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Bioorganic & Medicinal Chemistry

Print ISSN
0968-0896
Electronic ISSN
1464-3391
Impact factor
2.978
Publisher
Sciencedirect
URL
http://www.sciencedirect.com/science/journal/09680896
Usage rank
188
Article count
9843
Free count
134
Free percentage
0.0136137
PDFs via platforms
Sciencedirect from 1993, Proquest, Rcgp, Ingenta, Gale, and CSA

  1. An efficient synthesis and biological screening of benzofuran and benzo[d]isothiazole derivatives for Mycobacterium tuberculosis DNA GyrB in...

    Bioorganic & Medicinal Chemistry 22(23):6552 (2014)

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  2. Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis

    Bioorganic & Medicinal Chemistry (2013)

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  3. Effect of arginine methylation on the RNA recognition and cellular uptake of Tat-derived peptides

    Bioorganic & Medicinal Chemistry (2006)

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  4. Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries

    Bioorganic & Medicinal Chemistry (1992)

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  5. Discovery of biphenyl-based VEGFR-2 inhibitors. Part 3: Design, synthesis and 3D-QSAR studies.

    Bioorganic & Medicinal Chemistry 23(5):1044 (2015) PMID 25637123

    We designed and synthesized 33 biphenyl amides based on our previously reported lead compound. The biological results indicated that four compounds (18b, 20e, 20h and 20j) are potent VEGFR-2 inhibitors which are comparable to positive control. Compound 18b displayed the most potent VEGFR-2 inhibitio...
  6. Synthesis of new ligands for targeting the S1P1 receptor.

    Bioorganic & Medicinal Chemistry 23(5):1011 (2015) PMID 25656338

    We developed new agonists for the S1P1 receptor. The biological activity was tested in vivo and promising ligands were fluorinated at different positions to identify candidates for positron emission tomography (PET) imaging after [(18)F]-labelling. The radioligands shall enable the imaging of S1P1 r...
  7. Discovery of phenoxybutanoic acid derivatives as potent endothelin antagonists with antihypertensive activity.

    Bioorganic & Medicinal Chemistry 23(4):657 (2015) PMID 25614116

    A series of phenoxybutanoic acid derivatives were synthesized and tested for their antagonistic activity on the contraction of the rat thoracic aortic ring induced by endothelin-1. Preliminary screening results showed that 6e and 6g with benzoheterocycles demonstrated significant antagonistic activi...
  8. Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors...

    Bioorganic & Medicinal Chemistry 23(3):439 (2015) PMID 25573119

    We transformed naltrexone (5) with the morphinan skeleton into mesembrane (4) belonging to the Sceletium alkaloids via key intermediate 6, characterized by a cis-fused hydroindole skeleton with a suspended phenyl ring fixed by an epoxy bridge. We then investigated the binding affinities of 4 and the...
  9. Clofazimine analogs with antileishmanial and antiplasmodial activity

    Bioorganic & Medicinal Chemistry 23(1):55 (2015) PMID 25497962

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  10. Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors

    Bioorganic & Medicinal Chemistry 22(23):6647 (2014)

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