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The International Journal of Biochemistry & Cell Biology

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Sciencedirect from 1995, Rcgp, Gale, CSA, Proquest, and Ingenta

  1. CD73 on B16F10 melanoma cells in CD73-deficient mice promotes tumor growth, angiogenesis, neovascularization, macrophage infiltration and metastasis

    The International Journal of Biochemistry & Cel... 69:1 (2015)

    Ecto-5′-nucleotidase (CD73), an enzyme providing interstitial adenosine, mediates diverse physiological and pathological responses. In tumor progression, it has primarily an immunosuppressive role but is also thought to regulate neovascularization. However, the latter role is still in ...
  2. Prolonged cultures of unstimulated human neutrophils lead to the apparition and persistence of rest-in-plate structures (RIPs) recognized by professional phagocytes in vitro and in vivo

    The International Journal of Biochemistry & Cel... 69:62 (2015)

    Polymorphonuclear neutrophil cells (PMNs) are known to spontaneously undergo apoptosis and then eliminated by professional phagocytes to prevent inflammation, a process called efferocytosis. However, when efferocytosis is impaired, PMNs will fall into secondary necrosis. Whether this s...
  3. Brain diseases and tumorigenesis: The good and bad cops of pentraxin3

    The International Journal of Biochemistry & Cel... 69:70 (2015)

    The prototype of long pentraxins, Pentraxin 3 (PTX3), is an evolutionarily conserved multifunctional, pattern-recognition protein constituted by a cyclic multimeric structure. PTX3 interacts with a variety of ligands, such as growth factors, extracellular matrix components, molecules o...
  4. Hippo circuitry and the redox modulation of hippo components in cancer cell fate decisions

    The International Journal of Biochemistry & Cel... 69:20 (2015)

    Meticulous and precise control of organ size is undoubtedly one of the most pivotal processes in mammalian development and regeneration along with cell differentiation, morphogenesis and programmed cell death. These processes are strictly regulated by complex and highly coordinated mec...
  5. Mitofusin 2 ameliorates hypoxia-induced apoptosis via mitochondrial function and signaling pathways

    The International Journal of Biochemistry & Cel... 69:29 (2015)

    Mitochondrial dynamics play a critical role in mitochondrial function and signaling. Although mitochondria play a critical role in hypoxia/ischemia, the further mechanisms between mitochondrial dynamics and ischemia are still unclear. The current study aimed to determine the role of mi...
  6. A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process

    The International Journal of Biochemistry & Cel... 69:11 (2015)

    Dietary zinc is the principal source of zinc in eukaryotes, with its uptake and distribution controlled by a complex network of numerous membrane-spanning transport proteins. Dietary absorption is achieved by members of the SLC39A (ZIP) gene family, which encode proteins that are gener...
  7. Suppression of AGO2 by miR-132 as a determinant of miRNA-mediated silencing in human primary endothelial cells

    The International Journal of Biochemistry & Cel... 69:75 (2015)

    The abundance of miR-132 ranges from constitutively high in the brain where it is necessary for neuronal development and function, to inducible expression in haematopoietic and endothelial cells where it controls angiogenesis and immune activation. We show that expression of AGO2, a pr...
  8. Inhibition of MEF2A prevents hyperglycemia-induced extracellular matrix accumulation by blocking Akt and TGF-β1/Smad activation in cardiac fibroblasts

    The International Journal of Biochemistry & Cel... 69:52 (2015)

    Myocyte enhancer factor 2A (MEF2A) functions in muscle-specific and/or growth factor-related transcription and is involved in cell growth, survival, and apoptosis. To evaluate the role of this transcription factor in cardiac fibroblasts (CFs) in diabetes mellitus, we performed a series...
  9. The Ccz1 mediates the autophagic clearance of damaged mitochondria in response to oxidative stress in Candida albicans

    The International Journal of Biochemistry & Cel... 69:41 (2015)

    Autophagy plays a critical role in response to numerous cellular stresses, such as nutrient deprivation, hypoxia, starvation and organelle damage. The disruption of autophagy pathway affects multiple aspects of cellular stress response. Here we for the first time identified Ccz1 as an ...
  10. Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex

    The International Journal of Biochemistry & Cel... 69:105 (2015)