Canadian Journal of Neurological Sciences

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  1. 320-Row Multidetector CT Angiography in the Detection of Critical Cerebrovascular Anomalies.

    Canadian Journal of Neurological Sciences 43(4):543 (2016) PMID 26963444

    The acquisition of a new 320-row multidetector computed tomography angiography (CTA) scanner at the Montreal Neurological Institute and Hospital has provided higher quality imaging with less radiation exposure and shorter time of acquisition. However, its reliability has not been fully proven in...
  2. Circle of Willis Collateral During Temporary Internal Carotid Artery Occlusion I: Observations From Digital Subtraction Angiography.

    Canadian Journal of Neurological Sciences 43(4):533 (2016) PMID 27030296

    Impaired collateral circulation can lead to stroke during carotid endarterectomy. Carotid stump pressure (CSP) is used as a surrogate measure of collateral flow. The objective was to determine whether anatomical features obtained from digital subtraction angiography correlate with CSP during tem...
  3. Brainstem Developmental Venous Anomaly Causing Hemifacial Spasm - Case Report and Review of the Literature.

    Canadian Journal of Neurological Sciences 43(4):606 (2016) PMID 27133013

  4. The Incidence and Evolution of Parkinsonian Rigidity in Rett Syndrome: A Pilot Study.

    Canadian Journal of Neurological Sciences 43(4):567 (2016) PMID 27050783

    Patients with Rett syndrome (RTT) may demonstrate parkinsonian features. Here, we report a preliminary cross-sectional and prospective evaluation of the evolution, regional distribution, and eventual incidence of rigid tone in a cohort of MECP2 mutation-positive patients. In 51 participants, mus...
  5. What is the Future of Pediatric Neurology in Canada? Resident and Faculty Perceptions of Training and Workforce Issues.

    Canadian Journal of Neurological Sciences 43(4):549 (2016) PMID 26972229

    Pediatric neurology trainee numbers have grown considerably in Canada; recent research, however, has shown that the number of pediatric neurology graduates is outpacing the need for future pediatric neurologists. The purpose of this study was to seek the opinion of pediatric neurology program di...
  6. Circle of Willis Collateral During Temporary Internal Carotid Artery Occlusion II: Observations From Computed Tomography Angiography.

    Canadian Journal of Neurological Sciences 43(4):538 (2016) PMID 27027491

    The Circle of Willis (CoW) is the most effective collateral circulation to the brain during internal carotid artery (ICA) occlusion. Carotid stump pressure (CSP) is an established surrogate measure of the cerebral collateral circulation. This study aims to use hemodynamic and computed tomography...
  7. Depressive Symptoms Negatively Impact Montreal Cognitive Assessment Performance: A Memory Clinic Experience.

    Canadian Journal of Neurological Sciences 43(4):513 (2016) PMID 26842678

    The Montreal Cognitive Assessment (MoCA) is a general cognitive screening tool that has shown sensitivity in detecting mild levels of cognitive impairment in various clinical populations. Although mood dysfunction is common in referrals to memory clinics, the influence of mood on the MoCA has to...
  8. Franciscus Sylvius on Clinical Teaching, Iatrochemistry and Brain Anatomy.

    Canadian Journal of Neurological Sciences 43(4):596 (2016) PMID 26911424

    Born in Hanau, Germany, in 1614, Franciscus (Dele Boë) Sylvius received his medical doctor diploma from Basel University in 1637 and became Professor of Practical Medicine at Leiden University in 1658. One of the founders of medical biochemistry, Sylvius was also an outstanding anatomopathologis...
  9. Sensory Neuronopathy in CANVAS: Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia.

    Canadian Journal of Neurological Sciences 43(4):604 (2016) PMID 26837948

  10. Pyogenic Ventriculitis as Clinical Presentation of Diverticulitis.

    Canadian Journal of Neurological Sciences 43(4):576 (2016) PMID 26928780

  11. Predictors of Hospitalization in Patients With Transient Ischemic Attack or Minor Ischemic Stroke.

    Canadian Journal of Neurological Sciences 43(4):523 (2016) PMID 27025846

    Transient ischemic attack (TIA) and minor stroke are associated with a substantial risk of subsequent stroke; however, there is uncertainty about whether such patients require admission to hospital for their initial management. We used data from a clinical stroke registry to determine the freque...
  12. Pompe Disease: Diagnosis and Management. Evidence-Based Guidelines from a Canadian Expert Panel.

