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Medical Hypotheses

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  1. Quantum dot-based diabetic foot mapping for diagnosing osteomyelitis and Charcot neuroarthropathy

    Medical Hypotheses 85(1):7 (2015) PMID 25801484

    The location of osteomyelitis is very important in Charcot neuroarthropathy (CN), especially when a physician is considering amputation of the affected extremity. In diabetic CN, the presence of osteomyelitis is likely. Thus, to identify the infected tissue that needs to be r...
  2. Brain motion and volume transmission: Keeping the interstice flowing

    Medical Hypotheses 85(1):41 (2015) PMID 25840847

    Human brain undergoes two different kinds of movements: subtle pulsatile ones associated with the cardiac cycle and others of a greater magnitude related to breathing activity. These motions constitute a pumping force for the circulation of cerebrospinal fluid (CSF). Moreover, brain mo...
  3. Assigning appropriate primary cause of death and indication for medical procedures

    Medical Hypotheses 85(1):79 (2015) PMID 25892489

    The most appropriate primary cause of death in a patient who had multiple medical conditions is that medical condition which initiated the chain of events that led to the other medical conditions that resulted in death. In clinical practice, there are deceased patients who had several ...
  4. Is riluzole a potential therapy for Rett syndrome?

    Medical Hypotheses 85(1):76 (2015) PMID 25858436

    Rett syndrome (RTT) is a severe neurodevelopmental disorder with autistic features and is caused by loss-of-function mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2) in the majority of cases. Besides symptomatic treatment, no therapeutic trials have shown effectivene...
  5. Simple radiosensitizing of hypoxic tumor tissues by N2O/Br− mixture

    Medical Hypotheses 85(1):37 (2015) PMID 25812437

    The radiosensitization model of hypoxic tumor tissues based on the N2O/Br− mixture is described. The well-documented radiolysis of water in the presence of N2O and Br− ions at a low concentration supports this model. An aqueous solution saturated with N2O gas during the radiolysis gene...
  6. Roles of lymphocyte Kv1.3-channels in gut mucosal immune system: Novel therapeutic implications for inflammatory bowel disease

    Medical Hypotheses 85(1):61 (2015) PMID 25847395

    In the gastrointestinal mucosal immune system, T-lymphocytes are activated to produce pro-inflammatory cytokines, and the over-activation of the lymphocytes is primarily responsible for the development of inflammatory bowel disease (IBD). Despite our understanding of the molecular invo...
  7. A Central Theory of Biology

    Medical Hypotheses 85(1):49 (2015) PMID 25911556 PMCID PMC4447538

    The history of physiologic cellular–molecular interrelationships can be traced all the way back to the unicellular state by following the pathway formed by lipids ubiquitously accommodating calcium homeostasis, and its consequent adaptive effects on oxygen uptake by cells, tissues and ...
  8. Epistemological implications of near-death experiences and other non-ordinary mental expressions: Moving beyond the concept of altered state of consciousness

    Medical Hypotheses 85(1):85 (2015) PMID 25892488

    During the last decades an increasing interest has developed in the so-called altered state of consciousness (ASCs); among these, near-death experiences (NDEs) are one of the most intriguing and debated examples. NDEs are deep and universal experiences with a clear phenomenology and in...
  9. Activation of NMDA receptor by elevated homocysteine in chronic liver disease contributes to encephalopathy

    Medical Hypotheses 85(1):64 (2015) PMID 25881985

    Liver diseases lead to a complex syndrome characterized by neurological, neuro-psychiatric and motor complications, called hepatic encephalopathy, which is prevalent in patients and animal models of acute, sub-chronic and chronic liver failure. Although alterations in GABAergic, glutam...
  10. Engineering β-cell islets or islet-like structures for type 1 diabetes treatment

    Medical Hypotheses 85(1):82 (2015) PMID 25892491

    Type 1 diabetes mellitus is a disease characterized by the destruction of the β-cells in the pancreatic islets of Langerhans. The current primary treatment for type 1 diabetes is insulin injections administered multiple times throughout the day. However, this treatment cannot provide s...