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Molecular Cell

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  1. Pausing of RNA Polymerase II Regulates Mammalian Developmental Potential through Control of Signaling Networks

    Molecular Cell 58(2):311 (2015)

    The remarkable capacity for pluripotency and self-renewal in embryonic stem cells (ESCs) requires a finely tuned transcriptional circuitry wherein the pathways and genes that initiate differentiation are suppressed, but poised to respond rapidly to developmental signals. To elucidate t...
  2. Greetings from the Planet Croton

    Molecular Cell 58(2):195 (2015)

    In this issue of Molecular Cell, Sabari et al. (2015) discover that levels of intracellular crotonyl-CoA impact the histone acylation landscape, providing deeper insight into the exotic histone modification, crotonylation, and exploring new avenues by which cellular metabolism can infl...
  3. A Tail of Two Sites: A Bipartite Mechanism for Recognition of Notch Ligands by Mind Bomb E3 Ligases

    Molecular Cell 58(2) (2015)

  4. Distinct Spatial Ca2+ Signatures Selectively Activate Different NFAT Transcription Factor Isoforms

    Molecular Cell 58(2):232 (2015)

    Protein isoforms are widely expressed in biological systems. How isoforms that co-exist within the same sub-cellular domain are differentially activated remains unclear. Here, we compare the regulatory mechanism of two closely related transcription factor isoforms, NFAT1 and NFAT4, tha...
  5. Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

    Molecular Cell 58(2):203 (2015)

    Acetylation of histones at DNA regulatory elements plays a critical role in transcriptional activation. Histones are also modified by other acyl moieties, including crotonyl, yet the mechanisms that govern acetylation versus crotonylation and the functional consequences of this “choice...
  6. Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing

    Molecular Cell 58(2):216 (2015)

    Chromosomes of metazoan organisms are partitioned in the interphase nucleus into discrete topologically associating domains (TADs). Borders between TADs are formed in regions containing active genes and clusters of architectural protein binding sites. The transcription of most genes is...
  7. Retraction Notice To: L-Type Ca2+ Channel Facilitation Mediated by Phosphorylation of the β Subunit by CaMKII

    Molecular Cell 58(2):388 (2015)

  8. Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling during DNA Replication

    Molecular Cell 58(1):194 (2015)

  9. TOPping Off Meiosis

    Molecular Cell 57(6) (2015)

  10. Bacterial Riboswitches Cooperatively Bind Ni2+ or Co2+ Ions and Control Expression of Heavy Metal Transporters

    Molecular Cell 57(6):1088 (2015) PMID 25794617

    Bacteria regularly encounter widely varying metal concentrations in their surrounding environment. As metals become depleted or, conversely, accrue to toxicity, microbes will activate cellular responses that act to maintain metal homeostasis. A suite of metal-sensing regulatory (“metal...