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Journal of Molecular Endocrinology

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CSA, Proquest, Ama, Aacr, Endocrine, Csh, Highwire from 1988, Aaas, Rupress, and Nephrology

  1. Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.

    Journal of Molecular Endocrinology 54(1):39 (2015) PMID 25527620

    We investigated the relationship between pathogenic mutants of MCT8 and their capacity to form dimers (presumably oligomeric structures) as a potential regulatory parameter of the transport function of MCT8. Fourteen pathogenic variants of MCT8 were investigated in vitro with respect to their capaci...
  2. Editorial.

    Journal of Molecular Endocrinology 40(1):1 (2008) PMID 18096991

    We had previously achieved, because of the way it is calculated. We have also increased the journal's online frequency to monthly, ensuring that the journal is poised ready for the rapid publication of greater numbers of higher quality papers. With this legacy, I am pleased to hand over the reins of...
  3. Mutations in the 'DRY' motif of the CB1 cannabinoid receptor result in biased receptor variants.

    Journal of Molecular Endocrinology 54(1):75 (2015) PMID 25510402

    We found that the CB1R-R3.50A mutant displays a partial decrease in its ability to activate heterotrimeric Go proteins (∼80% of WT CB1R (CB1R-WT)). Moreover, this mutant showed an enhanced basal β-arrestin2 (β-arr2) recruitment. More strikingly, the double-mutant CB1R-D3.49A/R3.50A was biased toward...
  4. Molecular evolution of GPCRs: Melanocortin/melanocortin receptors.

    Journal of Molecular Endocrinology 52(3):T29 (2014) PMID 24868105

    The melanocortin receptors (MCRs) are a family of G protein-coupled receptors that are activated by melanocortin ligands derived from the proprotein, proopiomelanocortin (POMC). During the radiation of the gnathostomes, the five receptors have become functionally segregated (i.e. melanocortin 1 rece...
  5. Essential roles of 11β-HSD1 in regulating brown adipocyte function.

    Journal of Molecular Endocrinology 50(1):103 (2013) PMID 23197361

    We investigated the roles of 11β-HSD1 in regulating BAT function. We observed a significant increase in the expression of BAT-specific genes, including UCP1, Cidea, Cox7a1, and Cox8b, in BVT.2733 (a selective inhibitor of 11β-HSD1)-treated and 11β-HSD1-deficient primary brown adipocytes of mice. By...
  6. Role of sex hormones in modulation of brown adipose tissue activity.

    Journal of Molecular Endocrinology 49(1):R1 (2012) PMID 22460126

    The recent demonstration that metabolically active brown adipose tissue (BAT) is present with a high prevalence in humans undoubtedly represents one of the major advancements in the field of metabolic research in the last few years. The increasing interest in BAT is justified by preclinical observat...
  7. Characterization of the human SLC30A8 promoter and intronic enhancer.

    Journal of Molecular Endocrinology 47(3):251 (2011) PMID 21798992 PMCID PMC3185167

    Genome-wide association studies have shown that a polymorphic variant in SLC30A8, which encodes zinc transporter-8, is associated with altered susceptibility to type 2 diabetes (T2D). This association is consistent with the observation that glucose-stimulated insulin secretion is decreased in islets...
  8. GATA transcription factors regulate LHβ gene expression.

    Journal of Molecular Endocrinology 47(1):45 (2011) PMID 21571865

    We demonstrate expression of both GATA2 and GATA4 in primary mouse gonadotropes and the gonadotrope cell line, LβT2. Based on the transient transfection in fibroblast cells, GATA factors increase LH β-subunit gene (LHβ) promoter activity alone and in synergy with the orphan nuclear receptors steroid...
  9. Dietary restriction of mice on a high-fat diet induces substrate efficiency and improves metabolic health.

    Journal of Molecular Endocrinology 47(1):81 (2011) PMID 21830320

    We report that HF-DR improves metabolic health of mice compared with mice receiving the same diet on an ad libitum basis (HF-AL). Already after five weeks of restriction, the serum levels of cholesterol and leptin were significantly decreased in HF-DR mice, whereas their glucose sensitivity and seru...
  10. Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody.

    Journal of Molecular Endocrinology 46(2):81 (2011) PMID 21247981

    A complex of the TSH receptor extracellular domain (amino acids 22-260; TSHR260) bound to a blocking-type human monoclonal autoantibody (K1-70) was purified, crystallised and the structure solved at 1.9 Å resolution. K1-70 Fab binds to the concave surface of the TSHR leucine-rich domain (LRD) formin...