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  1. Cracking the ANP32 whips: Important functions, unequal requirement, and hints at disease implications.

    Bioessays 36(11):1062 (2014) PMID 25156960

    We present a concept of the ANP32s as having a whip-like structure. We also present hypotheses that ANP32C and other intronless sequences should not currently be considered bona fide family members, that their disparate necessity in development may be due to compensatory mechanisms, that their contr...
  2. Synthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene ...

    Bioessays 36(10):979 (2014) PMID 25100403

    Synthetic biology is an emerging engineering discipline that attempts to design and rewire biological components, so as to achieve new functions in a robust and predictable manner. The new tools and strategies provided by synthetic biology have the potential to improve therapeutics for neurodegenera...
  3. Of early animals, anaerobic mitochondria, and a modern sponge.

    Bioessays 36(10):924 (2014) PMID 25118050

    The origin and early evolution of animals marks an important event in life's history. This event is historically associated with an important variable in Earth history - oxygen. One view has it that an increase in oceanic oxygen levels at the end of the Neoproterozoic Era (roughly 600 million years...
  4. How discordant morphological and molecular evolution among microorganisms can revise our notions of biodiversity on Earth.

    Bioessays 36(10):950 (2014) PMID 25156897

    We highlight examples of such discordance, focusing on exemplary lineages such as testate amoebae, ciliates, and cyanobacteria. These have long histories of morphological study, enabling deeper analyses on both the molecular and morphological sides. We discuss examples in two main categories: (i) mo...
  5. Defining 'medical necessity' in an age of personalised medicine: A view from Canada.

    Bioessays 36(9):813 (2014) PMID 25059840

    The concept of medical necessity plays a central role in many healthcare systems, including Canada's, by helping determine which healthcare services will receive funding. Despite its significance in health policy frameworks, medical necessity has proven to be notoriously difficult to define and oper...
  6. BioEssays - Next Issue.
    Author(s) unavailable

    Bioessays 36(9) (2014) PMID 25118022

  7. MicroRNA binding sites in the coding region of mRNAs: extending the repertoire of post-transcriptional gene regulation.

    Bioessays 36(6):617 (2014) PMID 24737341

    We propose that these domain-dependent effects serve to diversify the functional repertoire of post-transcriptional gene expression control. Possible regulatory benefits may include tuning the time-scale and magnitude of post-transcriptional regulation, regulating protein abundance depending on or i...
  8. BioEssays - Next Issue.
    Author(s) unavailable

    Bioessays 36(3) (2014) PMID 24848594

  9. Integrating DNA methylation dynamics into a framework for understanding epigenetic codes.

    Bioessays 36(1):107 (2014) PMID 24242211

    We discuss paradigms associated with the various components of DNA methylation/demethylation and recent advances in the understanding of its dynamic regulation in the genome, integrating these mechanisms into a framework to explain how DNA methylation could contribute to epigenetic codes. © 2014 WI...
  10. Connecting the dots between G proteins, G protein coupled receptors, and neuronal nicotinic acetylcholine receptors (Comment on DOI 10.1002/...

    Bioessays 35(12):1022 (2013) PMID 24242098