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TLR4 signaling induces retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 in mesangial cells.
It is known that recognition of bacterial lipopolysaccharide (LPS) and various endogenous ligands by Toll-like receptor 4 (TLR4) induces inflammatory reactions. However, the role of TLR4 activation in mesangial inflammation remains to be elucidated. Retinoic acid-inducible gene-I (RIG-I) and melanom...
Cardiac valve calcification: an immutable pathologic finding in chronic kidney disease?
Although less frequent than vascular calcification, cardiac valve calcification (CVC) is a relevant clinical problem affecting about 2%-10% of adults from the general population aged 75 years and older, and is 5- to 10-fold more prevalent in individuals with impaired kidney function. An expanding bo...
Ultrafiltration in acute decompensated heart failure: friend or foe for the kidney?
The available evidence, also including recent data from a randomized clinical trial comparing ultrafiltration with adequately managed diuretic therapy (the CARRESS study), does not support its extensive employment as an alternative to well protocolized conventional diuretic therapy, especially in pa...
An uncommon presentation of an uncommon nephropathy: the karyomegalic interstitial nephritis.
We report a case of KIN with atypical clinical presentation in a young patient with progressive kidney failure without proteinuria or hematuria or history of recurrent respiratory infections....
Hemodialysis prescription education decreases intradialytic hypotension.
We studied the impact of an education program and hemodialysis (HD) prescription optimization on the frequency of IDH. We compared chronic HD patients during 2 retrospective time periods: a control period and the study period which occurred after 2 months of physician education and HD prescription o...
Soluble TWEAK is associated with atherosclerotic burden in patients with chronic kidney disease.
A significant reduction in sTWEAK and increment in CD163 plasma levels were observed in patients with more severe atherosclerosis. Our results indicate that sTWEAK could be a novel biomarker of atherosclerotic burden in CKD patients....
Effect of serum electrolyte and bicarbonate concentration changes during hemodialysis sessions on heart rate variability.
We aimed to determine the effect of sudden changes in serum electrolyte, bicarbonate concentration and blood pressure on HRV during hemodialysis (HD) sessions in chronic HD patients. The study population included 75 HD patients (mean age 44.5 ± 10.3 years; 53% female, 13% diabetic) and 35 healthy vo...
National primary care guidelines for England: impact on chronic kidney disease prevention in South Asian populations.
WE adults diagnosed with diabetes in 2004 and 2007 were carried out in a total sample of 707 patients across 18 general practices within Luton, Leicester and West London. Four hundred patients (SA: n=241, and WE: n=159) were diagnosed as diabetic in 2004, and 307 (SA: n=178, and WE: n=129) in 2007....
Usefulness of the multidimensional prognostic index (MPI) in the management of older patients with chronic kidney disease.
In older patients, given the central role of prognosis in clinical decision-making, there is an urgent need to develop accurate, validated, and rigorously tested prognostic indices. Current data suggest that in older patients not only physical but also psychological, cognitive, functional, nutrition...
Instruments for geriatric assessment: new multidimensional assessment approaches.
During the last century the considerable increase in life expectancy has led to important demographic changes and, consequently, to new clinical scenarios. Nowadays, chronic conditions, comorbidities and socio-economic factors constitute a relevant health management issue. In particular, the definit...