The International Journal of Biochemistry & Cell Biology
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- Sciencedirect from 1995, Rcgp, Gale, CSA, Proquest, and Ingenta
Tumour progression and cancer-induced pain: a role for protease-activated receptor-2?
The role of proteases in modifying the microenvironment of tumour cells has long been recognised. With the discovery of the protease-activated receptor family of G protein-coupled receptors a mechanism for cells to sense and respond directly to proteases in their microenvironment was revealed. Many...
Deer antler--a novel model for studying organ regeneration in mammals.
We can impart a greater potential of these periosteal cells to proliferate, we might at least be able to partially regenerate limbs lost from humans. Taken together, a greater understanding of the mechanisms that regulate the regeneration of antlers may provide a valuable insight to aid the field of...
MicroRNAs in development and disease
Erratum to: Impairment of IGF-I gene splicing and MGF expression associated with muscle wasting
Editorial board / Publication Information
RBM5 and p53 expression after rat spinal cord injury: Implications for neuronal apoptosis.
We performed an acute SCI model in adult rats in this study. Our results showed RBM5 was unregulated significantly after SCI, which was accompanied with an increase in the levels of apoptotic proteins such as p53, Bax, and active caspase-3. Immunofluorescent labeling also showed that traumatic SCI i...
The immune receptor Tim-3 mediates activation of PI3 kinase/mTOR and HIF-1 pathways in human myeloid leukaemia cells.
We reveal the detailed mechanism of action underlying the biological responses mediated by the Tim-3 receptor in myeloid cells. Our studies demonstrate that Tim-3 triggers growth factor type responses in acute myeloid leukaemia cells by activating a phosphatidylinositol-3 kinase (PI-3K)/mammalian ta...