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Molecular Microbiology

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CSA, Ovid from 2000, Ingenta, Gale, Wiley from 1987, Rcgp, and Proquest

  1. Transcriptome changes in STSV2-infected Sulfolobus islandicus REY15A undergoing continuous CRISPR spacer acquisition.

    Molecular Microbiology (2015) PMID 26514343

    A transcriptome study was performed on Sulfolobus islandicus REY15A actively undergoing CRISPR spacer acquisition from the crenarchaeal monocaudavirus STSV2 in rich and basal media over a 6 day period. Spacer acquisition preceded strong host growth retardation, altered transcriptional activity of...
  2. ppGpp and DksA likely regulate the activity of the extracytoplasmic stress factor sigmaE in Escherichia coli by both direct and indirect mechanisms.

    Molecular Microbiology 67(3):619 (2008) PMID 18086212

    One of the major signalling pathways responsible for intercompartmental communication between the cell envelope and cytoplasm in Escherichia coli is mediated by the alternative sigma factor, sigmaE. sigmaE has been studied primarily for its role in response to the misfolding of outer membrane po...
  3. The antibacterial activity of peptides derived from human beta-2 glycoprotein I is inhibited by protein H and M1 protein from Streptococcus pyogenes.

    Molecular Microbiology 67(3):482 (2008) PMID 18093092

    During the last years, the importance of antibacterial peptides has attracted considerable attention. We report here that peptides derived from the fifth domain of beta-2 glycoprotein I (beta(2)GPI), a human heparin binding plasma protein, have antibacterial activities against Gram-positive and ...
  4. A mitochondrial topoisomerase IA essential for late theta structure resolution in African trypanosomes.

    Molecular Microbiology 67(4):820 (2008) PMID 18179422

    Trypanosomes and Leishmania, protozoans that cause major human diseases, have a topologically intricate mitochondrial DNA (kinetoplast or kDNA) in the form of a network of thousands of interlocked circles. This unusual system provides a useful reporter for studying topoisomerase functions in viv...
  5. GTP-dependent polymerization of the tubulin-like RepX replication protein encoded by the pXO1 plasmid of Bacillus anthracis.

    Molecular Microbiology 67(4):881 (2008) PMID 18179418

    RepX protein encoded by the pXO1 plasmid of Bacillus anthracis is required for plasmid replication. RepX harbours the tubulin signature motif and contains limited amino acid sequence homology to the bacterial cell division protein FtsZ. Although replication proteins are not known to polymerize, ...
  6. Escherichia coli DnaA interacts with HU in initiation at the E. coli replication origin.

    Molecular Microbiology 67(4):781 (2008) PMID 18179598

    Escherichia coli HU protein is a dimer encoded by two closely related genes whose expression is growth phase-dependent. As a major component of the bacterial nucleoid, HU binds to DNA non-specifically, but acts at the chromosomal origin (oriC) during initiation by stimulating strand opening in v...
  7. The Scl1 protein of M6-type group A Streptococcus binds the human complement regulatory protein, factor H, and inhibits the alternative pathway of complement.

    Molecular Microbiology 67(3):584 (2008) PMID 18093091

    Non-specific activation of the complement system is regulated by the plasma glycoprotein factor H (FH). Bacteria can avoid complement-mediated opsonization and phagocytosis through acquiring FH to the cell surface. Here, we characterize an interaction between the streptococcal collagen-like prot...
  8. SaPI mutations affecting replication and transfer and enabling autonomous replication in the absence of helper phage.

    Molecular Microbiology 67(3):493 (2008) PMID 18086210

    The SaPIs are chromosomal islands in staphylococci and other Gram-positive bacteria that carry genes for superantigens, virulence factors, resistance and certain metabolic functions. They have intimate relationships with certain temperate phages involving phage-induced excision, replication and ...
  9. Distinct regulators control the expression of methanol methyltransferase isozymes in Methanosarcina acetivorans C2A.

    Molecular Microbiology 67(3):649 (2008) PMID 18086201

    The mtaCB1, mtaCB2 and mtaCB3 operons encode isozymes of methanol methyltransferases in Methanosarcina acetivorans C2A and are among the most highly regulated genes known in Archaea. Here we identify cis and trans acting elements that affect the expression of these operons. In vivo reporter gene...
  10. Small mobile sequences in bacteria display diverse structure/function motifs.

    Molecular Microbiology 67(3):475 (2008) PMID 18086200 PMCID PMC2229807

    Small repeat sequences in bacterial genomes, which represent non-autonomous mobile elements, have close similarities to archaeon and eukaryotic miniature inverted repeat transposable elements. These repeat elements are found in both intergenic and intragenic chromosomal regions, and contain an a...