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Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.
We tested whether a primary deficit in microglia was sufficient to induce some autism-related behavioral and functional connectivity deficits. Mice lacking the chemokine receptor Cx3cr1 exhibit a transient reduction of microglia during the early postnatal period and a consequent deficit in synaptic...
Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits.
We found that dentate gyrus cells, long believed to not project to CA2, send functional monosynaptic inputs to CA2 pyramidal cells through abundant longitudinal projections. CA2 innervated CA1 to complete an alternate trisynaptic circuit, but, unlike CA3, projected preferentially to the deep, rather...
Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward.
We devised a new conditional bacterial artificial chromosome rescue strategy to show, in mice, that targeted MOR expression in a subpopulation of striatal direct-pathway neurons enriched in the striosome and nucleus accumbens, in an otherwise MOR-null background, restores opiate reward and opiate-in...
Attention points to the future.
Fragile balance: RNA editing tunes the synapse.
How hard is the CNS hardware?
Prime time for stress.
Neural substrates of motor memory consolidation depend on practice structure.
We investigated the manner in which offline neural networks are modulated by practice structures that affect motor-skill retention. Interference to dorsolateral-prefrontal cortex (DLPFC), but not to primary motor cortex (M1), after variable practice attenuated motor-skill retention, whereas interfer...
A genomic atlas of mouse hypothalamic development.
We performed microarray analysis at 12 different developmental time points. We then conducted developmental in situ hybridization for 1,045 genes that were dynamically expressed over the course of hypothalamic neurogenesis. We identified markers that stably labeled each major hypothalamic nucleus ov...
Ensuring data integrity