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Attached Segment Has Higher CD34(+) Cells and CFU-GM Than the Main Bag After Thawing.
We used 245 nonconforming CBUs for allogeneic transplantation. After thawing the cryopreserved CBU, the number of total nucleated cells (TNCs), CD34(+) cells, and CFUs in CB from main bags and segments, as well as cell viability and apoptosis, were examined. The comparative analysis showed that the...
Administration of autologous bone marrow derived mononuclear cells in children with incurable neurological disorders and injury is safe and ...
Neurological disorders such as muscular dystrophy, cerebral palsy and injury to the brain and spine currently, have no known definitive treatments or cures. A study was carried out on seventy one children suffering from such incurable neurological disorders and injury. They were intr...
Intracerebral Transplantation of Differentiated Human Embryonic Stem Cells to Hemiparkinsonian Monkeys
Our study suggests that immunological issues are obstacles for preclinical evaluation of hES cells and that improved immunosuppression paradigms and/or alternative cell sources that do not elicit immune rejection are needed for long-term preclinical studies....
Cardiac Stem Cell Therapy: Advances From 2008.
Advances on multiple scientific fronts have brought insights into mechanisms of tissue healing and uncovered new potential to cellular recovery and replacement. With the unabated rise in the prevalence of cardiovascular disease, the interventional community is increasingly faced with...
Evaluation of a Peritoneal-Generated Cardiac Patch in a Rat Model of Heterotopic Heart Transplantation.
Our study also offers a viable rat model for screening and evaluating new concepts in cardiac reconstruction and engineering....
Two-dimensional speckle-tracking strain analysis for efficacy assessment of myocardial cell therapy.
Two patients died during the follow-up period. In the remaining 10 patients, mean LVEF increased from 24.5+/-10% to 32.1+/-11% (p=0.02). A moderate improvement of systolic function was noted in ischemic control segments by both, wall motion score (WMS) and 2-D strain echocardiography (2-DSE). In BMC...
Ex-vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cells enhances vasculogenesis.
We report a nanofiber based ex-vivo stem cell expansion technology and proangiogenic growth factors overexpression of the human umbilical cord blood (UCB)-derived progenitor cells to enhance angiogenic potential of therapeutic stem cell. The progenitor cells were expanded approximately 225 fold on n...
Stem cell salvage of injured peripheral nerve.
We previously developed a collagen tube filled with autologous skin-derived stem cells (SDSCs) for bridging long rat sciatic nerve gaps. Here we present a case report describing a compassionate use of this graft for repairing the polyinjured motor and sensory nerves of the upper arms of a patient. P...
Enhancement of in vitro and in vivo function of agarose-encapsulated porcine islets by changes in the islet microenvironment.
We describe optimization of the agarose matrix that results in improved islet function. Porcine islets (500 IEQs) from retired breeding sows were encapsulated in 1.5% SeaKem Gold (SG), 0.8% SG, or 0.8% Litex (Li) agarose, followed by an outer capsule of 5% SG agarose. Insulin production by the encap...
The therapeutic potential of anti-interleukin-20 monoclonal antibody.
We demonstrated that IL-20 plays pivotal roles in these three diseases. In experimental models, anti-IL-20 monoclonal antibody ameliorates arthritis severity, protects against ovariectomized-induced bone loss, and inhibits breast tumor-induced osteolysis. This review presents the clinical implicatio...