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Matrix Biology

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  1. Announcement - MBE Meeting.

    Matrix Biology 33:77 (2014) PMID 24559888

  2. Pathophysiology of the microfibril/elastic fiber system: introduction

    Matrix Biology 19(6):455 (2000)

  3. Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells.

    Matrix Biology 18(2):163 (1999) PMID 10372557

    Perlecan, a major heparan sulfate proteoglycan of vascularized tissues, was immunopurified from media conditioned by human endothelial cells of both arterial and venous origin. The heparan sulfate moiety of perlecan from cultured arterial cells differed in amount and/or composition from that produce...
  4. Ehlers-Danlos syndrome: a showcase of conditions that lead to understanding matrix biology.

    Matrix Biology 33:10 (2014) PMID 23920413

    We provide an overview of how these disorders inform our understanding of matrix biology, including the role of collagens (types I, III and V), proteoglycans and other proteins. Published by Elsevier B.V....
  5. Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2).

    Matrix Biology 31(7-8):380 (2012) PMID 23085623 PMCID PMC3513585

    An innovative approach to enhance the selectivity of matrix metalloproteinase (MMP) inhibitors comprises targeting these inhibitors to catalytically required substrate binding sites (exosites) that are located outside the catalytic cleft. In MMP-2, positioning of collagen substrate molecules occurs...
  6. Identification and analysis of the human hyaluronan synthase 1 gene promoter reveals Smad3- and Sp3-mediated transcriptional induction.

    Matrix Biology 31(7-8):373 (2012) PMID 23123404

    We investigated the mechanism of HAS1 transcriptional up-regulation in response to these cytokines. We used 5'-rapid amplification of cDNA ends analysis to identify the 5' end of HAS1 transcripts, resulting in an increase of 26 nucleotides to the HAS1 exon 1 sequence of reference sequence NM_001523....
  7. A biomechanical role for perlecan in the pericellular matrix of articular cartilage.

    Matrix Biology 31(6):320 (2012) PMID 22659389 PMCID PMC3437241

    Chondrocytes are surrounded by a narrow pericellular matrix (PCM) that is biochemically, structurally, and biomechanically distinct from the bulk extracellular matrix (ECM) of articular cartilage. While the PCM is often defined by the presence of type VI collagen, other macromolecules such as perlec...
  8. Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms.

    Matrix Biology 31(3):178 (2012) PMID 22266026 PMCID PMC3295861

    Thrombospondin 1 (TSP1) plays major roles in both physiologic and pathologic tissue repair. TSP1 through its type 1 repeats is a known regulator of latent TGF-β activation and plays a role in wound healing and fibrosis. Binding of the TSP N-terminal domain to cell surface calreticulin in complex wit...
  9. Clonal overgrowth of esophageal smooth muscle cells in diffuse leiomyomatosis-Alport syndrome caused by partial deletion inCOL4A5andCOL4A6ge...

    Matrix Biology 30(1):3 (2011) PMID 20951201

    We have identified a novel deletion of 194-kb in length, encompassing COL4A5–COL4A6 promoters as well as nearly the entire large intron 1 of COL4A5 and intron 2 of COL4A6. To uncover the relationship of the esophagus-specific occurrence of the tumor and the expression of those g...
  10. Formation of lamellar cross bridges in the annulus fibrosus of the intervertebral disc is a consequence of vascular regression

    Matrix Biology 30(4):267 (2011) PMID 21504791 PMCID PMC3114275

    We hypothesized that cross bridges are the pathways left by these receding blood vessels. Initially, the presence of cross bridges was confirmed in cadaveric human discs aged 25 and 53 years. Next, L1–L2 intervertebral discs ( n = 4) from sheep ranging in age from 75...