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Molecular Cell

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  1. Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth

    Molecular Cell 60(2):195 (2015) PMID 26474064

    Cancer cells adapt metabolically to proliferate under nutrient limitation. Here we used combined transcriptional-metabolomic network analysis to identify metabolic pathways that support glucose-independent tumor cell proliferation. We found that glucose deprivation stimulated re-wiring...
  2. DNase H Activity of Neisseria meningitidis Cas9

    Molecular Cell 60(2):242 (2015) PMID 26474066 PMCID PMC4609032

    Type II CRISPR systems defend against invasive DNA by using Cas9 as an RNA-guided nuclease that creates double-stranded DNA breaks. Dual RNAs (CRISPR RNA [crRNA] and tracrRNA) are required for Cas9’s targeting activities observed to date. Targeting requires a protospacer adjacent motif...
  3. RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation

    Molecular Cell 60(2):338 (2015)

  4. Regulation of KLF4 Turnover Reveals an Unexpected Tissue-Specific Role of pVHL in Tumorigenesis

    Molecular Cell 60(2):339 (2015)

  5. EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling

    Molecular Cell 60(2):307 (2015) PMID 26455392 PMCID PMC4609298

    Epidermal growth factor receptor (EGFR) gene amplification and mutations are the most common oncogenic events in glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth are not well understood. Here, through integrated epigenome and transcriptome analyses o...
  6. Endless Quarrels at the End of Genes

    Molecular Cell 60(2):192 (2015) PMID 26474063

    Two recent papers in Molecular Cell, Fong et al. (2015) and Zhang et al. (2015), reopen the debate between the contribution of the allosteric versus the torpedo model of transcription termination.
  7. TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export

    Molecular Cell 60(1):89 (2015) PMID 26431026

    Hereditary spastic paraplegias (HSPs) are a diverse group of neurodegenerative diseases that are characterized by axonopathy of the corticospinal motor neurons. A mutation in the gene encoding for Tectonin β-propeller containing protein 2 (TECPR2) causes HSP that is complicated by neur...
  8. Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair

    Molecular Cell 60(1):163 (2015) PMID 26344098

    Human Timeless helps stabilize replication forks during normal DNA replication and plays a critical role in activation of the S phase checkpoint and proper establishment of sister chromatid cohesion. However, it remains elusive whether Timeless is involved in the repair of damaged DNA....
  9. Parallel Parkin: Cdc20 Takes a New Partner

    Molecular Cell 60(1):3 (2015) PMID 26431023

    CDC20 and CDH1 are well-established substrate receptors for the Anaphase Promoting Complex/Cyclosome (APC/C). In this issue of Molecular Cell, Lee et al. (2015) show that these adaptors can also target cell cycle proteins for destruction through a second ubiquitin ligase, Parkin.
  10. The Long, the Short, and the Unstructured: A Unifying Model of miRNA Biogenesis

    Molecular Cell 60(1):4 (2015) PMID 26431024

    In this issue, Fang and Bartel (2015) report the identification of novel sequence and structural features of human pri-miRNAs, which—together with previously identified sequence motifs—define a unifying model of mammalian pri-miRNAs and advances the de novo design of artificial pri-miR...