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Adipose inflammation induced by acute alcohol exposure and burn trauma
The role of cold-inducible RNA binding protein (CIRP) in acute alcohol exposure induced brain injury
Chronic ethanol exposure alters MK-801 binding sites in the cerebral cortex of the near-term fetal guinea pig.
The mechanism of ethanol central nervous system (CNS) teratogenesis, resulting from chronic maternal ingestion of high-dose ethanol during pregnancy, is not clearly understood. One of the target sites for ethanol-induced damage in the developing brain is the cerebral cortex. It has been proposed tha...
Effects of lifelong ethanol consumption on rat sympathetic neurons.
We studied the effects of aging and lifelong ethanol consumption on rat peripheral sympathetic neurons. The aim was to find out the possible differences in the vulnerability to ethanol-induced neuronal degeneration between rats of both genders, or between the alcohol-avoiding (ANA) and the alcohol-p...
Exposure to sucrose-quinine solutions does not increase ethanol consumption.
The taste of ethanol can be aversive or preferred based on prior experience with ethanol consumption. A preference for ethanol's taste is thought to result from the association of ethanol's taste with its neuropharmacological activity. However, acclimation to ethanol's aversive taste may also play a...
Alcohol consumption inhibits osteoblastic cell proliferation and activity in vivo.
We used a rodent animal model system to compare osteoblast activity and number in alcohol-fed, pair-fed, and chow-fed animals. Adult, virgin female Sprague-Dawley rats were assigned to alcohol-fed, pair-fed, and chow groups based on weights. Alcohol animals were fed a liquid diet containing 35% etha...
Tumor necrosis factor-alpha internalization and degradation by isolated hepatocytes of rats exposed to ethanol.
Internalization and degradation of human recombinant [125I]TNF-alpha was studied in hepatocytes isolated from rats exposed to ethanol (EtOH) either acutely (i.p. injection, 2.2 g kg(-1) b.wt.) or chronically (14-16 weeks of EtOH feeding in liquid diet). Both acute and chronic EtOH exposure diminishe...
Ethanol enhances cholesterol synthesis and secretion in human hepatomal cells.
We investigated the effects of ethanol at the cellular level by employing a human hepatomal cell line (HepG2) and by evaluating the biosyntheses of lipid classes from different labeled precursors. Incubation of cells with 2% ethanol resulted in a decreased labeling of phospholipids and in an increas...
Magnesium deficiency exacerbates brain injury and stroke mortality induced by alcohol: a 31P-NMR in vivo study.
Mimicking in rats the reduced level of dietary magnesium (Mg) intake, seen in present-day Western World populations, short-term (4 weeks) restriction of Mg intake (30-35% normal) resulted in a 40% loss in brain intracellular free Mg2+ ions ([Mg2+]i) and significant rises in brain intracellular pH (p...
Continuous osmotic minipump infusion of alcohol into brain decreases brain [Mg2+] and brain bioenergetics and enhances susceptibility to hem...
Our alcohol pump-implanted rats also might provide a new model of slow, moderate alcohol intoxication....