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Journal of Biomedical Optics

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  1. Publisher’s Note: Three-dimensional anterior segment imaging in patients with type 1 Boston Keratoprosthesis with switchable full depth range swept source optical coherence tomography

    Journal of Biomedical Optics 18(8):089802 (2013) PMCID PMC3763930

  2. Resolution in the ApoTome and the confocal laser scanning microscope: comparison.

    Journal of Biomedical Optics 14(1):014022 (2009) PMID 19256710

    The essential feature of the confocal laser scanning microscope (cLSM) is the generation of optical sections by the removal of out-of-focus light. About ten years ago, structured illumination microscopy (SIM) was introduced as an alternative method for obtaining optical sections from biological ...
  3. Fluorescence spectroscopy of oral tissue: Monte Carlo modeling with site-specific tissue properties.

    Journal of Biomedical Optics 14(1):014009 (2009) PMID 19256697 PMCID PMC2722954

    A Monte Carlo model with site-specific input is used to predict depth-resolved fluorescence spectra from individual normal, inflammatory, and neoplastic oral sites. Our goal in developing this model is to provide a computational tool to study how the morphological characteristics of the tissue a...
  4. Automated retinal shadow compensation of optical coherence tomography images.

    Journal of Biomedical Optics 14(1):010503 (2009) PMID 19256685

    We present an automated numerical method of compensating for retinal shadows in the choroid. In this method, signal extinction caused by retinal vessels is estimated by subtracting median A-scans obtained from beneath the retinal vessels and A-scans from the surrounding area. Adding the obtained...
  5. Optical spectroscopy for in-vitro differentiation of pediatric neoplastic and epileptogenic brain lesions.

    Journal of Biomedical Optics 14(1):014028 (2009) PMID 19256716

    The objective of this in vitro tissue study is to investigate the feasibility of using optical spectroscopy to differentiate pediatric neoplastic and epileptogenic brain from normal brain. Specimens are collected from 17 patients with brain tumors, and from 26 patients with intractable epilepsy ...
  6. Combination of different noninvasive measuring techniques: a new approach to increase accuracy of peripheral near infrared spectroscopy.

    Journal of Biomedical Optics 14(1):014014 (2009) PMID 19256702

    One of the problems of near-infrared-spectroscopy (NIRS) measurements is low reproducibility. The aim of the present study was to introduce quality criteria to increase reproducibility of peripheral NIRS measurements. In a prospective cohort study in 40 neonates, repeated NIRS measurements were ...
  7. Colloidal mesoporous silica nanoparticles with protoporphyrin IX encapsulated for photodynamic therapy.

    Journal of Biomedical Optics 14(1):014012 (2009) PMID 19256700

    Protoporphyrin IX (PpIX)-encapsulated mesoporous silica nanoparticles were synthesized, characterized, and utilized for photodynamic therapy (PDT) of cancer. Silica encapsulation is relatively transparent for activated light and can protect the PpIX against denaturation induced by the extreme bi...
  8. Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopy.

    Journal of Biomedical Optics 14(1):014004 (2009) PMID 19256692 PMCID PMC2813673

    Highly localized reflectance measurements can be used to directly quantify scatter changes in tissues. We present a microsampling approach that is used to raster scan tumors to extract parameters believed to be related to the tissue ultrastructure. A confocal reflectance imager was developed to ...
  9. Dynamic analysis of internal and external mental sweating by optical coherence tomography.

    Journal of Biomedical Optics 14(1):014026 (2009) PMID 19256714

    Mental sweating is human sweating that is accelerated via the sympathetic nerve by application of mental or physical stress. In the neurosciences, there is keen interest in this type of sweating, because the amount of sweat in response to a stress applied to a volunteer directly reflects activit...
  10. In-vivo photoacoustic microscopy of nanoshell extravasation from solid tumor vasculature.

    Journal of Biomedical Optics 14(1):010507 (2009) PMID 19256687

    In this study, high resolution backward-mode photoacoustic microscopy (PAM) is used to noninvasively image progressive extravasation and accumulation of nanoshells within a solid tumor in vivo. PAM takes advantage of the strong near-infrared absorption of nanoshells and their extravasation tende...