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Seminars in Immunology

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  1. The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury
    Author(s) unavailable

    Seminars in Immunology 2012

    Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Seq...
  2. Cancer vaccines: the state of the art.

    Seminars in Immunology 22(3):103 (2010) PMID 20552730

  3. B cell maintenance and function in aging.

    Seminars in Immunology 24(5):342 (2012) PMID 22560930

    We discuss the changes that occur in the B lymphocyte compartment of mice and humans as they progress to old age, focusing on recent advances in this important area of research. Primary areas considered include increased morbidity and mortality in the elderly following infection, and decreased respo...
  4. Cell surface immunoglobulin receptors in B cell development
    Author(s) unavailable

    Seminars in Immunology 2012

    We assess the regulatory functions of different components of the sIg receptor complex during early development in experimental systems from evolutionarily distinct species....
  5. Challenges and opportunities in targeting the costimulation pathway in solid organ transplantation

    Seminars in Immunology 23(3):157 (2011) PMID 21856169

    Highlights ► Costimulation pathways are involved in T cell regulation. ► Belatacept blocks an important costimulatory pathway (CD28:CD80/86). ► In transplantation belatacept has demonstrated significant renal preservation. ► Optimal use of belatacept is in a lower intensity regimen in EBV...
  6. Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation

    Seminars in Immunology 23(5):368 (2011) PMID 21920773

    Highlights ► Gfi1 is required for T-cell development. ► Gfi1 is required for B-cell development and restricts Immunoglobulin production. ► Gfi1 promotes Th2 development and inhibits Th17 and iTreg development.
  7. Temporal and spatial regulatory functions of the V(D)J recombinase.

    Seminars in Immunology 22(6):362 (2010) PMID 21036059

    In developing lymphocytes, V(D)J recombination is subject to tight spatial and temporal regulation. An emerging body of evidence indicates that some of these constraints, particularly with respect to locus specificity and cell cycle phase, are enforced by regulatory cues that converge directly on th...
  8. The role of the immune system in the initiation and persistence of the Euprymna scolopes--Vibrio fischeri symbiosis.

    Seminars in Immunology 22(1):48 (2010) PMID 20036144 PMCID PMC3992935

    The squid-vibrio symbiosis is an experimental system being studied as a model of the chronic colonization of animal epithelia by bacterial partners. One principal question being asked with this model is: what is the role of the immune system in the dynamics of the onset and maintenance of the symbio...
  9. Beyond αβ/γδ lineage commitment: TCR signal strength regulates γδ T cell maturation and effector fate

    Seminars in Immunology 22(4):247 (2010) PMID 20452783 PMCID PMC3129014

    We discuss how a strong TCR signal is a recurring theme in γδ T cell development and activation....
  10. Towards a molecular understanding of the differential signals regulating αβ/γδ T lineage choice

    Seminars in Immunology 22(4):237 (2010) PMID 20471282 PMCID PMC2906684

    We review evidence addressing the importance of differences in signal strength/longevity, how signals differing in intensity/longevity may be generated, and finally how such signals modulate the activity of downstream effectors to promote the opposing developmental fates....