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Seminars in Immunology

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  1. The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury
    Author(s) unavailable

    Seminars in Immunology in press

    Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Seq...
  2. Injury-induced immune responses in Hydra.

    Seminars in Immunology 26(4):277 (2014) PMID 25086685

    The impact of injury-induced immune responses on animal regenerative processes is highly variable, positive or negative depending on the context. This likely reflects the complexity of the innate immune system that behaves as a sentinel in the transition from injury to regeneration. Early-branching...
  3. Epithelial gp130/Stat3 functions: an intestinal signaling node in health and disease.

    Seminars in Immunology 26(1):29 (2014) PMID 24434062

    We discuss recent insights arising from situations where persistent activation of the gp130/Stat3 signaling cascades result from excessive abundance of IL6 family cytokines. In particular, we highlight novel and unique roles for IL11 in promoting intestinal wound-healing and, in its corrupted form,...
  4. The interleukin-1 receptor family.

    Seminars in Immunology 25(6):394 (2013) PMID 24246227

    The activity of each member of the IL-1 family of ligands is mediated by its own receptor. Each ligand binds specifically to the extracellular "ligand binding chain" containing three Ig-like regions. With the exception of the IL-1 and IL-36 receptor antagonists, a second chain, termed the "accessory...
  5. The dialog between microbiota and the immune system: shaping the partners through development and evolution.

    Seminars in Immunology 24(1):1 (2012) PMID 22177884

  6. Regulatory T cell lineage commitment in the thymus.

    Seminars in Immunology 23(6):401 (2011) PMID 21733719

    We will review our current understanding of how T cell receptor stimulation, cytokine signaling, co-stimulation, epigenetic modifications and T cell intrinsic developmental tuning synergize during T(reg) cell differentiation, and how instructive signals converge at the Foxp3 gene-locus during entry...
  7. External influences on the immune system via activation of the aryl hydrocarbon receptor.

    Seminars in Immunology 23(2):99 (2011) PMID 21288737

    The aryl hydrocarbon receptor (AhR), subject of intensive research over three decades by the pharmacology/toxicology field has recently made its entry into mainstream immunology research and is set to continue to intrigue with ever more complex modes of modulating immune responses. The discovery of...
  8. Antigen recognition by CD1d-restricted NKT T cell receptors.

    Seminars in Immunology 22(2):61 (2010) PMID 19945889

    I (for CD8 T cells) or MHC class II (for CD4 T cells) antigen-presenting molecules. However, it is now clear that some T cell lineages express TCRs that are specialized for recognition of lipid-based antigens presented by the MHC class I-like CD1 family. Recently, the molecular basis for the TCR rec...
  9. IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity.

    Seminars in Immunology 21(6):363 (2009) PMID 19447046

    We summarize what we know about the genetics of T1D with an emphasis on the contributions of mouse Il2 and human IL2RA polymorphisms and the IL-2-IL-2R pathway to autoimmunity and, more specifically, Treg development and function....
  10. Development of human lymph nodes and Peyer's patches.

    Seminars in Immunology 20(3):164 (2008) PMID 18424165

    We will highlight current knowledge on human lymph node and Peyer's patch development and will temporally align observations made in humans with data available from murine studies. In the final paragraphs we will put this knowledge in the context of human malignancies in which interactions between l...