Seminars in Immunology
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- Sciencedirect from 1993, CSA, Proquest, Gale, Rcgp, and Ingenta
TWEAK/Fn14 axis: the current paradigm of tissue injury-inducible function in the midst of complexities.
TNF-like weak inducer of apoptosis (TWEAK), a TNF family ligand, and its only known signaling receptor, FGF-inducible molecule-14 (Fn14), have emerged as a key molecular pathway regulating tissue responses after acute tissue injury and in contexts of chronic injury and disease, including autoimmunit...
Ectodysplasin research--where to next?
Ectodysplasin (Eda) is the most studied tumor necrosis ligand in the field of developmental biology. In all vertebrates studied so far, inactivating germline mutations in Eda lead to the genetic disease called hypohidrotic ectodermal dysplasia (HED). In humans, HED is a life-threatening condition in...
The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury
Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Seq...
Cancer vaccines: the state of the art.
Human natural killer cell development in secondary lymphoid tissues.
For nearly a decade it has been appreciated that critical steps in human natural killer (NK) cell development likely occur outside of the bone marrow and potentially necessitate distinct microenvironments within extramedullary tissues. The latter include the liver and gravid uterus as well as second...
The interleukin-1 receptor family.
The activity of each member of the IL-1 family of ligands is mediated by its own receptor. Each ligand binds specifically to the extracellular "ligand binding chain" containing three Ig-like regions. With the exception of the IL-1 and IL-36 receptor antagonists, a second chain, termed the "accessory...
Complement inhibition in cancer therapy.
For decades, complement has been recognized as an effector arm of the immune system that contributes to the destruction of tumor cells. In fact, many therapeutic strategies have been proposed that are based on the intensification of complement-mediated responses against tumors. However, recent studi...
AIDing antibody diversity by error-prone mismatch repair.
We here review the current understanding of this MMR-mediated process and describe how the MMR signaling cascade downstream of AID diverges in a locus dependent manner and even within the Ig locus itself to differentially promote somatic hypermutation (SHM) and class switch recombination (CSR) in B...
Does DNA repair occur during somatic hypermutation?
We analyze the roles of base excision repair, mismatch repair, and mutagenesis during somatic hypermutation of rearranged variable genes. The emerging view is that faithful base excision repair occurs simultaneously with mutagenesis, whereas faithful mismatch repair is mostly absent. Published by El...
Chemokines: attractive mediators of the immune response
An effective inflammatory immune response first requires the recruitment of cells to the site of inflammation and then their appropriate activation and regulation. Chemokines are critical in this response since they are both chemotactic and immunoregulatory molecules. In this regard, the interaction...