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Medical Hypotheses

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  1. A processual model for functional analyses of carcinogenesis in the prospective cohort design

    Medical Hypotheses 85(4):494 (2015)

    Traditionally, the prospective design has been chosen for risk factor analyses of lifestyle and cancer using mainly estimation by survival analysis methods. With new technologies, epidemiologists can expand their prospective studies to include functional genomics given either as transc...
  2. Mood instability underlies the relationship between impulsivity and internalizing psychopathology

    Medical Hypotheses 85(4):447 (2015)

    Impulsivity, the tendency to act without adequate forethought, has been associated with various internalizing disorders. Mood instability, the tendency to experience rapid and intense mood swings, relates to both internalizing disorders and impulsivity. We hypothesized that the associa...
  3. Hypothesis: Pentoxifylline explores new horizons in treatment of preeclampsia

    Medical Hypotheses 85(4):468 (2015)

    Preeclampsia, the leading cause of maternal morbidity and perinatal mortality, initiates as inappropriate immune response to trophoblastic invasion impairs placentation and placental circulation. A poorly perfused placenta generates superoxide anions as well as anti-angiogenic factors ...
  4. Propranolol during pregnancy for large chorioangioma

    Medical Hypotheses 85(4):513 (2015)

    Large chorioangiomas are frequently associated with adverse perinatal outcome. Its treatment remains invasive and controversial. Infantile hemangiomas which have numerous similarities with chorioangiomas are now usually treated with propranolol. This drug has been extensively used with...
  5. Could sewage epidemiology be a strategy to assess lifestyle and wellness of a large scale population?

    Medical Hypotheses 85(4):408 (2015)

    The use of sewage epidemiology to estimate the behavior of a large scale population has mainly been used to assess illicit drug use within a community. The systemic oxidative stress marker, 8-isoprostane, is a wildly accepted biomarker for various diseases such as diabetes, and cardiov...
  6. Plausible etiology of brain dysconnectivity in autism – Review and prospectus

    Medical Hypotheses 85(4):405 (2015)

    This report summarizes recent findings related to the neuropathology of autism. Combining the relevant observations assessed here, a comprehensive, coherent hypothesis explaining the etiology of juvenile autism may be deduced. This proposed mechanism describes a process initiated by in...
  7. Intravenous infusion of haptoglobin for the prevention of adverse clinical outcome in Sickle Cell Disease

    Medical Hypotheses 85(4):424 (2015)

    Sickle Cell Disease (SCD) is a genetic condition which manifests as altered hemoglobin (Hb) protein that can aggregate under hypoxic conditions. The resultant sickled erythrocytes experience premature hemolysis, releasing an estimated 10g of free Hb (fHb) into the intravascular space. ...
  8. Reduced insulin-receptor mediated modulation of striatal dopamine release by basal insulin as a possible contributing factor to hyperdopaminergia in schizophrenia

    Medical Hypotheses 85(4):391 (2015)

    Schizophrenia is a severe and chronic neuropsychiatric disorder which affects 1% of the world population. Using the brain imaging technique positron emission tomography (PET) it has been demonstrated that persons with schizophrenia have greater dopamine transmission in the striatum com...
  9. Dietary methanol and autism

    Medical Hypotheses 85(4):441 (2015)

    The authors sought to establish whether maternal dietary methanol during pregnancy was a factor in the etiology of autism spectrum disorders. A seven item questionnaire was given to women who had given birth to at least one child after 1984. The subjects were solicited from a...
  10. Loss of binocular vision as direct cause for misrouting of temporal retinal fibers in albinism

    Medical Hypotheses 85(4):458 (2015)

    In humans, the nasal retina projects to the contralateral hemisphere, whereas the temporal retina projects ipsilaterally. The nasotemporal line that divides the retina into crossed and uncrossed parts coincides with the vertical meridian through the fovea. This normal projection of the...