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Sensory inputs control the integration of neurogliaform interneurons into cortical circuits.
We report that, during early development, superficially positioned Reelin-expressing neurogliaform interneurons in the mouse somatosensory cortex receive afferent innervation from both cortical and thalamic excitatory sources. Attenuation of ascending sensory, but not intracortical, excitation leads...
Changes in house rules
Corrigendum: Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys
Kuru, moral peril and the creation of value in science
Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons.
We found that some mesoaccumbens fibers have vesicular transporters for dopamine (VMAT2) in axon segments that are continuous with axon terminals that lack VMAT2, but contain vesicular glutamate transporters type 2 (VGluT2). In vivo overexpression of VMAT2 did not change the segregation of the two v...
GDNF is not required for catecholaminergic neuron survival in vivo.
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.
We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics. We combined this score across disorders to find common pathways across three adult...
Change the neural code, change the message.
Impaired spatial selectivity and intact phase precession in two-dimensional virtual reality.
We measured hippocampal activity from body-fixed rodents exploring a two-dimensional virtual reality (VR). Compared to that in RW, spatial selectivity was markedly reduced during random foraging and goal-directed tasks in VR. Instead we found small but significant selectivity to distance traveled. D...
Retinal output changes qualitatively with every change in ambient illuminance.
We recorded from isolated mouse and pig retina and from mouse dorsal lateral geniculate nucleus in vivo at up to seven ambient light levels covering the scotopic to photopic regimes. Across each luminance transition, most ganglion cells exhibited qualitative response changes, whereas they maintained...