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Medical Hypotheses

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  1. Helicobacter pylori might be a potential therapeutic target in epilepsy.

    Medical Hypotheses 76(5):763 (2011) PMID 21356577

  2. Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy

    Medical Hypotheses 58(6):4 (2002)

  3. Prostaglandins in semen compromise the immune response against sexually transmitted pathogens.

    Medical Hypotheses 83(2):208 (2014) PMID 24837236

    We have recently shown that exposure to seminal plasma induces the differentiation of dendritic cells into a tolerogenic profile through a mechanism dependent on the activation of the prostanoid receptors EP2 and EP4 by seminal PGE. Our hypothesis proposes that this tolerogenic response induced by s...
  4. Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias.

    Medical Hypotheses 83(1):32 (2014) PMID 24780284 PMCID PMC4070182

    The considerable heterogeneity in the number and severity of symptoms observed in autism spectrum disorders (ASD) has been regarded as an obstacle to any future research. Some authors believe that clinical heterogeneity results from the complex interplay of the many genetic and environmental factors...
  5. Muscle as a molecular machine for protecting joints and bones by absorbing mechanical impacts.

    Medical Hypotheses 83(1):6 (2014) PMID 24810676 PMCID PMC4112738

    We hypothesize that dissipation of mechanical energy of external impact to absorb mechanical shock is a fundamental function of skeletal muscle in addition to its primary function to convert chemical energy into mechanical energy. In physical systems, the common mechanism for absorbing mechanical sh...
  6. Is insulin the new intermittent hypoxia?

    Medical Hypotheses 82(6):730 (2014) PMID 24690299 PMCID PMC4023546

    We propose the carotid chemoreceptors contribute to insulin-mediated sympathoexcitation and the persistent rise in MSNA in patients with sustained hyperinsulinemia. If the carotid chemoreceptors sense and respond to changes in systemic insulin levels, these organs may provide a viable target for the...
  7. Glaucoma--diabetes of the brain: a radical hypothesis about its nature and pathogenesis.

    Medical Hypotheses 82(5):535 (2014) PMID 24582331

    We here present a hypothesis inspired by studies across many areas of molecular and clinical sciences in an integrative manner that leads to a uniquely unconventional understanding of this disorder. Our hypothesis postulates that glaucoma may possibly be the diabetes of the brain. Based on the remar...
  8. Low maternal progesterone may contribute to both obstetrical complications and autism.

    Medical Hypotheses 82(3):313 (2014) PMID 24485701

    We hypothesized that low levels of the hormone progesterone is responsible since it is supplied to the fetus maternally and does not only support pregnancy but also promotes brain development. Following a review of the literature, we report findings from a survey of mothers of autistic children (n=8...
  9. Altitude is a risk factor for completed suicide in bipolar disorder.

    Medical Hypotheses 82(3):377 (2014) PMID 24495565 PMCID PMC3981603

    Bipolar disorder (BD) is a severe brain disease that is associated with a significant risk for suicide. Recent studies indicate that altitude of residence significantly affects overall rate of completed suicide, and is associated with a higher incidence of depressive symptoms. Bipolar disorder has s...
  10. Air pollution, inflammation and preterm birth: a potential mechanistic link.

    Medical Hypotheses 82(2):219 (2014) PMID 24382337 PMCID PMC3928635

    We hypothesize that air pollution may act together with other biological factors to induce systemic inflammation and influence the duration of pregnancy. Evaluation and testing of this hypothesis is currently being conducted in a prospective cohort study in Mexico City and will provide an understand...