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TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement.
We identify retinal transforming growth factor (TGF)-β as a key regulator of neuronal C1q expression and synaptic pruning in the developing visual system. Mice lacking TGF-β receptor II (TGFβRII) in retinal neurons had reduced C1q expression in RGCs and reduced synaptic localization of complement, a...
Corrigendum: Orthogonal micro-organization of orientation and spatial frequency in primate primary visual cortex.
Corrigendum: A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
The translation of translational control by FMRP: therapeutic targets for FXS.
De novo protein synthesis is necessary for long-lasting modifications in synaptic strength and dendritic spine dynamics that underlie cognition. Fragile X syndrome (FXS), characterized by intellectual disability and autistic behaviors, holds promise for revealing the molecular basis for these long-t...
Unconventional gene regulation in the CNS.
An illusion predicted by V1 population activity implicates cortical topography in shape perception.
We combined computational modeling, voltage-sensitive dye imaging (VSDI) in behaving monkeys and behavioral measurements in humans to investigate whether the large-scale topography of V1 population responses influences shape judgments. Specifically, we used a computational model to design visual sti...
Starvation favors glioma stem cells.
Context-dependent plasticity in a sensory circuit.
Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity.
Our findings suggest that synergistic interactions among transcription factors determine the specificity of their recruitment to cell type-specific binding sites and illustrate how a single transcription factor can be repurposed to program different cell types....
SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction.
We report a water-based optical clearing agent, SeeDB, which clears fixed brain samples in a few days without quenching many types of fluorescent dyes, including fluorescent proteins and lipophilic neuronal tracers. Our method maintained a constant sample volume during the clearing procedure, an imp...