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Molecular Cell

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  1. RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation

    Molecular Cell 60(2):338 (2015)

  2. Regulation of KLF4 Turnover Reveals an Unexpected Tissue-Specific Role of pVHL in Tumorigenesis

    Molecular Cell 60(2):339 (2015)

  3. CRL4VprBP E3 Ligase Promotes Monoubiquitylation and Chromatin Binding of TET Dioxygenases

    Molecular Cell 59(6):1043 (2015)

  4. Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance

    Molecular Cell (2015)

    The essential functions of the conserved Smc5/6 complex remain elusive. To uncover its roles in genome maintenance, we established Saccharomyces cerevisiae cell cycle-regulated alleles that enable restriction of Smc5/6 components to S or G2/M. Unexpectedly, the essential functions of S...
  5. The CENP-L-N complex forms a critical node in an integrated meshwork of interactions at the centromere-kinetochore interface

    Molecular Cell (2015)

    During mitosis, the macromolecular kinetochore complex assembles on the centromere to orchestrate chromosome segregation. The properties and molecular architecture of the 16-subunit Constitutive Centromere Associated Network (CCAN) that allow it to build a robust platform are poorly un...
  6. Structural basis of neurohormone perception by the receptor tyrosine kinase Torso

    Molecular Cell (2015)

    In insects, brain derived Prothoracicotropic hormone (PTTH) activates the receptor tyrosine kinase (RTK) Torso to initiate metamorphosis through the release of ecdysone. We have determined the crystal structure of silkworm PTTH in complex with the ligand-binding region of Torso. Here w...
  7. PrimPol is required for replicative tolerance of G quadruplexes in vertebrate cells

    Molecular Cell (2015)

    G quadruplexes (G4s) can present potent blocks to DNA replication. Accurate and timely replication of G4s in vertebrates requires multiple specialised DNA helicases and polymerases to prevent genetic and epigenetic instability. Here we report that PrimPol, a recently described primase-...
  8. Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance

    Molecular Cell 59(1):9 (2015) PMID 26051177

    Within bacterial populations, a small fraction of persister cells is transiently capable of surviving exposure to lethal doses of antibiotics. As a bet-hedging strategy, persistence levels are determined both by stochastic induction and by environmental stimuli called responsive divers...
  9. The Ubiquitin Ligase SCFUcc1 Acts as a Metabolic Switch for the Glyoxylate Cycle

    Molecular Cell 59(1):22 (2015) PMID 25982115

    Despite the crucial role played by the glyoxylate cycle in the virulence of pathogens, seed germination in plants, and sexual development in fungi, we still have much to learn about its regulation. Here, we show that a previously uncharacterized SCFUcc1 ubiquitin ligase mediates protea...
  10. Approaching the Golden Fleece a Molecule at a Time: Biophysical Insights into Argonaute-Instructed Nucleic Acid Interactions

    Molecular Cell 59(1):4 (2015) PMID 26140366

    Argonaute proteins act at the core of nucleic acid-guided interference pathways that regulate gene expression and defend organisms against foreign genetic elements in all domains of life. Here, we review recent biophysical studies on how Argonaute proteins instruct oligonucleotides in ...