Current Biology

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  1. Rph1/KDM4 Mediates Nutrient-Limitation Signaling that Leads to the Transcriptional Induction of Autophagy

    Current Biology 25(5):546 (2015) PMID 25660547 PMCID PMC4348152

    Background Autophagy is a conserved process mediating vacuolar degradation and recycling. Autophagy is highly upregulated upon various stresses and is essential for cell survival in deleterious conditions. Autophagy defects are associated with severe pathologies, whereas unch...
  2. Drosophila Sugar Receptors in Sweet Taste Perception, Olfaction, and Internal Nutrient Sensing

    Current Biology 25(5):621 (2015) PMID 25702577

    Identification of nutritious compounds is dependent on expression of specific taste receptors in appropriate taste-cell types [1]. In contrast to mammals, which rely on a single, broadly tuned heterodimeric sugar receptor [2], the Drosophila genome harbors a small subfamily of eight, c...
  3. Distinct Organization and Regulation of the Outer Kinetochore KMN Network Downstream of CENP-C and CENP-T

    Current Biology 25(5):671 (2015) PMID 25660545 PMCID PMC4348146

    The kinetochore provides a vital connection between chromosomes and spindle microtubules [1, 2]. Defining the molecular architecture of the core kinetochore components is critical for understanding the mechanisms by which the kinetochore directs chromosome segregation. The KNL1/Mis12 c...
  4. Development of Connectivity in a Motoneuronal Network in Drosophila Larvae

    Current Biology 25(5):568 (2015) PMID 25702582 PMCID PMC4353686

    Background Much of our understanding of how neural networks develop is based on studies of sensory systems, revealing often highly stereotyped patterns of connections, particularly as these diverge from the presynaptic terminals of sensory neurons. We know considerably less a...
  5. A Massive Expansion of Effector Genes Underlies Gall-Formation in the Wheat Pest Mayetiola destructor

    Current Biology 25(5):613 (2015) PMID 25660540

    Gall-forming arthropods are highly specialized herbivores that, in combination with their hosts, produce extended phenotypes with unique morphologies [1]. Many are economically important, and others have improved our understanding of ecology and adaptive radiation [2]. However, the mec...
  6. Ube3a Imprinting Impairs Circadian Robustness in Angelman Syndrome Models

    Current Biology 25(5):537 (2015) PMID 25660546 PMCID PMC4348236

    Background The paternal allele of Ube3a is silenced by imprinting in neurons, and Angelman syndrome (AS) is a disorder arising from a deletion or mutation of the maternal Ube3a allele, which thereby eliminates Ube3a neuronal expression. Sleep disorders such as short sleep dur...
  7. Multisensory Perception: Pinpointing Visual Enhancement by Appropriate Odors

    Current Biology 25(5):R196 (2015) PMID 25734268

    Multisensory contributions to perception are well studied, but their underlying brain mechanisms are poorly understood. A new study has exploited advances in fly optogenetics to pinpoint mechanisms that enhance responses to visual motion in the presence of ecologically relevant odors. ...
  8. Patrick Bateson

    Current Biology 25(5):R180 (2015)

    An interview with Patrick Bateson, retired ethologist with a particular interest in animal welfare.
  9. Targeted Conservation to Safeguard a Biodiversity Hotspot from Climate and Land-Cover Change

    Current Biology 25(5) (2015)

  10. Dogs Can Discriminate Emotional Expressions of Human Faces

    Current Biology 25(5):601 (2015) PMID 25683806

    The question of whether animals have emotions and respond to the emotional expressions of others has become a focus of research in the last decade [1–9]. However, to date, no study has convincingly shown that animals discriminate between emotional expressions of heterospecifics, exclud...
  11. Neuronal Wiring: Linking Dendrite Placement to Synapse Formation

    Current Biology 25(5):R190 (2015) PMID 25734265

    Understanding the processes that drive the formation of synapses between specific neurons within a circuit is critical to understanding how neural networks develop. A new study of synapse formation between motor neurons and pre-synaptic partners highlights the importance of dendrite pl...
  12. Inverse Size Scaling of the Nucleolus by a Concentration-Dependent Phase Transition

    Current Biology 25(5):641 (2015) PMID 25702583 PMCID PMC4348177

    Just as organ size typically increases with body size, the size of intracellular structures changes as cells grow and divide. Indeed, many organelles, such as the nucleus [1, 2], mitochondria [3], mitotic spindle [4, 5], and centrosome [6], exhibit size scaling, a phenomenon in which o...
  13. Gamma power reductions accompany stimulus-specific representations of dynamic events

    Current Biology 25(5) (2014) PMID 25683804

    Neural representations of specific stimuli rely on activity patterns in distributed neural assemblies [1-4]. According to one influential view, these assemblies are characterized by synchronized gamma-band activity (GBA) [5-11] which reflects stimulus-specific representations [12-14]. ...
  14. Attention reduces spatial uncertainty in human ventral temporal cortex

    Current Biology 25(5) (2014) PMID 25702580 PMCID PMC4348205

    Ventral temporal cortex (VTC) is the latest stage of the ventral 'what' visual pathway, which is thought to code the identity of a stimulus regardless of its position or size [1, 2]. Surprisingly, recent studies show that position information can be decoded from VTC [3-5]. However, the...
  15. Asymmetric localizations of the ABC transporter PaPDR1 trace paths of directional strigolactone transport

    Current Biology 25(5) (2014) PMID 25683808

    Strigolactones, firstly discovered as germination stimulants for parasitic weeds [1], are carotenoid-derived phytohormones that play major roles in inhibiting lateral bud outgrowth and promoting plant-mycorrhizal symbiosis [2-4]. Furthermore strigolactones are involved in the regulatio...
  16. Spliceosomes

    Current Biology 25(5) (2014) PMID 25734262

    Chen and Moore provide a Quick guide on spliceosomes, the multimegadalton ribonucleoprotein complexes found in eukaryotic nuclei that are responsible for pre-mRNA splicing.
  17. Genome Evolution: Groping in the Soil Interstices

    Current Biology 25(5) (2014) PMID 25734267

    Centipedes are a very old lineage of terrestrial animals. The first completely sequenced myriapod genome reveals that the blind centipede Strigamia maritima has no gene for light-sensory proteins, lacks the canonical circadian clock and possesses unusual features related to chemosensor...
  18. Left–Right Asymmetry: Cilia and Calcium Revisited

    Current Biology 25(5) (2009) PMID 25734272

    Leftward flow generated by motile cilia is known to underlie left–right asymmetry in vertebrate embryos. A new study now links intraciliary calcium oscillations to cilia motility and the downstream nodal signaling cascade that drives left-sided development.
  19. Cortical Control: Learning from the Lamprey

    Current Biology 25(5) (1870) PMID 25734271

    The function of the motor cortex has been a persistent mystery. A recent study has found striking correspondence between the descending projections of lamprey pallium and mammalian motor cortex, encouraging comparative studies of the origin (and role) of forebrain motor control.