Seminars in Immunology
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- Sciencedirect from 1993, CSA, Proquest, Gale, Rcgp, and Ingenta
The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury
Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Seq...
Recent advances in regulatory T cells.
The TCR-mediated signaling pathways that control the direction of helper T cell differentiation
In the periphery, upon antigen recognition by alphabetaTCR, naïve CD4 T cells undergo functional differentiation and acquire the ability to produce a specific set of cytokines. At least four Th cell subsets, i.e., Th1, Th2, Th17 and iTreg cells have so far been identified and the di...
Role of thymic cortex-specific self-peptides in positive selection of T cells
During T cell development in the thymus, a virgin repertoire of diverse TCRalphabeta recognition specificities in immature thymocytes is selected through positive and negative selection to form an immunocompetent and self-tolerant repertoire of mature T cells. Positive selection supports the surviva...
Cancer vaccines: the state of the art.
Vaccines based on abnormal self-antigens as tumor-associated antigens: Immune regulation
We review recent work in pre-clinical transgenic mouse models and in clinical trials that has elucidated multiple regulatory mechanisms that interfere with the induction of effective immunity. We discuss these as being either part of the normal function of the immune system or being driven by the tu...
Generation of Immunoglobulin diversity in human gut-associated lymphoid tissue
The organised gut associated lymphoid tissue (GALT) exists adjacent to an extensive and diverse luminal flora. The follicle associated epithelium and associated dendritic cells and lymphocytes form a tightly fortified gateway between the flora and the host that permits connectivity between them and...
Giving T cells a chance to come back
Antigen-specific regulatory T cells-Ex vivo expansion and therapeutic potential
We consider the importance of antigen specificity in Treg function and discuss recent advances for the expansion of antigen-specific Treg and the therapeutic potential of Treg in controlling autoimmunity and GVHD....
IL-7: A key regulator of B lymphopoiesis
We have shown that differentiation of IL-7-responsive cells in these cultures is influenced by CD45, pre-B cell receptor, and other downstream signaling molecules. A common, but often overlooked aspect of IL-7 containing cultures is the routine maturation of cells to the sIgM(+) stage. The productio...