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European Neuropsychopharmacology

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  1. Chronic THC during adolescence increases the vulnerability to stress-induced relapse to heroin seeking in adult rats.

    European Neuropsychopharmacology 24(7):1037 (2014) PMID 24412506

    We treated adolescent rats from postnatal day (PND) 35 to PND-46 with increasing daily doses of THC (2.5-10mg/kg). One week after intoxication, the rats were tested for anxiety-like behavior in the elevated plus maze (EPM) test. One month later (starting from PND 75), rats were trained to operantly...
  2. Corticosteroid-endocannabinoid loop supports decrease of fear-conditioned response in rats.

    European Neuropsychopharmacology 24(7):1091 (2014) PMID 24491954

    The endocannabinoid (eCB) and glucocorticoid systems contribute to the modulation of emotional states. Noteworthy, glucocorticoid hormones are released by adrenal glands during stressful events and endocannabinoids are released in the brain during fear-conditioned responses. Since it was already sug...
  3. Abnormal thermoregulation in drug-free male schizophrenia patients.

    European Neuropsychopharmacology 11(4):285 (2001) PMID 11532382

    We hypothesized that a standardized exercise-heat tolerance test [two 50-min bouts of walking a motor-driven treadmill at 40 degrees C (relative humidity=40%)] would reveal abnormal thermoregulation in drug-free schizophrenia patients. Six drug-free schizophrenia outpatients and seven healthy compar...
  4. Pindolol can be effectively given once or twice daily for augmentation in psychiatric patients.

    European Neuropsychopharmacology 10(6):511 (2000) PMID 11115742

  5. Neuroimaging of serotonin uptake sites and antidepressant binding sites in the thalamus of humans and 'higher' animals.

    European Neuropsychopharmacology 9(6):537 (1999) PMID 10625123

    This review presents the results of in vitro, ex vivo and in vivo studies carried out primarily for identifying serotonin uptake sites and/or antidepressant binding sites in the brain of humans and 'higher' animals, namely nonhuman primates and pigs. Five lines of evidence are considered. First, stu...
  6. Missing action of carbamazepine on postsynaptic GABA-responses of hippocampal CA3-neurons (slice, guinea pig).

    European Neuropsychopharmacology 8(4):353 (1998) PMID 9928928

    Conflicting data exist concerning the interaction of carbamazepine (CBZ) and GABA-receptors involved in the pathophysiology of neuropsychiatric disorders. The present study reveals that CBZ failed to alter membrane potential fluctuations mediated by an activation of postsynaptic GABA(A)- and GABA(B)...
  7. Dizocilpine (MK-801) and tetrodotoxin influence accumbal dopamine release evoked by intrapallidal morphine.

    European Neuropsychopharmacology 8(1):47 (1998) PMID 9452940

    We examined whether changes in accumbal dopamine and its metabolites produced by intrapallidal morphine a) are associated with local excitatory amino acid neurotransmission b) are determined by impulse propagation in dopamine neurons and c) are observed both ipsi- and contralateral to the morphine a...
  8. Tianeptine and alcohol dependence.

    European Neuropsychopharmacology 7 Suppl 3:S347 (1997) PMID 9405962

    Several arguments are in favour of the use of antidepressant drugs in alcohol-dependent patients, especially those acting on the serotoninergic system: (1) neurochemical data indicate the interaction between alcohol and 5-HT metabolism, (2) pharmacological studies show an improvement in the behaviou...
  9. The effects of antidepressants on psychomotor function with particular reference to reboxetine.

    European Neuropsychopharmacology 7 Suppl 1:S17 (1997) PMID 9169307

    This review assesses the relative efficacy and side-effect profile of the currently available treatment options for major depression and the new selective noradrenergic agent, reboxetine. The effects of these treatments on psychomotor function are reviewed using: choice reaction time (CRT) and criti...
  10. The effect of prolonged exposure to morphine on canine cerebral 5-HT2A receptors measured with (123)I-R91150 SPECT.

    European Neuropsychopharmacology 24(7):1133 (2014) PMID 24726581

    Down-stream neuronal alterations, including changes in the 5-HT-2A receptor system, play an important role in the etiology and treatment of depression. The present study examined the effect of prolonged opioid treatment on cerebral 5-HT2A receptors. Cerebral 5-HT2A receptor availability was estimate...