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The influence of family history of diabetes on disease prevalence and associated metabolic risk factors among Sri Lankan adults.
To describe the influence of family history on diabetes prevalence and associated metabolic risk factors in a nationally representative sample from Sri Lanka. A cross sectional national survey was conducted among 5000 adults in Sri Lanka. Family history was evaluated at three levels: (1) parents, (2...
Comment on 'A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure'.
The implementation of nutritional advice for people with diabetes.
Positive association of free triiodothyronine with pancreatic β-cell function in people with prediabetes.
To analyse the effects of thyroid hormones on β-cell function and glucose metabolism in people with prediabetes who are euthyroid. A total of 111 people who were euthyroid underwent 75-g oral glucose tolerance tests, of whom 52 were assigned to the normal glucose tolerance and 59 to the prediabetes...
Association between the extent of urinary albumin excretion and glycaemic variability indices measured by continuous glucose monitoring.
We examined whether there is an independent association between indices of glycaemic variability in continuous glucose monitoring and extent of albuminuria. A total of 173 patients with Type 2 diabetes (without insulin therapy, n = 96; with insulin therapy, n = 77) who had unexplained large fluctuat...
Cost of diabetic foot disease to the National Health Service in England.
We estimate that more than half this sum (£307 m) was spent on care for ulceration in primary and community settings. Of hospital admissions with recorded diabetes, 8.8% included ulcer care or amputation. Regression analysis suggests that foot disease was associated with a 2.51-fold (95% CI 2.43-2.5...
What factors influence concordance with medications? Findings from the U.K. Asian Diabetes study.
To investigate concordance with medication, as assessed at baseline and at 1- and 2-year follow-up, and to examine factors associated with non-concordance in a UK-resident South-Asian population. Data from the UK Asian Diabetes Study were analysed. Concordance with medications was assessed and recor...
High prevalence in Malawi of sight-threatening retinopathy and visual impairment caused by diabetes: identification of population-specific t...
We report baseline data from a 24-month prospective cohort study. Subjects were systematically sampled from two hospital-based, primary care diabetes clinics. Visual acuity, glycaemic control, systolic blood pressure, HIV status, urine albumin-creatinine ratio, and haemoglobin and serum lipid levels...
Increasing capacity to deliver diabetes self-management education: results of the DESMOND lay educator non-randomized controlled equivalence...
We conducted an equivalence trial with non-randomized participant allocation to a Diabetes Education and Self Management for Ongoing and Newly Diagnosed Type 2 diabetes (DESMOND) course, delivered in the standard format by two trained healthcare professional educators (to the control group) or by on...
Molecular and clinical characterization of glucokinase maturity-onset diabetes of the young (GCK-MODY) in Japanese patients.
We enrolled 78 Japanese patients with GCK-MODY from 41 families (55 probands diagnosed at the age of 0-14 years and their 23 adult family members). Mutations were identified by direct sequencing or multiplex ligation-dependent probe amplification of all exons of the GCK gene. Detailed clinical and l...