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Molecular Cell

Print ISSN
1097-2765
Electronic ISSN
1097-4164
Impact factor
14.194
Publisher
Sciencedirect
URL
http://www.sciencedirect.com/science/journal/10972765
Usage rank
74
Article count
4758
Free count
3067
Free percentage
0.644599
PDFs via platforms
Sciencedirect from 1997, Proquest, Rcgp, Gale, CSA, and Ingenta

  1. RNA Targeting by the Type III-A CRISPR-Cas Csm Complex of Thermus thermophilus

    Molecular Cell 56(4):518 (2014)

    We report the structure and function of the effector complex of the Type III-A CRISPR-Cas system of Thermus thermophilus: the Csm complex (TtCsm). TtCsm is composed of five different protein subunits (Csm1–Csm5) with an uneven stoichiometry and a single crRNA of variable size (35–53 nt). The TtCsm c...
  2. RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

    Molecular Cell 56(4):481 (2014)

    Receptor-interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease. Here, three selective small-molecule compounds are shown to inhibit RIP3 kinase-dependent necroptosis, although their therapeutic val...
  3. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.

    Molecular Cell 14(3):405 (2004) PMID 15125843

    We report the crystal structure of the BRCT repeats of human BRCA1 bound to a phosphorylated BACH1 peptide at 2.3 A resolution. The phosphorylated serine 990 and phenylalanine 993 of BACH1 anchor the binding to BRCA1 through specific interactions with a surface cleft at the junction of the two BRCT...
  4. Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1.

    Molecular Cell 14(3):363 (2004) PMID 15125839

    We crystallized the full-length human Dmc1 protein and solved the structure of the Dmc1 octameric ring. The monomeric structure of the Dmc1 protein closely resembled those of the human and archaeal Rad51 proteins. In addition to the polymerization motif that was previously identified in the Rad51 pr...
  5. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

    Molecular Cell 4(1):1 (1999) PMID 10445022

    We report that inactivation of cell cycle checkpoints responsive to mitotic spindle disruption, by mutant forms of p53 or Bub1, relieves growth arrest and initiates neoplastic transformation in primary cells homozygous for truncated Brca2. Tumors from Brca2-deficient animals exhibit dysfunction of t...
  6. Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

    Molecular Cell 56(2):193 (2014) PMID 25242146

    We defined a mechanism of cellular signaling by which neural stem/precursor cells (NPCs) communicate with the microenvironment via extracellular vesicles (EVs), and we elucidated its molecular signature and function. We observed cytokine-regulated pathways that sort proteins and mRNAs into EVs. We d...
  7. The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites.

    Molecular Cell 55(5):791 (2014) PMID 25155612

    We mapped the genomic binding sites for two highly expressed human lncRNAs, NEAT1 and MALAT1. We show that NEAT1 and MALAT1 localize to hundreds of genomic sites in human cells, primarily over active genes. NEAT1 and MALAT1 exhibit colocalization to many of these loci, but display distinct gene body...
  8. SWR1 and INO80 chromatin remodelers contribute to DNA double-strand break perinuclear anchorage site choice.

    Molecular Cell 55(4):626 (2014) PMID 25066231

    We characterize and distinguish the two binding sites. First, DSB-pore interaction occurs independently of cell-cycle phase and requires neither the chromatin remodeler INO80 nor recombinase Rad51 activity. In contrast, Mps3 binding is S and G2 phase specific and requires both factors. SWR1-dependen...
  9. Molecular basis for coordinating transcription termination with noncoding RNA degradation.

    Molecular Cell 55(3):467 (2014) PMID 25066235 PMCID PMC4186968

    We provide structural and functional evidence demonstrating that the same domain of Nrd1p interacts with RNA polymerase II and Trf4p in a mutually exclusive manner, thus defining two alternative forms of the NNS complex, one involved in termination and the other in degradation. We show that the Nrd1...
  10. Regulation of pri-miRNA processing by a long noncoding RNA transcribed from an ultraconserved region.

    Molecular Cell 55(1):138 (2014) PMID 24910097

    We show that a long ncRNA, Uc.283+A, controls pri-miRNA processing. Regulation requires complementarity between the lower stem region of the pri-miR-195 transcript and an ultraconserved sequence in Uc.283+A, which prevents pri-miRNA cleavage by Drosha. Mutation of the site in either RNA molecule unc...