Seminars in Immunology
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- Sciencedirect from 1993, CSA, Proquest, Gale, Rcgp, and Ingenta
The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury
Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Seq...
Cancer vaccines: the state of the art.
Biology of IL-36 cytokines and their role in disease.
IL-36α, IL-36β, IL-36γ, and IL-36Ra, collectively called IL-36 cytokines, are part of the IL-1 family. IL-36α, IL-36β, and IL-36γ are IL-36 receptor (IL-36R) agonists, while IL-36Ra is a receptor antagonist that blocks the activation of IL-36R signaling. IL-36 cytokines require processing in order t...
An epithelial armamentarium to sense the microbiota
• Intestinal epithelial cells express a wide variety of pattern recognition receptors. • Detection of the microbiota through these receptors plays a major role in the...
CD4 CTL: Living up to the challenge
• The thymic CD4 Th-lineage commitment is not fixed. • ThPOK, directs the Th-lineage fate of MHC class II restricted thymocytes....
Carbohydrates and T cells: a sweet twosome.
Carbohydrates as T cell-activating antigens have been generating significant interest. For many years, carbohydrates were thought of as T-independent antigens, however, more recent research had demonstrated that mono- or oligosaccharides glycosidically linked to peptides can be recognized by T cells...
The biochemistry of activation-induced deaminase and its physiological functions.
We review the enzymatic features of AID, such as the parameters that govern substrate binding and catalysis. We discuss how these properties of AID relate to secondary antibody diversification processes and the manners in which they may regulate the targeting of AID to various loci. Based on the cur...
Introduction: FDC in health and disease
Targeted antigen delivery and activation of dendritic cells in vivo: Steps towards cost effective vaccines
We discuss strategies to target antigens to distinct DC subsets and to simultaneously employ adjuvants to activate these cells to induce immunity....
Harnessing dendritic cells for immunotherapy
We discuss the features of the DC subsets, their handling of antigens for MHCI- and MHCII-restricted presentation, how their functions are regulated by foreign and endogenous signals, the consequences on the type of immune response induced, and how they provide insights on the design of immunotherap...