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Molecular and Cellular Neuroscience

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Sciencedirect from 1990, CSA, Rcgp, Ingenta, Proquest, and Gale

  1. Delayed post-treatment with bone marrow-derived mesenchymal stem cells is neurorestorative of striatal medium-spiny projection neurons and improves motor function after neonatal rat hypoxia–ischemia

    Molecular and Cellular Neuroscience 68:56 (2015) PMID 25828540

    Perinatal hypoxia–ischemia is a major cause of striatal injury and may lead to cerebral palsy. This study investigated whether delayed administration of bone marrow-derived mesenchymal stem cells (MSCs), at one week after neonatal rat hypoxia–ischemia, was neurorestorative of striatal ...
  2. Matrix metalloproteinase-2 and -9 in the cerebellum of teleost fish: Functional implications for adult neurogenesis

    Molecular and Cellular Neuroscience 68:9 (2015) PMID 25827096

    Matrix metalloproteinases (MMPs) are a family of highly conserved zinc-dependent proteases involved in both development and pathogenesis. The present study examines the role of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in adult neurogenesis, using the corpus cerebelli, a subdivisio...
  3. A concerted action of L- and T-type Ca2 + channels regulates locus coeruleus pacemaking

    Molecular and Cellular Neuroscience 68:293 (2015) PMID 26319746

    Dysfunction of noradrenergic locus coeruleus (LC) neurons is involved in psychiatric and neurodegenerative diseases and is an early hallmark of Parkinson's disease (PD). The analysis of ion channels underlying the autonomous electrical activity of LC neurons, which is ultimately couple...
  4. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate firing of globus pallidus neurons in vivo

    Molecular and Cellular Neuroscience 68:46 (2015) PMID 25858108

    The globus pallidus plays a significant role in motor control under both health and pathological states. Recent studies have revealed that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels occupy a critical position in globus pallidus pacemaking activity. Morphological...
  5. Downregulated AEG-1 together with inhibited PI3K/Akt pathway is associated with reduced viability of motor neurons in an ALS model

    Molecular and Cellular Neuroscience 68:303 (2015) PMID 26320681

    Astrocyte elevated gene-1 (AEG-1) has been reported to regulate the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and is also regulated by it. This study investigated how AEG-1 participates in the survival pathway of motor neurons in amyotrophic lateral sclerosis (ALS). We found red...
  6. Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production

    Molecular and Cellular Neuroscience 68:314 (2015) PMID 26311509

    Hippocampal synapses play a key role in memory and learning processes by inducing long-term potentiation and depression. Wnt signaling is essential in the development and maintenance of synapses via several mechanisms. We have previously found that Wnt5a induces the production of nitri...
  7. Depletion of the AMPAR reserve pool impairs synaptic plasticity in a model of hepatic encephalopathy

    Molecular and Cellular Neuroscience 68:331 (2015) PMID 26363416

    Hepatic encephalopathy (HE) is the most common neuropsychiatric complication of acute or chronic liver failure. Clinical symptoms include cognitive and intellectual dysfunction as well as impaired motor activity and coordination. There is general consensus that increased levels of ammo...
  8. Statin-modified dendritic cells regulate humoral immunity in experimental autoimmune myasthenia gravis

    Molecular and Cellular Neuroscience 68:284 (2015) PMID 26311508

    We previously demonstrated that atorvastatin induced immature dendritic cells (DCs) derived from spleen in vitro. Administration of these tolerogenic DCs led to amelioration of experimental autoimmune myasthenia gravis (EAMG). The protective effect was mainly mediated by inhibited cell...
  9. Oxytocin excites nucleus accumbens shell neurons in vivo

    Molecular and Cellular Neuroscience 68:323 (2015) PMID 26343002

    Oxytocin modulates reward-related behaviors. The nucleus accumbens shell (NAcSh) is a major relay in the brain reward pathway and expresses oxytocin receptors, but the effects of oxytocin on the activity of NAcSh neurons in vivo are unknown. Hence, we used in vivo extracellular recordi...
  10. ZDHHC17 promotes axon outgrowth by regulating TrkA–tubulin complex formation

    Molecular and Cellular Neuroscience 68:194 (2015) PMID 26232532

    Correct axonal growth during nervous system development is critical for synaptic transduction and nervous system function. Proper axon outgrowth relies on a suitable growing environment and the expression of a series of endogenous neuronal factors. However, the mechanisms of these neur...