    Canadian Journal of Neurological Sciences 43(4):472 (2016) PMID 27055517

    Pompe disease is a lysosomal storage disorder caused by a deficiency of the enzyme acid alpha-glucosidase. Patients have skeletal muscle and respiratory weakness with or without cardiomyopathy. The objective of our review was to systematically evaluate the quality of evidence from the literature...
  13. Eligibility Criteria for Deep Brain Stimulation in Parkinson's Disease, Tremor, and Dystonia.

    Canadian Journal of Neurological Sciences 43(4):462 (2016) PMID 27139127

    In this review, the available evidence to guide clinicians regarding eligibility for deep brain stimulation (DBS) in the main conditions in which these forms of therapy are generally indicated-Parkinson's disease (PD), tremor, and dystonia-is presented. In general, the literature shows that DBS ...
  14. Dural Reduction Surgery: A Treatment Option for Frontotemporal Brain Sagging Syndrome.

    Canadian Journal of Neurological Sciences 43(4):593 (2016) PMID 26972054

    Frontotemporal brain sagging syndrome is a dementia associated with hypersomnolence, personality changes, and features of intracranial hypotension on magnetic resonance imaging. The literature is sparse with respect to treatment options; many patients simply worsen. We present a case in which th...
  15. Physician Preferences for Botulinum Toxin Injections in Anticoagulated Patients with Spasticity.

    Canadian Journal of Neurological Sciences 43(4):581 (2016) PMID 26940640

    To understand physician preferences and bleeding complication rates of intramuscular botulinum neurotoxin type A injections for spasticity management in anticoagulated patients, questionnaires were mailed to 138 physicians across Canada. The international normalized ratio comfort range for injec...
  16. Reflex Seizures Triggered by Diaper Change in Dravet Syndrome.

    Canadian Journal of Neurological Sciences 43(4):585 (2016) PMID 26889571

    Dravet syndrome (DS) is a severe epilepsy syndrome characterized by early onset of multiple types of seizures. We report the first case of reflex seizures triggered by diaper change in a girl at 9 months old and 2 years old with a mutation in the SCN1A gene causing DS. Reflex seizures have been ...
  17. Multifocal Cerebral and Bilateral Middle Cerebellar Peduncle Infarctions in CADASIL.

    Canadian Journal of Neurological Sciences 43(4):574 (2016) PMID 26956688

  18. Immunological Aspects of Malignant Gliomas.

    Canadian Journal of Neurological Sciences 43(4):494 (2016) PMID 27324313

    Glioblastoma Multiforme (GBM) is the most common malignant primary brain neoplasm having a mean survival time of <24 months. This figure remains constant, despite significant progress in medical research and treatment. The lack of an efficient anti-tumor immune response and the micro-invasive na...
  19. Nε-(carboxymethyl)-lysine, White Matter, and Cognitive Function in Diabetes Patients.

    Canadian Journal of Neurological Sciences 43(4):518 (2016) PMID 26889714

    To study the relationship of Nε-(carboxymethyl)-lysine level (CML) with microstructure changes of white matter (WM), and cognitive impairment in patients with type 2 diabetes mellitus (T2DM) and to discuss the potential mechanism underlying T2DM-associated cognitive impairment. The study was per...
  20. Experience with Canada's First Policy on Concussion Education and Management in Schools.

    Canadian Journal of Neurological Sciences 43(4):554 (2016) PMID 27142787

    In response to the rising incidence of concussions among children and adolescents, the province of Ontario recently introduced the Ontario Policy/Program Memorandum on Concussions (PPM No. 158) requiring school boards to develop a concussion protocol. As this is the first policy of its kind in C...