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Axially chiral biscarbazoles and biological evaluation of the constituents from Murraya koenigii.
Chemical investigation of the fruit pulp of Murraya koenigii resulted in the identification of two new dimeric carbazole alkaloids, bisgerayafoline D (1) and bismahanimbinol (2) along with four known alkaloids, bispyrayafoline (3), O-methyl mahanine (4), O-methyl mukonal (5), and mahanine (6). Struc...
Potential targets by pentacyclic triterpenoids from Callicarpa farinosa against methicillin-resistant and sensitive Staphylococcus aureus.
The evolution of antibiotic resistance in Staphylococcus aureus showed that there is no long-lasting remedy against this pathogen. The limited number of antibacterial classes and the common occurrence of cross-resistance within and between classes reinforce the urgent need to discover new compounds...
Vasorelaxant activity of some structurally related triterpenic acids from Phoradendron reichenbachianum (Viscaceae) mainly by NO production:...
The aim of the current study was to investigate the vasorelaxant activity of five structurally-related triterpenic acids namely ursolic (1), moronic (2), morolic (3), betulinic (4) and 3,4-seco-olean-18-ene-3,28-dioic (5) acids. The vasorelaxant effect of compounds 1-5 were determine...
Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans.
Bioassay-guided isolation of the stems of Gelsemium elegans has led to the isolation of two new Gelsemium alkaloids, 21-(2-oxopropyl)-koumine (1) and 11-methoxygelselegine (2), and two known alkaloids, koumine (3) and gelselegine (4). The structures of 1-2 were determined by spectros...
Cytotoxic triterpene saponins from the leaves of Aralia elata.
Phytochemical investigation of the leaves of Aralia elata has led to the isolation of four new compounds, 3-O-β-d-glucopyranosyl (1→3)-β-d-glucopyranosyl (1→3)-β-d-glucopyranosyl oleanolic acid (1), 3-O-[β-d-glucopyranosyl (1→3)-β-d-glucopyranosyl (1→3)]-[β-d-glucopyran...
Potent and selective butyrylcholinesterase inhibitors from Ficus foveolata.
Four stilbenes (1-4), one inseparable mixture of two alkyl diferulates (5a, 5b), one alkyl ferulate (6) and four flavonoids (7-10) were isolated from Ficus foveolata Wall. Except for quercetin (10), the other ten constituents were isolated from F. foveolata for the first time. In add...
Chemical constituents of the aerial part of Derris elliptica.
A new coumaronochromone, 6,4'-dihydroxy-7,5'-dimethoxy-coumaronochromone (1), together with eleven known flavonoids (2-12) were isolated from the ethanol extract of the aerial part of Derris elliptica. Their structures were elucidated on the basis of spectroscopic analysis. Compounds...
Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects.
Roots of Morinda citrifolia (Noni or Yor in Thai) have been used traditionally for thousands of years to treat chronic diseases such as cancer and heart disease. In this study, three new anthraquinones together with 15 known compounds were isolated from the roots of M. citrifolia (Rubiaceae). Their s...
Protective effect of Spirulina fusiformis on chemical-induced genotoxicity in mice.
Spirulina fusiformis given by oral route to mice at doses of 250, 500 and 1000 mg kg(-1) significantly inhibit the genotoxicity induced by cisplatin and urethane. In addition, a significant reduction in the extent of lipid peroxidation with concomitant increase in the liver enzymatic (GPx, GST, SOD,...
Antimicrobial activity of Psychotria microlabastra.
The methanol extracts of leaves, root and stem barks of Psychotria microlabastra showed a broad spectrum of antibacterial activity, that was increased on fractionation (petrol, dichloromethane, ethyl acetate), particularly in the ethyl acetate fractions. None of the extractives showed activity again...