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Matrix Biology

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  1. Announcement - MBE Meeting.

    Matrix Biology 33:77 (2014) PMID 24559888

  2. Pathophysiology of the microfibril/elastic fiber system: introduction

    Matrix Biology 19(6):455 (2000)

  3. Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells.

    Matrix Biology 18(2):163 (1999) PMID 10372557

    Perlecan, a major heparan sulfate proteoglycan of vascularized tissues, was immunopurified from media conditioned by human endothelial cells of both arterial and venous origin. The heparan sulfate moiety of perlecan from cultured arterial cells differed in amount and/or composition from that produce...
  4. Metabolic control of hyaluronan synthases.

    Matrix Biology 35:8 (2014) PMID 24134926

    We address the metabolic regulation of HA synthesis. In contrast with other glycosaminoglycans, which are synthesized in the Golgi apparatus, HA is produced at the plasma membrane by HA synthases (HAS1-3), which use cytoplasmic UDP-glucuronic acid and UDP-N-acetylglucosamine as substrates. UDP-GlcUA...
  5. A decorin-deficient matrix affects skin chondroitin/dermatan sulfate levels and keratinocyte function.

    Matrix Biology 35:91 (2014) PMID 24447999

    We analyzed the glycosaminoglycan content of Dcn(-/-) and wild-type mouse skin. The total amount of chondroitin/dermatan sulfate (CS/DS) was increased in the Dcn(-/-) skin, but was overall less sulfated with a significant reduction in bisulfated ΔDiS2,X (X=4 or 6) disaccharide units, due to the redu...
  6. Chondrocalcin is internalized by chondrocytes and triggers cartilage destruction via an interleukin-1β-dependent pathway.

    Matrix Biology 32(7-8):443 (2013) PMID 23851124

    I pro-collagen supported identical cell-penetration, suggesting that this property may be conserved among C-propeptides of fibrillar pro-collagens. Structural modeling localized this peptide to the tips of procollagen C-propeptide trimers. Our findings shed light on unexpected function and mechanism...
  7. Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies

    Matrix Biology 32(6):325 (2013) PMID 23507196

    We recently demonstrated that cartilage oligomeric matrix protein (COMP) functions as organizer of the dermal collagen I network in healthy human skin (Agarwal et al., 2012). Here we show that COMP deposition is enhanced in the dermis in various fibrotic conditions. COMP levels were significantly in...
  8. Dermatopontin promotes adhesion, spreading and migration of cardiac fibroblasts in vitro.

    Matrix Biology 32(1):23 (2013) PMID 23262218

    We evaluated the expression pattern of DPT mRNA and protein as well as its secretion in cultured neonatal rat cardiomyocytes (CMs) and cardiac fibroblasts (CFs) under conditions of hypoxia and serum deprivation (hypoxia/SD). Further, we tested the possible roles of DPT in CFs adhesion, spreading, mi...
  9. Quantification of type II procollagen splice forms using alternative transcript-qPCR (AT-qPCR).

    Matrix Biology 31(7-8):412 (2012) PMID 22974592 PMCID PMC3536491

    We show that this widely used method is inaccurate due to mismatched amplification efficiency of different-sized PCR products. We have developed the TaqMan®-based AT-qPCR (Alternative Transcript-qPCR) assay to more accurately quantify alternatively spliced mRNA, and demonstrate the measurement of Co...
  10. Tumor suppression by collagen XV is independent of the restin domain.

    Matrix Biology 31(5):285 (2012) PMID 22531369 PMCID PMC3373166

    We previously showed that collagen XV functions as a dose-dependent suppressor of tumorigenicity in cervical carcinoma cells. The carboxyl terminus of another non-fibrillar collagen (XVIII) is cleaved to produce endostatin, which has anti-angiogenic effects and thus may act as a tumor suppressor in...