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Veterinary Research

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  1. Two novel HLA-A*0201 T-cell epitopes in avian H5N1 viral nucleoprotein induced specific immune responses in HHD mice.

    Veterinary Research 41(2):24 (2010) PMID 19941812 PMCID PMC2820229

    We identified two novel HLA-A*0201 restricted NP epitopes, named H5N1 NP373-381 AMDSNTLEL (NP373) and NP458-466 FQGRGVFEL (NP458), using computational bioinformatic analysis. The NP peptides showed a high binding affinity to HLA-A*0201 on T2 cells, and were able to induce the activation of the cytot...
  2. Apoptosis induction in BEFV-infected Vero and MDBK cells through Src-dependent JNK activation regulates caspase-3 and mitochondria pathways.

    Veterinary Research 41(2):15 (2010) PMID 19846041

    Our previous report demonstrated that bovine ephemeral fever virus (BEFV)-infected cultured cells could induce caspase-dependent apoptosis. This study aims to further elucidate how BEFV activates the caspase cascade in bovine cells. BEFV replicated and induced apoptosis in Vero and Madin-Darby bovin...
  3. Initial adherence of EPEC, EHEC and VTEC to host cells.

    Veterinary Research 41(5):57 (2010) PMID 20423697

    Initial adherence to host cells is the first step of the infection of enteropathogenic Escherichia coli (EPEC), enterohaemorrhagic Escherichia coli (EHEC) and verotoxigenic Escherichia coli (VTEC) strains. The importance of this step in the infection resides in the fact that (1) adherence is the fir...
  4. Effects of growth conditions on biofilm formation by Actinobacillus pleuropneumoniae.

    Veterinary Research 41(1):3 (2010) PMID 19737507 PMCID PMC2762130

    We compared biofilm formation by the serotype 1 reference strain S4074 of A. pleuropneumoniae grown in five different culture media. We observed that strain S4074 of A. pleuropneumoniae is able to form biofilms after growth in one of the culture conditions tested brain heart infusion (BHI medium, su...
  5. Modulation of the immunogenicity of the Trypanosoma congolense cysteine protease, congopain, through complexation with alpha(2)-macroglobuli...

    Veterinary Research 40(6):52 (2009) PMID 19549486 PMCID PMC2713678

    The protozoan parasite Trypanosoma congolense is the main causative agent of livestock trypanosomosis. Congopain, the major lysosomal cysteine proteinase of T. congolense, contributes to disease pathogenesis, and antibody-mediated inhibition of this enzyme may contribute to mechanisms of trypanotole...
  6. State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology.

    Veterinary Research 40(5):48 (2009) PMID 19505422 PMCID PMC2704333

    Scrapie is a fatal, neurodegenerative disease of sheep and goats. It is also the earliest known member in the family of diseases classified as transmissible spongiform encephalopathies (TSE) or prion diseases, which includes Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy (BSE)...
  7. The Marek's disease virus (MDV) protein encoded by the UL17 ortholog is essential for virus growth.

    Veterinary Research 40(4):28 (2009) PMID 19284966 PMCID PMC2695128

    We wished to address the characterization of capsid/tegument genes which may intervene in the maturation of intranuclear capsids. Orthologs of UL17 are present in all herpesviruses and, in all reported case, were shown to be essential for viral growth, playing a role in capsid maturation and DNA pac...
  8. Francisella tularensis: an arthropod-borne pathogen.

    Veterinary Research 40(2):7 (2009) PMID 18950590 PMCID PMC2695023

    Arthropod transmission of tularemia occurs throughout the northern hemisphere. Few pathogens show the adaptability of Francisella tularensis to such a wide array of arthropod vectors. Nonetheless, arthropod transmission of F. tularensis was last actively investigated in the first half of the 20th ce...
  9. M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit.

    Veterinary Research 40(1):11 (2009) PMID 19019281 PMCID PMC2695013

    Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus). MYXV has a linear double-stranded DNA genome that encodes several factors important for evasion from the host immune system. Among them, f...
  10. Bovine papillomaviruses, papillomas and cancer in cattle.

    Veterinary Research 39(5):45 (2008) PMID 18479666

    Bovine papillomaviruses (BPV) are DNA oncogenic viruses inducing hyperplastic benign lesions of both cutaneous and mucosal epithelia in cattle. Ten (BPV 1-10) different viral genotypes have been characterised so far. BPV 1-10 are all strictly species-specific but BPV 1/2 may also infect equids induc...