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Journal of Biomedical Optics

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  1. Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopy.

    Journal of Biomedical Optics 14(1):014004 (2009) PMID 19256692 PMCID PMC2813673

    Highly localized reflectance measurements can be used to directly quantify scatter changes in tissues. We present a microsampling approach that is used to raster scan tumors to extract parameters believed to be related to the tissue ultrastructure. A confocal reflectance imager was developed to ...
  2. Mapping microscope object polarized emission to the back focal plane pattern.

    Journal of Biomedical Optics 14(3):034036 (2009) PMID 19566329 PMCID PMC2745092

    The back focal plane (BFP) intensity pattern from a high-aperture objective separately maps far- and near-field emission from dipoles near a bare glass or metal-film-coated glass/aqueous interface. Total internal reflection (TIR) excitation of a fluorescent sample gave a BFP pattern interpreted ...
  3. Effects of Er:YAG laser irradiation and manipulation treatments on dentin components, part 1: Fourier transform-Raman study.

    Journal of Biomedical Optics 14(2):024001 (2009) PMID 19405731

    The effects of laser etching, decontamination, and storage treatments on dentin components were studied using Fourier transform (FT)-Raman spectroscopy. Thirty bovine incisors were prepared to expose the dentin surface and then divided in two main groups based upon the decontamination process an...
  4. Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging.

    Journal of Biomedical Optics 14(2):021007 (2009) PMID 19405720

    Nanophotothermolysis with long laser pulses for treatment of scattered cancer cells and their clusters is introduced with the main focus on real-time monitoring of temperature dynamics inside and around individual cancer cells labeled with carbon nanotubes. This technique utilizes advanced time-...
  5. Dynamic analysis of internal and external mental sweating by optical coherence tomography.

    Journal of Biomedical Optics 14(1):014026 (2009) PMID 19256714

    Mental sweating is human sweating that is accelerated via the sympathetic nerve by application of mental or physical stress. In the neurosciences, there is keen interest in this type of sweating, because the amount of sweat in response to a stress applied to a volunteer directly reflects activit...
  6. Raman spectroscopy of synovial fluid as a tool for diagnosing osteoarthritis.

    Journal of Biomedical Optics 14(3):034013 (2009) PMID 19566306 PMCID PMC2705867

    For many years, viscosity has been the primary method used by researchers in rheumatology to assess the physiochemical properties of synovial fluid in both normal and osteoarthritic patients. However, progress has been limited by the lack of methods that provide multiple layers of information, u...
  7. Simultaneous photoacoustic imaging technique using an acoustic imaging lens.

    Journal of Biomedical Optics 14(3):030511 (2009) PMID 19566292

    A simultaneous photoacoustic (PA) tomography imaging technique in multilayer samples was developed. Instead of using the PA image reconstruction methods on the basis of complex algorithms, obtaining a two-dimensional PA image in real time is available by using an acoustic lens that has the abili...
  8. Noninvasive in vitro and in vivo assessment of epidermal hyperkeratosis and dermal fibrosis in atopic dermatitis.

    Journal of Biomedical Optics 14(1):014008 (2009) PMID 19256696

    Atopic dermatitis (AD) is characterized by hyperkeratosis of epidermis and fibrosis within dermis in chronic skin lesions. Thus far, the histology of skin lesions has been evaluated only by examination of excised specimens. A noninvasive in vivo tool is essential to evaluate the histopathologica...
  9. Imaging of glioma tumor with endogenous fluorescence tomography.

    Journal of Biomedical Optics 14(3):030501 (2009) PMID 19566285 PMCID PMC2810635

    Tomographic imaging of a glioma tumor with endogenous fluorescence is demonstrated using a noncontact single-photon counting fan-beam acquisition system interfaced with microCT imaging. The fluorescence from protoporphyrin IX (PpIX) was found to be detectable, and allowed imaging of the tumor fr...
  10. New cross-talk measure of near-infrared spectroscopy and its application to wavelength combination optimization.

    Journal of Biomedical Optics 14(3):034017 (2009) PMID 19566310

    In near-infrared spectroscopy, concentration changes in oxygenated and deoxygenated hemoglobin are calculated from the changes in the attenuation of the measurement light. This is done by solving a linear equation based on the modified Lambert-Beer law. To solve this equation, we need to know th...