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Medical Hypotheses

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  1. Immuno-PCI: A proposal for the implementation of "seed and soil" concept in the treatment of peritoneal carcinomatosis from colorectal cance...

    Medical Hypotheses 83(2):137 (2014) PMID 24893828

    We believe that it is high time to attempt a further evolution of the current practice, by incorporating in the above mentioned quantification scores parameters indicative of the immune-response against the disease progression, fact which will probably reflect more accurately the dynamics of cancer...
  2. Helicobacter pylori might be a potential therapeutic target in epilepsy.

    Medical Hypotheses 76(5):763 (2011) PMID 21356577

  3. Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy

    Medical Hypotheses 58(6):4 (2002)

  4. Telomere length - A cellular aging marker for depression and Post-traumatic Stress Disorder.

    Medical Hypotheses 83(2):182 (2014) PMID 24875221

    We focus on the discussion of findings in studies of the relationships between stress-related disorders (e.g., depression and PTSD) and telomeres. We also present direct evidence that TL is associated with traumatic stress, depression, and PTSD, and hypothesize that traumatic stress affects not only...
  5. Benefits of the povidone-iodine: simultaneously decrease risk of infection and tumor seeding after percutaneous endoscopic gastrostomy.

    Medical Hypotheses 82(6):678 (2014) PMID 24650418

    Percutaneous endoscopic gastrostomy (PEG) is a well-established enteral feeding modality in patients with oropharyngeal/esophageal cancer; however, these patients are at risk for two possible PEG-related complications. First, oropharyngeal organisms may be transported to the PEG stoma and thus incre...
  6. Low dietary sodium in diabetes nephropathy.

    Medical Hypotheses 82(5):551 (2014) PMID 24581676

    We hypothesise that in diabetic nephropathy, ACE-I or ARB treatment attenuates any rise in RAS hormones that might result from dietary salt restriction and that the beneficial effects of the salt restriction such as a lower blood pressure outweigh any potentially negative consequences of RAS activat...
  7. The putative role of proteolytic pathways in the pathogenesis of Type 1 diabetes mellitus: the 'autophagy' hypothesis.

    Medical Hypotheses 82(5):553 (2014) PMID 24582332

    I and class II self-antigen presentation at the basis of the autoimmunity process. Furthermore cross-talk among different proteolytic pathways was recently highlighted i.e. components processed in the ubiquitin/proteasome system possibly engaged in autophagic pathways. T1D is an autoimmune disease c...
  8. Clinical markers of endometriosis: have we been too quick to judge?

    Medical Hypotheses 82(4):493 (2014) PMID 24559691

    We postulate that the diversity of clinical presentations, patient objectives, and complexity of the pathophysiology of endometriosis mandates rigorous attention to study design and standardization of procedures and questionnaires that has heretofore been overlooked in the pursuit of clinical marker...
  9. Relationships between sleep and addiction: the role of drug-environment conditioning.

    Medical Hypotheses 82(3):374 (2014) PMID 24468577

    We hypothesized that sleep deprivation is a potential detrimental factor to the extinction process of previously established drug-environment conditioning. Therefore, sleep deprivation would extend the pairing between the cocaine reinforcing effects and the environmental cues, thereby leading drug a...
  10. A simple scoring system based on neutrophil count in sepsis patients.

    Medical Hypotheses 82(3):382 (2014) PMID 24495564

    We proposed a novel scoring system identify predictive factors using a simple blood cell count that may be associated with mortality in ICU patients. Our novel scoring system (n-score) was calculated as follows: ranges of neutrophils of 0-4999 cells/mm(3) and 5000-9999 cells/mm(3) were defined as 3...