Seminars in Immunology

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  1. Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development

    Seminars in Immunology 26(1):75 (2014)

    • IL-6 is a pleiotropic cytokine involved in the regulation of innate and adaptive immunity. • IL-6 regulates chronic intestinal inflammation by regulating the bal...
  2. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

    Seminars in Immunology 26(1):54 (2014) PMID 24552665

    • The IL-6 family of cytokines includes IL-6, IL-11, IL-27, IL-31, LIF, OSM, CNTF, CT-1 and CLC. • The IL-6 family of cytokines regulates cell proliferation, survi...
  3. Toward a new STATe: The role of STATs in mitochondrial function

    Seminars in Immunology 26(1):20 (2014) PMID 24434063 PMCID PMC4321820

    • Recent studies have demonstrated a pool of STAT3 resides in the mitochondria where it has actions distinct from its role as a nuclear transcription factor. • Mit...
  4. Interleukin-6 in inflammatory and malignant diseases of the pancreas

    Seminars in Immunology 26(1):80 (2014) PMID 24572992

    • IL-6 levels correlate with disease severity in both experimental and human pancreatitis and pancreatic cancer. • IL-6 trans-signaling has been suggested as an im...
  5. A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy

    Seminars in Immunology 26(1):88 (2014) PMID 24594001

    • Tocilizumab is used as a biologic drug for rheumatoid arthritis, juvenile idiopathic arthritis, and Castleman's disease. • IL-6 blockade strategy will be widely ...
  6. Inhibition of IL-6 family cytokines by SOCS3

    Seminars in Immunology 26(1):13 (2014)

    • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. ...
  7. The biology of interleukin-6 in the 21st century

    Seminars in Immunology 26(1):1 (2014) PMID 24556601

  8. The two faces of IL-6 in the tumor microenvironment

    Seminars in Immunology 26(1):38 (2014)

    • IL-6 signaling supports tumor initiation and progression. • Activation of IL-6 trans-signaling improves T cell trafficking in lymphoid organs. ...
  9. Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities

    Seminars in Immunology 26(1):2 (2014) PMID 24325804

    • The IL-6 receptor can be shed from the cellular membrane by the protease ADAM17. • The complex of IL-6 and IL-6 receptor induces signaling on cells only expressi...
  10. Epithelial gp130/Stat3 functions: An intestinal signaling node in health and disease

    Seminars in Immunology 26(1):29 (2014) PMID 24434062

    • Epithelial Stat3 signaling promotes wound-healing of the gastrointestinal lining. • Aberrant gp130/Stat3 signaling supports the growth of gastric and intestinal ...
  11. Induction and stability of the anergic phenotype in T cells

    Seminars in Immunology 25(4):313 (2013) PMID 24211041 PMCID PMC3927995

    • Anergy is a long-term state of hyporesponsiveness that is established in T cells in response to suboptimal stimulation. • T cells integrate different signals to ...
  12. MicroRNAs in T helper cell differentiation and plasticity

    Seminars in Immunology 25(4):291 (2013) PMID 24216176

    • miRNAs are critical players in the regulation of CD4 T cell differentiation. • T cell activation and the threshold of TCR signaling are modulated by miRNAs. ...
  13. CD4 CTL: Living up to the challenge

    Seminars in Immunology 25(4):273 (2013) PMID 24246226 PMCID PMC3886800

    • The thymic CD4 Th-lineage commitment is not fixed. • ThPOK, directs the Th-lineage fate of MHC class II restricted thymocytes. ...
  14. Reasons for rarity of Th17 cells in inflammatory sites of human disorders

    Seminars in Immunology 25(4):299 (2013) PMID 24211040

    • Despite their important pathogenic role, Th17 cells are rare in inflammatory sites. • The rarity of human Th17 cells is due to limited expansion and shifting to ...
  15. The plasticity of human Treg and Th17 cells and its role in autoimmunity

    Seminars in Immunology 25(4):305 (2013) PMID 24211039 PMCID PMC3905679

    • Human CD4+ T cells can display a high grade of plasticity. • Th17 cells can adapt Th1- and Th2-type phenotypes. • ...
  16. Early T helper cell programming of gene expression in human

    Seminars in Immunology 25(4):282 (2013) PMID 24246225

    • Studies on human Th cell differentiation are scarce compared with mouse. • Comparative studies are needed for successful translational research. ...
  17. The CD4-centered universe of human T cell subsets

    Seminars in Immunology 25(4):252 (2013) PMID 24183700

    • Continuous exposure to pathogens generates complex human T cell pools. • T cell subsets are classified by cytokine production and tissue localization. ...
  18. Identity crisis of Th17 cells: Many forms, many functions, many questions

    Seminars in Immunology 25(4):263 (2013) PMID 24239567

    • Th17 cells are potent regulators linked to induction and persistence of inflammation. • The human Th17 compartment is heterogeneous with pro- and anti-inflammato...
  19. The many faces of CD4 T cells: Roles in immunity and disease

    Seminars in Immunology 25(4):249 (2013) PMID 24262948

  20. Complement: More than killing

    Seminars in Immunology 25(1):1 (2013)