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Medical Hypotheses

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  1. The effects of steroid hormone exposure on direct gene regulation.

    Medical Hypotheses 83(4):436 (2014) PMID 25113166

    We discuss the impact of normal reproductive templates on the pulsatility and amplitude of potential gene-regulating treatment protocols. By examining the interactions of estradiol (E2) and progesterone (P4) in women, we propose that changes in physiologic reproductive hormone templates of exposure...
  2. Glycogenolysis: Is muscle glycogen phosphorylase differentially activated depending on the conditions of hypoxia and exercise?

    Medical Hypotheses 83(4):513 (2014) PMID 25175714

  3. Helicobacter pylori might be a potential therapeutic target in epilepsy.

    Medical Hypotheses 76(5):763 (2011) PMID 21356577

  4. Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy

    Medical Hypotheses 58(6):4 (2002)

  5. Folliculo-stellate cells - Potential mediators of the inflammaging-induced hyperactivity of the hypothalamic-pituitary-adrenal axis in healt...

    Medical Hypotheses 83(4):501 (2014) PMID 25175404

    We assumed that folliculo-stellate cells were the target structures through which the elevated levels of cytokines, as a part of the inflammaging phenomenon, would cause the overactivation of the HPA axis in healthy elderly individuals. Folliculo-stellate cells are non-endocrine cells that were orig...
  6. Autologous stem cell transplant with gene therapy for Friedreich ataxia.

    Medical Hypotheses 83(3):296 (2014) PMID 24962209 PMCID PMC4145018

    We advance the overarching hypothesis that stem cell therapy is a potent treatment for Friedreich's ataxia (FRDA). Here, we discuss the feasibility of autologous transplantation in FRDA, highlighting the need for the successful isolation of the FRDA patient's bone marrow-derived mesenchymal stem cel...
  7. Prostaglandins in semen compromise the immune response against sexually transmitted pathogens.

    Medical Hypotheses 83(2):208 (2014) PMID 24837236

    We have recently shown that exposure to seminal plasma induces the differentiation of dendritic cells into a tolerogenic profile through a mechanism dependent on the activation of the prostanoid receptors EP2 and EP4 by seminal PGE. Our hypothesis proposes that this tolerogenic response induced by s...
  8. Benefits of the povidone-iodine: simultaneously decrease risk of infection and tumor seeding after percutaneous endoscopic gastrostomy.

    Medical Hypotheses 82(6):678 (2014) PMID 24650418

    Percutaneous endoscopic gastrostomy (PEG) is a well-established enteral feeding modality in patients with oropharyngeal/esophageal cancer; however, these patients are at risk for two possible PEG-related complications. First, oropharyngeal organisms may be transported to the PEG stoma and thus incre...
  9. Low dietary sodium in diabetes nephropathy.

    Medical Hypotheses 82(5):551 (2014) PMID 24581676

    We hypothesise that in diabetic nephropathy, ACE-I or ARB treatment attenuates any rise in RAS hormones that might result from dietary salt restriction and that the beneficial effects of the salt restriction such as a lower blood pressure outweigh any potentially negative consequences of RAS activat...
  10. The putative role of proteolytic pathways in the pathogenesis of Type 1 diabetes mellitus: the 'autophagy' hypothesis.

    Medical Hypotheses 82(5):553 (2014) PMID 24582332

    I and class II self-antigen presentation at the basis of the autoimmunity process. Furthermore cross-talk among different proteolytic pathways was recently highlighted i.e. components processed in the ubiquitin/proteasome system possibly engaged in autophagic pathways. T1D is an autoimmune disease c...