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Bioorganic & Medicinal Chemistry

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  1. Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines

    Bioorganic & Medicinal Chemistry 22(23):6638 (2014)

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  2. An efficient synthesis and biological screening of benzofuran and benzo[d]isothiazole derivatives for Mycobacterium tuberculosis DNA GyrB in...

    Bioorganic & Medicinal Chemistry 22(23):6552 (2014)

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  3. Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis

    Bioorganic & Medicinal Chemistry (2013)

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  4. A peptide affinity reagent for isolating an intact and catalytically active multi-protein complex from mammalian cells

    Bioorganic & Medicinal Chemistry (2010)

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  5. Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries

    Bioorganic & Medicinal Chemistry (1992)

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  6. Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors...

    Bioorganic & Medicinal Chemistry 23(3):439 (2015) PMID 25573119

    We transformed naltrexone (5) with the morphinan skeleton into mesembrane (4) belonging to the Sceletium alkaloids via key intermediate 6, characterized by a cis-fused hydroindole skeleton with a suspended phenyl ring fixed by an epoxy bridge. We then investigated the binding affinities of 4 and the...
  7. Bioactive metabolites from Chaetomium aureum: Structure elucidation and inhibition of the Hsp90 machine chaperoning activity.

    Bioorganic & Medicinal Chemistry 23(1):126 (2015) PMID 25482429 PMCID PMC4274242

    Chemical investigation of the EtOAc extract of the fungus Chaetomium aureum, an endophyte of the Moroccan medicinal plant Thymelaea lythroides, afforded one new resorcinol derivative named chaetorcinol, together with five known metabolites. The structures of the isolated compounds were determined on...
  8. Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors

    Bioorganic & Medicinal Chemistry 22(23):6647 (2014)

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  9. Synthesis, insecticidal activities and SAR of novel phthalamides targeting calcium channel.

    Bioorganic & Medicinal Chemistry 22(22):6366 (2014) PMID 25438760

    In order to find novel and environmental friendly insecticides targeting the ryanodine receptor, three series of novel phthalamides containing heptafluoroisopropyl group, low fluorine atoms group and non-fluorine group were designed and synthesized. 35 novel structures of three series were obtained....
  10. Synthesis and in vitro evaluation of radioiodinated indolequinones targeting NAD(P)H: quinone oxidoreductase 1 for internal radiation therap...

    Bioorganic & Medicinal Chemistry 22(21):6039 (2014) PMID 25281270

    We aimed to develop an NQO1-targeted radiolabeled agent to establish a novel internal radiation therapy that amplifies the therapeutic effects when combined with external radiation therapy. We designed three NQO1-targeted radioiodinated compounds including two ether linkage compounds ([(125)I]1 and...