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Bioorganic & Medicinal Chemistry

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Sciencedirect from 1993, Proquest, Rcgp, Ingenta, Gale, and CSA

  1. The effect of C(5) cytosine methylation at CpG sequences on mitomycin-DNA bonding profiles.

    Bioorganic & Medicinal Chemistry 9(4):863 (2001) PMID 11354669

    We have determined the bonding profiles for mitomycin monoalkylation in two DNA restriction fragments where the CpG sequences were methylated. Three mitomycin substrates were used and two different enzymatic assays employed to monitor the extent of drug modification at the individual base sites. Dru...
  2. TRH mimetics: differentiation of antiamnesic potency from antidepressant effect.

    Bioorganic & Medicinal Chemistry 5(11):2029 (1997) PMID 9416420

    We were pursuing an approach that consists of two steps: (1) 'obligatory' replacement of histidine with glutamine in TRH and (2) the application of conformational constraints for putative bioactive conformation I stabilized by an intramolecular hydrogen bond between C-terminal carboxamide proton and...
  3. Exploring the biological promiscuity of high-throughput screening hits through DFT calculations.

    Bioorganic & Medicinal Chemistry 22(8):2461 (2014) PMID 24656802

    The goal of this study is the understanding of biologically promiscuous compounds (frequent hitters) in HTS outcomes through their chemical behavior estimated via reactivity descriptors. Chemical reactivity is often an undesirable property due to the lack in biological selectivity of compounds compr...
  4. Camphor-based symmetric diimines as inhibitors of influenza virus reproduction

    Bioorganic & Medicinal Chemistry 22(7):2141 (2014) PMID 24631360

  5. Peptide-based immunoadsorbents: molecular grafting of IgG-Fc-binding epitopes of Protein A onto a de novo-designed helix-loop-helix peptide.

    Bioorganic & Medicinal Chemistry 22(6):1845 (2014) PMID 24556503

    We designed peptide immunoadsorbents by molecular grafting of the IgG-Fc binding epitopes of Protein A onto a de novo-designed helix-loop-helix peptide. Linear (linG7A5) and cyclic (cyG7A5) grafted peptides were synthesized to test their binding affinity and specificity. Peptide cyG7A5 demonstrated...
  6. Alkynyl-coumarinyl ethers as MAO-B inhibitors.

    Bioorganic & Medicinal Chemistry 22(6):1916 (2014) PMID 24560738

    In this study, alkynyl-coumarinyl ethers were developed as inhibitors of human monoamine oxidase B (MAO-B). A series of 31 new, ether-connected coumarin derivatives was synthesized via hydroxycoumarins, whose phenolic group at position 6, 7 or 8 was converted by means of the Mitsunobu reaction. The...
  7. Binding ability of a thymine-functionalized oligolysine towards nucleic acids

    Bioorganic & Medicinal Chemistry 22(3):997 (2014) PMID 24411200

  8. Graphical contents list
    Author(s) unavailable

    Bioorganic & Medicinal Chemistry 22(3):929 (2014)

  9. Synthesis and antifungal activity of substituted 2,4,6-pyrimidinetrione carbaldehyde hydrazones

    Bioorganic & Medicinal Chemistry 22(2):813 (2014) PMID 24361188

  10. Preclinical evaluation of a CXCR4-specific68Ga-labelled TN14003 derivative for cancer PET imaging

    Bioorganic & Medicinal Chemistry 22(2):796 (2014) PMID 24365390