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Molecular Microbiology

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CSA, Ovid from 2000, Ingenta, Gale, Wiley from 1987, Rcgp, and Proquest

  1. SaPI mutations affecting replication and transfer and enabling autonomous replication in the absence of helper phage.

    Molecular Microbiology 67(3):493 (2008) PMID 18086210

    The SaPIs are chromosomal islands in staphylococci and other Gram-positive bacteria that carry genes for superantigens, virulence factors, resistance and certain metabolic functions. They have intimate relationships with certain temperate phages involving phage-induced excision, replication and ...
  2. Escherichia coli DnaA interacts with HU in initiation at the E. coli replication origin.

    Molecular Microbiology 67(4):781 (2008) PMID 18179598

    Escherichia coli HU protein is a dimer encoded by two closely related genes whose expression is growth phase-dependent. As a major component of the bacterial nucleoid, HU binds to DNA non-specifically, but acts at the chromosomal origin (oriC) during initiation by stimulating strand opening in v...
  3. Linker histone H1 represses recombination at the ribosomal DNA locus in the budding yeast Saccharomyces cerevisiae.

    Molecular Microbiology 67(4):906 (2008) PMID 18179596

    Several epigenetic phenomena occur at ribosomal DNA loci in eukaryotic cells, including the silencing of Pol I and Pol II transcribed genes, silencing of replication origins and repression of recombination. In Saccharomyces cerevisiae, studies focusing on the silencing of Pol II transcription an...
  4. Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei.

    Molecular Microbiology 67(4):762 (2008) PMID 18179414 PMCID PMC2253726

    Post-translational histone modifications have been studied intensively in several eukaryotes. It has been proposed that these modifications constitute a 'histone code' that specifies epigenetic information for transcription regulation. With a limited number of histone-modifying enzymes, implying...
  5. A small protein from the bop-brp intergenic region of Halobacterium salinarum contains a zinc finger motif and regulates bop and crtB1 transcription.

    Molecular Microbiology 67(4):772 (2008) PMID 18179416 PMCID PMC2253796

    Bacteriorhodopsin, the photosynthetic protein of Halobacterium salinarum, is optimally expressed under anaerobic growth conditions. We identified Brz (OE3104F, bacteriorhodopsin-regulating zinc finger protein), a new regulator of the bop gene. It is a small protein with a zinc finger motif, enco...
  6. Vitamin B12 partners the CarH repressor to downregulate a photoinducible promoter in Myxococcus xanthus.

    Molecular Microbiology 67(4):804 (2008) PMID 18315685

    A light-inducible promoter, P(B), drives expression of the carB operon in Myxococcus xanthus. Repressed by CarA in the dark, P(B) is activated when CarS, produced in the light, sequesters CarA to prevent operator-CarA binding. The MerR-type, N-terminal domain of CarA, which mediates interactions...
  7. The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.

    Molecular Microbiology 67(4):830 (2008) PMID 18179421 PMCID PMC3025603

    The Bacillus subtilis extracytoplasmic function (ECF) sigma(M) factor is activated by cell envelope stress elicited by antibiotics, and by acid, heat, ethanol and superoxide stresses. Here, we have used several complementary approaches to identify genes controlled by sigma(M). In many cases, exp...
  8. Polymorphism and regulation of the spxB (pyruvate oxidase) virulence factor gene by a CBS-HotDog domain protein (SpxR) in serotype 2 Streptococcus pneumoniae.

    Molecular Microbiology 67(4):729 (2008) PMID 18179423

    spxB-encoded pyruvate oxidase is a major virulence factor of Streptococcus pneumoniae. During aerobic growth, SpxB synthesizes H2O2 and acetyl phosphate, which play roles in metabolism, signalling, and oxidative stress. We report here the first cis- and trans-acting regulatory elements for spxB ...
  9. Molecular basis of gene regulation by the THI-box riboswitch.

    Molecular Microbiology 67(4):793 (2008) PMID 18179415

    Riboswitches are genetic control elements located mainly within the 5' untranslated regions of messenger RNAs. These RNA elements undergo conformational changes that modulate gene expression upon binding of regulatory signals including vitamins, amino acids, nucleobases and uncharged tRNA. The t...
  10. Post-transcriptional cross-talk between pro- and anti-colonization pili biosynthesis systems in Vibrio cholerae.

    Molecular Microbiology 67(4):849 (2008) PMID 18179420

    The pathogen Vibrio cholerae modulates the expression of many genes in order to transition from its environmental reservoir to its niche in the human host. Among these are genes encoding two related Type IV pili, the mannose-sensitive haemagglutinin (MSHA) pilus, which aids V. cholerae persisten...