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Cell Transplantation

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  1. Autologous G-CSF-mobilized peripheral blood CD34+ cell therapy for diabetic patients with chronic nonhealing ulcer.

    Cell Transplantation 23(2):167 (2014) PMID 23107450

    We performed a prospective clinical trial phase I/IIa study of autologous G-CSF-mobilized peripheral blood (PB) CD34(+) cell transplantation for nonhealing diabetic foot patients. Diabetic patients with nonhealing foot ulcers were treated with 2 × 10(7) cells of G-CSF-mobilized PB CD34(+) cells as E...
  2. The potential of endothelial colony-forming cells to improve early graft loss after intraportal islet transplantation.

    Cell Transplantation 23(3):273 (2014) PMID 23294520

    We examined if ECFC-coated porcine islets would prevent early graft loss in vivo. Human ECFCs were prepared from cord blood and cocultured with islets to make composite grafts. Diabetic nude mice underwent intraportal transplantation. Blood glucose levels were monitored, and morphological examinatio...
  3. Islet engraftment and revascularization in clinical and experimental transplantation.

    Cell Transplantation 22(2):243 (2013) PMID 22584061

    We developed a novel noninvasive imaging method, based on adenoviral transduction of islets with a hypoxia responsive reporter gene, for continuous in vivo monitoring of hypoxia in islet grafts in a mouse model. In addition, morphological data were obtained from a deceased patient previously subjec...
  4. Histidine-tryptophan-ketoglutarate and University of Wisconsin solution demonstrate equal effectiveness in the preservation of human pancrea...

    Cell Transplantation 22(7):1113 (2013) PMID 23031661 PMCID PMC3759240

    We previously reported a small-scale study on the efficacy of histidine-tryptophan-ketoglutarate (HTK) solution versus University of Wisconsin (UW) solution on pancreas preservation for islet isolation. In this large-scale, retrospective analysis (n = 252), we extend our initial description of the i...
  5. PET imaging of serotonin transporters with 4-[18F]-ADAM in a Parkinsonian rat model.

    Cell Transplantation 22(7):1295 (2013) PMID 23127756

    We have also determined that 4-[18F]-ADAM/micro-PET can be used to detect serotonergic neuron loss, monitor the progress of Parkinson's disease, and oversee the effectiveness of therapy....
  6. Donor-matched functional and molecular characterization of canine mesenchymal stem cells derived from different origins.

    Cell Transplantation 22(12):2311 (2013) PMID 23068964

    Canine mesenchymal stem cells (cMSCs) have generated a great interest as a promising source for cell-based therapies. To understand the basic biological properties of cMSCs derived from bone marrow (cBM-MSCs), adipose tissue (cA-MSCs), and dermal skin (cDS-MSCs) from a single donor, the present stud...
  7. Effects of exercise interventions in graft-versus-host disease models.

    Cell Transplantation 22(12):2409 (2013) PMID 23127525

    We evaluated the effects of an 11-week moderate-intensity exercise (treadmill) training program performed after allo-HSCT in a murine acute (aGVHD) and chronic GVHD model (cGVHD). Female mice (aged 8-12 weeks) were randomly assigned to the exercise or the control group. They completed a maximal trea...
  8. Intracranial transplant of olfactory ensheathing cells can protect both upper and lower motor neurons in amyotrophic lateral sclerosis.

    Cell Transplantation 22 Suppl 1:S51 (2013) PMID 23993044

    We have previously demonstrated that transplantation of neonatal olfactory ensheathing cells (OECs) into the dorsal funiculus of the spinal cord of mutant SOD1(G93A) transgenic rats increases the survival of spinal motor neurons and remyelinates the impaired axons through the pyramidal tract. In the...
  9. Comparative study of human dental follicle cell sheets and periodontal ligament cell sheets for periodontal tissue regeneration.

    Cell Transplantation 22(6):1061 (2013) PMID 23007138

    We hypothesized that DFC sheets might be more effective and suitable for periodontal tissue regeneration than PDLC sheets. In this study, we compared the biological characteristics of DFC sheets and PDLC sheets in vitro. To investigate the potential for periodontal tissue regeneration in vivo, compl...
  10. Have Fun and Enjoy it Together at the Joint JSOPMB/CTS Conference.

    Cell Transplantation 21(2):385 (2012) PMID 22793045