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Stress-induced gastrointestinal motility is responsible for epileptic susceptibility.
In order to explain observations linking epileptic EEG patterns (3Hz spike wave complexes and β-γ activity of 25-40Hz) and the involuntary slow wave of the gut (3c/min) and colonic contractile electrical complexes (25-40c/min), the physiological and pathological electrographic patterns recorded from...
6R-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4): A potential treatment for all symptom domains of schizophrenia.
Current psychopharmacological treatment of schizophrenia is suboptimal and the available antipsychotic medications have little or no effect on negative and cognitive symptom domains of the disorder. 6R-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is a cofactor involved in the synthesis of dopamine, s...
Helicobacter pylori might be a potential therapeutic target in epilepsy.
Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy
Is sleep-disordered breathing associated with miscarriages? An emerging hypothesis.
Sleep-disordered breathing (SDB) is a common disorder that has numerous medical consequences including cardiovascular morbidity. The clinical presentation in women is frequently vague, leading to its under-recognition in this population. Sleep is known to influence several female hormonal cycles inc...
Obsessive-compulsive disorder and gut microbiota dysregulation.
Obsessive-compulsive disorder (OCD) is a debilitating disorder for which the cause is not known and treatment options are modestly beneficial. A hypothesis is presented wherein the root cause of OCD is proposed to be a dysfunction of the gut microbiome constituency resulting in a susceptibility to o...
Neuroinflammation in ischemic brain injury as an adaptive process.
We argue that another important distinction is between dysregulated and regulated processes. Although intervening in the course of dysregulated processes may be neuroprotective, this is unlikely to be true for regulated processes. This is because from an evolutionary perspective, regulated complex p...
Cirrhosis development probably arises from chronic micro-vascular ischemia.
Every patient with atrial fibrillation has his (her) own optimal heart rate.
We propose that every AF patient has his (her) own optimal heart rate, or to say that, the target for rate control in each AF patient should be individualized. This optimal heart rate can be defined by pulse counting, echocardiography or cardiopulmonary exercise test. With this new target, patients...
Extracorporeal membrane oxygenation and lethal diseases: a new perspective.
Our hypothesis is that the new ECMO technological improvement could make this technique available to other setting, such as lethal cancer and infectious diseases, where it can provide a safe base to overwhelm acute cardiac and pulmonary toxicity of chemotoxic drugs and techniques. New drugs and old...