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Seminars in Immunology

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  1. TWEAK/Fn14 axis: the current paradigm of tissue injury-inducible function in the midst of complexities.

    Seminars in Immunology 26(3):229 (2014) PMID 24636536

    TNF-like weak inducer of apoptosis (TWEAK), a TNF family ligand, and its only known signaling receptor, FGF-inducible molecule-14 (Fn14), have emerged as a key molecular pathway regulating tissue responses after acute tissue injury and in contexts of chronic injury and disease, including autoimmunit...
  2. Ectodysplasin research--where to next?

    Seminars in Immunology 26(3):220 (2014) PMID 24928340

    Ectodysplasin (Eda) is the most studied tumor necrosis ligand in the field of developmental biology. In all vertebrates studied so far, inactivating germline mutations in Eda lead to the genetic disease called hypohidrotic ectodermal dysplasia (HED). In humans, HED is a life-threatening condition in...
  3. The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury
    Author(s) unavailable

    Seminars in Immunology 2012

    Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Seq...
  4. Cancer vaccines: the state of the art.

    Seminars in Immunology 22(3):103 (2010) PMID 20552730

  5. The TNF family: only the surface has been scratched.

    Seminars in Immunology 26(3):181 (2014) PMID 24993570

  6. B cell maintenance and function in aging.

    Seminars in Immunology 24(5):342 (2012) PMID 22560930

    We discuss the changes that occur in the B lymphocyte compartment of mice and humans as they progress to old age, focusing on recent advances in this important area of research. Primary areas considered include increased morbidity and mortality in the elderly following infection, and decreased respo...
  7. Changes in primary lymphoid organs with aging.

    Seminars in Immunology 24(5):309 (2012) PMID 22559987 PMCID PMC3415579

    Aging is associated with decreased immune function that leads to increased morbidity and mortality in the elderly. Immune senescence is accompanied by age-related changes in two primary lymphoid organs, bone marrow and thymus, that result in decreased production and function of B and T lymphocytes....
  8. Cell surface immunoglobulin receptors in B cell development
    Author(s) unavailable

    Seminars in Immunology 2012

    We assess the regulatory functions of different components of the sIg receptor complex during early development in experimental systems from evolutionarily distinct species....
  9. Immuno-intervention for the induction of transplantation tolerance through mixed chimerism.

    Seminars in Immunology 23(3):165 (2011) PMID 21839648 PMCID PMC3178004

    We have extended the use of this modality for tolerance induction from mice to large animal models, we have attempted to design preparative regimens that avoid both of these complications. In this article, we review our studies of mixed chimerism in mice, miniature swine and monkeys, as well as the...
  10. Challenges and opportunities in targeting the costimulation pathway in solid organ transplantation

    Seminars in Immunology 23(3):157 (2011) PMID 21856169

    Highlights ► Costimulation pathways are involved in T cell regulation. ► Belatacept blocks an important costimulatory pathway (CD28:CD80/86). ► In transplantation belatacept has demonstrated significant renal preservation. ► Optimal use of belatacept is in a lower intensity regimen in EBV...