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Announcement - MBE Meeting.
Pathophysiology of the microfibril/elastic fiber system: introduction
Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells.
Perlecan, a major heparan sulfate proteoglycan of vascularized tissues, was immunopurified from media conditioned by human endothelial cells of both arterial and venous origin. The heparan sulfate moiety of perlecan from cultured arterial cells differed in amount and/or composition from that produce...
Ehlers-Danlos syndrome: a showcase of conditions that lead to understanding matrix biology.
We provide an overview of how these disorders inform our understanding of matrix biology, including the role of collagens (types I, III and V), proteoglycans and other proteins. Published by Elsevier B.V....
Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2).
An innovative approach to enhance the selectivity of matrix metalloproteinase (MMP) inhibitors comprises targeting these inhibitors to catalytically required substrate binding sites (exosites) that are located outside the catalytic cleft. In MMP-2, positioning of collagen substrate molecules occurs...
Identification and analysis of the human hyaluronan synthase 1 gene promoter reveals Smad3- and Sp3-mediated transcriptional induction.
We investigated the mechanism of HAS1 transcriptional up-regulation in response to these cytokines. We used 5'-rapid amplification of cDNA ends analysis to identify the 5' end of HAS1 transcripts, resulting in an increase of 26 nucleotides to the HAS1 exon 1 sequence of reference sequence NM_001523....
A biomechanical role for perlecan in the pericellular matrix of articular cartilage.
Chondrocytes are surrounded by a narrow pericellular matrix (PCM) that is biochemically, structurally, and biomechanically distinct from the bulk extracellular matrix (ECM) of articular cartilage. While the PCM is often defined by the presence of type VI collagen, other macromolecules such as perlec...
Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms.
Thrombospondin 1 (TSP1) plays major roles in both physiologic and pathologic tissue repair. TSP1 through its type 1 repeats is a known regulator of latent TGF-β activation and plays a role in wound healing and fibrosis. Binding of the TSP N-terminal domain to cell surface calreticulin in complex wit...
Clonal overgrowth of esophageal smooth muscle cells in diffuse leiomyomatosis-Alport syndrome caused by partial deletion inCOL4A5andCOL4A6ge...
We have identified a novel deletion of 194-kb in length, encompassing COL4A5–COL4A6 promoters as well as nearly the entire large intron 1 of COL4A5 and intron 2 of COL4A6. To uncover the relationship of the esophagus-specific occurrence of the tumor and the expression of those g...
Formation of lamellar cross bridges in the annulus fibrosus of the intervertebral disc is a consequence of vascular regression
We hypothesized that cross bridges are the pathways left by these receding blood vessels. Initially, the presence of cross bridges was confirmed in cadaveric human discs aged 25 and 53 years. Next, L1–L2 intervertebral discs ( n = 4) from sheep ranging in age from 75...