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  1. Metal promiscuity and metal-dependent substrate preferences of Trypanosoma brucei methionine aminopeptidase 1

    Biochimie 115:35 (2015) PMID 25921435

    Methionine aminopeptidases play a major role in posttranslational protein processing and are therefore promising targets for the discovery of novel therapeutical agents. We here describe the heterologous expression, purification, and characterization of recombinant Trypanosoma brucei m...
  2. The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs

    Biochimie 115:17 (2015) PMID 25934589 PMCID PMC4500675

    The POT1 protein plays a critical role in telomere protection and telomerase regulation. POT1 binds single-stranded 5′-TTAGGGTTAG-3′ and forms a dimer with the TPP1 protein. The dimer is recruited to telomeres, either directly or as part of the Shelterin complex. Human POT1 contains tw...
  3. Structural basis for the NAD binding cooperativity and catalytic characteristics of sperm-specific glyceraldehyde-3-phosphate dehydrogenase

    Biochimie 115:28 (2015) PMID 25936797

    Catalytic properties of enzymes used in biotechnology can be improved by eliminating those regulatory mechanisms that are not absolutely required for their functioning. We exploited mammalian glyceraldehyde-3-phosphate dehydrogenase as a model protein and examined the structural basis ...
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    Author(s) unavailable

    Biochimie 113:IFC (2015)

  5. Ribosomal proteomics: Strategies, approaches, and perspectives

    Biochimie 113:69 (2015) PMID 25869001

    Over the past few decades, proteomic research has seen unprecedented development due to technological advancement. However, whole-cell proteomics still has limitations with respect to sample complexity and the accuracy of determining protein locations. To deal with these limitations, s...
  6. An overview of pentatricopeptide repeat proteins and their applications

    Biochimie 113:93 (2015) PMID 25882680

    Pentatricopeptide repeat (PPR) proteins are a large family of modular RNA-binding proteins which mediate several aspects of gene expression primarily in organelles but also in the nucleus. These proteins facilitate processing, splicing, editing, stability and translation of RNAs. While...
  7. The roles of nucleolin subcellular localization in cancer

    Biochimie 113:78 (2015) PMID 25866190

    Nucleolin (NCL) is one of the most abundant non ribosomal protein of the nucleolus where it plays a central role in polymerase I transcription. NCL is also found outside of the nucleolus, in the nucleoplasm, cytoplasm as well as on the cell membrane. It acts in all cell compartments to...
  8. Transcriptional regulation of the apolipoprotein F (ApoF) gene by ETS and C/EBPα in hepatoma cells

    Biochimie 112:1 (2015) PMID 25726912

    Apolipoprotein F (ApoF) inhibits cholesteryl ester transfer protein (CETP) activity and plays an important role in lipid metabolism. In the present study, the full-length human ApoF promoter was cloned, and the molecular mechanism of the regulation of ApoF was investigated. The ApoF pr...
  9. PPIase is associated with the diversity of conotoxins from cone snail venom glands

    Biochimie 112:129 (2015) PMID 25769415

    Cone snails are incredibly rich sources of bioactive conopeptides with potential for use in neuroscience research and novel drug development. In order to investigate the synthesis of diversified conopeptides in venom glands, the proteome and peptidome profiles of conus venom were analy...
  10. Conformational dynamics of bacterial and human cytoplasmic models of the ribosomal A-site

    Biochimie 112:96 (2015) PMID 25748164

    The aminoacyl-tRNA binding site (A-site) is located in helix 44 of small ribosomal subunit. The mobile adenines 1492 and 1493 (Escherichia coli numbering), forming the A-site bulge, act as a functional switch that ensures mRNA decoding accuracy. Structural data on the oligonucleotide m...