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Molecular Cell

Print ISSN
1097-2765
Electronic ISSN
1097-4164
Impact factor
14.194
Publisher
Sciencedirect
URL
http://www.sciencedirect.com/science/journal/10972765
Usage rank
74
Article count
4758
Free count
3067
Free percentage
0.644599
PDFs via platforms
Sciencedirect from 1997, Proquest, Rcgp, Gale, CSA, and Ingenta

  1. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.

    Molecular Cell 14(3):405 (2004) PMID 15125843

    We report the crystal structure of the BRCT repeats of human BRCA1 bound to a phosphorylated BACH1 peptide at 2.3 A resolution. The phosphorylated serine 990 and phenylalanine 993 of BACH1 anchor the binding to BRCA1 through specific interactions with a surface cleft at the junction of the two BRCT...
  2. Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1.

    Molecular Cell 14(3):363 (2004) PMID 15125839

    We crystallized the full-length human Dmc1 protein and solved the structure of the Dmc1 octameric ring. The monomeric structure of the Dmc1 protein closely resembled those of the human and archaeal Rad51 proteins. In addition to the polymerization motif that was previously identified in the Rad51 pr...
  3. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

    Molecular Cell 4(1):1 (1999) PMID 10445022

    We report that inactivation of cell cycle checkpoints responsive to mitotic spindle disruption, by mutant forms of p53 or Bub1, relieves growth arrest and initiates neoplastic transformation in primary cells homozygous for truncated Brca2. Tumors from Brca2-deficient animals exhibit dysfunction of t...
  4. Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

    Molecular Cell 56(2):193 (2014) PMID 25242146

    We defined a mechanism of cellular signaling by which neural stem/precursor cells (NPCs) communicate with the microenvironment via extracellular vesicles (EVs), and we elucidated its molecular signature and function. We observed cytokine-regulated pathways that sort proteins and mRNAs into EVs. We d...
  5. The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites.

    Molecular Cell 55(5):791 (2014) PMID 25155612

    We mapped the genomic binding sites for two highly expressed human lncRNAs, NEAT1 and MALAT1. We show that NEAT1 and MALAT1 localize to hundreds of genomic sites in human cells, primarily over active genes. NEAT1 and MALAT1 exhibit colocalization to many of these loci, but display distinct gene body...
  6. SWR1 and INO80 chromatin remodelers contribute to DNA double-strand break perinuclear anchorage site choice.

    Molecular Cell 55(4):626 (2014) PMID 25066231

    We characterize and distinguish the two binding sites. First, DSB-pore interaction occurs independently of cell-cycle phase and requires neither the chromatin remodeler INO80 nor recombinase Rad51 activity. In contrast, Mps3 binding is S and G2 phase specific and requires both factors. SWR1-dependen...
  7. Molecular basis for coordinating transcription termination with noncoding RNA degradation.

    Molecular Cell 55(3):467 (2014) PMID 25066235 PMCID PMC4186968

    We provide structural and functional evidence demonstrating that the same domain of Nrd1p interacts with RNA polymerase II and Trf4p in a mutually exclusive manner, thus defining two alternative forms of the NNS complex, one involved in termination and the other in degradation. We show that the Nrd1...
  8. Regulation of pri-miRNA processing by a long noncoding RNA transcribed from an ultraconserved region.

    Molecular Cell 55(1):138 (2014) PMID 24910097

    We show that a long ncRNA, Uc.283+A, controls pri-miRNA processing. Regulation requires complementarity between the lower stem region of the pri-miR-195 transcript and an ultraconserved sequence in Uc.283+A, which prevents pri-miRNA cleavage by Drosha. Mutation of the site in either RNA molecule unc...
  9. VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress.

    Molecular Cell 54(4):559 (2014) PMID 24746698

    We show that VEGF activates UPR mediators through a PLCγ-mediated crosstalk with the mTORC1 complex without accumulation of unfolded proteins in the ER. Activation of ATF6 and PERK contributes to the survival effect of VEGF on endothelial cells (ECs) by positively regulating mTORC2-mediated phosphor...
  10. HDMX folds the nascent p53 mRNA following activation by the ATM kinase.

    Molecular Cell 54(3):500 (2014) PMID 24813712

    We show that following phosphorylation by the ataxia telangiectasia mutated (ATM) kinase at serine 403, the C-terminal RING domain of HDMX binds the nascent p53 mRNA to promote a conformation that supports the p53 mRNA-HDM2 interaction and the induction of p53 synthesis. HDMX and its homolog HDM2 bi...