Journal of Biomedical Optics
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- Society of Photo-Optical Instrumentation Engineers, Proquest, and CSA
Hyperspectral fluorescence imaging for cellular iron mapping in the in vitro model of Parkinson's disease.
ABSTRACT. Parkinson's disease (PD) is characterized by progressive dopaminergic cell loss in the substantia nigra (SN) and elevated iron levels demonstrated by autopsy. Direct visualization of iron with live imaging techniques has not yet been successful. The aim of this study is to visualize and qu...
Microfluidic approach for direct and uniform laser irradiation to study biochemical state changes on Jurkat-T cells.
We investigated the potential for using polydimethylsiloxane microfluidic devices in a biological assay to explore the cellular stress response (CSR) associated with hyperthermia induced by exposure to laser radiation. In vitro studies of laser-tissue interaction traditionally involved exposing a mo...
Three-dimensional stereoscopic imaging modality based on a single optical channel and detector.
These results are expected to facilitate the practical use of a 3D-SIM in medicine....
Practicability and safety of laser-assisted reduction surgery.
We have presented an innovative laser-assisted reduction surgery (LARS) based on plasma-induced ablation and photodisruption effects. In addition, we developed a laser operation system. Fetuses of mice from the Institute for Cancer Research that were immersed in physiological saline were irradiated...
Spectral dependence of absorption sensitivity on concentration of oxygenated hemoglobin: pulse oximetry implications.
We find that the highest temporal modulation due to heart function for a thick sample, like an arm, is at 940 nm, a significant shift from 710 nm measured for a finger. The most favorable spectral region for a thick transmission sample, such as a forearm, is the domain defined by intervals [900 nm...
Spectral correlation analysis of Amyloid β plaque inhomogeneity from double staining experiments.
We demonstrate the use of the correlation analysis approach in double-staining experiments and how it is possible to relate these to structural/spectral changes in biological samples....
Comparison of cerebral tissue oxygenation values in full term and preterm newborns by the simultaneous use of two near-infrared spectroscopy...
We find that mean cerebral StO2 values are similar between devices for term and preterm babies, but INVOS shows StO2 values spread over a wider range, with wider standard deviations than shown by the FORE-SIGHT. There is relatively good agreement with a bias up to 3.5% and limits of agreement up to...
Errata: High-sensitivity detection of breast tumors in vivo by use of a pH-sensitive near-infrared fluorescence probe.
Computer-aided diagnosis of rheumatoid arthritis with optical tomography, Part 1: feature extraction.
This is the first part of a two-part paper on the application of computer-aided diagnosis to diffuse optical tomography (DOT). An approach for extracting heuristic features from DOT images and a method for using these features to diagnose rheumatoid arthritis (RA) are presented. Feature extraction i...
DNA-templated nanoantennas for single-molecule detection at elevated concentrations.
We show how bottom-up nanoantennas enhance the fluorescence intensity in a reduced hotspot, ready for biological applications. We use self-assembled DNA origami structures as a breadboard where gold nanoparticle (NP) dimers are positioned with nanometer precision. A maximum of almost 100-fold intens...