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Seminars in Immunology

Print ISSN
1044-5323
Electronic ISSN
1096-3618
Impact factor
8.337
Publisher
Sciencedirect
URL
http://www.sciencedirect.com/science/journal/10445323
Usage rank
1634
Article count
1065
Free count
24
Free percentage
0.0225352
PDFs via platforms
Sciencedirect from 1993, CSA, Proquest, Gale, Rcgp, and Ingenta

  1. Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development

    Seminars in Immunology 26(1):75 (2014)

    • IL-6 is a pleiotropic cytokine involved in the regulation of innate and adaptive immunity. • IL-6 regulates chronic intestinal inflammation by regulating the bal...
  2. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

    Seminars in Immunology 26(1):54 (2014) PMID 24552665

    • The IL-6 family of cytokines includes IL-6, IL-11, IL-27, IL-31, LIF, OSM, CNTF, CT-1 and CLC. • The IL-6 family of cytokines regulates cell proliferation, survi...
  3. Toward a new STATe: The role of STATs in mitochondrial function

    Seminars in Immunology 26(1):20 (2014) PMID 24434063 PMCID PMC4321820

    • Recent studies have demonstrated a pool of STAT3 resides in the mitochondria where it has actions distinct from its role as a nuclear transcription factor. • Mit...
  4. Interleukin-6 in inflammatory and malignant diseases of the pancreas

    Seminars in Immunology 26(1):80 (2014) PMID 24572992

    • IL-6 levels correlate with disease severity in both experimental and human pancreatitis and pancreatic cancer. • IL-6 trans-signaling has been suggested as an im...
  5. A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy

    Seminars in Immunology 26(1):88 (2014) PMID 24594001

    • Tocilizumab is used as a biologic drug for rheumatoid arthritis, juvenile idiopathic arthritis, and Castleman's disease. • IL-6 blockade strategy will be widely ...
  6. Clinical experience of IL-6 blockade in rheumatic diseases—Implications on IL-6 biology and disease pathogenesis

    Seminars in Immunology 26(1):97 (2014) PMID 24389239

    • IL-6 plays a significant role in many rheumatic diseases. • IL-6 blockade in rheumatoid arthritis, systemic and polyarticular juvenile idiopathic arthritis is cl...
  7. Inhibition of IL-6 family cytokines by SOCS3

    Seminars in Immunology 26(1):13 (2014)

    • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. ...
  8. The biology of interleukin-6 in the 21st century

    Seminars in Immunology 26(1):1 (2014) PMID 24556601

  9. The two faces of IL-6 in the tumor microenvironment

    Seminars in Immunology 26(1):38 (2014)

    • IL-6 signaling supports tumor initiation and progression. • Activation of IL-6 trans-signaling improves T cell trafficking in lymphoid organs. ...
  10. Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities

    Seminars in Immunology 26(1):2 (2014) PMID 24325804

    • The IL-6 receptor can be shed from the cellular membrane by the protease ADAM17. • The complex of IL-6 and IL-6 receptor induces signaling on cells only expressi...