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Seminars in Immunology

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  1. Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development

    Seminars in Immunology 26(1):75 (2014)

    • IL-6 is a pleiotropic cytokine involved in the regulation of innate and adaptive immunity. • IL-6 regulates chronic intestinal inflammation by regulating the bal...
  2. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

    Seminars in Immunology 26(1):54 (2014) PMID 24552665

    • The IL-6 family of cytokines includes IL-6, IL-11, IL-27, IL-31, LIF, OSM, CNTF, CT-1 and CLC. • The IL-6 family of cytokines regulates cell proliferation, survi...
  3. Toward a new STATe: The role of STATs in mitochondrial function

    Seminars in Immunology 26(1):20 (2014) PMID 24434063 PMCID PMC4321820

    • Recent studies have demonstrated a pool of STAT3 resides in the mitochondria where it has actions distinct from its role as a nuclear transcription factor. • Mit...
  4. Interleukin-6 in inflammatory and malignant diseases of the pancreas

    Seminars in Immunology 26(1):80 (2014) PMID 24572992

    • IL-6 levels correlate with disease severity in both experimental and human pancreatitis and pancreatic cancer. • IL-6 trans-signaling has been suggested as an im...
  5. A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy

    Seminars in Immunology 26(1):88 (2014) PMID 24594001

    • Tocilizumab is used as a biologic drug for rheumatoid arthritis, juvenile idiopathic arthritis, and Castleman's disease. • IL-6 blockade strategy will be widely ...
  6. Clinical experience of IL-6 blockade in rheumatic diseases—Implications on IL-6 biology and disease pathogenesis

    Seminars in Immunology 26(1):97 (2014) PMID 24389239

    • IL-6 plays a significant role in many rheumatic diseases. • IL-6 blockade in rheumatoid arthritis, systemic and polyarticular juvenile idiopathic arthritis is cl...
  7. Inhibition of IL-6 family cytokines by SOCS3

    Seminars in Immunology 26(1):13 (2014)

    • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. ...
  8. The biology of interleukin-6 in the 21st century

    Seminars in Immunology 26(1):1 (2014) PMID 24556601

  9. The two faces of IL-6 in the tumor microenvironment

    Seminars in Immunology 26(1):38 (2014)

    • IL-6 signaling supports tumor initiation and progression. • Activation of IL-6 trans-signaling improves T cell trafficking in lymphoid organs. ...
  10. Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities

    Seminars in Immunology 26(1):2 (2014) PMID 24325804

    • The IL-6 receptor can be shed from the cellular membrane by the protease ADAM17. • The complex of IL-6 and IL-6 receptor induces signaling on cells only expressi...