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Molecular Microbiology

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CSA, Ovid from 2000, Ingenta, Gale, Wiley from 1987, Rcgp, and Proquest

  1. The bacterial 'mitochondrium'.

    Molecular Microbiology 94(4):751 (2014) PMID 25287615

    Organelles are membrane-enclosed compartments that serve a dedicated physiological purpose. While eukaryotic organelles are common textbook knowledge, bacteria were long thought to lack such subcellular organization. However, Planctomycetes were proposed to comprise a compartmentalized cell plan, in...
  2. Steve Harris appointed editor for molecular biology and pathogenesis of fungi.

    Molecular Microbiology 91(6):1053 (2014) PMID 24606419

  3. The genetic and structural basis of two distinct terminal side branch residues in stewartan and amylovoran exopolysaccharides and their pote...

    Molecular Microbiology 83(1):195 (2012) PMID 22111898

    We report that the pyruvyl transferase gene in P. stewartii is non-functional, while the terminal glucosyl transferase is catalytically active. Conversely, in E. amylovora, the homologous glucosyl tranferase activity appears to be relatively ineffective, while the pyruvyl transferase function predom...
  4. Exposing the third chromosome of Burkholderia cepacia complex strains as a virulence plasmid.

    Molecular Microbiology 83(2):362 (2012) PMID 22171913

    We isolated three mutants during a transposon mutagenesis screen that were non-pathogenic in a Caenorhabditis elegans infection model. It was demonstrated that these mutants had lost chromosome 3 (c3), and that the observed attenuation of virulence was a consequence of this. We constructed a c3 mini...
  5. Sorting of an integral outer membrane protein via the lipoprotein-specific Lol pathway and a dedicated lipoprotein pilotin.

    Molecular Microbiology 80(3):655 (2011) PMID 21338419

    We present indirect evidence that PulD protomers do not assemble into the secretin dodecamer before they reach the outer membrane, and that PulS reaches the outer membrane in a soluble heterodimer with the general lipoprotein chaperone LolA. However, we could not find any direct evidence for PulD pr...
  6. SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages.

    Molecular Microbiology 79(4):929 (2011) PMID 21299648

    We previously identified a conserved sporozoite-specific protein, SAP1, which has an essential role in Plasmodium liver infection. Targeted deletion of SAP1 in Plasmodium yoelii caused the depletion of a number of selectively tested UIS transcripts in sporozoites, resulting in a complete early liver...
  7. Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transc...

    Molecular Microbiology 79(4):1008 (2011) PMID 21299653

    We characterize a novel physiological determinant of osmostress tolerance, which involves the Hog1-dependent transcriptional downregulation of ergosterol biosynthesis genes (ERG). Yeast cells considerably lower their sterol content in response to high osmolarity. The transcriptional repressors Mot3...
  8. Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response.

    Molecular Microbiology 78(5):1259 (2010) PMID 21091509

    We demonstrated that the Aspergillus nidulans calC2 mutation in protein kinase C pkcA was able to confer tolerance to farnesol (FOH), an isoprenoid that has been shown to inhibit proliferation and induce apoptosis. Here, we investigate in more detail the role played by A. nidulans pkcA in FOH tolera...
  9. Vancomycin tolerance in clinical and laboratory Streptococcus pneumoniae isolates depends on reduced enzyme activity of the major LytA autol...

    Molecular Microbiology :no (2010) PMID 20598082

    We examined two vancomycin-tolerant clinical isolates, i.e., a purported autolysin negative (LytA(-)), serotype 23F isolate (strain S3), and the serotype 14 strain "Tupelo" which is considered a paradigm of vancomycin tolerance. S3 was characterized here as carrying a frameshift mutation in the lytA...
  10. Phytoplasma PMU1 exists as linear chromosomal and circular extrachromosomal elements and has enhanced expression in insect vectors compared ...

    Molecular Microbiology 77(6):1406 (2010) PMID 20662777

    We show that AY-WB has a chromosomal linear PMU1 (L-PMU1) and an extrachromosomal circular PMU1 (C-PMU1). The C-PMU1 copy number was consistently higher by in average ca. 5-fold in insects compared to plants and PMU1 gene expression levels were also considerably higher in insects indicating that C-P...