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Medical Hypotheses

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  1. Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy

    Medical Hypotheses 58(6):4 (2002)

  2. Application of a medial buttress plate may prevent many treatment failures seen after fixation of vertical femoral neck fractures in young a...

    Medical Hypotheses (1996)

    We propose that the concepts of modern fracture care should be applied together for vertical femoral neck fractures in young adults. Specifically, we propose that anatomic reduction and fixation of vertically oriented femoral neck fractures with the addition of a medial buttress plate to resist shea...
  3. Is copper imbalance an environmental factor influencing keratoconus development?

    Medical Hypotheses (1984)

    We propose a hypothesis linking all the putative pathways of keratoconus development and suggest that copper imbalance in corneal tissue may be an independent risk factor for the disease. The assessment of copper levels and its distribution in keratoconic corneas warrants further investigation....
  4. Autologous Hematopoietic Stem Cells transplantation and genetic modification of CCR5 m303/m303 mutant patient for HIV/AIDS.

    Medical Hypotheses 84(3):216 (2015) PMID 25613565

    HIV and AIDS is one of the biggest challenges all over the world. There are an approximately 34 million people living with the virus, and a large number of them become infected each year. Although there are some antiviral drugs for HIV viral load reduction, they are not sufficient. There is no cure...
  5. Beneficial effects of cellular autofluorescence following ionization radiation: Hypothetical approaches for radiation protection and enhanci...

    Medical Hypotheses 84(3):194 (2015) PMID 25613566

    We suggested that this cellular autofluorescence can activate some synthetic drugs called photo-activated agents that are injected in human body after radiation exposures scenarios. Photo activated agents can activate biological pathways such as DNA repair and immunostimulation pathways, bystander s...
  6. Persistent endothelial dysfunction turns the frequent exacerbator COPD from respiratory disorder into a progressive pulmonary and systemic v...

    Medical Hypotheses 84(2):155 (2015) PMID 25539899

    We hypothesize that frequent exacerbator COPD is a progressive and generalised vascular disease, not only an isolated respiratory disorder with ancillary systemic effects. Our opinion is that differences in COPD phenotype do not only determine the clinical picture but could also be of key importance...
  7. Allogeneic and autologous mode of stem cell transplantation in regenerative medicine: which way to go?

    Medical Hypotheses 83(6):787 (2014) PMID 25456787

    We hypothesize that allogeneic transplantation could be more effective and cost-effective as compared to autologous transplantation specifically in older subjects who are the likely victims of degenerative diseases. This analysis is based on the scientific logic that allogeneic stem cells extracted...
  8. Assigning appropriate and comprehensive diagnosis for scientific report.

    Medical Hypotheses 83(6):681 (2014) PMID 25459133

    We have proposed: (i) a simple, potentially reliable and stepwise guide that can be used to assign the single most appropriate main principal diagnosis to each patient and illustrated this with case reports (ii) how to simultaneously report the main and other diagnoses in a scientific paper. It is h...
  9. Pre-eclampsia - The "uterine reinnervation" view.

    Medical Hypotheses 83(5):575 (2014) PMID 25216751

    Difficult vaginal deliveries, gynaecological surgery, and, persistent straining during defaecation injure uterine nerves. Cytokines released from injured, uterine nerves cause regeneration of new nerves with altered structures and functions. In structural terms, these new nerves proliferate in chaot...
  10. "Clinical brain profiling": a neuroscientific diagnostic approach for mental disorders.

    Medical Hypotheses 83(4):450 (2014) PMID 25155246

    We review the nature and motivation for clinical brain profiling. This involves a description of the key aspects of functional anatomy that can lead to psychopathology. These features constitute the dimensions or categories for a profile of brain disorders based upon pathophysiology. The second sect...