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Effects of retinoic acid isomers on proteomic pattern in human breast cancer MCF-7 cell line.
Our data offer novel information on the proteomic pattern of proteins evaluated after treatment of MCF-7 cells with retinoic acid isomers. Keywords: retinoic acid isomers, retinoid, breast cancer, malignant cells, proteomic analysis....
Is vitamin D supplementation a new hope for the therapy of the septic shock?
Vitamin D is mainly known for its traditional role in the bone mineralization and calcium homeostasis. Recent studies have shown that vitamin D receptors (VDR) are present in almost all the tissues and cells in the human body. In addition, several studies have revealed that vitamin D is important in...
Thyroid volume, iodine intake, autoimmune thyroid disorders, inborn factors, and endocrine disruptors: twenty-year studies of multiple effe...
The aim of this study was to evaluate multiple interrelations between several endogenous and exogenous effects and the thyroid volume and function in large groups of children, adolescents, and adults with a sufficient whole life intake of the iodine. The data were obtained either by cross sectioned...
Risk of malignancy in non-diagnostic thyroid fine-needle aspiration biopsy in multinodular goitre patients.
Although the majority of biopsies is adequate for a cytological diagnosis, 5-20 % will be insufficient or nondiagnostic. Patients with nondiagnostic FNABs (ND-FNAB) may be further managed by continued observation, repeated FNAB, or thyroidectomy. The aim of this study was to determine the risk of mal...
Animal model of metastatic pheochromocytoma: evaluation by MRI and PET.
MRI was able to detect liver lesions as small as 0.5mm in diameter. Small animal PET imaging using [18F]-DA and [18F]-DOPA detected liver, adrenal gland, and ovarian lesions. CONCLUSION: We conclude that MRI is a valuable technique for tumor growth monitoring from very early to late stages of tumor...
Dynamic pattern of IGF-I and chosen biochemical markers of bone metabolism in a rat model of postmenopausal osteoporosis.
I procollagen - PICP, cross-linked carboxyterminal telopeptide of type I collagen - ICTP in serum as well as urinary excretion of hydroxyproline - HYP and total calcium - Ca) were measured before (group 0) and 1, 2, 3, 4, 6, 8, 12, 16, 20, 24 and 28 weeks after the operation. In a model of experimen...
Influence of hemithyroidectomy on bromodeoxyuridine incorporation into DNA of rat thyroid follicular cells.
To examine the bromodeoxyuridine (BrdU) incorporation into DNA of thyroid follicular cells (TFC) in the remaining thyroid lobe after hemithyroidectomy (hemiTx) in 1, 2, 3 and 4 weeks time after surgery. The experiment was performed on male Wistar rats. The Cell Proliferation Kit (Amersham, UK) was u...
Retinoic acid receptor status in mouse spleen during a primary immune response against beta-galactosidase.
Evaluation of the dynamics of all-trans retinoic acid receptor binding properties in mouse spleen nuclear extracts during a primary immune response against beta-galactosidase. Female BALB/c mice, aged between 5 and 6 weeks were immunized intradermally into the shaved back (4 spots each) with 100 mic...
Changes in plasma catecholamine and corticosterone levels and gene expression of key enzymes of catecholamine biosynthesis in partially hepa...
The first peak of catecholamine and corticosterone levels might result from unspecific stressor associated with the surgery. These levels could be accompanied with the mechanism of the rat liver regeneration. Prolonged elevations of EPI found after PH seems to be specific for liver regeneration indi...
Effect of POMC-derived peptides on corticosterone secretion during the stress hypo-responsive period in rat.
We have observed that administration of ACTH during 3 consecutive days is followed by a striking increase in corticosterone response to an acute ACTH test. A comparable potentiation of corticosterone secretion was observed after a similar treatment with Lys gamma 3-MSH. The 3 day-treatment with each...