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Molecular Cell

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Sciencedirect from 1997, Proquest, Rcgp, Gale, CSA, and Ingenta

  1. SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.

    Molecular Cell (2015) PMID 26387735

    Mitochondrial permeability transition is a phenomenon in which the mitochondrial permeability transition pore (PTP) abruptly opens, resulting in mitochondrial membrane potential (??m) dissipation, loss ofニATP production, and cell death. Several genetic candidates have been proposed to form the PT...
  2. A Role for WDR5 in Integrating Threonine 11 Phosphorylation to Lysine 4 Methylation on Histone H3 during Androgen Signaling and in Prostate Cancer

    Molecular Cell 58(3):557 (2015)

  3. A Tail of Two Sites: A Bipartite Mechanism for Recognition of Notch Ligands by Mind Bomb E3 Ligases

    Molecular Cell 58(2) (2015)

  4. Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling during DNA Replication

    Molecular Cell 58(1) (2015)

  5. TOPping Off Meiosis

    Molecular Cell 57(6):1142 (2015)

  6. Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex

    Molecular Cell 57(5):812 (2015) PMID 25661486 PMCID PMC4352764

    Chromosomal replication is entwined with DNA damage tolerance (DDT) and chromatin structure establishment via elusive mechanisms. Here we examined how specific replication conditions affecting replisome architecture and repriming impact on DDT. We show that Saccharomyces cerevisiae Pol...
  7. Interferon α/β Enhances the Cytotoxic Response of MEK Inhibition in Melanoma

    Molecular Cell 57(5):784 (2015) PMID 25684207 PMCID PMC4355234

    Drugs that inhibit the MAPK pathway have therapeutic benefit in melanoma, but responses vary between patients, for reasons that are still largely unknown. Here we aim at explaining this variability using pre- and post-MEK inhibition transcriptional profiles in a panel of melanoma cell ...
  8. Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G

    Molecular Cell 57(5):887 (2015) PMID 25702870 PMCID PMC4352763

    Deubiquitinating enzymes (DUBs) control vital processes in eukaryotes by hydrolyzing ubiquitin adducts. Their activities are tightly regulated, but the mechanisms remain elusive. In particular, the DUB UCH-L5 can be either activated or inhibited by conserved regulatory proteins RPN13 a...
  9. Sequential Multisite Phospho-Regulation of KNL1-BUB3 Interfaces at Mitotic Kinetochores

    Molecular Cell 57(5):824 (2015) PMID 25661489

    Regulated recruitment of the kinase-adaptor complex BUB1/BUB3 to kinetochores is crucial for correcting faulty chromosome-spindle attachments and for spindle assembly checkpoint (SAC) signaling. BUB1/BUB3 localizes to kinetochores by binding phosphorylated MELT motifs (MELpT) in the ki...
  10. Molecular Mechanism and Evolution of Guanylate Kinase Regulation by (p)ppGpp

    Molecular Cell 57(4):735 (2015) PMID 25661490 PMCID PMC4336630

    The nucleotide (p)ppGpp mediates bacterial stress responses, but its targets and underlying mechanisms of action vary among bacterial species and remain incompletely understood. Here, we characterize the molecular interaction between (p)ppGpp and guanylate kinase (GMK), revealing the i...