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Cell Transplantation

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  1. Administration of autologous bone marrow derived mononuclear cells in children with incurable neurological disorders and injury is safe and ...

    Cell Transplantation (2012) PMID 22469130

    Neurological disorders such as muscular dystrophy, cerebral palsy and injury to the brain and spine currently, have no known definitive treatments or cures. A study was carried out on seventy one children suffering from such incurable neurological disorders and injury. They were intr...
  2. Intracerebral Transplantation of Differentiated Human Embryonic Stem Cells to Hemiparkinsonian Monkeys
    Author(s) unavailable

    Cell Transplantation (2012) PMID 22710103

    Our study suggests that immunological issues are obstacles for preclinical evaluation of hES cells and that improved immunosuppression paradigms and/or alternative cell sources that do not elicit immune rejection are needed for long-term preclinical studies....
  3. Losartan enhances the success of myoblast transplantation.

    Cell Transplantation 21(1):139 (2012) PMID 21535912

    Our aim was to verify whether the success of human myoblast transplantation in immunodeficient dystrophic mice is enhanced with losartan, a molecule that down-regulates TGF-β expression. In vitro, blocking TGF-β activity with losartan increased proliferation and fusion and decreased apoptosis in h...
  4. GMP-compliant culture of human hair follicle cells for encapsulation and transplantation.

    Cell Transplantation 21(1):373 (2012) PMID 21439132

    Human hair follicle cells, both bulge and dermal papilla cells, were isolated and cultured in a GMP cell factory, in order to obtain an in vitro hair follicle source for encapsulation end transplantation in alopecia regenerative cell therapy. An in vitro model, constituted by organot...
  5. Transcriptional profiling of the hematopoietic support of interleukin-stimulated human umbilical vein endothelial cells (HUVECs).

    Cell Transplantation 21(1):251 (2012) PMID 21669038

    We identified hematopoietic progenitor cell (HPC) expansion or survival benefit induced by IL-1ß, IL-3 and IL-6 stimulated human umbilical vein endothelial cells (HUVECs) supernatants. In order to identify molecular mechanisms that support hematopoiesis, we examined the time dependent expression pr...
  6. Collagen IV significantly enhances migration and transplantation of embryonic stem cells: involvement of α2β1 integrin-mediated actin remode...

    Cell Transplantation 20(6):893 (2011) PMID 21176409

    We investigated ES cell migration under the influence of various extracellular matrix (ECM) proteins, which have been shown to stimulate cell migration in various cell models with unclear effects on ES cells. Using two mouse ES (mES) cell lines, ESC 26GJ9012-8-2 and ES-D3 GL, to generate embryoid bo...
  7. Injectable VEGF hydrogels produce near complete neurological and anatomical protection following cerebral ischemia in rats.

    Cell Transplantation 19(9):1063 (2010) PMID 20412616

    Vascular endothelial growth factor (VEGF) is a potent proangiogenic peptide and its administration has been considered as a potential neuroprotective strategy following cerebral stroke. Because VEGF has a short half-life and limited access to the brain parenchyma following systemic administration, a...
  8. Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs.

    Cell Transplantation 19(9):1103 (2010) PMID 20412634

    We have demonstrated that spinal grafting of rat or human neuronal precursors or human postmitotic hNT neurons leads to progressive amelioration of spasticity and rigidity and corresponding improvement in ambulatory function. In the present study, we characterized the optimal dosing regimen and safe...
  9. Stem cell research in cell transplantation: sources, geopolitical influence, and transplantation.

    Cell Transplantation 19(11):1493 (2010) PMID 21054954

    If the rapidly progressing field of stem cell research reaches its full potential, successful treatments and enhanced understanding of many diseases are the likely results. However, the full potential of stem cell science will only be reached if all possible avenues can be explored and on a worldwid...
  10. Cell labeling with a novel contrast agent of magnetic resonance imaging.

    Cell Transplantation 19(6):887 (2010) PMID 20587147

    We developed a novel contrast agent of magnetic resonance imaging (MRI), TMADM-02. TMADM-02 was efficiently transduced into cells without toxicity. However, the aggregation of TMADM-02 was observed because of its low stability in culture medium. Therefore, TMADM-02 may have led to a false-positive t...