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Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors.
We investigated the mechanism linking chromatin dynamics to neurobiological phenomena by applying engineered transcription factors to selectively modify chromatin at a specific mouse gene in vivo. We found that histone methylation or acetylation at the Fosb locus in nucleus accumbens, a brain reward...
The epigenetic landscape of Alzheimer's disease.
Two independent epigenome-wide association studies of Alzheimer’s disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer’s disease. These studies also suggest that epigenetic changes contribute more to Alz...
Attention points to the future.
Fragile balance: RNA editing tunes the synapse.
How hard is the CNS hardware?
Prime time for stress.
Neural substrates of motor memory consolidation depend on practice structure.
We investigated the manner in which offline neural networks are modulated by practice structures that affect motor-skill retention. Interference to dorsolateral-prefrontal cortex (DLPFC), but not to primary motor cortex (M1), after variable practice attenuated motor-skill retention, whereas interfer...
Ensuring data integrity
Approach sensitivity in the retina processed by a multifunctional neural circuit
We combined genetic labeling of cell types, two-photon microscopy, electrophysiology and theoretical modeling to address this question. We identify an approach-sensitive ganglion cell type in the mouse retina, resolve elements of its afferent neural circuit, and describe how these confer approach se...
Changes in house rules