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- Ebscoatoz, Ingenta, Ebsco, Wiley from 1997, Gale, Rcgp, Ovid from 2001, and Ebsconet
p53 and mitogen-activated protein kinase pathway protein profiles in fresh and frozen spermatozoa.
We observed that p53 protein residue at Ser 15 was phosphorylated after cryopreservation. Because MAPK pathway activations may be involved in p53 phosphorylation, MAPK/ERK, Stress-activated protein kinases (SAPK)/JNK and p38MAPK proteins were also investigated. Analysis showed that p38MAPK phosphory...
Oestrogen receptor alpha gene polymorphisms relationship with semen variables in infertile men.
This study aimed to assess the association of oestrogen receptor alpha (ER-α) gene polymorphisms and semen variables in infertile oligoasthenoteratozoospermic (OAT) men. In all, 141 men were grouped into fertile men (n = 60) and infertile OAT men (n = 81). They were subjected to assessment of semen...
The CAG repeat polymorphism of mitochondrial polymerase gamma (POLG) is associated with male infertility in Tunisia.
We explored a possible role of the (POLG) gene polymorphism in male infertility in Tunisian men. The polymorphic CAG repeat in the nuclear POLG gene was studied in 339 male subjects (216 patients with infertility (69 azoospermic, 115 oligoasthenoteratospermic and 32 normospermic) and 123 fertile) af...
Scrotal infrared digital thermography in assessment of varicocele--pilot study to assess diagnostic criteria.
The aim of this study was to assess scrotal thermography in diagnostics of varicocele and suggest potential diagnostic criteria. Twelve patients with clinically diagnosed varicocele were examined with scrotal infrared digital thermography, physical examination and ultrasound/doppler. The main outcome...
Biochemical identification and characterisation of changes associated with capacitation of mannosylated glycoproteins in murine sperm.
We used Lens culinaris agglutinin (LCA) to characterise mannosylated glycoconjugates in mouse sperm and their changes in distribution associated with capacitation. In freshly isolated sperm, three biochemically distinct sperm populations (type I, II and III) with specific LCA labelling were noted. P...
Assessment of the effect of testosterone on the acrosome reaction of human spermatozoa.
In the acrosome reaction, the spermatozoon plasma membrane fuses with the outer acrosomal membrane, resulting in the release of the acrosomal content. Several compounds, such as sex steroids, are known to modulate the acrosomal exocytosis. Testosterone regulates various functions in...
Human sperm DNA oxidation, motility and viability in the presence of L-carnitine during in vitro incubation and centrifugation.
We investigated the effect of LC on human sperm motility, viability and DNA oxidation after incubation and centrifugation, following the sperm preparation protocols of assisted reproduction. Normozoospermic semen samples (n = 55) were analysed according to the World Health Organization (WHO) gui...
Effect of α-lipoic acid on sperm quality, reproductive tract measures in thinner exposed rats.
The aim of this study was to investigate the effect of alpha lipoic acid (ALA, an universal antioxidant) on thinner-induced testicular toxicity regarding spermatological features, body and reproductive tract measures in rats. Adult male Sprague-Dawley rats were divided into five trea...
Increased receptor for advanced glycation end products in spermatozoa of diabetic men and its association with sperm nuclear DNA fragmentati...
We hypothesised that it may be involved in sperm nuclear DNA fragmentation. RAGE levels were determined using ELISA and western blot analysis in sperm samples from 32 diabetic and 35 nondiabetic men. Sperm DNA fragmentation was assessed using TUNEL assay. Diabetic men had significantly higher mean l...
Evaluation of serum oxidative and antioxidative status in patients with erectile dysfunction.
We evaluated and compared serum oxidative and antioxidative parameters of patients with erectile dysfunction (ED) and control subjects. Twenty married male patients with ED for at least 12 months (Group 1) and 20 volunteer healthy, sexually active, married and age-matched men (Group 2) were includ...