Development and Psychopathology
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Genomic structural variation in psychiatric disorders.
We will discuss CNVs, the current state of evidence for their role in the pathogenesis of classical psychiatric disorders, and the application of such knowledge in clinical settings....
Instantiating the multiple levels of analysis perspective in a program of study on externalizing behavior.
We describe how multiple levels of analysis research has informed our current thinking about antisocial and borderline personality development among trait impulsive and therefore vulnerable individuals. Our approach extends the multiple levels of analysis perspective beyond simple Biology × Environ...
Impact of fathers on risky sexual behavior in daughters: a genetically and environmentally controlled sibling study.
Girls receiving lower quality paternal investment tend to engage in more risky sexual behavior (RSB) than peers. Whereas paternal investment theory posits that this effect is causal, it could arise from environmental or genetic confounds. To distinguish between these competing explan...
Language and cognitive outcomes in internationally adopted children.
We propose a speculative model linking language and cognitive changes to underlying neural circuitry alterations that reflect the impact of chronic stress, due to adoptees' experience of noncontingent, nonindividualized caregiving. Thus, the present study provides support for a relationship between...
Transactional relations across contextual strain, parenting quality, and early childhood regulation and adaptation in a high-risk sample.
This investigation examined transactional relations across contextual strain, parenting quality, and child adjustment in 209 mothers and children at 24, 42, and 72 months of age. Independent ratings of mothers' stressful life events, social support, and relationship quality provided an objective mea...
A cascade model connecting life stress to risk behavior among rural African American emerging adults.
A three-wave cascade model linking life stress to increases in risk behavior was tested with 347 African American emerging adults living in the rural South. Data analyses using structural equation modeling and latent growth curve modeling demonstrated that life stress was linked to increases in risk...
Gene-environment interaction between peer victimization and child aggression.
Although peer victimization places children at serious risk for aggressive behavior, not all victimized children are aggressive. The diathesis-stress hypothesis of disease proposes that an environmental stressor such as peer victimization should to lead to maladjustment mostly in those individuals w...
Changes in the neural bases of emotion regulation associated with clinical improvement in children with behavior problems.
We examined neurophysiological markers associated with emotion regulation in children comorbid for externalizing and internalizing problems before and after treatment. We hypothesized that treatment success would correspond with reduced ventral prefrontal activation, and increased dorsomedial prefro...
Effortful control as modifier of the association between negative emotionality and adolescents' mental health problems.
This study examined the extent to which effortful control moderated the risk of internalizing or externalizing problems associated with high negative emotionality in a Dutch population sample of pre- and early adolescents (N = 1,922). Internalizing and externalizing problems were assessed with the C...
The role of culture in moderating the links between early ecological risk and young children's adaptation.
To examine the effects of risk on infant development within cultural contexts, 141 dual-earner Israeli and Palestinian couples and their first-born child were observed at 5 months and again at 34 months. Eight ecological determinants were examined as potential risk factors, including the infant's ob...