Tissue Engineering (United States)
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Induction of dopamine-releasing cells from primate embryonic stem cells enclosed in agarose microcapsules.
We expect that the study using cESCs will provide useful information for cell transplantation therapy of Parkinson's disease....
Design and characterization of poly(ethylene glycol) photopolymerizable semi-interpenetrating networks for chondrogenesis of human mesenchym...
We have developed a photopolymerizable poly(ethylene glycol diacrylate) (PEGDA) and poly(ethylene glycol) (PEG) semi-interpenetrating network that facilitates the in vitro chondrogenesis of human MSCs (hMSCs). Network parameters were altered and tested for their effects on subsequent matrix elaborat...
Facilitated endogenous repair: making tissue engineering simple, practical, and economical.
Facilitated endogenous repair is a novel approach to tissue engineering that avoids the ex vivo culture of autologous cells and the need for manufactured scaffolds, while minimizing the number and invasiveness of associated clinical procedures. The strategy relies on harnessing the intrinsic regener...
Three-dimensional cell culture and tissue engineering in a T-CUP (tissue culture under perfusion).
The aim of this study was to develop and validate a simple and compact bioreactor system for perfusion cell seeding and culture through 3-dimensional porous scaffolds. The developed Tissue Culture Under Perfusion (T-CUP) bioreactor is based on the concept of controlled and confined alternating motio...
A model for normothermic preservation of the rat liver.
We describe a rat NELP system that is simple and cost-effective to run. We show that rat livers that underwent NELP for 6 h could be routinely transplanted into syngeneic recipient rats with excellent 1-month survival. During perfusion, the release of cytosolic enzymes, bile and urea production, and...
The role of collagen cross-links in biomechanical behavior of human aortic heart valve leaflets--relevance for tissue engineering.
A major challenge in tissue engineering of functional heart valves is to determine and mimic the dominant tissue structures that regulate heart valve function and in vivo survival. In native heart valves, the anisotropic matrix architecture assures sustained and adequate functioning under high-press...
Recombinant matrix protein for maintenance of undifferentiated primate embryonic stem cells.
We examined the combination of serum-free conditioned medium of human mesenchymal stem cells (hMSCs) and surfaces coated with recombinant attachment factors, ProNectin F Plus, for the embryonic stem cell (ESC) culture system using cynomolgus monkey ES (cESCs). After 22 passages, cESCs still expresse...
Review: gene- and stem cell-based therapeutics for bone regeneration and repair.
Many clinical conditions require regeneration or implantation of bone. This is one focus shared by neurosurgery and orthopedics. Current therapeutic options (bone grafting and protein-based therapy) do not provide satisfying solutions to the problem of massive bone defects. In the past few years, ge...
Osteogenic response of bone marrow stromal cells from normal and ovariectomized rats treated with a low dose of basic fibroblast growth fact...
We investigated the responsiveness of bone marrow stromal cells (BMSCs) explanted from 7-month-old normal and ovariectomized (OVX) rats that were intravenously treated with a low dose of bFGF (25 microg/kg) for 2 weeks. The BMSCs were obtained using femoral aspiration and maintained in an osteogenic...
Superior survival and durability of neurons and astrocytes on 3-dimensional aragonite biomatrices.
We compared for the first time the viability of hippocampal neurons and astrocytes grown on conventional 2-dimensional (2D) conditions with that of cells grown on an aragonite bioactive 3-dimensional (3D) scaffold prepared from coralline exoskeleton. Cultures in 3D showed significantly lower mortali...