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Matrix Biology

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  1. The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche

    Matrix Biology 47:13 (2015) PMID 25963142

    The microfibril-associated glycoproteins MAGP-1 and MAGP-2 are extracellular matrix proteins that interact with fibrillin to influence microfibril function. The two proteins are related through a 60 amino acid matrix-binding domain but their sequences differ outside of this region. A d...
  2. The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation?

    Matrix Biology 47:3 (2015) PMID 25957947

    The fibrillins, large extracellular matrix molecules, are polymerized to form “microfibrils.” The fibrillin microfibril scaffold is populated by microfibril-associated proteins and by growth factors, which are likely to be latent. The scaffold, associated proteins, and bound growth fac...
  3. Deletion of ADAMTS5 does not affect aggrecan or versican degradation but promotes glucose uptake and proteoglycan synthesis in murine adipose derived stromal cells

    Matrix Biology 47:66 (2015) PMID 25840345

    ADAMTS5 (TS5), a member of the aggrecanase clade (TS1, 4, 5, 8, 9, 15) of ADAMTS-proteases, has been considered largely responsible for the proteolysis of the hyalectans, aggrecan (Acan) and versican (Vcan), in vivo. However, we have reported that ts5-knockout (KO) mice show joint prot...
  4. The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

    Matrix Biology 47:54 (2015) PMID 25960420

    Physiological tissue repair aims at restoring the mechano-protective properties of the extracellular matrix. Consequently, redundant regulatory mechanisms are in place ensuring that tissue remodeling terminates once matrix homeostasis is re-established. If these mechanisms fail, stroma...
  5. Introduction to the mini-review series “Extracellular determinants of cell signaling”

    Matrix Biology 47:1 (2015) PMID 25957948

  6. Latent TGF-β-binding proteins

    Matrix Biology 47:44 (2015) PMID 25960419

    The LTBPs (or latent transforming growth factor β binding proteins) are important components of the extracellular matrix (ECM) that interact with fibrillin microfibrils and have a number of different roles in microfibril biology. There are four LTBPs isoforms in the human genome (LTBP-...
  7. In vitro 3-D model based on extending time of culture for studying chronological epidermis aging

    Matrix Biology 47:85 (2015) PMID 25840344

    Skin aging is a complex phenomenon in which several mechanisms operate simultaneously. Among them, intrinsic aging is a time-dependent process, which leads to gradual skin changes affecting its structure and function such as thinning down of both epidermal and dermal compartments and a...
  8. ADAMTS proteins as modulators of microfibril formation and function

    Matrix Biology 47:34 (2015) PMID 25957949

    The ADAMTS (a disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs) protein superfamily includes 19 secreted metalloproteases and 7 secreted ADAMTS-like (ADAMTSL) glycoproteins. The possibility of functional linkage between ADAMTS proteins and fibrillin micro...
  9. TGFβ signaling promotes matrix assembly during mechanosensitive embryonic salivary gland restoration

    Matrix Biology 43:109 (2015) PMID 25652203

    Mechanical properties of the microenvironment regulate cell morphology and differentiation within complex organs. However, methods to restore morphogenesis and differentiation in organs in which compliance is suboptimal are poorly understood. We used mechanosensitive mouse salivary gla...
  10. Loss of PTEN expression by mouse fibroblasts results in lung fibrosis through a CCN2-dependent mechanism

    Matrix Biology 43:35 (2015) PMID 25644104

    Elevated adhesive signaling promotes fibrosis. Protein phosphatase and tensin homologue (PTEN) dephosphorylates focal adhesion kinase and suppresses the activation of Akt and hence suppresses adhesive signaling. Loss of PTEN expression is associated with lung fibrosis, but whether PTEN...