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The laxative effect of emodin is attributable to increased aquaporin 3 expression in the colon of mice and HT-29 cells.
We investigated whether the laxative effect of emodin is associated with the regulation of AQP3 in the colon. Our results showed that treatment with emodin increased the fecal water content in the colon of mice and evaluation index of defecation in a dose-dependent manner. More interestingly, emodin...
Plant based products: use and development as repellents against mosquitoes: A review.
Global warming and deforestation have resulted in the relocation of many living creatures including insects during the recent years. This has affected the population balance of disease vectors including mosquitoes resulting in outbreaks. Traditionally, mankind has been using plants as means of prote...
Vasorelaxant activity of some structurally related triterpenic acids from Phoradendron reichenbachianum (Viscaceae) mainly by NO production:...
The aim of the current study was to investigate the vasorelaxant activity of five structurally-related triterpenic acids namely ursolic (1), moronic (2), morolic (3), betulinic (4) and 3,4-seco-olean-18-ene-3,28-dioic (5) acids. The vasorelaxant effect of compounds 1-5 were determine...
Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans.
Bioassay-guided isolation of the stems of Gelsemium elegans has led to the isolation of two new Gelsemium alkaloids, 21-(2-oxopropyl)-koumine (1) and 11-methoxygelselegine (2), and two known alkaloids, koumine (3) and gelselegine (4). The structures of 1-2 were determined by spectros...
Cytotoxic triterpene saponins from the leaves of Aralia elata.
Phytochemical investigation of the leaves of Aralia elata has led to the isolation of four new compounds, 3-O-β-d-glucopyranosyl (1→3)-β-d-glucopyranosyl (1→3)-β-d-glucopyranosyl oleanolic acid (1), 3-O-[β-d-glucopyranosyl (1→3)-β-d-glucopyranosyl (1→3)]-[β-d-glucopyran...
Potent and selective butyrylcholinesterase inhibitors from Ficus foveolata.
Four stilbenes (1-4), one inseparable mixture of two alkyl diferulates (5a, 5b), one alkyl ferulate (6) and four flavonoids (7-10) were isolated from Ficus foveolata Wall. Except for quercetin (10), the other ten constituents were isolated from F. foveolata for the first time. In add...
Chemical constituents of the aerial part of Derris elliptica.
A new coumaronochromone, 6,4'-dihydroxy-7,5'-dimethoxy-coumaronochromone (1), together with eleven known flavonoids (2-12) were isolated from the ethanol extract of the aerial part of Derris elliptica. Their structures were elucidated on the basis of spectroscopic analysis. Compounds...
Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects.
Roots of Morinda citrifolia (Noni or Yor in Thai) have been used traditionally for thousands of years to treat chronic diseases such as cancer and heart disease. In this study, three new anthraquinones together with 15 known compounds were isolated from the roots of M. citrifolia (Rubiaceae). Their s...
Protective effect of Spirulina fusiformis on chemical-induced genotoxicity in mice.
Spirulina fusiformis given by oral route to mice at doses of 250, 500 and 1000 mg kg(-1) significantly inhibit the genotoxicity induced by cisplatin and urethane. In addition, a significant reduction in the extent of lipid peroxidation with concomitant increase in the liver enzymatic (GPx, GST, SOD,...
Antimicrobial activity of Psychotria microlabastra.
The methanol extracts of leaves, root and stem barks of Psychotria microlabastra showed a broad spectrum of antibacterial activity, that was increased on fractionation (petrol, dichloromethane, ethyl acetate), particularly in the ethyl acetate fractions. None of the extractives showed activity again...