Blood Cells, Molecules, and Diseases
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Genomic analyses of RH alleles to improve transfusion therapy in patients with sickle cell disease.
Red cell (RBC) blood group alloimmunization remains a major problem in transfusion medicine. Patients with sickle cell disease (SCD) are at particularly high risk for developing alloantibodies to RBC antigens compared to other multiply transfused patient populations. Hemagglutination is the classica...
Fluorescence in situ hybridization panel for monitoring of minimal residual disease in patients with double minute chromosomes.
We investigated the incidence and characteristics of dmins in hematologic malignancies, and the quantitative changes during the treatment follow-up. Once a dmin was observed in conventional G-banding, it was characterized using fluorescence in situ hybridization (FISH) with the panel of MYC, NMYC, a...
Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryocytic cell differentiation
Hypoxia alters progression of the erythroid program
Nuclear positioning of tissue-specific genes during hematopoietic differentiation of primary progenitors from human cord blood
Cellular and myeloablative requirements for correction of murine SCD
NF-E2 is required for the proximity of LCR and adult β-globin genes in transcriptional activation
Genome-wide computational screen for bloon stem cell enhancers integrates RUNX1 and the BMP signaling pathway into the SCL transcriptional n...
A lentiviral based RNAi screen for reactivation of γ-globin expression
Bone marrow cell gene expression profiles characterize several mechanisms of action of hydroxyurea in sickle cell anemia