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Helicobacter pylori might be a potential therapeutic target in epilepsy.
Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy
Prostaglandins in semen compromise the immune response against sexually transmitted pathogens.
We have recently shown that exposure to seminal plasma induces the differentiation of dendritic cells into a tolerogenic profile through a mechanism dependent on the activation of the prostanoid receptors EP2 and EP4 by seminal PGE. Our hypothesis proposes that this tolerogenic response induced by s...
Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias.
The considerable heterogeneity in the number and severity of symptoms observed in autism spectrum disorders (ASD) has been regarded as an obstacle to any future research. Some authors believe that clinical heterogeneity results from the complex interplay of the many genetic and environmental factors...
Muscle as a molecular machine for protecting joints and bones by absorbing mechanical impacts.
We hypothesize that dissipation of mechanical energy of external impact to absorb mechanical shock is a fundamental function of skeletal muscle in addition to its primary function to convert chemical energy into mechanical energy. In physical systems, the common mechanism for absorbing mechanical sh...
Is insulin the new intermittent hypoxia?
We propose the carotid chemoreceptors contribute to insulin-mediated sympathoexcitation and the persistent rise in MSNA in patients with sustained hyperinsulinemia. If the carotid chemoreceptors sense and respond to changes in systemic insulin levels, these organs may provide a viable target for the...
Glaucoma--diabetes of the brain: a radical hypothesis about its nature and pathogenesis.
We here present a hypothesis inspired by studies across many areas of molecular and clinical sciences in an integrative manner that leads to a uniquely unconventional understanding of this disorder. Our hypothesis postulates that glaucoma may possibly be the diabetes of the brain. Based on the remar...
Low maternal progesterone may contribute to both obstetrical complications and autism.
We hypothesized that low levels of the hormone progesterone is responsible since it is supplied to the fetus maternally and does not only support pregnancy but also promotes brain development. Following a review of the literature, we report findings from a survey of mothers of autistic children (n=8...
Altitude is a risk factor for completed suicide in bipolar disorder.
Bipolar disorder (BD) is a severe brain disease that is associated with a significant risk for suicide. Recent studies indicate that altitude of residence significantly affects overall rate of completed suicide, and is associated with a higher incidence of depressive symptoms. Bipolar disorder has s...
Air pollution, inflammation and preterm birth: a potential mechanistic link.
We hypothesize that air pollution may act together with other biological factors to induce systemic inflammation and influence the duration of pregnancy. Evaluation and testing of this hypothesis is currently being conducted in a prospective cohort study in Mexico City and will provide an understand...