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Journal of Molecular Endocrinology

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CSA, Proquest, Ama, Aacr, Endocrine, Csh, Highwire from 1988, Aaas, Rupress, and Nephrology

  1. The predominant cAMP-stimulated 3 x 5 kb StAR mRNA contains specific sequence elements in the extended 3'UTR that confer high basal instability.

    Journal of Molecular Endocrinology 38(1-2):159 (2007) PMID 17242178

    cAMP stimulation of rodent steroidogenic cells produces two StAR transcripts, a major 3.5 kb and a minor 1.6 kb mRNA, differing only in their 3' untranslated regions (3' UTR). They exhibit very different responses to stimulation and removal of 8-Br-cAMP, with the 3.5 kb form increasing and decli...
  2. Altered endocytosis of epidermal growth factor receptor in androgen receptor positive prostate cancer cell lines.

    Journal of Molecular Endocrinology 38(1-2):51 (2007) PMID 17242169

    Although androgens and the androgen receptor (AR) are involved in tumorigenesis of prostate cancer (PC) in initial phases, less clear is the role played in advanced androgen-independent (AI) stages of the disease. Several recent reports indicated that re-expression of AR in PC-derived cell lines...
  3. Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone beta subunit transcription.

    Journal of Molecular Endocrinology 38(1-2):315 (2007) PMID 17293449

    Transforming growth factor beta superfamily ligands regulate pituitary FSH production and secretion. The best-described examples are the activins and inhibins, which respectively stimulate and hinder Fshb subunit transcription in gonadotrope cells. More recently, members of the bone morphogeneti...
  4. The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone.

    Journal of Molecular Endocrinology 38(1-2):331 (2007) PMID 17293450

    The human progesterone receptor (PR) is a ligand-dependent transcription factor and two isoforms, (PRA and PRB), can be distinguished. PROGINS, a PR polymorphic variant, affects PRA and PRB and acts as a risk-modulating factor in several gynaecological disorders. Little is known about the functi...
  5. Biological activities of recombinant Manchurian trout FSH and LH: their receptor specificity, steroidogenic and vitellogenic potencies.

    Journal of Molecular Endocrinology 38(1-2):99 (2007) PMID 17242173

    Gonadotropins (GTHs), FSH and LH, play central roles in vertebrate reproduction. Here, we report the production of biologically-active recombinant FSH (r-mtFSH) and LH (r-mtLH) of an endangered salmon species, Manchurian trout (Brachymystax lenok), by baculovirus in silkworm (Bombyx mori) larvae...
  6. Thyroid hormone receptor TRbeta1 mediates Akt activation by T3 in pancreatic beta cells.

    Journal of Molecular Endocrinology 38(1-2):221 (2007) PMID 17293442

    It has recently been recognized that thyroid hormones may rapidly generate biological responses by non-genomic mechanisms that are unaffected by inhibitors of transcription and translation. The signal transduction pathways underlying these effects are just beginning to be defined. We demonstrate...
  7. Further delineation of the continuous human neoplastic enterochromaffin cell line, KRJ-I, and the inhibitory effects of lanreotide and rapamycin.

    Journal of Molecular Endocrinology 38(1-2):181 (2007) PMID 17242179

    Small intestinal carcinoids (SICs) are the most prevalent gastrointestinal carcinoid and characterized by local invasion metastasis and protean symptomatology. The proliferative and secretory regulation of the cell of origin, the enterochromaffin (EC) cell has not been characterized. The absence...
  8. Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway.

    Journal of Molecular Endocrinology 38(1-2):19 (2007) PMID 17242167

    Growth hormone-deficient (GHD) patients show a decreased number of adipocytes, which is normalized by GH replacement, indicating an adipogenic effect of GH. However, the precise mechanisms underlying this effect remain to be clarified. In this study, we investigated the adipogenic effect of GH. ...
  9. Efficient and controlled gene expression in mouse pancreatic islets by arterial delivery of tetracycline-inducible adenoviral vectors.

    Journal of Molecular Endocrinology 38(1-2):127 (2007) PMID 17242175

    Gene transfer with adenovirus vectors has been used extensively for pancreatic islet research. However, infection efficiency varies among reports. We reevaluated the infection efficiency, defined here as the percentage of islet cells expressing transgenes, in mouse islets. When the isolated isle...
  10. Molecular cloning of equine 17beta-hydroxysteroid dehydrogenase type 1 and its downregulation during follicular luteinization in vivo.

    Journal of Molecular Endocrinology 38(1-2):67 (2007) PMID 17242170

    The type 1 form of 17beta-hydroxysteroid dehydrogenase (17betaHSD1) was the first isoform to be identified and is capable of converting estrone to 17beta-estradiol. This study was aimed at characterizing the molecular structure of the equine 17betaHSD1 gene and cDNA, as well as its molecular reg...