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Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy
Bottom-up subspace clustering suggests a paradigm shift to prevent fall injuries.
Despite over 10,000 publications since 1990, fall injury rates for older people are still increasing, over and above population ageing. Developing new ways to explore highly dimensional health data and better understand high risk individuals is imperative. The hypothesis investigated is: Falls are a...
A novel high throughput approach to screen for cardiac arrhythmic events following stem cell treatment.
We propose to develop a novel screening system to evaluate arrhythmic risk associated with stem cell therapy using a high-throughput multielectrode array system that can measure conduction velocity and action potential duration in cardiomyocytes co-cultured with different types of stem cells, such a...
Measuring sickness behavior in the context of pancreatic cancer.
We developed a version of a sickness behavior measure (the Sickness Behavior Inventory or SBI) and conducted a preliminary examination of its scale properties. Specifically, we hypothesized that a measure of sickness behavior would be significantly associated with five biomarkers of immune functioni...
South-Asian population has a higher likelihood for diabetes risk for statins regardless of potency.
Higher potency statins are associated with increased risk of new-onset diabetes (NOD) in Western populations. South-Asians phenotype, with certain unique features such as young onset of diabetes and lower threshold for diabetes risk factors, present a higher likelihood for NOD risk for statins regar...
Corrigendum to "Role of the glomerular-tubular imbalance with tubular predominance in the arterial hypertension pathophysiology" [Med. Hypot...
M. paratuberculosis and Parkinson's disease--is this a trigger.
Genetic linkage studies and genome wide analysis have provided insights into complex medical diseases. Mycobacterium avium ss. paratuberculosis (MAP) causes Johne's disease, an important enteric inflammatory disease mostly studied in ruminant animals. MAP is also the putative cause of Crohn's diseas...
Is red blood cell a mediator of remote ischaemic preconditioning?
Our hypothesis links these two known mechanisms. Remote ischaemic preconditioning and local RBC autoregulation might share a common mechanism using the ATP sensitive potassium channels. Therefore, we hypothesize that the signal transduction by RBC might be partly responsible for this protection agai...
The effects of steroid hormone exposure on direct gene regulation.
We discuss the impact of normal reproductive templates on the pulsatility and amplitude of potential gene-regulating treatment protocols. By examining the interactions of estradiol (E2) and progesterone (P4) in women, we propose that changes in physiologic reproductive hormone templates of exposure...
Remote ischemic preconditioning as prevention of transfusion-related acute lung injury.
Transfusion-related acute lung injury (TRALI) is a serious complication of transfusion medicine, considered now as the leading cause of transfusion-related mortality. It may occur in up to 1 in 5000 transfusions and carries an elevated morbidity and mortality. Clinically it presents as hypoxia and n...