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Oncogene

Print ISSN
0950-9232
Electronic ISSN
1476-5594
Impact factor
7.414
Publisher
nature
URL
http://www.nature.com/onc/
Usage rank
98
Article count
15971
Free count
8085
Free percentage
0.50623
PDFs via platforms
CSA, Gale, Proquest, Nature, and Ovid from 2003

  1. Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines.

    Oncogene 30(16):1963 (2011) PMID 21132008

    We investigate the role of B-cell lymphoma 2 (Bcl-2) family members Bcl-2, Bcl-x(L) and Mcl-1, known to regulate cell survival and death, in a panel of fourteen NSCLC cell lines. NSCLC cell lines express high levels of Mcl-1 and Bcl-x(L), but not Bcl-2. Silencing the expression of Mcl-1 with small i...
  2. Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity.

    Oncogene 29(44):5935 (2010) PMID 20697359

    We report that p76(MDM2) antagonizes MDM4 inhibitory function. We show that p76(MDM2) possesses intrinsic ubiquitinating and degrading activity, and through these activities controls MDM4 levels. Furthermore, the presence of p76(MDM2) decreases the association of MDM4 with p53 and p90(MDM2), and ant...
  3. EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor.

    Oncogene 29(30):4352 (2010) PMID 20514024

    We report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. The SS18-SSX oncoprotein, characteristic of synovial sarcoma, maintains EGR1 expression at low levels, whereas it is significant...
  4. OTX1 expression in breast cancer is regulated by p53.

    Oncogene 30(27):3104 (2011) PMID 21734711

  5. A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs.

    Oncogene 30(49):4910 (2011) PMID 21643012

    We employed stable silencing of EWS/Fli1, the most common of the oncogenic fusions, and global miR profiling to identify EWS/Fli1-regulated miRs with oncogenesis-modifying roles in Ewing sarcoma. In this report, we characterize a group of miRs (100, 125b, 22, 221/222, 27a and 29a) strongly repressed...
  6. Efficient in vivo microRNA targeting of liver metastasis

    Oncogene 30(12):1481 (2010) PMID 21102518

    We provide proof of principle for the safety and efficacy of miRNA targeting against metastatic tumors. We tested the impact of targeting miR-182, a pro-metastatic miRNA frequently overexpressed in melanoma, the in vitro silencing of which represses invasion and induces apoptosis. Specifically, we a...
  7. Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer.

    Oncogene 29(49):6464 (2010) PMID 20802524

    We identified that TBX5 was preferentially methylated in cancer using methylation-sensitive arbitrarily primed PCR. We aim to clarify the epigenetic inactivation, biological function and clinical significance of TBX5 in colon cancer. Promoter methylation was evaluated by combined bisulfite restricti...
  8. Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands.

    Oncogene 29(32):4599 (2010) PMID 20531309 PMCID PMC3164491

    We investigated mechanisms for CXCR7-dependent uptake of chemokines. Breast cancer cells expressing CXCR7 accumulated chemokines CXCL12 and CXC11 present at concentrations <1 ng/ml, unlike cells expressing CXCR4. CXCR7-dependent accumulation of chemokines was reduced by inhibitors of clathrin-mediat...
  9. The stromal gene encoding the CD274 antigen as a genetic modifier controlling survival of mice with γ-radiation-induced T-cell lymphoblastic...

    Oncogene 29(38):5265 (2010) PMID 20639904

    We have identified a critical region on chromosome 19 that regulates survival of mice suffering from T-cell lymphoblastic lymphomas. Mapped on this region, the gene encoding the Cd274 ligand is able to trigger an inhibitory effect that modulates T-cell receptor (TCR) signalling and affects thymocyte...
  10. T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells

    Oncogene 29(22):3252 (2010) PMID 20348948

    We show that TBX2 drives proliferation in breast cancer cells and this is abrogated after TBX2 small interfering RNA (siRNA) knockdown or after the expression of a dominant-negative TBX2 protein. Using microarray analysis we identified a large cohort of novel TBX2-repressed target genes including th...