European Journal of Pain
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- CSA, Gale, Proquest, Sciencedirect from 1997, and Wiley
Evaluation of the effects of a metabotropic glutamate receptor 5-antagonist on electrically induced pain and central sensitization in health...
This study aimed to investigate the effect of a single dose of the mGluR5-antagonist AZD9272 on electrically induced pain, central sensitization and axon reflex flare. This was a randomized, double-blind, placebo-controlled crossover study. Twenty-five healthy male volunteers received a single oral...
TRPA1 and TRPV1 are differentially involved in heat nociception of mice.
Our results indicate that in addition to TRPV1, TRPA1 plays a role in heat nociception, in particular in definition of the heat threshold, and might therefore serve as a therapeutic target in acute inflammatory pain. © 2013 European Federation of International Association for the Study of Pain Chapt...
Pre-medication with sublingual fentanyl did not relieve pain associated with bone marrow aspiration and biopsy: a randomized feasibility tri...
Bone marrow aspiration and/or biopsy (BMAB) is often an unpleasant and painful procedure in spite of local anaesthetic infiltration. This randomized placebo-controlled trial compared the pain relieving effect of sublingual fentanyl and placebo during BMAB. One hundred sixty patients were randomized...
The L-kynurenine-probenecid combination reduces neuropathic pain in rats.
l-Kynurenine has antinociceptive effects in acute and inflammatory pain. This study determined the effect of l-kynurenine and its metabolite (kynurenic acid) on rats subjected to neuropathic pain. L5/L6 spinal nerve ligation induced tactile allodynia as measured with von Frey filaments using the up-...
Transforming pain medicine: Adapting to science and society.
We offer our patients. In the long-term these approaches will contribute to providing better diagnoses and more effective treatments to lessen the current challenges in pain medicine. © 2013 European Federation of International Association for the Study of Pain Chapters....
Validity evidence for the back beliefs questionnaire in the general population.
Despite common usage of the back beliefs questionnaire (BBQ) in a variety of studies, important validity evidence is missing. The objective of this study was to examine the validity of the BBQ in the general population. A population-based, cross-sectional study design was used. Adult residents in tw...
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.
β-caryophyllene (BCP) is a common constitute of the essential oils of numerous spice, food plants and major component in Cannabis. The present study investigated the contribution of peripheral cannabinoid (CB) and opioid systems in the antinociception produced by intraplantar (i.pl.) injection of BC...
Low back pain-related beliefs and likely practice behaviours among final-year cross-discipline health students.
Evidence points to clinicians' beliefs and practice behaviours related to low back pain (LBP), which are discordant with contemporary evidence. While interventions to align beliefs and behaviours with evidence among clinicians have demonstrated effectiveness, a more sustainable and cost-effective ap...
Modulation of pain by emotional sounds: A laser-evoked potential study.
Previous studies have shown increases in experimental pain during induction of a negative emotion with visual stimuli, verbal statements or unpleasant odours. The goal of the present study was to analyse the spatio-temporal activation patterns underlying pain augmentation during negative emotional s...
Does acupuncture activate endogenous analgesia in chronic whiplash-associated disorders? A randomized crossover trial.
Many patients with chronic pain, including those with chronic whiplash-associated disorders (WAD), show features of central sensitization. Randomized trials examining whether treatments are able to influence the process of central sensitization in patients with chronic WAD are emerging. Therefore, t...