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5-OMe-uridine-5′-O-(α-boranodiphosphate), a novel nucleotide derivative highly active at the human P2Y6 receptor protects against death-rece...
Neuroscience Letters 578:80 (2014)We investigate human P2Y6 nucleotide receptor-mediated cytoprotection. • Stereoisomers of PαBH3-substituted nucleotides show increased potency and selectivity. • We apply the n...
C4 - CONTENTS
Neuroscience Letters 569:CO4 (2014)
β1-adrenoceptor stimulation enhances the differentiation of mouse induced pluripotent stem cells into neural progenitor cells.
We examined the involvement of β-adrenoceptor signaling on the differentiation of mouse induced pluripotent stem (iPS) cells into neural progenitor cells. Mouse iPS cells were cultured on ultra-low-attachment dishes to induce embryoid body (EB) formation. All-trans retinoic acid (ATRA, 1μM) and/or...
Use of dynamic weight bearing as a novel end-point for the assessment of Freund's Complete Adjuvant induced hypersensitivity in mice.
Animal models are an integral part of pain research. However, current models tend to rely on evoked responses and there is a belief that non-evoked responses may be a more relevant behavioural readout as the animal responds in a more natural manner. Here, dynamic weight bearing (DWB)...
Spinocerebellar ataxia type 27 (SCA27) is an uncommon cause of dominant ataxia among Chinese Han population.
We performed molecular genetic analysis in 67 unrelated familial ataxia cases and 500 normal controls by denaturing high-performance liquid chromatography (DHPLC) and DNA direct sequencing. Interestingly, we found a pair of siblings carried the same heterozygous variation (c.-10delC) characterized b...
The tDCS effect on alpha brain oscillation for correct vs. incorrect object use. The contribution of the left DLPFC.
Representation of the instrumentally incorrect use of an object was explored in the present research taking into account the role of the dorsolateral prefrontal cortex (DLPFC). Specifically the "inhibitory" effect performed by tDCS (transcranial Direct Current Stimulation) on DLPFC w...
Prefrontal brain asymmetry and aggression in imprisoned violent offenders.
We examined the topographic characteristics of alpha and beta activity, the relation of both asymmetry metrics to trait aggression, and whether alpha asymmetry was extreme in anterior regions according to clinical standards in a group of imprisoned violent offenders. As expected, these individuals w...
Feedback about isometric force production yields more random variations.
We investigated the relation between visual feedback and the degree of structure versus randomness in the variability of single-digit, isometric force output. Participants were instructed to maintain a constant level of force during the presence or absence of visual feedback about force output. The...
Phenylbutenoid dimers isolated from Zingiber purpureum exert neurotrophic effects on cultured neurons and enhance hippocampal neurogenesis i...
Trans-3-(3'4'-dimethoxyphenyl)-4-[(E)-3″,4″-dimethoxystyryl]cyclohex-1-ene (Comp.1) and cis-3-(3'4'-dimethoxyphenyl)-4-[(E)-3″,4″-dimethoxystyryl]cyclohex-1-ene (Comp.2), phenylbutenoid dimers, have been isolated as neurotrophic molecules from an Indonesian medicinal plant, Z...
The characterization of gene expression during mouse neural stem cell differentiation in vitro.
We identified gene networks that were associated with BMP and TGF-beta2 signaling pathways using Ingenuity Pathway Analysis. Our results suggest that the differentiation of E15 NSCs into astrocytes is based on a combinatorial network of various signaling pathways, including cell cycle, BMP and TGF-b...