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Hematology/Oncology Clinics of North America

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  1. The role of adhesion receptors in the pathogenesis of multiple myeloma.

    Hematology/Oncology Clinics of North America 13(6):1127 (1999) PMID 10626140

    There is now an improved understanding of the types of adhesion receptors present on normal and malignant plasma cells. This knowledge has been helpful in identifying plasma cells and in beginning to understand the pathogenesis of myeloma. Future research is needed to delineate the signaling pathway...
  2. Infusion of donor peripheral blood mononuclear cells to treat relapse after transplantation for chronic myelogenous leukemia.

    Hematology/Oncology Clinics of North America 12(1):123 (1998) PMID 9523229

    Until recently, the only curative therapy for patients with chronic myelogenous leukemia (CML) who relapse after allogeneic bone marrow transplantation (BMT) has been second allogeneic BMT. Recently, donor mononuclear cells have been given to patients with relapsed CML to induce a potent graft-versu...
  3. Autotransplants in multiple myeloma: pushing the envelope.

    Hematology/Oncology Clinics of North America 11(2):363 (1997) PMID 9137975

    Substantial progress has been made in understanding the role of autotransplants in multiple myeloma. High dose therapy consistently induces a higher remission rate, longer remission duration, and overall survival. This article summarizes the results of several major studies to illustrate the above c...
  4. Bone marrow metastases.

    Hematology/Oncology Clinics of North America 10(2):321 (1996) PMID 8707758

    This article discusses the clinical significance of bone marrow metastases and the current methods being used to detect tumor cells in marrow. The strategies being investigated for eradicating cancer cells from marrow in patients receiving hematopoietic cell autografts also are reviewed.
  5. Coagulation abnormalities in liver disease.

    Hematology/Oncology Clinics of North America 6(6):1247 (1992) PMID 1333467

    Hemostasis is intimately related to liver function, because most coagulation factors are synthesized by liver parenchymal cells and the liver's reticuloendothelial system serves an important role in the clearance of activation products. The extent of coagulation abnormalities depends upon the degree...
  6. Hemostatic abnormalities in multiple myeloma and related disorders.

    Hematology/Oncology Clinics of North America 6(6):1301 (1992) PMID 1452513

    Patients with multiple myeloma, Waldenström's macroglobulinemia, benign monoclonal gammopathy, and other B-cell disorders associated with high titer serum paraproteins can manifest unique hemostatic disorders. Most of these disorders predispose the patient to hemorrhage, especially following surgic...
  7. Drug-induced alterations of hemostasis and fibrinolysis.

    Hematology/Oncology Clinics of North America 6(6):1229 (1992) PMID 1452510

    The hemostatic and fibrinolytic systems contribute significantly to the overall pathophysiologic status of a patient in a given clinical setting. Drug modulation of these systems plays a crucial role in the facilitation of the therapeutic effects but may also produce bleeding or thrombotic disorders....
  8. Mechanisms of cancer cachexia.

    Hematology/Oncology Clinics of North America 5(1):103 (1991) PMID 2026566

    It is currently hypothesized that the mechanisms of cancer cachexia involve the host's production of inflammatory cytokines, which in turn orchestrate a series of complex interrelated steps that ultimately lead to a chronic state of wasting, malnourishment, and death (see Fig. 1). The metabolic chan...
  9. Chemoprevention of cancer.

    Hematology/Oncology Clinics of North America 5(1):69 (1991) PMID 2026569

    We have presented a general overview of the concepts as well as the status of ongoing clinical trials using the most promising agents in selected populations. The reader is referred to recent excellent reviews presenting more detailed discussions of the various topics discussed, such as the selectio...
  10. Nutritional support of the surgical oncology patient.

    Hematology/Oncology Clinics of North America 5(1):125 (1991) PMID 1902827

    Malnutrition is a common manifestation of cancer patients and has a significant negative impact on treatment and survival. The metabolic aberrations associated with tumor growth are complex, and nutritional repletion cannot always be accomplished with nutritional support. Ultimate survival depends u...