Molecular and Cellular Neuroscience
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- Sciencedirect from 1990, CSA, Rcgp, Ingenta, Proquest, and Gale
Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN.
We have provided evidence that inhibition or knockdown of PTEN (phosphatase and tensin homologue deleted on chromosome ten) dramatically increases adult peripheral axon outgrowth, especially in preconditioned neurons (Christie et al., 2010). PTEN appears to operate as an endogenous brake to regenera...
Desensitization of the human D(1) dopamine receptor: Evidence for Involvement of both cyclic AMP-dependent and receptor-specific protein kin...
Our results suggest that desensitization of human D(1) dopamine receptors involves both PKA and a receptor-specific kinase and that the action of both kinases in intact cells requires agonist-occupied receptors....
Evidence for the presence of guanylate cyclase-coupled receptors for atrial natriuretic peptide on pituicytes of the neurohypophysis.
We conclude that in the NL, as well as in brain tissue cultures, the guanylate cyclase-NP receptor complex (most probably the ANP-A subtype) is localized on pituicytes/filial cells rather than on nerve fibers/cells and that cyclic GMP may not be directly involved in the regulation of vasopressin out...
In situ hybridization analysis of the induction of interleukin-1beta mRNA by methamphetamine in the rat hypothalamus.
The induction of interleukin-1beta (IL-1beta) mRNA in the rat hypothalamus by systemic treatment with methamphetamine was studied using in situ hybridization. IL-1beta mRNA was expressed throughout the hypothalamus of methamphetamine-treated rats with no apparent signals in that of untreated rats; i...
Families of potassium channel genes in mammals: Toward an understanding of the molecular basis of potassium channel diversity.
Kinesin KIF4A transports integrin β1 in developing axons of cortical neurons.
We confirm that integrins (represented by subunits β1 and α5) are present in early cortical axons in vitro but are excluded from mature axons. Ribosomal protein and L1 show selective axonal transport through association with kinesin kif4A; we have therefore examined the hypothesis that integrin tran...
Regionally specific expression of high-voltage-activated calcium channels in thalamic nuclei of epileptic and non-epileptic rats.
We investigated a possible contribution of HVA channels to the epileptic phenotype using a rodent genetic model of absence epilepsy. In this study, HVA Ca(2+) currents were recorded from neurons of three different thalamic nuclei that are involved in both sensory signal transmission and rhythmic-syn...
Temporal alterations in aquaporin and transcription factor HIF1α expression following penetrating ballistic-like brain injury (PBBI).
We examined the temporal alterations in the multiple isoforms of AQP4 and AQP9, and its possible upstream regulation by HIF1α, and evaluated whether different severities of penetrating injury influence these mechanisms. In the penetrating ballistic-like brain injury (PBBI) model, a temporary cavity...
Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-κB activation in spinal astrocytes.
It has been previously reported that spinal clock genes controlled under circadian rhythm contribute to the regulation of astrocytic function, which in turn is involved in diverse processes such as nociceptive transduction and the induction of inflammation. However, how clock genes expressed in spin...
The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development.
We assessed whether the development of the main CNS structure involved in the control of balance and coordination, namely the cerebellum, was affected by the absence of HNF-6. Firstly, we observed that Hnf6 was expressed transiently during the first week after birth in the Purkinje cells of wild typ...