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Medical Hypotheses

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  1. Gamma-aminobutyric acid receptor agonists, aquaporin-4, and neuromyelitis optica: a potential link

    Medical Hypotheses 85(5):628 (2015)

    Neuromyelitis optica (NMO; also termed Devic’s disease) is a severely disabling autoimmune disorder of the central nervous system (CNS), which predominantly affects the optic nerves and spinal cord. In up to 80% of cases, NMO is associated with antibodies to aquaporin-4 (AQP4-IgG), the...
  2. A natural therapeutic approach for the treatment of periodontitis by MK615

    Medical Hypotheses 85(5):618 (2015)

    Periodontitis is a chronic inflammatory disease that affects the tooth-supporting tissues. Gingival fibroblasts are the most abundant cells in periodontal tissues and they participate actively in the host inflammatory response to periodontal pathogens that is known to mediate local tis...
  3. Ultrasonographic demonstration of the superior ophthalmic vein in the orbit of premature infants with and without retinopathy of prematurity

    Medical Hypotheses 85(5):565 (2015)

    Retinopathy of prematurity (ROP), which develops due to abnormal retinal vascularization in premature babies, can lead to irreversible vision loss. B-scan ocular ultrasonography is a noninvasive examination which makes it possible to image the eye and orbit. Our purpose was to echograp...
  4. Why is microRNA action tissue specific? A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA?

    Medical Hypotheses 85(5):530 (2015)

    MicroRNAs as endogenous mediators of RNA interference and epigenetic regulation are involved in the regulation of numerous basic physiological processes. Both their expression and action is tissue specific, as microRNA target different messenger RNA molecules in different tissues and h...
  5. Primary vascular dysregulation syndrome: Possible implications for inner ear acute diseases?

    Medical Hypotheses 85(5):586 (2015)

    Primary vascular dysregulation syndrome has been reported as a possible cause for different eye diseases. Signs or symptoms of this syndrome not only may consist in a series of ocular disorders, as they possibly concern or are associated to various systemic conditions; even the damage ...
  6. Management and visual outcome of SCH in vitrectomized eye

    Medical Hypotheses 85(5):548 (2015)

    Suprachoroidal hemorrhage is a rare complication of all types of intraocular surgery and is always associated with poor visual outcome or even eye enucleation. Better understanding of SCH during various types of intraocular surgery can help surgeons to avoid this devastating complicati...
  7. The natural immunity to evolutionary atavistic endotoxin for human cancer

    Medical Hypotheses 85(5):701 (2015)

    We propose a new theory of the immunological control of cancer corresponding to the hypothesis that the specific natural immunity to evolutionary atavistic endotoxin has a potential role in human cancer prevention. The results of our studies have shown that IgMNAE, i.e. endogenous or s...
  8. We need to move more: Neurobiological hypotheses of physical exercise as a treatment for Parkinson’s disease

    Medical Hypotheses 85(5):537 (2015)

    Parkinson’s disease (PD) is one of the most prevalent neurodegenerative diseases in the world. The degeneration of dopaminergic neurons in the substantia nigra and chronic inflammation impair specific brain areas, which in turn result in lesser motor control, behavioral changes and cog...
  9. Is palatal vault height a determinant for nasopharyngeal carcinoma: A hypothesis?

    Medical Hypotheses 85(5):534 (2015)

    Although environmental and genetic factors are known for nasopharyngeal carcinoma, the present study is an attempt to provide a hypothesis behind the development of NPC with regards to the anatomical factor, the hypothesis being that patients with a deeper palatal vault tend to have a ...
  10. Hypnosis and music interventions (HMIs) inactivate HIF-1: A potential curative efficacy for cancers and hypertension

    Medical Hypotheses 85(5):551 (2015)

    Hypnosis and music interventions (HMIs) have shown positive influence on cancers for nearly 200years, but the underlying mechanisms were rarely explored systematically. The hypothesis suggests a potential curative efficacy of HMIs on cancers by inhibiting hypoxia inducible factor-1 (HI...