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Renal sympathetic denervation for resistant hypertension - An alternate view.
Catheter-based renal denervation (RDN) is an effective treatment for resistant hypertension. But negative results with this procedure are also not uncommon. It is believed that the effectiveness of RDN is due to decreased sympathetic activity. It is suggested that the beneficial action of RDN could...
Prophylactic broad spectrum antibiotics as a new anti-myeloma therapy.
We proposed a simple, inexpensive, and new approach for anti-myeloma therapy that, to the best of our knowledge, is the first one concerning the prophylactic, long-term use of broad-spectrum antibiotics during the course of disease regardless of the chosen concomitant regimens. Prophylactic treatmen...
Unique variation in genetic selection among Black North American women and its potential influence on pregnancy outcome.
We hypothesize that variations in the frequency of genetic polymorphisms, reflecting ancestral differences in living conditions and exposure to microorganisms, increase susceptibility to adverse pregnancy outcome among present day Black North American women. Striking differences were observed in the...
Atrial ganglionated plexi stimulation may be an effective therapeutic tool for the treatment of heart failure.
Our recent studies showed that ablation of the main atrial ganglionated plexi (GP) facilitated the occurrence of ventricular arrhythmias in acute myocardial ischemic heart while low-intensity atrial GP stimulation inhibited the occurrence of ventricular arrhythmias during acute myocardial ischemia a...
Contralateral suppression of distortion-product otoacoustic emissions: A potential diagnostic tool to evaluate the vestibular nerve.
We assumed that DPOAE would not be suppressed by contralateral sound stimulation in patients with vestibular nerve lesion as long as the specific pathway conveying that efferent innervation is affected. To test this hypothesis, we compared the amount of DPOAE contralateral suppression in patients wi...
Dromosagnosia, or why some people lose their sense of direction while driving.
We coined a new word, "dromosagnosia", from the Greek words, dromos ("way, road") + agnosia, to describe the loss of direction while driving, an orientation disorder similar to but different from pure topographic disorientation. Historically, human beings have moved more quickly, from using domestic...
The role of hyperhomocysteinemia in neurological features associated with coeliac disease.
We hypothesise that hyperhomocysteinemia might, by damaging the blood-brain barrier, expose neuronal tissue to all neuro-irritative metabolites, such as homocysteine itself, a neurotoxic excitatory and proconvulsant amino acid. Neurons respond to these stimuli through hyperexcitability, thereby pred...
Temporomandibular joint ankylosis: is hypercoagulable state of blood a predisposing factor?
We try to answer the question that why only a minor subset of condylar injuries progress to ankylosis and why others do not? The hypothesis follows a report of 4 cases that had bilateral TMJ ankylosis with extrahepatic portal venous obstruction (EHPVO) secondary to protein C deficiency. It is postul...
CGRP-alpha application: A potential treatment to improve osseoperception of endosseous dental implants.
Dental implants have been used to restore missing teeth for several decades. However, the capacity of implants to feel the mechanical stimuli and transmit neural signals remains lower than that of natural teeth. The poor osseoperception of dental implants is due to the absence of periodontal ligamen...
Synbiotic formulation of probiotic and lactulose combination for hepatic encephalopathy treatment: A realistic hope?
We hypothesize that oral administration of a synbiotic formulation prepared from a combination of selected microbial strains of probiotics and lactulose will offer additional protection against hepatic encephalopathy via intra-intestinal extraction of toxic solutes in patients with cirrhosis. Copyr...