Nature Medicine

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  1. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.

    Nature Medicine (2016) PMID 27892954

    Obesity and type 2 diabetes are associated with low-grade inflammation and specific changes in gut microbiota composition. We previously demonstrated that administration of Akkermansia muciniphila to mice prevents the development of obesity and associated complications. However, the underlying me...
  2. Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human.

    Nature Medicine 13(11):1363 (2007) PMID 17952091

    Proteoglycans are a family of extracellular macromolecules comprised of glycosaminoglycan chains of a repeated disaccharide linked to a central core protein. Proteoglycans have critical roles in chondrogenesis and skeletal development. The glycosaminoglycan chains found in cartilage proteoglycan...
  3. Deacetylase inhibition promotes the generation and function of regulatory T cells.

    Nature Medicine 13(11):1299 (2007) PMID 17922010

    Histone/protein deacetylases (HDACs) regulate chromatin remodeling and gene expression as well as the functions of more than 50 transcription factors and nonhistone proteins. We found that administration of an HDAC inhibitor (HDACi) in vivo increased Foxp3 gene expression, as well as the product...
  4. TLR4 enhances TGF-beta signaling and hepatic fibrosis.

    Nature Medicine 13(11):1324 (2007) PMID 17952090

    Hepatic injury is associated with a defective intestinal barrier and increased hepatic exposure to bacterial products. Here we report that the intestinal bacterial microflora and a functional Toll-like receptor 4 (TLR4), but not TLR2, are required for hepatic fibrogenesis. Using Tlr4-chimeric mi...
  5. APC and colon cancer: two hits for one.

    Nature Medicine 13(11):1286 (2007) PMID 17987022

  6. Microarrays: retracing steps.

    Nature Medicine 13(11):1276 (2007) PMID 17987014

  7. Blue's clues.

    Nature Medicine 13(11):1272 (2007) PMID 17987010

  8. Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease.

    Nature Medicine 13(11):1308 (2007) PMID 17934471

    The role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in immune responses mediated by T-helper 2 (T(H)2) lymphocytes is unknown. Here we characterize the development of allergic airway disease in TRAIL-deficient (Tnfsf10(-/-)) mice and in mice exposed to short interfering R...
  9. STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression.

    Nature Medicine 13(11):1341 (2007) PMID 17922009

    Although STAT5A and STAT5B have some nonredundant functional properties, their distinct contributions to carcinogenesis are not clearly defined. Here we report that STAT5A expression is selectively inhibited by DNA methylation of the STAT5A gene promoter region in cells expressing the oncogenic ...
  10. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

    Nature Medicine 13(11):1382 (2007) PMID 17965722

    Measurements of early tumor responses to therapy have been shown, in some cases, to predict treatment outcome. We show in lymphoma-bearing mice injected intravenously with hyperpolarized [1-(13)C]pyruvate that the lactate dehydrogenase-catalyzed flux of (13)C label between the carboxyl groups of...
  11. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.

    Nature Medicine 13(11):1349 (2007) PMID 17982464

    Data providing direct evidence for a causative link between endothelial dysfunction, microvascular disease and diabetic end-organ damage are scarce. Here we show that activated protein C (APC) formation, which is regulated by endothelial thrombomodulin, is reduced in diabetic mice and causally l...
  12. Reply to 'Poor trial design leaves gene therapy death a mystery'.

    Nature Medicine 13(11):1276 (2007) PMID 17987015

  13. Reply to 'pH paper trumps expensive kits in measuring acidity'.

    Nature Medicine 13(11):1275 (2007) PMID 17987012

  14. Program targets undergrads to make an early start on science.

    Nature Medicine 13(11):1268 (2007) PMID 17987007

  15. Straight talk from... Victoria Hale.

    Nature Medicine 13(11):1274 (2007) PMID 17987011

  16. Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes.

    Nature Medicine 13(11):1375 (2007) PMID 17952092

    Atopic allergy is characterized by an increase in IgE antibodies that signal through the high-affinity Fcepsilon receptor (FcepsilonRI) to induce the release of inflammatory mediators from mast cells. For unknown reasons, the prevalence of allergic diseases has recently increased steeply in the ...
  17. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation.

    Nature Medicine 13(11):1316 (2007) PMID 17982463

    T helper cells can support the functions of CD8(+) T cells against persistently infecting viruses such as murine lymphocytic choriomeningitis virus (LCMV), cytomegalovirus, hepatitis C virus and HIV. These viruses often resist complete elimination and remain detectable at sanctuary sites, such a...
  18. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins.

    Nature Medicine 13(11):1359 (2007) PMID 17934472

    A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impa...
  19. B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates.

    Nature Medicine 13(11):1295 (2007) PMID 17965721

    We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitutio...
  20. Reply to 'Arsenic patent keeps drug for rare cancer out of reach for many'.

    Nature Medicine 13(11):1278 (2007) PMID 17987017