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  1. HIF-prolyl hydroxylase is a potential molecular target for esculetin-mediated anti-colitic effects

    Fitoterapia 103:55 (2015) PMID 25797536

    We investigated a potential molecular target for anti-colitic effects of esculetin, 6,7-dihydroxycoumarin. Esculetin administered rectally effectively ameliorated TNBS-induced rat colitis and attenuated the expression of pro-inflammatory mediators in the inflamed colon. In human colon ...
  2. Sesquiterpenes from the essential oil of Curcuma wenyujin and their inhibitory effects on nitric oxide production

    Fitoterapia 103:143 (2015) PMID 25819782

    Three new sesquiterpenes including a new elemane-type sesquiterpene, 5βH-elem-1,3,7,8-tetraen-8,12-olide (1), and two new carabrane-type sesquiterpenes, 7α,11-epoxy-6α-methoxy-carabrane-4,8-dione (2) and 8,11-epidioxy-8-hydroxy-4-oxo-6-carabren (3), together with eight known sesquiterp...
  3. Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities

    Fitoterapia 103:289 (2015) PMID 25963162

    A new prenylated isoflavan, iconisoflavan (1), and a new prenylated isoflav-3-ene, iconisoflaven (2) were isolated from the roots of Glycyrrhiza iconica together with four known ones namely (3S)-licoricidin (3), licorisoflavan A (4), topazolin (5) and glycycoumarin (6). The structures ...
  4. Dolabrane-type diterpenes from the mangrove plant Ceriops tagal with antitumor activities

    Fitoterapia 103:277 (2015) PMID 25936771

    Chemical examination of the barks of mangrove plant Ceriops tagal resulted in the isolation of six new dolabrane-type diterpenes with the trivial names of tagalenes A–F (1–6), together with 10 known analogues. The structures of new compounds were elucidated by extensive spectroscopic d...
  5. Nitric oxide inhibitory flavonoids from traditional Chinese medicine formula Baoyuan Decoction

    Fitoterapia 103:252 (2015) PMID 25889071

    Three new flavonoid glycosides, (3R)-(+)-isomucronulatol-2′-O-β-D-glucopyranoside (1), (3R)-(−)-isomucronulatol-7-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside (2), and (2S)-(−)-7,8-dihydroxylflavanone-4′-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside (3), along with eight flavanones (4, ...
  6. Attenuation of stress-induced gastrointestinal motility disorder by gentiopicroside, from Gentiana macrophylla Pall

    Fitoterapia 103:265 (2015) PMID 25936770

    Aim The current study was designed to explore the mechanism of the prokinetic activity of Gentiopicroside (Ge), from Gentiana macrophylla Pall which is widely used to strengthen gastric motility in clinic.
  7. Identification of anti-HIV active dicaffeoylquinic- and tricaffeoylquinic acids in Helichrysum populifolium by NMR-based metabolomic guided fractionation

    Fitoterapia 103:155 (2015) PMID 25841639

    South Africa being home to more than 35% of the world's Helichrysum species (c.a. 244) of which many are used in traditional medicine, is seen potentially as a significant resource in the search of new anti-HIV chemical entities. It was established that five of the 30 Helichrysum speci...
  8. A renal-targeted triptolide aminoglycoside (TPAG) conjugate for lowering systemic toxicities of triptolide

    Fitoterapia 103:242 (2015) PMID 25869848

    Triptolide (TP), a naturally derived compound, is proven effective in the treatment of nephritis and chronic allograft nephropathy. However, the severe multiorgan toxicity greatly limited it from further clinic use. 2-Glucosamine was demonstrated as a potential targeting ligand that co...
  9. Anti-TMV activity flavones from the leaves of Yunnan local air cured tobacco

    Fitoterapia 103:260 (2015) PMID 25937499

    Four new flavones, tobaflavones E–H (1–4), together with two known flavones (5 and 6), were isolated from the leaves of Dali Tiandeng tobacco (a variety of Yunnan local air cured tobacco). Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR tec...
  10. Insights into drug discovery from natural products through structural modification

    Fitoterapia 103:231 (2015) PMID 25917513

    Natural products (NPs) have played a key role in drug discovery and are still a prolific source of novel lead compounds or pharmacophores for medicinal chemistry. Pharmacological activity and druggability are two indispensable components advancing NPs from leads to drugs. Although natu...