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European Neuropsychopharmacology

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  1. Effects of biperiden on the treatment of cocaine/crack addiction: A randomised, double-blind, placebo-controlled trial.

    European Neuropsychopharmacology 24(8):1196 (2014) PMID 24974353

    We evaluated the efficacy of biperiden (a cholinergic antagonist) in reducing craving and the amount used, and in increasing compliance with treatment for cocaine/crack addiction. It was a study double-blind, randomised, placebo-controlled, 8-week trial of 111 cocaine or crack addicted male patients...
  2. Abnormal thermoregulation in drug-free male schizophrenia patients.

    European Neuropsychopharmacology 11(4):285 (2001) PMID 11532382

    We hypothesized that a standardized exercise-heat tolerance test [two 50-min bouts of walking a motor-driven treadmill at 40 degrees C (relative humidity=40%)] would reveal abnormal thermoregulation in drug-free schizophrenia patients. Six drug-free schizophrenia outpatients and seven healthy compar...
  3. Pindolol can be effectively given once or twice daily for augmentation in psychiatric patients.

    European Neuropsychopharmacology 10(6):511 (2000) PMID 11115742

  4. Neuroimaging of serotonin uptake sites and antidepressant binding sites in the thalamus of humans and 'higher' animals.

    European Neuropsychopharmacology 9(6):537 (1999) PMID 10625123

    This review presents the results of in vitro, ex vivo and in vivo studies carried out primarily for identifying serotonin uptake sites and/or antidepressant binding sites in the brain of humans and 'higher' animals, namely nonhuman primates and pigs. Five lines of evidence are considered. First, stu...
  5. Missing action of carbamazepine on postsynaptic GABA-responses of hippocampal CA3-neurons (slice, guinea pig).

    European Neuropsychopharmacology 8(4):353 (1998) PMID 9928928

    Conflicting data exist concerning the interaction of carbamazepine (CBZ) and GABA-receptors involved in the pathophysiology of neuropsychiatric disorders. The present study reveals that CBZ failed to alter membrane potential fluctuations mediated by an activation of postsynaptic GABA(A)- and GABA(B)...
  6. Dizocilpine (MK-801) and tetrodotoxin influence accumbal dopamine release evoked by intrapallidal morphine.

    European Neuropsychopharmacology 8(1):47 (1998) PMID 9452940

    We examined whether changes in accumbal dopamine and its metabolites produced by intrapallidal morphine a) are associated with local excitatory amino acid neurotransmission b) are determined by impulse propagation in dopamine neurons and c) are observed both ipsi- and contralateral to the morphine a...
  7. Tianeptine and alcohol dependence.

    European Neuropsychopharmacology 7 Suppl 3:S347 (1997) PMID 9405962

    Several arguments are in favour of the use of antidepressant drugs in alcohol-dependent patients, especially those acting on the serotoninergic system: (1) neurochemical data indicate the interaction between alcohol and 5-HT metabolism, (2) pharmacological studies show an improvement in the behaviou...
  8. The effects of antidepressants on psychomotor function with particular reference to reboxetine.

    European Neuropsychopharmacology 7 Suppl 1:S17 (1997) PMID 9169307

    This review assesses the relative efficacy and side-effect profile of the currently available treatment options for major depression and the new selective noradrenergic agent, reboxetine. The effects of these treatments on psychomotor function are reviewed using: choice reaction time (CRT) and criti...
  9. Use of band-pass filter analysis to evaluate outcomes in an antidepressant trial for treatment resistant patients.

    European Neuropsychopharmacology 24(8):1188 (2014) PMID 25012515

    We applied band-pass filters to re-analyze data from a negative antidepressant trial (NCT00739908) evaluating CX157 (a reversible and selective monoamine oxidase inhibitor-A) versus placebo. 360 patients from 29 trial sites were randomized to either CX157 treatment (n=182) or placebo (n=178). We app...
  10. Pain exacerbates chronic mild stress-induced changes in noradrenergic transmission in rats.

    European Neuropsychopharmacology 24(6):996 (2014) PMID 24491949

    We studied locus coeruleus activity using immunofluorescence and electrophysiological approaches in rats subjected to unpredictable chronic mild stress (CMS, an experimental model of depression) and/or chronic constriction injury (CCI, a model of chronic neuropathic pain) for 2 weeks. CCI alone had...