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Bone Marrow-Derived c-kit(+) Cells Attenuate Neonatal Hyperoxia-Induced Lung Injury.
We tested the hypothesis that administration of BM-derived c-kit(+) cells would improve angiogenesis in neonatal rats with HILI. To determine whether intratracheal (IT) administration of BM-derived c-kit(+) cells attenuates neonatal HILI, rat pups exposed to either normobaric normoxia (21% O2) or hy...
Neural stem cell-conditioned medium protects neurons and promotes propriospinal neurons relay neural circuit reconnection after spinal cord ...
We examined the possibility that NSCs may have neuroprotective activities. The present article studied the action of hNSCs on protecting neurons and promoting corticospinal tract (CST) axon regeneration after SCI. hNSCs were isolated from the cortical tissue of spontaneously aborted human fetuses. T...
Intra-Arterial Bone Marrow Mononuclear Cell Transplantation Correlates With GM-CSF, PDGF-BB, and MMP-2 Serum Levels in Stroke Patients: Resu...
We tested whether BM-MNC transplantation in stroke patients induces changes in serum levels of cytokines and GFs. A phase I/II trial was conducted in middle cerebral artery (MCA) stroke patients with autologous intra-arterial BM-MNC transplantation between 5 and 9 days after stroke. Follow-up was do...
Potential Barriers to Human Hepatocyte Transplantation in MUP-uPA(tg(+/+))Rag2(-/-)γC(-/-) Mice.
We compared the engraftment efficiencies between adult human, fetal human, and adult porcine hepatocytes after transplantation into MUP-uPA(tg(+/+))Rag2(-/-)γC(-/-)mice. Transplantation of adult human hepatocytes yielded a 1,000-fold higher serum albumin level compared to transplantation of fetal hu...
Administration of autologous bone marrow derived mononuclear cells in children with incurable neurological disorders and injury is safe and ...
Neurological disorders such as muscular dystrophy, cerebral palsy and injury to the brain and spine currently, have no known definitive treatments or cures. A study was carried out on seventy one children suffering from such incurable neurological disorders and injury. They were intr...
Intracerebral Transplantation of Differentiated Human Embryonic Stem Cells to Hemiparkinsonian Monkeys
Our study suggests that immunological issues are obstacles for preclinical evaluation of hES cells and that improved immunosuppression paradigms and/or alternative cell sources that do not elicit immune rejection are needed for long-term preclinical studies....
Cardiac Stem Cell Therapy: Advances From 2008.
Advances on multiple scientific fronts have brought insights into mechanisms of tissue healing and uncovered new potential to cellular recovery and replacement. With the unabated rise in the prevalence of cardiovascular disease, the interventional community is increasingly faced with...
Evaluation of a Peritoneal-Generated Cardiac Patch in a Rat Model of Heterotopic Heart Transplantation.
Our study also offers a viable rat model for screening and evaluating new concepts in cardiac reconstruction and engineering....
Two-dimensional speckle-tracking strain analysis for efficacy assessment of myocardial cell therapy.
Two patients died during the follow-up period. In the remaining 10 patients, mean LVEF increased from 24.5+/-10% to 32.1+/-11% (p=0.02). A moderate improvement of systolic function was noted in ischemic control segments by both, wall motion score (WMS) and 2-D strain echocardiography (2-DSE). In BMC...
Ex-vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cells enhances vasculogenesis.
We report a nanofiber based ex-vivo stem cell expansion technology and proangiogenic growth factors overexpression of the human umbilical cord blood (UCB)-derived progenitor cells to enhance angiogenic potential of therapeutic stem cell. The progenitor cells were expanded approximately 225 fold on n...