Molecular and Cellular Neuroscience
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- Sciencedirect from 1990, CSA, Rcgp, Ingenta, Proquest, and Gale
Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN.
We have provided evidence that inhibition or knockdown of PTEN (phosphatase and tensin homologue deleted on chromosome ten) dramatically increases adult peripheral axon outgrowth, especially in preconditioned neurons (Christie et al., 2010). PTEN appears to operate as an endogenous brake to regenera...
Desensitization of the human D(1) dopamine receptor: Evidence for Involvement of both cyclic AMP-dependent and receptor-specific protein kin...
Our results suggest that desensitization of human D(1) dopamine receptors involves both PKA and a receptor-specific kinase and that the action of both kinases in intact cells requires agonist-occupied receptors....
Evidence for the presence of guanylate cyclase-coupled receptors for atrial natriuretic peptide on pituicytes of the neurohypophysis.
We conclude that in the NL, as well as in brain tissue cultures, the guanylate cyclase-NP receptor complex (most probably the ANP-A subtype) is localized on pituicytes/filial cells rather than on nerve fibers/cells and that cyclic GMP may not be directly involved in the regulation of vasopressin out...
In situ hybridization analysis of the induction of interleukin-1beta mRNA by methamphetamine in the rat hypothalamus.
The induction of interleukin-1beta (IL-1beta) mRNA in the rat hypothalamus by systemic treatment with methamphetamine was studied using in situ hybridization. IL-1beta mRNA was expressed throughout the hypothalamus of methamphetamine-treated rats with no apparent signals in that of untreated rats; i...
Families of potassium channel genes in mammals: Toward an understanding of the molecular basis of potassium channel diversity.
Expression of background potassium channels in rat DRG is cell-specific and down-regulated in a neuropathic pain model.
We also studied mRNA expression of these channels in L4-L5 DRGs in control conditions and up to 4 weeks after spared nerve injury lesion. We found that TWIK1 expression is much higher than TASK1 and TASK3 and is strongly decreased 1, 2 and 4 weeks after neuropathic injury. TASK3 expression, on the o...
Fused in sarcoma (FUS): an oncogene goes awry in neurodegeneration.
We summarize what is known about the physiological functions of the FET proteins in the nucleus and cytoplasm and review the distinctive pathomechanisms that lead to the deposition of only FUS in ALS-FUS, but all three FET proteins in FTLD-FUS. We suggest that ALS-FUS is caused by a selective dysfun...
C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis.
We show that CtBPs are downregulated in cerebellar granule neurons (CGNs) induced to undergo apoptosis by a variety of stressors. Moreover, antisense-mediated downregulation of CtBP1 is sufficient to cause CGN apoptosis. Similarly, the CtBP inhibitor, 4-methylthio-2-oxobutyric acid, induces expressi...
Mitochondria and ALS: implications from novel genes and pathways.
We provide a brief update on the subject in the light of newly discovered genes (such as TDP-43 and FUS/TLS) associated to familial ALS and of a deeper knowledge of the mechanisms of derangement of mitochondria. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction...
An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress.
The activity of mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is severely reduced in human pathologies where oxidative stress is traditionally thought to play an important role, such as familial and sporadic forms of Alzheimer's disease and other age-related neurodegenerative disea...