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Medical Hypotheses

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  1. Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy

    Medical Hypotheses 58(6):4 (2002)

  2. Autologous Hematopoietic Stem Cells transplantation and genetic modification of CCR5 m303/m303 mutant patient for HIV/AIDS.

    Medical Hypotheses 84(3):216 (2015) PMID 25613565

    HIV and AIDS is one of the biggest challenges all over the world. There are an approximately 34 million people living with the virus, and a large number of them become infected each year. Although there are some antiviral drugs for HIV viral load reduction, they are not sufficient. There is no cure...
  3. Beneficial effects of cellular autofluorescence following ionization radiation: Hypothetical approaches for radiation protection and enhanci...

    Medical Hypotheses 84(3):194 (2015) PMID 25613566

    We suggested that this cellular autofluorescence can activate some synthetic drugs called photo-activated agents that are injected in human body after radiation exposures scenarios. Photo activated agents can activate biological pathways such as DNA repair and immunostimulation pathways, bystander s...
  4. Allogeneic and autologous mode of stem cell transplantation in regenerative medicine: which way to go?

    Medical Hypotheses 83(6):787 (2014) PMID 25456787

    We hypothesize that allogeneic transplantation could be more effective and cost-effective as compared to autologous transplantation specifically in older subjects who are the likely victims of degenerative diseases. This analysis is based on the scientific logic that allogeneic stem cells extracted...
  5. Assigning appropriate and comprehensive diagnosis for scientific report.

    Medical Hypotheses 83(6):681 (2014) PMID 25459133

    We have proposed: (i) a simple, potentially reliable and stepwise guide that can be used to assign the single most appropriate main principal diagnosis to each patient and illustrated this with case reports (ii) how to simultaneously report the main and other diagnoses in a scientific paper. It is h...
  6. Pre-eclampsia - The "uterine reinnervation" view.

    Medical Hypotheses 83(5):575 (2014) PMID 25216751

    Difficult vaginal deliveries, gynaecological surgery, and, persistent straining during defaecation injure uterine nerves. Cytokines released from injured, uterine nerves cause regeneration of new nerves with altered structures and functions. In structural terms, these new nerves proliferate in chaot...
  7. "Clinical brain profiling": a neuroscientific diagnostic approach for mental disorders.

    Medical Hypotheses 83(4):450 (2014) PMID 25155246

    We review the nature and motivation for clinical brain profiling. This involves a description of the key aspects of functional anatomy that can lead to psychopathology. These features constitute the dimensions or categories for a profile of brain disorders based upon pathophysiology. The second sect...
  8. Role of the primary motor cortex in the maintenance and treatment of pain in fibromyalgia.

    Medical Hypotheses 83(3):332 (2014) PMID 24992875

    We hypothesize that M1 is a major modulator of pain in fibromyalgia and therefore its baseline activity reflects this strong feedback between M1 and pain-related neural areas. However, the feedback loop between M1 and the pain matrix is not enough to decrease pain in fibromyalgia per se, thus increa...
  9. Telomere length - a cellular aging marker for depression and Post-traumatic Stress Disorder.

    Medical Hypotheses 83(2):182 (2014) PMID 24875221

    We focus on the discussion of findings in studies of the relationships between stress-related disorders (e.g., depression and PTSD) and telomeres. We also present direct evidence that TL is associated with traumatic stress, depression, and PTSD, and hypothesize that traumatic stress affects not only...
  10. Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias.

    Medical Hypotheses 83(1):32 (2014) PMID 24780284 PMCID PMC4070182

    The considerable heterogeneity in the number and severity of symptoms observed in autism spectrum disorders (ASD) has been regarded as an obstacle to any future research. Some authors believe that clinical heterogeneity results from the complex interplay of the many genetic and environmental factors...