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Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α.
We describe the translational program that underlies mGluR-LTD and identify the translation factor eIF2α as its master effector. Genetically reducing eIF2α phosphorylation, or specifically blocking the translation controlled by eIF2α phosphorylation, prevented mGluR-LTD and the internalization of su...
Dynamic circuit motifs underlying rhythmic gain control, gating and integration.
We structure recent empirical advances that link synchronized activity to the activation of so-called dynamic circuit motifs. These motifs explicitly relate (1) synaptic and cellular properties of circuits to (2) identified timescales of rhythmic activation and to (3) canonical circuit computations...
Maintenance of postmitotic neuronal cell identity.
We provide an overview of studies in invertebrate and vertebrate model systems that have carved out the general and not commonly appreciated principle that neuronal identity is maintained in postmitotic neurons by the sustained, and often autoregulated, expression of the same transcription factors t...
Attention points to the future.
Fragile balance: RNA editing tunes the synapse.
How hard is the CNS hardware?
Prime time for stress.
Neural substrates of motor memory consolidation depend on practice structure.
We investigated the manner in which offline neural networks are modulated by practice structures that affect motor-skill retention. Interference to dorsolateral-prefrontal cortex (DLPFC), but not to primary motor cortex (M1), after variable practice attenuated motor-skill retention, whereas interfer...
Ensuring data integrity
Approach sensitivity in the retina processed by a multifunctional neural circuit
We combined genetic labeling of cell types, two-photon microscopy, electrophysiology and theoretical modeling to address this question. We identify an approach-sensitive ganglion cell type in the mouse retina, resolve elements of its afferent neural circuit, and describe how these confer approach se...