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Matrix Biology

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  1. Nanomechanical phenotype of chondroadherin-null murine articular cartilage.

    Matrix Biology 38:84 (2014) PMID 24892719

    We used atomic force microscopy (AFM)-based nanoindentation to quantify the effects of CHAD deletion on changes in the biomechanical function of murine cartilage. In comparison to wild-type (WT) mice, CHAD-deletion resulted in a significant ≈70-80% reduction in the indentation modulus, Eind, of the...
  2. Announcement - MBE Meeting.

    Matrix Biology 33:77 (2014) PMID 24559888

  3. Pathophysiology of the microfibril/elastic fiber system: introduction

    Matrix Biology 19(6):455 (2000)

  4. Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells.

    Matrix Biology 18(2):163 (1999) PMID 10372557

    Perlecan, a major heparan sulfate proteoglycan of vascularized tissues, was immunopurified from media conditioned by human endothelial cells of both arterial and venous origin. The heparan sulfate moiety of perlecan from cultured arterial cells differed in amount and/or composition from that produce...
  5. The hinge region of type VII collagen is intrinsically disordered.

    Matrix Biology 36:77 (2014) PMID 24810542

    We investigated a heterologous expressed peptide by CD and NMR spectroscopy. CD spectroscopy implies that the hinge region is intrinsically disordered. Resonance assignment was performed and allowed secondary structure analysis based on the chemical shift values. Seven amino acids in the N-terminal...
  6. Heparan sulfate 3-O-sulfation: a rare modification in search of a function.

    Matrix Biology 35:60 (2014) PMID 24361527 PMCID PMC4039620

    I herpes simplex virus. In mammals, a family of seven heparan sulfate 3-O-sulfotransferases installs sulfate groups at this position and constitutes the largest group of sulfotransferases involved in heparan sulfate formation. However, to date very few proteins or biological systems have been descri...
  7. Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies

    Matrix Biology 32(6):325 (2013) PMID 23507196

    We recently demonstrated that cartilage oligomeric matrix protein (COMP) functions as organizer of the dermal collagen I network in healthy human skin (Agarwal et al., 2012). Here we show that COMP deposition is enhanced in the dermis in various fibrotic conditions. COMP levels were significantly in...
  8. Dermatopontin promotes adhesion, spreading and migration of cardiac fibroblasts in vitro.

    Matrix Biology 32(1):23 (2013) PMID 23262218

    We evaluated the expression pattern of DPT mRNA and protein as well as its secretion in cultured neonatal rat cardiomyocytes (CMs) and cardiac fibroblasts (CFs) under conditions of hypoxia and serum deprivation (hypoxia/SD). Further, we tested the possible roles of DPT in CFs adhesion, spreading, mi...
  9. Quantification of type II procollagen splice forms using alternative transcript-qPCR (AT-qPCR).

    Matrix Biology 31(7-8):412 (2012) PMID 22974592 PMCID PMC3536491

    We show that this widely used method is inaccurate due to mismatched amplification efficiency of different-sized PCR products. We have developed the TaqMan®-based AT-qPCR (Alternative Transcript-qPCR) assay to more accurately quantify alternatively spliced mRNA, and demonstrate the measurement of Co...
  10. Tumor suppression by collagen XV is independent of the restin domain.

    Matrix Biology 31(5):285 (2012) PMID 22531369 PMCID PMC3373166

    We previously showed that collagen XV functions as a dose-dependent suppressor of tumorigenicity in cervical carcinoma cells. The carboxyl terminus of another non-fibrillar collagen (XVIII) is cleaved to produce endostatin, which has anti-angiogenic effects and thus may act as a tumor suppressor in...