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Medical Hypotheses

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  1. Prolyl hydroxylase domain-2 (PHD2) inhibition may be a better therapeutic strategy in renal anemia.

    Medical Hypotheses 82(5):547 (2014) PMID 24581673

    Recombinant human erythropoietin (rHuEPO) has revolutionized the life of dialysis patients with anemia of chronic kidney disease (CKD). Newer erythropoietin analogues with improved profile have been introduced recently. However, there are many concerns such as safety, economy and patient compliance...
  2. Regulatory mechanism of performance in chronic cognitive fatigue.

    Medical Hypotheses 82(5):567 (2014) PMID 24594236

    Chronic cognitive fatigue is characterized by a sensation of long-lasting fatigue that impairs cognitive functions. Facilitation and inhibition systems in the central nervous system play primary roles in determining the output to the peripheral system, that is, performance. Sensory input from the pe...
  3. Review and rhyme - Of birth of cancers and selfish epigenomes.

    Medical Hypotheses 82(5):639 (2014) PMID 24612784

  4. Posterior reversible encephalopathy syndrome: The endothelial hypotheses.

    Medical Hypotheses 82(5):619 (2014) PMID 24613735

    We here describe the hypothesis of the crucial role of endothelial dysfunction and activation in PRES pathogenesis. Our hypothesis offers a common pathogenetic mechanism in which every PRES-related condition can be set. In our model, the activation of immune system and the consequent endothelial act...
  5. Recently discovered properties of aspirin may be doubly helpful in bipolar disorders.

    Medical Hypotheses 82(5):640 (2014) PMID 24650419

  6. Helicobacter pylori might be a potential therapeutic target in epilepsy.

    Medical Hypotheses 76(5):763 (2011) PMID 21356577

  7. Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy

    Medical Hypotheses 58(6):4 (2002)

  8. "Stress entropic load" as a transgenerational epigenetic response trigger.

    Medical Hypotheses 82(3):271 (2014) PMID 24405889

    We propose a theory which states that stress, or, more specifically, the energy cost of an individual's adaptation to stress, represents a viable candidate for the transgenerational transmission trigger of a given acquired trait. It has been reported recently that the higher lifetime entropy generat...
  9. Relative lymphocyte count is a prognostic parameter in cancer patients with catumaxomab immunotherapy.

    Medical Hypotheses 82(3):295 (2014) PMID 24411128

    I and II studies. Recently, it was approved in the EU for treatment of peritoneal carcinomatosis and malignant ascites. Aim of this hypothesis-generating study was to identify predictive or prognostic biomarkers with relevance for overall survival. 34 patients with PC in phase I/II studies with catu...
  10. Is rheumatoid arthritis a B-cell haematological disease with a predilection for the joints? Following the B cell thread to its logical concl...

    Medical Hypotheses 82(3):266 (2014) PMID 24447777

    B-cell depleting therapy (BCDT) is effective in suppressing synovitis and erosions in rheumatoid arthritis suggesting that a cell of the B-lymphocyte lineage is critical in the pathogenesis of this disease. Non-Hodgkins lymphoma (NHL) also responds to BCDT but multiple myeloma (MM), does not as cell...