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Molecular and Cellular Neuroscience

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Sciencedirect from 1990, CSA, Rcgp, Ingenta, Proquest, and Gale

  1. Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN.

    Molecular and Cellular Neuroscience 50(2):179 (2012) PMID 22561198

    We have provided evidence that inhibition or knockdown of PTEN (phosphatase and tensin homologue deleted on chromosome ten) dramatically increases adult peripheral axon outgrowth, especially in preconditioned neurons (Christie et al., 2010). PTEN appears to operate as an endogenous brake to regenera...
  2. Desensitization of the human D(1) dopamine receptor: Evidence for Involvement of both cyclic AMP-dependent and receptor-specific protein kin...

    Molecular and Cellular Neuroscience 2(6):464 (1991) PMID 19912831

    Our results suggest that desensitization of human D(1) dopamine receptors involves both PKA and a receptor-specific kinase and that the action of both kinases in intact cells requires agonist-occupied receptors....
  3. Evidence for the presence of guanylate cyclase-coupled receptors for atrial natriuretic peptide on pituicytes of the neurohypophysis.

    Molecular and Cellular Neuroscience 2(5):363 (1991) PMID 19912820

    We conclude that in the NL, as well as in brain tissue cultures, the guanylate cyclase-NP receptor complex (most probably the ANP-A subtype) is localized on pituicytes/filial cells rather than on nerve fibers/cells and that cyclic GMP may not be directly involved in the regulation of vasopressin out...
  4. In situ hybridization analysis of the induction of interleukin-1beta mRNA by methamphetamine in the rat hypothalamus.

    Molecular and Cellular Neuroscience 2(3):259 (1991) PMID 19912807

    The induction of interleukin-1beta (IL-1beta) mRNA in the rat hypothalamus by systemic treatment with methamphetamine was studied using in situ hybridization. IL-1beta mRNA was expressed throughout the hypothalamus of methamphetamine-treated rats with no apparent signals in that of untreated rats; i...
  5. Families of potassium channel genes in mammals: Toward an understanding of the molecular basis of potassium channel diversity.

    Molecular and Cellular Neuroscience 2(2):89 (1991) PMID 19912787

  6. Molecular mechanisms underlying activity-dependent AMPA receptor cycling in retinal ganglion cells.

    Molecular and Cellular Neuroscience 56:384 (2013) PMID 23911793 PMCID PMC3809769

    We have previously demonstrated in electrophysiological studies that periods of low synaptic activity, brought about by housing animals in darkness, enhance the proportion of GluA2-lacking AMPARs at the On CBP-On RGC synapse by mobilizing surface GluA2 containing receptors into a receptor pool that...
  7. Pleiotropic and isoform-specific functions for Pitx2 in superior colliculus and hypothalamic neuronal development.

    Molecular and Cellular Neuroscience 52:128 (2013) PMID 23147109 PMCID PMC3540135

    We report the onset of Pitx2ab and Pitx2c isoform-specific expression by E9.5 in the developing mouse brain. Using isoform-specific Pitx2 deletion mouse strains, we show that collicular neuron migration requires PITX2AB and that collicular GABAergic differentiation and targeting of hypothalamic proj...
  8. IκBα is not required for axon initial segment assembly.

    Molecular and Cellular Neuroscience 50(1):1 (2012) PMID 22445657 PMCID PMC3383875

    We report here that the AIS clustering of ankyrinG and Na(+) channels in the brains of IκBα knockout (Nfkbia(-/-)) mice is comparable to that in wild-type littermates. Furthermore, we found that multiple phospho-specific antibodies against pIκBα Ser32/36 non-specifically label AIS in Nfkbia(-/-) cor...
  9. Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog.

    Molecular and Cellular Neuroscience 50(1):82 (2012) PMID 22521536 PMCID PMC3383945

    We demonstrate that a novel signaling pathway consisting of protein kinase Cα (PKCα) and integrin-linked kinase (ILK) mediates the negative guidance effects of high concentration of Shh on retinal ganglion cell (RGC) axons. Shh rapidly increased Ca(2+) level and activated PKCα and ILK in the growth...
  10. A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells.

    Molecular and Cellular Neuroscience 49(3):311 (2012) PMID 22270046

    We show that IL-1R1 is expressed on proliferating NPCs and that IL-1β treatment decreases cell proliferation and neurosphere growth. When NPCs were differentiated in the presence of IL-1β, a significant reduction in the percentages of newly-born neurons and post-mitotic neurons and a significant inc...