Blood Cells, Molecules, and Diseases
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Delineation of the molecular basis of borderline hemoglobin A2 in Chinese individuals.
We performed a comprehensive analysis of the globin genotypes and KLF1 gene mutations associated with borderline Hb A2 in 165 Chinese subjects. Fifteen (9.1%) were positive for a molecular defect in the α-,β-globin genes, of whom, α-thalassemia mutations and α-globin gene triplication were found in...
Haptoglobin and myeloperoxidase (- G463A) gene polymorphisms in Brazilian sickle cell patients with and without secondary iron overload.
We aimed to investigate the influence of haptoglobin (Hp) and myeloperoxidase (MPO - G463A; dbSNP rs2333227) gene polymorphisms on 78 sickle cell patients of a public hospital in the Federal District/Brazil with and without iron overload, to evaluate a possible association between these polymorphism...
Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryocytic cell differentiation
Hypoxia alters progression of the erythroid program
Nuclear positioning of tissue-specific genes during hematopoietic differentiation of primary progenitors from human cord blood
Cellular and myeloablative requirements for correction of murine SCD
NF-E2 is required for the proximity of LCR and adult β-globin genes in transcriptional activation
Genome-wide computational screen for bloon stem cell enhancers integrates RUNX1 and the BMP signaling pathway into the SCL transcriptional n...
A lentiviral based RNAi screen for reactivation of γ-globin expression
Bone marrow cell gene expression profiles characterize several mechanisms of action of hydroxyurea in sickle cell anemia