Journal of Molecular Endocrinology
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- CSA, Proquest, Ama, Aacr, Endocrine, Csh, Highwire from 1988, Aaas, Rupress, and Nephrology
Transcription of platelet-derived growth factor receptor α in Leydig cells involves specificity protein 1 and 3.
We isolated and characterized a 2.2 kb fragment of the rat Pdgfra 5' flanking sequence in the TM3 Leydig cell line, which endogenously express Pdgfra. A series of 5' progressive deletions of the Pdgfra promoter was generated and transfected in TM3 cells. Using this approach two regions (-183/-154 an...
Genes involved in human premature ovarian failure.
We review the principal X-linked and autosomal genes involved in syndromic and non syndromic forms of POI with the wish that this list will soon become upgraded because of the discovery of novel contributing mechanisms. A better understanding of POI pathogenesis will indeed allow the construction of...
Appearance of the pituitary factor Pit-1 increases chromatin remodeling at hypersensitive site III in the human GH locus.
We used human embryonic kidney 293 (HEK293) cells overexpressing wild-type and mutant Pit-1 proteins as a model system to gain insight into the mechanism by which Pit-1 gains access to the GH LCR. Addition of Pit-1 to these cells increased DNA accessibility at HS III, located 28 kb upstream of the h...
Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes.
Antioxidant-based treatments are emerging as an interesting approach to possibly counteract obesity fat accumulation complications, since this is accompanied by an increased systemic oxidative stress. The aim of this study was to analyze specific metabolic effects of vitamin C (VC) on epididymal pri...
Constant expression of hexose-6-phosphate dehydrogenase during differentiation of human adipose-derived mesenchymal stem cells.
We investigated the expression and the activity of H6PD in the course of the differentiation of human adipose-derived mesenchymal stem cells (ADMSCs) and murine 3T3-L1 cells. It was found that H6PD is already present in adipose-derived stem cells and in 3T3-L1 fibroblasts even before the induction o...
FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity.
The crystal structures of the leucine-rich repeat domain (LRD) of the FSH receptor (FSHR) in complex with FSH and the TSH receptor (TSHR) LRD in complex with the thyroid-stimulating autoantibody (M22) provide opportunities to assess the molecular basis of the specificity of glycoprotein hormone-rece...
We had previously achieved, because of the way it is calculated. We have also increased the journal's online frequency to monthly, ensuring that the journal is poised ready for the rapid publication of greater numbers of higher quality papers. With this legacy, I am pleased to hand over the reins of...
DNA damage and its repair in lymphocytes and thyroid nodule cells during radioiodine therapy in patients with hyperthyroidism.
Our results indicate high diversity in the level of DNA damage among the individual patients. However, in all cases, after 54 days the level of DNA damage in lymphocytes was similar or even lower than that in the controls. In contrast, in hot nodule the DNA damage persisted until the 54th day after...
Enhanced expression of a furin-cleavable proinsulin.
We investigated possible causes for this, including mRNA stability, the presence of additional CpG islands, and the amino acid substitutions within furin-cleavable proinsulin. Several furin-cleavable rat proinsulin I cDNAs were engineered and used to transfect human HEK293, rat L6 and mouse C(2)C(12...
Developmental and hormonal regulation of type II DNA topoisomerase in rat testis.
We report that rat testis topo II is developmentally and hormonally regulated. Topo IIalpha mRNA levels peaked prior to the onset of puberty, declined sharply thereafter and stabilized in adult testis. In contrast, the topo II enzyme content was lower in prepubertal testis but increased after the on...