Seminars in Immunology
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- Sciencedirect from 1993, CSA, Proquest, Gale, Rcgp, and Ingenta
The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury
Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Seq...
Cancer vaccines: the state of the art.
Special aspects of interleukin-33 and the IL-33 receptor complex.
Interleukin-33 (IL-33) is an unconventional member of the IL-1 family: it is a dual function cytokine. Many different cell types, tissue cells and leukocytes, produce IL-33 either constitutively or after stimulation and release it by a poorly defined molecular mechanism. Free IL-33 acts as a classic...
Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses.
We show how these approaches have revealed an uncontrolled inflammatory response as a contributor to the extreme virulence of the 1918 pandemic and avian H5N1 viruses, and how this response differs from that induced by the 2009 H1N1 viruses responsible for the most recent influenza pandemic. We also...
Complement inhibition in cancer therapy.
For decades, complement has been recognized as an effector arm of the immune system that contributes to the destruction of tumor cells. In fact, many therapeutic strategies have been proposed that are based on the intensification of complement-mediated responses against tumors. However, recent studi...
Anaphylatoxins in organ transplantation.
C3a and C5a (also called anaphylatoxins) are inflammatory peptides generated during complement activation. They do not only play important roles in innate immunity through the initiation and regulation of inflammatory responses, but also significantly influence adaptive immune responses. Organ trans...
B cell maintenance and function in aging.
We discuss the changes that occur in the B lymphocyte compartment of mice and humans as they progress to old age, focusing on recent advances in this important area of research. Primary areas considered include increased morbidity and mortality in the elderly following infection, and decreased respo...
D is for different—differences between H and L chain rearrangement
Analysis of B cell receptor production and rearrangementPart I. Light chain rearrangement
We have revived the purely probabilistic approach in a model that now includes receptor editing and allows for some multi-receptor B cells. We find that this model can explain the observed properties of B cells when the frequency of self-reactive B cells is high. Indeed, as we illustrate for anti-DN...
Follicular dendritic cell contributions to HIV pathogenesis
Early after infection, large quantities of HIV are trapped on follicular dendritic cells (FDCs) thus establishing a potent reservoir of infectious virus adjacent to highly susceptible CD4-bearing T lymphocytes. Throughout much of the disease course, active HIV infection is largely confined to sites s...