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Medical Hypotheses

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  1. Title page/Editorial Board
    Author(s) unavailable

    Medical Hypotheses 84(5):i (2015)

  2. Transcranial focused ultrasound as a possible treatment for major depression

    Medical Hypotheses 84(4):381 (2015) PMID 25665863

    Antidepressants are currently used as initial therapies for major depressive disorder (MDD). However, despite the remarkable increase in medications validated as effective in MDD, treatments are still plagued by inadequate responses in part of MDD patients. For MDD with inadequate resp...
  3. Teneurins and Alzheimer’s disease: A suggestive role for a unique family of proteins

    Medical Hypotheses 84(4):402 (2015) PMID 25665860

    Alzheimer’s disease is a debilitating age-related disorder characterized by distinct pathological hallmarks, such as progressive memory loss and cognitive impairment. During the last few years, several cellular signaling pathways have been associated with the pathogenesis of Alzheimer’...
  4. Risk factors for accelerated atherosclerosis in young women with hyperprolactinemia

    Medical Hypotheses 84(4):321 (2015) PMID 25649851

    Prolactin is a metabolic hormone. The hypothesis is that hyperprolactinemia can cause metabolic and inflammatory changes which are associated with accelerated atherosclerotic process, but the treatment of hyperprolactinemia with dopamine agonists, leads to reversibility of these proces...
  5. Is blue light, cryptochrome in the eye, and magnetite in the brain involved in the development of frontotemporal dementia and other diseases?

    Medical Hypotheses 84(4):379 (2015) PMID 25678234

    When cryptochrome in the retina is exposed to blue light, it undergo series of complicated chemical reactions. One of these intermediates has magnetic properties. It could be a link between the magnetic stage of cryptochrome in the retina and magnetite in the brain. A disturbance in th...
  6. Title page/Editorial Board
    Author(s) unavailable

    Medical Hypotheses 84(4):i (2015)

  7. Testosterone therapy, thrombophilia, and hospitalization for deep venous thrombosis–pulmonary embolus, an exploratory, hypothesis-generating study

    Medical Hypotheses 84(4):341 (2015) PMID 25648660

    Our hypothesis was that testosterone therapy (TT) interacts with previously undiagnosed thrombophilia–hypofibrinolysis, leading to hospitalization for deep venous thrombosis (DVT)–pulmonary emboli (PE). We determined the prevalence of DVT–PE associated with TT 147 men hospitalized in t...
  8. Vitamin K: The missing link to prostate health

    Medical Hypotheses 84(3):219 (2015) PMID 25613567

    Though age-related prostate enlargement is very common in Western societies, and the causes of benign prostate hyperplasia, BPH, have been diligently sought after, there is no biological, mechanistic explanation dealing with the root causes and progression of this very common disorder ...
  9. NOSH aspirin may have a protective role in Alzheimer’s disease

    Medical Hypotheses 84(3):262 (2015) PMID 25636606

    Evidence indicates that inflammation, oxidative stress, and the disruption of normal conformation of proteins might be directly linked to Alzheimer’s disease (AD). The present study was undertaken using literature data to find a possible drug to address the multiple disorders involved ...
  10. TCDD-induced activation of aryl hydrocarbon receptor regulates the skin stem cell population

    Medical Hypotheses 84(3):204 (2015) PMID 25618441

    The environmental toxin 2,3,7,8 tetrachlorodibenzo p-dioxin (TCDD) plays an important role in the development of chloracne. Chloracne is characterized by hyperkeratosis of the interfollicular squamous epithelium and metaplasia of sebaceous glands. Dysregulation of keratinocyte terminal...