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The effects of steroid hormone exposure on direct gene regulation.
We discuss the impact of normal reproductive templates on the pulsatility and amplitude of potential gene-regulating treatment protocols. By examining the interactions of estradiol (E2) and progesterone (P4) in women, we propose that changes in physiologic reproductive hormone templates of exposure...
Glycogenolysis: Is muscle glycogen phosphorylase differentially activated depending on the conditions of hypoxia and exercise?
Toxoplasmosis can be a sexually transmitted infection with serious clinical consequences. Not all routes of infection are created equal.
We present a hypothesis suggesting that toxoplasmosis is transmitted from infected men to noninfected women during unprotected sexual intercourse, which can result in the most serious form of disease, congenital toxoplasmosis. Arguments for the hypothesis: (1) Toxoplasma tachyzoites are present in t...
Helicobacter pylori might be a potential therapeutic target in epilepsy.
Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy
Folliculo-stellate cells - Potential mediators of the inflammaging-induced hyperactivity of the hypothalamic-pituitary-adrenal axis in healt...
We assumed that folliculo-stellate cells were the target structures through which the elevated levels of cytokines, as a part of the inflammaging phenomenon, would cause the overactivation of the HPA axis in healthy elderly individuals. Folliculo-stellate cells are non-endocrine cells that were orig...
Oxycodone recycling: A novel hypothesis of opioid tolerance development in humans.
We hypothesize that oxycodone (OC) recycling promotes sustained synaptic OC content, which prolongs OC's exposure to local μ-opioid receptors (μORs). In that way, OC recycling gives rise to OC tolerance in humans. To pilot test our hypothesis, we developed a whole-body OC mass transport tolerance re...
Salmonella as a biological "Trojan horse" for neoplasia: Future possibilities including brain cancer.
This manuscript considers available evidence that a specific Salmonella strain could be used as an effective orally-administered option for cancer therapy involving the brain. It has been established that Salmonella preferentially colonizes neoplastic tissue and thrives as a facultative anaerobe in...
CCNB1 is a prognostic biomarker for ER+ breast cancer.
We demonstrated that CCNB1 had significant predictive power in distant metastasis free survival, disease free survival, recurrence free survival and overall survival of ER+ breast cancer patients. We also found that CCNB1 was closely associated with hormone therapy resistance. In addition, gene set...
Prostaglandins in semen compromise the immune response against sexually transmitted pathogens.
We have recently shown that exposure to seminal plasma induces the differentiation of dendritic cells into a tolerogenic profile through a mechanism dependent on the activation of the prostanoid receptors EP2 and EP4 by seminal PGE. Our hypothesis proposes that this tolerogenic response induced by s...