Molecular Cell

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  1. RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation

    Molecular Cell 60(2):338 (2015)

  2. Regulation of KLF4 Turnover Reveals an Unexpected Tissue-Specific Role of pVHL in Tumorigenesis

    Molecular Cell 60(2):339 (2015)

  3. CRL4VprBP E3 Ligase Promotes Monoubiquitylation and Chromatin Binding of TET Dioxygenases

    Molecular Cell 59(6):1043 (2015)

  4. Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance

    Molecular Cell 59(1):9 (2015) PMID 26051177

    Within bacterial populations, a small fraction of persister cells is transiently capable of surviving exposure to lethal doses of antibiotics. As a bet-hedging strategy, persistence levels are determined both by stochastic induction and by environmental stimuli called responsive divers...
  5. The Ubiquitin Ligase SCFUcc1 Acts as a Metabolic Switch for the Glyoxylate Cycle

    Molecular Cell 59(1):22 (2015) PMID 25982115

    Despite the crucial role played by the glyoxylate cycle in the virulence of pathogens, seed germination in plants, and sexual development in fungi, we still have much to learn about its regulation. Here, we show that a previously uncharacterized SCFUcc1 ubiquitin ligase mediates protea...
  6. Approaching the Golden Fleece a Molecule at a Time: Biophysical Insights into Argonaute-Instructed Nucleic Acid Interactions

    Molecular Cell 59(1):4 (2015) PMID 26140366

    Argonaute proteins act at the core of nucleic acid-guided interference pathways that regulate gene expression and defend organisms against foreign genetic elements in all domains of life. Here, we review recent biophysical studies on how Argonaute proteins instruct oligonucleotides in ...
  7. Oxidative Modification of miR-184 Enables It to Target Bcl-xL and Bcl-w

    Molecular Cell 59(1):50 (2015) PMID 26028536

    MicroRNAs (miRNAs) are small non-coding RNAs, and they bind to complementary sequences in the three prime untranslated regions (3′ UTRs) of target mRNA transcripts, thereby inhibiting mRNA translation or promoting mRNA degradation. Excessive reactive oxygen species (ROS) can cause cell...
  8. Single-Molecule Analysis of the Target Cleavage Reaction by the Drosophila RNAi Enzyme Complex

    Molecular Cell 59(1):125 (2015) PMID 26140368

    Small interfering RNAs (siRNAs) direct cleavage of complementary target RNAs via an RNA-induced silencing complex (RISC) that contains Argonatute2 protein at its core. However, what happens after target cleavage remains unclear. Here we analyzed the cleavage reaction by Drosophila Argo...
  9. Remarkable Functional Convergence: Alarmone ppGpp Mediates Persistence by Activating Type I and II Toxin-Antitoxins

    Molecular Cell 59(1):1 (2015) PMID 26140365

    In this issue of Molecular Cell, Verstraeten et al. (2015) demonstrate that the conserved GTPase Obg and the second messenger ppGpp mediate persistence by activation of a type I toxin-antitoxin module (hokB/sokB) in E. coli.
  10. Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs

    Molecular Cell 59(1):117 (2015) PMID 26140367

    Argonaute is a key enzyme of various RNA silencing pathways. We use single-molecule fluorescence measurements to characterize the reaction mechanisms of the core-RISC (RNA-induced silencing complex) composed of human Argonaute 2 and a small RNA. We found that target binding of core-RIS...
  11. Erratum: Adaptive Regulation of Testis Gene Expression and Control of Male Fertility by the Drosophila Hairpin RNA Pathway

    Molecular Cell 58(6):1133 (2015)

  12. A Role for WDR5 in Integrating Threonine 11 Phosphorylation to Lysine 4 Methylation on Histone H3 during Androgen Signaling and in Prostate Cancer

    Molecular Cell 58(3):557 (2015)

  13. A Tail of Two Sites: A Bipartite Mechanism for Recognition of Notch Ligands by Mind Bomb E3 Ligases

    Molecular Cell 58(2) (2015)

  14. Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling during DNA Replication

    Molecular Cell 58(1) (2015)

  15. TOPping Off Meiosis

    Molecular Cell 57(6):1142 (2015)

  16. Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation

    Molecular Cell 57(1):202 (2015)

  17. Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier

    Molecular Cell 56(5):717 (2014)

  18. Localization of NADPH Production: A Wheel within a Wheel

    Molecular Cell 56(4):608 (2014)

  19. Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

    Molecular Cell 56(4):609 (2014)

  20. Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall

    Molecular Cell 56(4):609 (2014)