Molecular and Cellular Neuroscience
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- Sciencedirect from 1990, CSA, Rcgp, Ingenta, Proquest, and Gale
Prion degradation pathways: Potential for therapeutic intervention
We describe the cellular pathways that mediate PrPSc degradation and review possible targets for therapeutic intervention. This article is part of a Special Issue entitled ‘Neuronal Protein’....
Organizing effects of rapsyn on neuronal nicotinic acetylcholine receptors.
We have examined the possibility that rapsyn controls the distribution of nicotinic receptors on neurons as it does nicotinic receptors on muscle fibers. Cotransfection of QT6 cells with rapsyn and neuronal nicotinic receptor cDNA constructs produced receptor aggregates or clusters that codistribute...
Reovirus-mediated induction of ADAR1 (p150) minimally alters RNA editing patterns in discrete brain regions.
We used a neurotropic strain of reovirus to infect neonatal mice and quantify A-to-I editing in discrete brain regions using a multiplexed, high-throughput sequencing strategy. While intracranial injection of reovirus resulted in a widespread increase in the expression of ADAR1 (p150) in multiple br...
Myosin IIb controls actin dynamics underlying the dendritic spine maturation.
We demonstrate that the size of the stable actin pool increases during the neuronal maturation process. Simultaneously, the treadmilling rate of the dynamic actin pool increases. We further show that myosin IIb controls dendritic spine actin cytoskeleton by regulating these two different pools of F-...
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) protects against ceramide-induced cellular toxicity in rat brain astrocytes and neu...
We test the hypothesis that neuroprotection induced by PPARβ/δ could rely on the regulation of ceramide metabolism. We found that preincubation of neural cells with the PPARβ/δ agonist L-165041 exerts significant protection against ceramide-induced cell death. Most importantly, L-165041 protects aga...
Expression of background potassium channels in rat DRG is cell-specific and down-regulated in a neuropathic pain model.
We also studied mRNA expression of these channels in L4-L5 DRGs in control conditions and up to 4 weeks after spared nerve injury lesion. We found that TWIK1 expression is much higher than TASK1 and TASK3 and is strongly decreased 1, 2 and 4 weeks after neuropathic injury. TASK3 expression, on the o...
Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream...
We have studied IGF-1 and found that it protects cochlear hair cells from the damage caused by noise and ischemic trauma. Through a clinical trial, we have also confirmed that IGF-1 is an effective treatment for idiopathic sudden sensorineural hearing loss. In the current study, we attempted to iden...
RNA and splicing regulation in neurodegeneration.
An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress.
The activity of mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is severely reduced in human pathologies where oxidative stress is traditionally thought to play an important role, such as familial and sporadic forms of Alzheimer's disease and other age-related neurodegenerative disea...
D. melanogaster, mitochondria and neurodegeneration: small model organism, big discoveries.
In developed countries, increased life expectancy is accompanied by an increased prevalence of age-related disorders like cancer and neurodegenerative diseases. Albeit the molecular mechanisms behind the clinically, pathologically and etiologically heterogeneous forms of neurodegeneration are often...