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Journal of Structural Biology

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  1. X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins

    Journal of Structural Biology 192(1):37 (2015) PMID 26320075

    Misfolded prion proteins are the cause of neurodegenerative diseases that affect many mammalian species, including humans. Transmission of the prion diseases poses a considerable public-health risk as a specific prion disease such as bovine spongiform encephalopathy can be transferred ...
  2. Investigating interactions of the Bacillus subtilis spore coat proteins CotY and CotZ using single molecule force spectroscopy

    Journal of Structural Biology 192(1):14 (2015) PMID 26341943

    Spores formed by Bacillus subtilis are surrounded by a protective and multilayered shell, termed the coat, which grants the spores resistance to various environmental stresses and facilitates spore germination. The spore coat consists of more than seventy different proteins, arranged i...
  3. Local amino acid sequence patterns dominate the heterogeneous phenotype for the collagen connective tissue disease Osteogenesis Imperfecta resulting from Gly mutations

    Journal of Structural Biology 192(1):127 (2015) PMID 25980613

    Osteogenesis Imperfecta (OI), a hereditary connective tissue disease in collagen that arises from a single Gly→X mutation in the collagen chain, varies widely in phenotype from perinatal lethal to mild. It is unclear why there is such a large variation in the severity of the disease co...
  4. The REC domain mediated dimerization is critical for FleQ from Pseudomonas aeruginosa to function as a c-di-GMP receptor and flagella gene regulator

    Journal of Structural Biology 192(1):1 (2015) PMID 26362077

    FleQ is an AAA+ ATPase enhancer-binding protein that regulates both flagella and biofilm formation in the opportunistic pathogen Pseudomonas aeruginosa. FleQ belongs to the NtrC subfamily of response regulators, but lacks the corresponding aspartic acid for phosphorylation in the REC d...
  5. Structural and biochemical characterization of GTP cyclohydrolase II from Helicobacter pylori reveals its redox dependent catalytic activity

    Journal of Structural Biology 192(1):100 (2015) PMID 26272484

    GTP cyclohydrolase II (GCHII), catalyzes the conversion of GTP to 2,5-diamino-6-β-ribosyl-4(3H)-pyrimidinone-5′-phosphate and has been shown to be essential for pathogens. Here we describe the biochemical, kinetic and structural characterization of GCHII from Helicobacter pylori (hGCHI...
  6. Cover 2 - Editorial Board
    Author(s) unavailable

    Journal of Structural Biology 192(1):IFC (2015)

  7. Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis

    Journal of Structural Biology 192(1):76 (2015) PMID 26296329

    Family I inorganic pyrophosphatases (PPiases) are ubiquitous enzymes that are critical for phosphate metabolism in all domains of life. The detailed catalytic mechanism of these enzymes, including the identity of the general base, is not fully understood. We determined a series of crys...
  8. Structural insights on the catalytic site protection of human carbonyl reductase 1 by glutathione

    Journal of Structural Biology 192(1):138 (2015) PMID 26381805

    The NADPH-dependent human carbonyl reductase 1 (hCBR1), a member of the short-chain dehydrogenase/reductase protein family, plays an important role in the ubiquitous metabolism of endogenous and xenobiotic carbonyl containing compounds. Glutathione (GSH) is also a cofactor of hCBR1, ho...
  9. Multi-scale simulation of plant stem reinforcement by brachysclereids: A case study in apple fruit peduncles

    Journal of Structural Biology 192(1):116 (2015) PMID 26278981

    Sclereid formation in addition to or in gaps of fragmented fibre rings is common in dicotyledonous plant stems. Whether this sclereid formation is force-triggered remains open so far. In fruit peduncles of several Malus species as modified plant stems, for example, the persistent fibre...
  10. PAPP-A affects tendon structure and mechanical properties

    Journal of Structural Biology 192(1):59 (2015) PMID 26306763

    Pregnancy-associated plasma protein-A (PAPP-A) serves to increase local insulin-like growth factor (IGF) stimulation of proliferation and differentiation in many tissues through proteolysis of inhibitory IGF-binding proteins. The purpose of this study was to investigate the effects of ...