Advanced search×

Medical Hypotheses

Print ISSN
Electronic ISSN
Impact factor
Usage rank
Article count
Free count
Free percentage
PDFs via platforms
Gale, Sciencedirect from 1975, Rcgp, and Ingenta

  1. Helicobacter pylori might be a potential therapeutic target in epilepsy.

    Medical Hypotheses 76(5):763 (2011) PMID 21356577

  2. Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy

    Medical Hypotheses 58(6):4 (2002)

  3. Autologous stem cell transplant with gene therapy for Friedreich ataxia.

    Medical Hypotheses 83(3):296 (2014) PMID 24962209 PMCID PMC4145018

    We advance the overarching hypothesis that stem cell therapy is a potent treatment for Friedreich's ataxia (FRDA). Here, we discuss the feasibility of autologous transplantation in FRDA, highlighting the need for the successful isolation of the FRDA patient's bone marrow-derived mesenchymal stem cel...
  4. Prostaglandins in semen compromise the immune response against sexually transmitted pathogens.

    Medical Hypotheses 83(2):208 (2014) PMID 24837236

    We have recently shown that exposure to seminal plasma induces the differentiation of dendritic cells into a tolerogenic profile through a mechanism dependent on the activation of the prostanoid receptors EP2 and EP4 by seminal PGE. Our hypothesis proposes that this tolerogenic response induced by s...
  5. Benefits of the povidone-iodine: simultaneously decrease risk of infection and tumor seeding after percutaneous endoscopic gastrostomy.

    Medical Hypotheses 82(6):678 (2014) PMID 24650418

    Percutaneous endoscopic gastrostomy (PEG) is a well-established enteral feeding modality in patients with oropharyngeal/esophageal cancer; however, these patients are at risk for two possible PEG-related complications. First, oropharyngeal organisms may be transported to the PEG stoma and thus incre...
  6. Low dietary sodium in diabetes nephropathy.

    Medical Hypotheses 82(5):551 (2014) PMID 24581676

    We hypothesise that in diabetic nephropathy, ACE-I or ARB treatment attenuates any rise in RAS hormones that might result from dietary salt restriction and that the beneficial effects of the salt restriction such as a lower blood pressure outweigh any potentially negative consequences of RAS activat...
  7. The putative role of proteolytic pathways in the pathogenesis of Type 1 diabetes mellitus: the 'autophagy' hypothesis.

    Medical Hypotheses 82(5):553 (2014) PMID 24582332

    I and class II self-antigen presentation at the basis of the autoimmunity process. Furthermore cross-talk among different proteolytic pathways was recently highlighted i.e. components processed in the ubiquitin/proteasome system possibly engaged in autophagic pathways. T1D is an autoimmune disease c...
  8. Elevation of protective autophagy as a potential way for preventing developmental neurotoxicity of general anesthetics.

    Medical Hypotheses 82(2):177 (2014) PMID 24359684

    We thus intend to propose the possible role of autophagy in the developmental neurotoxicity of general anesthetics. Oxidative stress and neuronal apoptosis can activate autophagy, while autophagy conversely alleviates their levels in the neuron. Crosstalk among neuronal apoptosis, oxidative stress a...
  9. Molecular mechanisms of ischemic preconditioning and postconditioning as putative therapeutic targets to reduce tumor survival and malignanc...

    Medical Hypotheses 81(6):1141 (2013) PMID 24230458

    We hypothesize that the molecular mechanisms underlying intermittent hypoxia in tumor cells share some triggers, modulators, and end-effectors of the intermittent episodes of ischemia and reperfusion that characterize ischemic preconditioning and postconditioning. These are among the most effective...
  10. A proposed mechanism for exercise attenuated methylglyoxal accumulation: activation of the ARE-Nrf pathway and increased glutathione biosynt...

    Medical Hypotheses 81(5):813 (2013) PMID 24060484

    The dicarbonyl methylglyoxal (MGO) is an endogenous metabolite and a known intracellular precursor of advanced glycation endproducts (AGEs). High serum levels of MGO have been correlated with MGO-derived AGEs in individuals with type 2 diabetes (T2DM). Furthermore, there is human and animal evidence...