Advanced search×

Molecular Cell

Print ISSN
Electronic ISSN
Impact factor
Usage rank
Article count
Free count
Free percentage
PDFs via platforms
Sciencedirect from 1997, Proquest, Rcgp, Gale, CSA, and Ingenta

  1. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.

    Molecular Cell 14(3):405 (2004) PMID 15125843

    We report the crystal structure of the BRCT repeats of human BRCA1 bound to a phosphorylated BACH1 peptide at 2.3 A resolution. The phosphorylated serine 990 and phenylalanine 993 of BACH1 anchor the binding to BRCA1 through specific interactions with a surface cleft at the junction of the two BRCT...
  2. Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1.

    Molecular Cell 14(3):363 (2004) PMID 15125839

    We crystallized the full-length human Dmc1 protein and solved the structure of the Dmc1 octameric ring. The monomeric structure of the Dmc1 protein closely resembled those of the human and archaeal Rad51 proteins. In addition to the polymerization motif that was previously identified in the Rad51 pr...
  3. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

    Molecular Cell 4(1):1 (1999) PMID 10445022

    We report that inactivation of cell cycle checkpoints responsive to mitotic spindle disruption, by mutant forms of p53 or Bub1, relieves growth arrest and initiates neoplastic transformation in primary cells homozygous for truncated Brca2. Tumors from Brca2-deficient animals exhibit dysfunction of t...
  4. VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress.

    Molecular Cell 54(4):559 (2014) PMID 24746698

    We show that VEGF activates UPR mediators through a PLCγ-mediated crosstalk with the mTORC1 complex without accumulation of unfolded proteins in the ER. Activation of ATF6 and PERK contributes to the survival effect of VEGF on endothelial cells (ECs) by positively regulating mTORC2-mediated phosphor...
  5. HDMX folds the nascent p53 mRNA following activation by the ATM kinase.

    Molecular Cell 54(3):500 (2014) PMID 24813712

    We show that following phosphorylation by the ataxia telangiectasia mutated (ATM) kinase at serine 403, the C-terminal RING domain of HDMX binds the nascent p53 mRNA to promote a conformation that supports the p53 mRNA-HDM2 interaction and the induction of p53 synthesis. HDMX and its homolog HDM2 bi...
  6. Retraction notice to: Nuclear receptor function requires a TFTC-type histone acetyl transferase complex.
    Author(s) unavailable

    Molecular Cell 54(3):536 (2014) PMID 24932468

  7. The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability.

    Molecular Cell 54(1):80 (2014) PMID 24631283 PMCID PMC3988236

    We have refined the substrate specificity of budding yeast Cdc14 and, using this insight, identified the Holliday junction resolvase Yen1 as a DNA repair target of Cdc14. Cdc14 activation at anaphase triggers nuclear accumulation and enzymatic activation of Yen1, likely to resolve persistent recombi...
  8. Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function.

    Molecular Cell 54(1):67 (2014) PMID 24725595 PMCID PMC4039351

    In marmoset T cells transformed by Herpesvirus saimiri (HVS), a viral U-rich noncoding (nc) RNA, HSUR 1, specifically mediates degradation of host microRNA-27 (miR-27). High-throughput sequencing of RNA after crosslinking immunoprecipitation (HITS-CLIP) identified mRNAs targeted by miR-27 as enriche...
  9. Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions.

    Molecular Cell 53(6):929 (2014) PMID 24656130 PMCID PMC4004102

    We reconstitute an AgrC family member, AgrC-I, using nanometer-scale lipid bilayer discs. We show that AgrC-I requires membranes rich in anionic lipids to function. The agonist, AIP-I, binds AgrC-I noncooperatively in a 2:2 stoichiometry, while an antagonist ligand, AIP-II, functions as an inverse a...
  10. Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.

    Molecular Cell 53(3):444 (2014) PMID 24412065

    We report that internalization of the GSK3-containing Wnt-signalosome complex into MVBs is dependent on the dissociation of p120-catenin/cadherin from this complex. Disruption of cadherin-LRP5/6 interaction is controlled by cadherin phosphorylation and requires the previous separation of p120-cateni...