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Diabetic Medicine

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Rcgp, Gale, CSA, Wiley, Ingenta, Ovid from 2001, and Proquest

  1. Oestradiol replacement treatment and glucose homeostasis in two men with congenital aromatase deficiency: evidence for a role of oestradiol and sex steroids imbalance on insulin sensitivity in men.

    Diabetic Medicine 24(12):1491 (2007) PMID 17976198

    The role of sex steroids in glucose and insulin metabolism in men remains unclear. To investigate the effects of sex steroids and oestrogen on insulin sensitivity in men, we studied two male adults with aromatase deficiency (subject 1 and subject 2). The effects of transdermal oestradiol (tE(2))...
  2. An angled insertion technique using 6-mm needles markedly reduces the risk of intramuscular injections in children and adolescents.

    Diabetic Medicine 24(12):1400 (2007) PMID 18042081

    The aims of this study were (i) to establish which children with Type 1 diabetes are at risk of intramuscular or intradermal insulin injections and (ii) to determine a needle length and technique that reliably administers insulin into subcutaneous fat. Seventy-two healthy diabetic children (age ...
  3. Lipoatrophy is a thing of the past, or is it?

    Diabetic Medicine 24(12):1470 (2007) PMID 17976201

    We describe the development of severe lipoatrophy in a patient treated with biphasic aspart. This complication of insulin therapy was common in the past with the use of animal insulins and became less common with the increasing purification of these and the introduction of recombinant human insu...
  4. Pregnancy-associated plasma protein A in a large cohort of Type 1 diabetic patients with and without diabetic nephropathy-a prospective follow--up study.

    Diabetic Medicine 24(12):1381 (2007) PMID 17971180

    Pregnancy-associated plasma protein A (PAPP-A) has been implicated in the aetiology of acute coronary syndromes and carotid and peripheral artherosclerosis. Diabetic nephropathy is characterized by increased cardiovascular risk. We investigated the prognostic value of PAPP-A in a large cohort of...
  5. Serum angiotensin-converting enzyme and frequency of severe hypoglycaemia in Type 1 diabetes: does a relationship exist?

    Diabetic Medicine 24(12):1449 (2007) PMID 17894828

    An association has been described between elevated serum angiotensin-converting enzyme (ACE) and an increased risk of severe hypoglycaemia (SH). To ascertain whether this reported association could be replicated in a different country, it was re-examined in 300 individuals with Type 1 diabetes. ...
  6. Diagnostic potential of serum protein pattern in Type 2 diabetic nephropathy.

    Diabetic Medicine 24(12):1386 (2007) PMID 18042080

    Microalbuminuria is the earliest clinical sign of diabetic nephropathy (DN). However, the multifactorial nature of DN supports the application of combined markers as a diagnostic tool. Thus, another screening approach, such as protein profiling, is required for accurate diagnosis. Surface enhanc...
  7. Low-risk HLA genotype in Type 1 diabetes is associated with less destruction of pancreatic B-cells 12 months after diagnosis.

    Diabetic Medicine 24(12):1487 (2007) PMID 17971177

    The role of human leukocyte antigen (HLA) genes in the susceptibility to Type 1 diabetes (T1DM) is well known. However, we do not know whether the degree of pancreatic B-cell destruction depends on different HLA genetic risk. The aim of this study was to analyse the influence of DRB1* and DQB1* ...
  8. Inverse correlation between activated protein C generation and carotid atherosclerosis in Type 2 diabetic patients.

    Diabetic Medicine 24(12):1322 (2007) PMID 17971179

    Activated protein C (APC) is a key regulator of the clotting system and immune responses. We studied the relationship between the degree of atherosclerosis as measured by the intima-media thickness (IMT) of carotid artery and APC generation in Type 2 diabetic patients. Eighty-seven Type 2 diabet...
  9. Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes.

    Diabetic Medicine 24(12):1345 (2007) PMID 17971181

    To determine in Type 1 diabetes patients if levels of pigment epithelium-derived factor (PEDF), an anti-angiogenic, anti-inflammatory and antioxidant factor, are increased in individuals with complications and positively related to vascular and renal dysfunction, body mass index, glycated haemog...
  10. Significant bacteriuria in outpatient diabetic and non-diabetic persons.

    Diabetic Medicine 24(12):1455 (2007) PMID 17941860

    The prevalence of significant bacteriuria (SB) in diabetes mellitus has not been clearly established. Having previously investigated SB frequency in inpatient diabetic women, we now screened for SB (both asymptomatic and symptomatic forms) in outpatients. We examined 511 consecutive outpatients ...