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Expert Opinion on Investigational Drugs

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  1. Recent advances in natriuretic peptides in congestive heart failure.

    Expert Opinion on Investigational Drugs 13(6):643 (2004) PMID 15174950

    Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are secreted by the heart and play important roles in the compensation of congestive heart failure with their vasodilating, natriuretic, antiproliferative, lusitropic and neurohumoral-modulating properties. Based on these bene...
  2. Antibacterial drug discovery & development summit.

    Expert Opinion on Investigational Drugs 13(6):715 (2004) PMID 15174958

    Over 100 senior researchers and managers from academic and industrial research organisations attended this 2-day annual international discovery summit on antibacterial R&D. A number of firms, particularly biotechnology firms, presented compounds that are advancing through clinical development. I...
  3. Novel approaches to antifungal prophylaxis.

    Expert Opinion on Investigational Drugs 13(6):665 (2004) PMID 15174952

    Antifungal prophylaxis represents a significant advance in the management of patients at risk from fungal infections in a variety of settings. Identification of patients at the highest risk and the utilisation of safe and effective drugs maximises the benefits of prophylaxis. Situations in which...
  4. The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease.

    Expert Opinion on Investigational Drugs 13(6):653 (2004) PMID 15174951

    The Na(+)/Ca(2+) exchanger (NCX), a surface membrane antiporter, is the primary pathway for Ca(2+) efflux from the cardiac cell and a determinant of both the electrical and contractile state of the heart. Enhanced expression of NCX has recently been recognised as one of the molecular mechanisms ...
  5. Vaccines for the prevention of respiratory viral infections: problems and current status.

    Expert Opinion on Investigational Drugs 13(6):681 (2004) PMID 15174954

    Acute respiratory virus infections cause the majority of lower respiratory tract illnesses and hospitalisations of infants and the elderly. The emergence of new respiratory viruses and a high probability that influenza will cause further pandemics highlights the necessity for developing better p...
  6. Vascular biology support for the use of bevacizumab in colorectal cancer.

    Expert Opinion on Investigational Drugs 13(6):703 (2004) PMID 15174956

    In colorectal cancer, increased expression of the angiogenesis promoter vascular endothelial growth factor correlates with invasiveness, vascular density, metastases, recurrence and prognosis. Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor. In re...
  7. Molecular biological design of novel antineoplastic therapies.

    Expert Opinion on Investigational Drugs 13(6):577 (2004) PMID 15174947

    Novel therapies represent a new strategy for the development of anticancer agents. New targets derived from the knowledge of the molecular structure and genetic defects has been useful in developing anticancer drugs that prolong or stabilise the progression of tumours with minimal systemic toxic...
  8. Novel targeted agents in the treatment of lung cancer.

    Expert Opinion on Investigational Drugs 13(6):609 (2004) PMID 15174948

    Lung cancer is the leading cause of cancer-related mortality in the US. Although an improvement in outcome is possible with the continued advancement of cytotoxic-based treatment, clinical research is currently focused on utilising novel molecular targets with proven efficacy in preclinical mode...
  9. Cataract formation and prevention.

    Expert Opinion on Investigational Drugs 13(6):691 (2004) PMID 15174955

    Cataract, a leading cause of blindness worldwide, is a multifactorial eye disease. In developing countries the incidence of cataract among young generations is not uncommon due to malnutrition, excess exposure to ultraviolet radiation and so on. In developed countries, age-related cataract affec...
  10. Intensive lipid-lowering therapy in coronary artery disease: implications of the REVERSAL and PROVE-IT trials.

    Expert Opinion on Investigational Drugs 13(6):707 (2004) PMID 15174957

    Current international guidelines recommend that the goal of treatment with lipid-lowering therapy in patients with established coronary artery disease (CAD) should be a low-density lipoprotein cholesterol level of < 100 mg/dl. The question that remains to be answered is whether more aggressive l...