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The Journal of Nutritional Biochemistry

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  1. Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up-regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease

    The Journal of Nutritional Biochemistry 26(10):996 (2015) PMID 26033743 PMCID PMC4578989

    Nonalcoholic fatty liver disease (NAFLD) prevalence is increasing worldwide, with the affected US population estimated near 30%. Diet is a recognized risk factor in the NAFLD spectrum, which includes nonalcoholic steatohepatitis (NASH) and fibrosis. Low hepatic copper (Cu) was recently...
  2. Circulating profiling reveals the effect of a polyunsaturated fatty acid-enriched diet on common microRNAs

    The Journal of Nutritional Biochemistry 26(10):1095 (2015) PMID 26092372

    Background Consumption of long-chain polyunsaturated fatty acids (PUFAs), which are abundant in seafood and nuts, ameliorates components of the metabolic syndrome. Circulating microRNAs (miRNAs) have demonstrated to be valuable biomarkers of metabolic diseases. Here, we inves...
  3. High intrinsic aerobic capacity and pomegranate juice are protective against macrophage atherogenecity: studies in high- vs. low-capacity runner (HCR vs. LCR) rats

    The Journal of Nutritional Biochemistry 26(10):1015 (2015) PMID 26004903 PMCID PMC4578978

    We studied the rat model system of high- vs. low-capacity runner (HCR vs. LCR) rats to question the atherogenic properties (oxidative stress, triglycerides and cholesterol metabolism) in the rat macrophages, serum, liver and heart. Half of the LCR or HCR rats consumed pomegranate juice...
  4. Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome

    The Journal of Nutritional Biochemistry 26(10):1029 (2015) PMID 26164602

    Purple sweet potato color (PSPC), flavonoids isolated from purple sweet potato, has been well demonstrated for the pharmacological properties. In the present study, we attempt to explore whether the antisenescence was involved in PSPC-mediated protection against endothelium dysfunction...
  5. Vitamin D3 supplementation increases insulin level by regulating altered IP3 and AMPA receptor expression in the pancreatic islets of streptozotocin-induced diabetic rat

    The Journal of Nutritional Biochemistry 26(10):1041 (2015) PMID 26054778

    Pancreatic islets, particularly insulin-secreting β cells, share common characteristics with neurons. Glutamate is one of the major excitatory neurotransmitter in the brain and pancreas, and its action is mediated through glutamate receptors. In the present work, we analysed the role o...
  6. Table of Contents
    Author(s) unavailable

    The Journal of Nutritional Biochemistry 26(10):i (2015)

  7. Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway

    The Journal of Nutritional Biochemistry 26(10):1058 (2015) PMID 26101135

    The initiation of obesity entails an imbalance wherein energy intake exceeds expenditure. Obesity is increasing in prevalence and is now a worldwide health problem. Food-derived peroxisome proliferator-activated receptor δ (PPARδ) stimulators represent potential treatment options for o...
  8. Bone-specific gene expression patterns and whole bone tissue of female mice are programmed by early life exposure to soy isoflavones and folic acid

    The Journal of Nutritional Biochemistry 26(10):1068 (2015) PMID 26089235

    Female mice exposed to soy isoflavones (ISO) during early postnatal life have improved bone outcomes at adulthood. Since long-lasting effects may be mediated by DNA methylation, we hypothesized that providing supplemental folic acid (FA), a methyl donor, during early life, would enhanc...
  9. Choline deficiency impairs intestinal lipid metabolism in the lactating rat

    The Journal of Nutritional Biochemistry 26(10):1077 (2015) PMID 26092371

    Choline is a precursor to phosphatidylcholine (PC), a structural molecule in cellular membranes that is crucial for cell growth and function. PC is also required for the secretion of lipoprotein particles from liver and intestine. Choline requirements are increased during lactation whe...
  10. Composition and function of the undernourished neonatal mouse intestinal microbiome

    The Journal of Nutritional Biochemistry 26(10):1050 (2015) PMID 26070414

    Undernutrition remains one of the key global health challenges facing children today. Distinct microbial profiles have been associated with obesity and undernutrition, although mechanisms behind these associations are unknown. We sought to understand how protein–energy undernutrition a...