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Divide and conquer: The surprising link between motility and the cell cycle (retrospective on DOI 10.1002/bies.201200119).
Mitosis, double strand break repair, and telomeres: a view from the end: how telomeres and the DNA damage response cooperate during mitosis ...
Double strand break (DSB) repair is suppressed during mitosis because RNF8 and downstream DNA damage response (DDR) factors, including 53BP1, do not localize to mitotic chromatin. Discovery of the mitotic kinase-dependent mechanism that inhibits DSB repair during cell division was recently reported....
Unique features of DNA replication in mitochondria: a functional and evolutionary perspective.
We reported a new mechanism of DNA replication in mammals. It occurs inside mitochondria and entails the use of processed transcripts, termed bootlaces, which hybridize with the displaced parental strand as the replication fork advances. Here we discuss possible reasons why such an unusual mechanism...
Animals are both radially and bilaterally symmetrical: Accommodating seemingly mutually exclusive paradigms.
Mild cold-stress depresses immune responses: Implications for cancer models involving laboratory mice.
Physiologically accurate mouse models of cancer are critical in the pre-clinical development of novel cancer therapies. However, current standardized animal-housing temperatures elicit chronic cold-associated stress in mice, which is further increased in the presence of tumor. This cold-stress signi...
Transfer and functional consequences of dietary microRNAs in vertebrates: concepts in search of corroboration: negative results challenge th...
We review the evidence for and against a significant role for dietary miRNAs in influencing gene expression, and make recommendations for future studies. Also watch the Video Abstract. © 2014 The Authors. Bioessays published by WILEY Periodicals, Inc....
One hundred years of somatic mutation theory of carcinogenesis: is it time to switch?
BioEssays - Next Issue.
Homosexuality via canalized sexual development: a testing protocol for a new epigenetic model.
We recently synthesized and reinterpreted published studies to advance an epigenetic model for the development of homosexuality (HS). The model is based on epigenetic marks laid down in response to the XX vs. XY karyotype in embryonic stem cells. These marks boost sensitivity to testosterone in XY f...