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Matrix Biology

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  1. TGFβ signaling promotes matrix assembly during mechanosensitive embryonic salivary gland restoration

    Matrix Biology 43:109 (2015) PMID 25652203

    Mechanical properties of the microenvironment regulate cell morphology and differentiation within complex organs. However, methods to restore morphogenesis and differentiation in organs in which compliance is suboptimal are poorly understood. We used mechanosensitive mouse salivary gla...
  2. Loss of PTEN expression by mouse fibroblasts results in lung fibrosis through a CCN2-dependent mechanism

    Matrix Biology 43:35 (2015) PMID 25644104

    Elevated adhesive signaling promotes fibrosis. Protein phosphatase and tensin homologue (PTEN) dephosphorylates focal adhesion kinase and suppresses the activation of Akt and hence suppresses adhesive signaling. Loss of PTEN expression is associated with lung fibrosis, but whether PTEN...
  3. Normal Bone Deposition Occurs in Mice Deficient in Factor XIII-A and Transglutaminase 2

    Matrix Biology 43:85 (2015) PMID 25680676

    Transglutaminase activity has been widely implicated in bone deposition. A predominant role has been proposed for factor (F)XIII-A and a subsidiary role suggested for the homologous protein, transglutaminase 2. Full-length FXIII-A is an 83kDa protransglutaminase that is present both in...
  4. MiR-26a modulates extracellular matrix homeostasis in cartilage

    Matrix Biology 43:27 (2015) PMID 25766405

    MicroRNAs (miRNAs) may represent new therapeutic targets for bone and joint diseases. We hypothesized that several cartilage-specific proteins are targeted by a single miRNA and used bioinformatics to identify a miRNA that can modulate extracellular matrix (ECM) homeostasis in cartilag...
  5. Matrix Biologists in Action
    Author(s) unavailable

    Matrix Biology 43 (2015) PMID 25920559

  6. Inflammatory microenvironment and tumor necrosis factor alpha as modulators of periostin and CCN2 expression in human non-healing skin wounds and dermal fibroblasts

    Matrix Biology 43:71 (2015) PMID 25779637

    Non-healing skin wounds remain a significant clinical burden, and in recent years, the regulatory role of matricellular proteins in skin healing has received significant attention. Periostin and CCN2 are both upregulated at day 3 post-wounding in murine skin, where they regulate aspect...
  7. A novel intracellular fibulin-1D variant binds to the cytoplasmic domain of integrin beta 1 subunit

    Matrix Biology 43:97 (2015) PMID 25661773 PMCID PMC4446149

    Fibulin-1 is a member of a growing family of proteins that includes eight members and is involved in cellular functions such as adhesion, migration and differentiation. Fibulin-1 has also been implicated in embryonic development of the heart and neural crest-derived structures. It is a...
  8. Stephen M. Krane: A Scholar and a Gentleman
    Author(s) unavailable

    Matrix Biology 43 (2015)

  9. Leaflet-ICP&PPCTSS 2015
    Author(s) unavailable

    Matrix Biology 43 (2015)

  10. FEBS Advanced Lecture Course
    Author(s) unavailable

    Matrix Biology 43 (2015)