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Role of ADHD symptoms as a contributing factor to obesity in patients with MC4R mutations.
We focus on the relationship between MC4R gene mutations and ADHD in children with early-onset obesity. Mutations in the gene MC4R lead to the most common form of monogenic obesity. We hypothesize that dysregulated eating behavior in a subset of patients with MC4R mutation might be due to comorbid A...
South-Asian population has a higher likelihood for diabetes risk for statins regardless of potency
Medical Hypotheses (2014)Higher potency statins are associated with increased risk of new-onset diabetes (NOD) in Western populations. South-Asians phenotype, with certain unique features such as young onset of diabetes and lower threshold for diabetes risk factors, present a higher likelihood for NOD risk for sta...
Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy
The prestige model of spectrum bipolarity.
We examine the notion that the adaptive drive to social investment - prestige - provides clues to the bipolar spectrum. A seven node bipolar spectrum is proposed, based on a putative gradient of "bipolarity". It is conceived that this gradient may correlate with the drive to social investment (prest...
A gedanken experiment to find a neuroanatomical model for post-traumatic stress disorder.
Post-traumatic stress disorder is a persistent stress syndrome in which abnormal brain physiology persists long after cessation of the acute psychological event that causes it. Normal physiological homeostasis depends on equilibria. The basic unit of equilibrium is the negative feedback loop (NFL) a...
Mangiferin: A promising therapeutic agent for rheumatoid arthritis treatment.
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia and progressive joint destruction. Despite aggressive treatment with anti-rheumatic drugs, progressive destruction of joints continues to occur in RA patients, who subsequently require joint surgery. A...
Pulmonary arterial hypertension and sepsis: prothrombotic profile and inflammation can changes pulmonary mechanics?
Pulmonary arterial hypertension (PAH) is associated to cellular and structural alterations of lung vasculature. Endothelial dysfunction promotes vasoconstriction, smooth muscle hypertrophy, intimal proliferation, angioproliferative plexiform lesions, and in situ thrombosis increasing pulmonary vascu...
Toxoplasmosis can be a sexually transmitted infection with serious clinical consequences. Not all routes of infection are created equal.
We present a hypothesis suggesting that toxoplasmosis is transmitted from infected men to noninfected women during unprotected sexual intercourse, which can result in the most serious form of disease, congenital toxoplasmosis. Arguments for the hypothesis: (1) Toxoplasma tachyzoites are present in t...
A conceptual model of compensation/decompensation in lumbar segmental instability.
We hypothesize that a set of clinical and radiological criteria can be developed to identify patients with this target condition who are at high risk of 'irreversible' decompensated LSI for whom surgery becomes the treatment of choice. In LSI, structural deterioration of the lumbar disc initiates a...
Melatonin as potential inducer of Th17 cell differentiation.
The subset of T lymphocytes producing IL-17 (Th17) plays a key role in the immune system. It has been implicated in host defense, inflammatory diseases, tumorigenesis, autoimmune diseases, and transplant rejection. Careful analysis of the data available holds that Th17 cell subpopulation should be u...