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Cell Transplantation

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  1. Beneficial role of pancreatic microenvironment for angiogenesis in transplanted pancreatic islets.

    Cell Transplantation 18(1):23 (2009) PMID 19476206

    Pancreatic islets implanted heterotopically (i.e., into the kidney, spleen, or liver) become poorly revascularized following transplantation. We hypothesized that islets implanted into the pancreas would become better revascularized. Islets isolated from transgenic mice expressing enhanced yello...
  2. Toward improving human islet isolation from younger donors: rescue purification is efficient for trapped islets.

    Cell Transplantation 18(1):13 (2009) PMID 19476205 PMCID PMC3777447

    Several reports suggest that islets isolated from younger donor pancreata are of better quality for clinical islet transplantation. The relative inefficiency of the continuous gradient purification process (CGP) is one of the major obstacles to the utilization of these younger donor pancreata. T...
  3. Improved survival of fulminant liver failure by transplantation of microencapsulated cryopreserved porcine hepatocytes in mice.

    Cell Transplantation 18(1):101 (2009) PMID 19476213

    The aim of this study was to establish hepatocyte isolation in pigs, and to evaluate function of isolated hepatocytes after encapsulation, cryopreservation, and transplantation (Tx) in a mouse model of fulminant liver failure (FLF). After isolation, porcine hepatocytes were microencapsulated wit...
  4. Assessments of proliferation capacity and viability of New Zealand rabbit peripheral blood endothelial progenitor cells labeled with superparamagnetic particles.

    Cell Transplantation 18(2):171 (2009) PMID 19499705

    Magnetic resonance imaging (MRI) has proven to be effective in tracking the distribution of transplanted stem cells to target organs by way of labeling cells with superparamagnetic iron oxide particles (SPIO). However, the effect of SPIO upon labeled cells is still unclear on a cellular level. W...
  5. Microtransplantation of dopaminergic cell suspensions: further characterization and optimization of grafting parameters.

    Cell Transplantation 18(2):119 (2009) PMID 19499701

    Intracerebral transplantation of dopaminergic (DA) cells is currently further explored as a potential restorative therapy for Parkinson's disease (PD). However, before they can be considered for a more widespread clinical use a number of critical issues have to be resolved, including an optimize...
  6. Collagenase isoforms for pancreas digestion.

    Cell Transplantation 18(2):203 (2009) PMID 19499708

    The available information concerning the characteristics and composition of collagenase batches, which are effective in the digestion of human pancreas for islet transplants, is scarce and incomplete. A large inter- and intrabatched variability in activity and efficiency of blend enzymes availab...
  7. DAPI diffusion after intravitreal injection of mesenchymal stem cells in the injured retina of rats.

    Cell Transplantation 18(4):423 (2009) PMID 19622229

    To evaluate DAPI (4',6-diamidino-2-phenylindole) as a nuclear tracer of stem cell migration and incorporation it was observed the pattern of retinal integration and differentiation of mesenchymal stem cells (MSCs) injected into the vitreous cavity of rat eyes with retinal injury. For this purpos...
  8. ERas is expressed in primate embryonic stem cells but not related to tumorigenesis.

    Cell Transplantation 18(4):381 (2009) PMID 19622226

    The ERas gene promotes the proliferation of and formation of teratomas by mouse embryonic stem (ES) cells. However, its human orthologue is not expressed in human ES cells. This implies that the behavior of transplanted mouse ES cells would not accurately reflect the behavior of transplanted hum...
  9. Evaluation of a peritoneal-generated cardiac patch in a rat model of heterotopic heart transplantation.

    Cell Transplantation 18(3):275 (2009) PMID 19558776

    Tissue engineering holds the promise of providing new solutions for heart transplant shortages and pediatric heart transplantation. The aim of this study was to evaluate the ability of a peritoneal-generated, tissue-engineered cardiac patch to replace damaged myocardium in a heterotopic heart tr...
  10. NF-kappaB activity in endothelial cells is modulated by cell substratum interactions and influences chemokine-mediated adhesion of natural killer cells.

    Cell Transplantation 18(3):261 (2009) PMID 19558775 PMCID PMC2857529

    Because changes in subendothelial matrix composition are associated with alterations of the endothelial immune phenotype, we sought to understand if cytokine-induced NF-kappaB activity and downstream effects depend on substrate adherence of endothelial cells (EC). We compared the upstream phosph...