International Journal of Pharmaceutics
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In vivo evaluation of poly-l-asparagine nanocapsules as carriers for anti-cancer drug delivery.
We report the in vivo proof of-concept of a novel nanocarrier, poly-l-asparagine (PASN) nanocapsules, as an anticancer targeted drug delivery system. The nanocapsules were loaded with the fluorescent marker DiD (1,1'-dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine perchlorate) and also with the...
Physical aging in pharmaceutical polymers and the effect on solid oral dosage form stability.
The application of a polymeric film to a solid oral dosage form can be an effective technique to modify drug release. Most polymers used for such purposes are amorphous in nature and are subject to physical aging. This physical aging phenomenon has been shown to cause changes not only in the mechani...
Stability of aqueous polymeric controlled release film coatings.
Aqueous polymeric film coatings provide a great potential to accurately control the release rate of a drug from a pharmaceutical dosage form, while avoiding the various disadvantages associated with the use of organic solvents. However, long term instability of drug release, due to imperfect film fo...
Evaluation of solubility and partition properties of ampicillin-based ionic liquids.
We explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing L-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridiniu...
Formulation, characterization and pharmacokinetics of Morin hydrate niosomes prepared from various non-ionic surfactants.
Morin hydrate (MH), a bioflavonoid with antioxidant and anticancer activity as well as the ability to improve the bioavailability of other drugs on their concurrent use. Three differently optimized niosomal formulations using three different non-ionic surfactants (Span 60, Span 80 and Tween 60) were...
Effect of permeation enhancers on transdermal delivery of fluoxetine: in vitro and in vivo evaluation.
The aim of this study was to investigate the feasibility of transdermal fluoxetine (FX) delivery. The effects of chemical forms (base or salt) and permeation enhancers on in vitro skin permeation of FX were assessed using hairless mouse, rat and human cadaver skin. The optimized formulations from th...
'Formulating better medicines for children' - Setting the pace for the future.
Montmorillonite nanodevices for the colon metronidazole delivery.
The adsorption profiles of the antibiotic metronidazole (MNE) into the K10-montmorillonite (MMT-K10) clay and the subsequent release have been investigated as a function of pH and MNE/MMT-K10 ratio, in order to evaluate the potential of the MNE/MMT-K10 hybrids as controlled drug delivery system. The...
Skin electroporation for transdermal drug delivery: The influence of the order of different square wave electric pulses.
Our in vitro experimental results show that longer LV pulses significantly increase subsequent passive transport of calcein through dermatomed pig skin, while short HV pulses alone result in negligible calcein passive transdermal transport. Surprisingly, when the long LV pulses are preceded by short...
Characterization of novel lactoferrin loaded capsules prepared with polyelectrolyte complexes.
Novel capsules loaded with lactoferrin (LF) were prepared using polyelectrolyte complexes that were formed by water soluble chitosan (WSC), sodium cellulose sulfate (NaCS) and sodium polyphosphate (PPS). Normal chitosan (soluble in acidic conditions) was chosen as a control to prepare similar capsul...