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CSA, Gale, Proquest, Nature, and Ovid from 2003

  1. USP4 inhibits p53 and NF-?B through deubiquitinating and stabilizing HDAC2.

    Oncogene (2015) PMID 26411366

    Histone deacetylases (HDACs) are major epigenetic modulators involved in a broad spectrum of human diseases including cancers. As HDACs are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. In this study, we show that ubiquitin-specific peptidas...
  2. SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma.

    Oncogene (2015) PMID 26387547

    Cancer stem cells (CSCs) are a promising target for cancer therapy, particularly for metastatic lung cancers, but how CSCs are regulated is largely unknown. We identify two proteins, SLUG (encoded by SNAI2 gene) and SOX9, which are associated with advanced stage lung cancers and are implicated in...
  3. Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1.

    Oncogene (2015) PMID 26387545

    Osteosarcoma is the most common primary malignancy of the skeleton and is prevalent in children and adolescents. Survival rates are poor and have remained stagnant owing to chemoresistance and the high propensity to form lung metastases. In this study, we used in vivo transgenic models of c-fos o...
  4. NFATc2 is an intrinsic regulator of melanoma dedifferentiation.

    Oncogene (2015) PMID 26387540

    Melanoma dedifferentiation, characterized by the loss of MITF and MITF regulated genes and by upregulation of stemness markers as CD271, is implicated in resistance to chemotherapy, target therapy and immunotherapy. The identification of intrinsic mechanisms fostering melanoma dedifferentiation m...
  5. Molecular basis underlying resistance to Mps1/TTK inhibitors.

    Oncogene (2015) PMID 26364596

    Mps1/TTK is a dual-specificity kinase, with an essential role in mitotic checkpoint signaling, which has emerged as a potential target in cancer therapy. Several Mps1/TTK small-molecule inhibitors have been described that exhibit promising activity in cell culture and xenograft models. Here, we i...
  6. Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.

    Oncogene (2015) PMID 26364612

    The tumor microenvironment (TME) exerts critical pro-tumorigenic effects through cytokines and growth factors that support cancer cell proliferation, survival, motility and invasion. Insulin-like growth factor-1 (IGF-1) and signal transducer and activator of transcription 3 (STAT3) stimulate colo...
  7. LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer.

    Oncogene (2015) PMID 26364613

    Tamoxifen, an estrogen receptor (ER) antagonist, is the mainstay treatment of breast cancer and the development of resistance represents a major obstacle for a cure. Although long non-coding RNAs such as HOTAIR have been implicated in breast tumorigenesis, their roles in chemotherapy resistance r...
  8. Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.

    Oncogene (2015) PMID 26279304

    ZNF322A encoding a classical Cys2His2 zinc finger transcription factor was previously revealed as a potential oncogene in lung cancer patients. However, the oncogenic role of ZNF322A and its underlying mechanism in lung tumorigenesis remain elusive. Here we show ZNF322A protein overexpression in ...
  9. RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression.

    Oncogene (2015) PMID 26234677

    RNF126 is an E3 ubiquitin ligase. The deletion of RNF126 gene was observed in a wide range of human cancers and is correlated with improved disease-free and overall survival. These data highlight the clinical relevance of RNF126 in tumorigenesis and cancer therapy. However, the specific functions...
  10. TRM6/61 connects PKC? with translational control through tRNAi(Met) stabilization: impact on tumorigenesis.

    Oncogene (2015) PMID 26234676

    Accumulating evidence suggests that changes of the protein synthesis machinery alter translation of specific mRNAs and participate in malignant transformation. Here we show that protein kinase C ? (PKC?) interacts with TRM61, the catalytic subunit of the TRM6/61 tRNA methyltransferase. The TRM6/6...