Bioorganic & Medicinal Chemistry
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- Sciencedirect from 1993, Proquest, Rcgp, Ingenta, Gale, and CSA
Synthesis, GluN2B affinity and selectivity of benzoannulen-7-amines
An efficient synthesis and biological screening of benzofuran and benzo[d]isothiazole derivatives for Mycobacterium tuberculosis DNA GyrB in...
Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis
A peptide affinity reagent for isolating an intact and catalytically active multi-protein complex from mammalian cells
Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries
Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors...
We transformed naltrexone (5) with the morphinan skeleton into mesembrane (4) belonging to the Sceletium alkaloids via key intermediate 6, characterized by a cis-fused hydroindole skeleton with a suspended phenyl ring fixed by an epoxy bridge. We then investigated the binding affinities of 4 and the...
Bioactive metabolites from Chaetomium aureum: Structure elucidation and inhibition of the Hsp90 machine chaperoning activity.
Chemical investigation of the EtOAc extract of the fungus Chaetomium aureum, an endophyte of the Moroccan medicinal plant Thymelaea lythroides, afforded one new resorcinol derivative named chaetorcinol, together with five known metabolites. The structures of the isolated compounds were determined on...
Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors
Synthesis, insecticidal activities and SAR of novel phthalamides targeting calcium channel.
In order to find novel and environmental friendly insecticides targeting the ryanodine receptor, three series of novel phthalamides containing heptafluoroisopropyl group, low fluorine atoms group and non-fluorine group were designed and synthesized. 35 novel structures of three series were obtained....
Synthesis and in vitro evaluation of radioiodinated indolequinones targeting NAD(P)H: quinone oxidoreductase 1 for internal radiation therap...
We aimed to develop an NQO1-targeted radiolabeled agent to establish a novel internal radiation therapy that amplifies the therapeutic effects when combined with external radiation therapy. We designed three NQO1-targeted radioiodinated compounds including two ether linkage compounds ([(125)I]1 and...