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Molecular Cell

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  1. A Tail of Two Sites: A Bipartite Mechanism for Recognition of Notch Ligands by Mind Bomb E3 Ligases

    Molecular Cell 58(2) (2015)

  2. Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling during DNA Replication

    Molecular Cell 58(1):194 (2015)

  3. TOPping Off Meiosis

    Molecular Cell 57(6) (2015)

  4. Bacterial Riboswitches Cooperatively Bind Ni2+ or Co2+ Ions and Control Expression of Heavy Metal Transporters

    Molecular Cell 57(6):1088 (2015) PMID 25794617

    Bacteria regularly encounter widely varying metal concentrations in their surrounding environment. As metals become depleted or, conversely, accrue to toxicity, microbes will activate cellular responses that act to maintain metal homeostasis. A suite of metal-sensing regulatory (“metal...
  5. The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain

    Molecular Cell 57(6):1034 (2015) PMID 25794615

    DNA binding by numerous transcription factors including the p53 tumor suppressor protein constitutes a vital early step in transcriptional activation. While the role of the central core DNA binding domain (DBD) of p53 in site-specific DNA binding has been established, the contribution ...
  6. Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling during DNA Replication

    Molecular Cell 57(6):1124 (2015) PMID 25752575 PMCID PMC4369404

    The Mec1/Tel1 kinases (human ATR/ATM) play numerous roles in the DNA replication stress response. Despite the multi-functionality of these kinases, studies of their in vivo action have mostly relied on a few well-established substrates. Here we employed a combined genetic-phosphoproteo...
  7. Let a Hundred Flowers Bloom: The Role of Context Dependence in Creating Phenotypic Diversity following Targeted Therapy

    Molecular Cell 57(5):763 (2015) PMID 25747655

    Using a newly developed computational platform, COSPER, Litvin et al. (2015) identify context-dependent interactions between MEK and interferon signaling that underlie sensitivity and resistance to MEK inhibition in melanoma.
  8. A New Path to Leukemia with WIT

    Molecular Cell 57(4):573 (2015) PMID 25699704

    In this issue, Wang et al., 2015 describes that WT1 recruits TET2 to the DNA, an important feature of a new regulatory pathway linked to the development of acute myeloid leukemia (AML). This pathway consists of WT1, IDH1/2, and TET2 (WIT) genes, with exclusive mutations of the three ge...
  9. A Sensitive Approach to Map Genome-wide 5-Hydroxymethylcytosine and 5-Formylcytosine at Single-Base Resolution

    Molecular Cell 57(4):750 (2015) PMID 25639471

    Mapping genome-wide 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) at single-base resolution is important to understand their biological functions. We present a cost-efficient mapping method that combines 5hmC-specific restriction enzyme PvuRts1I with a 5hmC chemical labelin...
  10. Molecular Mechanism and Evolution of Guanylate Kinase Regulation by (p)ppGpp

    Molecular Cell 57(4):735 (2015) PMID 25661490 PMCID PMC4336630

    The nucleotide (p)ppGpp mediates bacterial stress responses, but its targets and underlying mechanisms of action vary among bacterial species and remain incompletely understood. Here, we characterize the molecular interaction between (p)ppGpp and guanylate kinase (GMK), revealing the i...