neurogenesis in adult CNS: from denial to opportunities and challenges for therapy.

    Bioessays 30(2):135 (2008) PMID 18200551

    The discovery of neurogenesis and neural stem cells (NSC) in the adult CNS has overturned a long-standing and deep-routed "dogma" in neuroscience, established at the beginning of the 20(th) century. This dogma lasted for almost 90 years and died hard when NSC were finally isolated from the adult...
  5. cAMP-dependent protein kinase A and the dynamics of epithelial cell surface domains: moving membranes to keep in shape.

    Bioessays 30(2):146 (2008) PMID 18200529

    Cyclic adenosine monophosphate (cAMP) and cAMP-dependent protein kinase A (PKA) are evolutionary conserved molecules with a well-established position in the complex network of signal transduction pathways. cAMP/PKA-mediated signaling pathways are implicated in many biological processes that coop...
  6. Paleogenomics in vertebrates, or the recovery of lost genomes from the mist of time.

    Bioessays 30(2):122 (2008) PMID 18200550

    Knowledge of the structure of ancestral genomes provides the basis of a new framework to better represent and interpret results from genomic and evolutionary studies. Because these ancestors lived tens of hundreds of million years ago, this knowledge will inevitably take the form of abstract rep...
  7. The gene-centric concept: a new liability?

    Bioessays 30(2):196 (2008) PMID 18200561

  8. Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging.

    Bioessays 30(2):102 (2008) PMID 18200563

    Critical cellular functions, including stem cell maintenance, fate determination, and cellular behavior, are governed by canonical Wnt signaling, an evolutionarily conserved pathway whose intracellular signal is transduced by beta-catentin. Emerging evidence suggests that canonical Wnt signaling...
  9. Differential pharmacological regulation of drug efflux and pharmacoresistant schizophrenia.

    Bioessays 30(2):183 (2008) PMID 18200566

    Pharmacoresistant schizophrenia is a significant impediment to the successful management of the disease. The expression and function of P-glycoprotein (P-gp) has recently been implicated in this phenomenon. P-gp is a multidrug efflux transporter that prevents drug substrates from crossing the bl...
  10. How does noncoding transcription regulate Hox genes?

    Bioessays 30(2):110 (2008) PMID 18200528

    Noncoding RNA has arrived at centre stage in recent years with the discovery of "hidden transcriptomes" in many higher organisms. Over two decades ago, noncoding transcripts were discovered in Drosophila Hox complexes, but their function has remained elusive. Recent studies1-3 have examined the ...