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The effects of steroid hormone exposure on direct gene regulation.
We discuss the impact of normal reproductive templates on the pulsatility and amplitude of potential gene-regulating treatment protocols. By examining the interactions of estradiol (E2) and progesterone (P4) in women, we propose that changes in physiologic reproductive hormone templates of exposure...
Glycogenolysis: Is muscle glycogen phosphorylase differentially activated depending on the conditions of hypoxia and exercise?
Helicobacter pylori might be a potential therapeutic target in epilepsy.
Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy
Folliculo-stellate cells - Potential mediators of the inflammaging-induced hyperactivity of the hypothalamic-pituitary-adrenal axis in healt...
We assumed that folliculo-stellate cells were the target structures through which the elevated levels of cytokines, as a part of the inflammaging phenomenon, would cause the overactivation of the HPA axis in healthy elderly individuals. Folliculo-stellate cells are non-endocrine cells that were orig...
Autologous stem cell transplant with gene therapy for Friedreich ataxia.
We advance the overarching hypothesis that stem cell therapy is a potent treatment for Friedreich's ataxia (FRDA). Here, we discuss the feasibility of autologous transplantation in FRDA, highlighting the need for the successful isolation of the FRDA patient's bone marrow-derived mesenchymal stem cel...
Prostaglandins in semen compromise the immune response against sexually transmitted pathogens.
We have recently shown that exposure to seminal plasma induces the differentiation of dendritic cells into a tolerogenic profile through a mechanism dependent on the activation of the prostanoid receptors EP2 and EP4 by seminal PGE. Our hypothesis proposes that this tolerogenic response induced by s...
Benefits of the povidone-iodine: simultaneously decrease risk of infection and tumor seeding after percutaneous endoscopic gastrostomy.
Percutaneous endoscopic gastrostomy (PEG) is a well-established enteral feeding modality in patients with oropharyngeal/esophageal cancer; however, these patients are at risk for two possible PEG-related complications. First, oropharyngeal organisms may be transported to the PEG stoma and thus incre...
Low dietary sodium in diabetes nephropathy.
We hypothesise that in diabetic nephropathy, ACE-I or ARB treatment attenuates any rise in RAS hormones that might result from dietary salt restriction and that the beneficial effects of the salt restriction such as a lower blood pressure outweigh any potentially negative consequences of RAS activat...
The putative role of proteolytic pathways in the pathogenesis of Type 1 diabetes mellitus: the 'autophagy' hypothesis.
I and class II self-antigen presentation at the basis of the autoimmunity process. Furthermore cross-talk among different proteolytic pathways was recently highlighted i.e. components processed in the ubiquitin/proteasome system possibly engaged in autophagic pathways. T1D is an autoimmune disease c...