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The International Journal of Biochemistry & Cell Biology

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Sciencedirect from 1995, Rcgp, Gale, CSA, Proquest, and Ingenta

  1. Functional and structural interaction of (−)-lobeline with human α4β2 and α4β4 nicotinic acetylcholine receptor subtypes

    The International Journal of Biochemistry & Cel... 64:15 (2015)

    To determine the pharmacologic activity of (−)-lobeline between human (h)α4β2 and hα4β4 nicotinic acetylcholine receptors (AChRs), functional and structural experiments were performed. The Ca2+ influx results established that (−)-lobeline neither actives nor enhances the function of th...
  2. Celsr3 and Fzd3 in axon guidance

    The International Journal of Biochemistry & Cel... 64:11 (2015)

    The assembly of functional neuronal circuits depends on the correct wiring of axons and dendrites. To reach their targets, axons are guided by a variety of extracellular guidance cues, including Netrins, Ephrins, Semaphorins and Slits. Corresponding receptors in the growth cone, the dy...
  3. Oxidative stress, mitochondrial perturbations and fetal programming of renal disease induced by maternal smoking

    The International Journal of Biochemistry & Cel... 64:81 (2015)

    An adverse in-utero environment is increasingly recognized to predispose to chronic disease in adulthood. Maternal smoking remains the most common modifiable adverse in-utero exposure leading to low birth weight, which is strongly associated with chronic kidney disease (CKD) in later l...
  4. Gut region-specific accumulation of reactive oxygen species leads to regionally distinct activation of antioxidant and apoptotic marker molecules in rats with STZ-induced diabetes

    The International Journal of Biochemistry & Cel... 62:125 (2015)

    The aim of this study was to seek possible links between the regionality along the digestive tract and the accumulation of reactive oxygen species, the effectiveness of the antioxidant defense system and the sensitivity to the types of demise in different gut regions of rats with strep...
  5. Mechanical stretch promotes matrix metalloproteinase-2 and prolyl-4-hydroxylase α1 production in human aortic smooth muscle cells via Akt-p38 MAPK-JNK signaling

    The International Journal of Biochemistry & Cel... 62:15 (2015)

    Hypertension can increase mechanical stretch on the vessel wall, an important stimulus that induces collagen remodeling. Prolyl-4-hydroxylaseα1 (P4Hα1) and matrix metalloproteinases (MMPs) are essential for collagen synthesis and degradation. However, the effect of mechanical strain an...
  6. Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrPSc in prion infected cell line via protein interaction

    The International Journal of Biochemistry & Cel... 62:24 (2015)

    Polo-like kinases (PLKs) family has long been known to be critical for cell cycle and recent studies have pointed to new dimensions of PLKs function in the nervous system. Our previous study has verified that the levels of PLK3 in the brain are severely downregulated in prion-related d...
  7. Early growth response-1 facilitates enterovirus 71 replication by direct binding to the viral genome RNA

    The International Journal of Biochemistry & Cel... 62:36 (2015)

    • EV71 activates EGR1 expression by activating the PKA/PKCɛ/PI3K/Akt cascade. • EGR1 in turn stimulates the IRES of EV71, resulting in enhanced viral replication. ...
  8. Glutenase and collagenase activities of wheat cysteine protease Triticain-α: Feasibility for enzymatic therapy assays

    The International Journal of Biochemistry & Cel... 62:115 (2015)

  9. CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): A focus on its role in cancer

    The International Journal of Biochemistry & Cel... 62:142 (2015)

    The matricellular protein WISP1 is a member of the CCN protein family. It is induced by WNT1 and is a downstream target of β-catenin. WISP1 is expressed during embryonic development, wound healing and tissue repair. Aberrant WISP1 expression is associated with various pathologies inclu...
  10. Role of discoidin domain receptor 1 in dysregulation of collagen remodeling by cyclosporin A

    The International Journal of Biochemistry & Cel... 62:80 (2015)

    • Cyclosporin A disrupts collagen homeostasis and causes fibrosis in gingival tissues. • Cyclosporin A inhibits cell binding to collagen, internalization of collag...