Advanced search×

The International Journal of Biochemistry & Cell Biology

Print ISSN
Electronic ISSN
Impact factor
Usage rank
Article count
Free count
Free percentage
PDFs via platforms
Sciencedirect from 1995, Rcgp, Gale, CSA, Proquest, and Ingenta

  1. Podoplanin is a substrate of presenilin-1/γ-secretase.

    The International Journal of Biochemistry & Cel... 46:68 (2014) PMID 24275092

    We provide evidence that the intracellular domain (ICD) of podoplanin is released into the cytosol following a sequential proteolytic processing by a metalloprotease and γ-secretase. Western blotting and cell fractionation studies revealed that HEK293T and MDCK cells transfected with an eGFP-tagged...
  2. miR-320a regulates erythroid differentiation through MAR binding protein SMAR1.

    The International Journal of Biochemistry & Cel... 45(11):2519 (2013) PMID 23876508

    We found that miR-320a inhibits erythroid differentiation by targeting Matrix Attachment Region binding protein SMAR1. miR-320a negatively regulates the expression of SMAR1 by directly binding to its 3'UTR. In response to mild DNA damage, miR-320a expression is decreased resulting in enhanced expres...
  3. Molecular mechanisms of muscle atrophy in myotonic dystrophies.

    The International Journal of Biochemistry & Cel... 45(10):2280 (2013) PMID 23796888

    Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2) are multisystemic diseases that primarily affect skeletal muscle, causing myotonia, muscle atrophy, and muscle weakness. DM1 and DM2 pathologies are caused by expansion of CTG and CCTG repeats in non-coding regions of the genes enco...
  4. Osmotic stress transcription factor 1b (Ostf1b) promotes migration properties with the modulation of epithelial mesenchymal transition (EMT)...

    The International Journal of Biochemistry & Cel... 45(8):1921 (2013) PMID 23732111

    We identified the osmotic stress transcription factor 1b (Ostf1b) in medaka and found that it is an early hypertonic responsive gene and can activate the c-Jun N-terminal kinase (JNK) pathway. In this report, we aim to know if Ostf1b plays the role in the migration. Ostf1b was ectopic expressed in t...
  5. Dysferlin interacts with calsequestrin-1, myomesin-2 and dynein in human skeletal muscle.

    The International Journal of Biochemistry & Cel... 45(8):1927 (2013) PMID 23792176

    Our objective was to unravel the proteins that constitute the dysferlin complex and their interaction within the complex using immunoprecipitation assays (IP), blue native gel electrophoresis (BN) in healthy adult skeletal muscle and healthy cultured myotubes, and fluorescence lifetime imaging-fluor...
  6. Diabetic retinopathy: neuron protection as a therapeutic target.

    The International Journal of Biochemistry & Cel... 45(7):1525 (2013) PMID 23506699

    Diabetic retinopathy (DR) has mainly been regarded as a microvascular disease that is caused by hyperglycaemia and characterized by retinal vascular leakage, macular oedema and preretinal neovascularisation. Increasing clinical evidence from electroretinographic, contrast sensitivity, perimetric, an...
  7. Collagen represses canonical Notch signaling and binds to Notch ectodomain.

    The International Journal of Biochemistry & Cel... 45(7):1274 (2013) PMID 23579095 PMCID PMC3683383

    We found that type IV collagen inhibited Notch signaling in H460 and A7R5 cell lines. Moreover, Notch-stimulated expression of mature smooth muscle genes SMA, MHC, SM22, and calponin, which define the physiologic phenotype of normal vascular smooth muscle, was inhibited by type IV collagen in A7R5 c...
  8. Beclin-1: autophagic regulator and therapeutic target in cancer.

    The International Journal of Biochemistry & Cel... 45(5):921 (2013) PMID 23420005

    Beclin-1 (the mammalian ortholog of yeast ATG6) has been well-characterized to play a pivotal role in autophagy that is a major catabolic pathway in which the cell degrades macromolecules and damaged organelles. Beclin-1 structure has been identified to contain three identifiable domains, including...
  9. Cortical F-actin affects the localization and dynamics of SNAP-25 membrane clusters in chromaffin cells.

    The International Journal of Biochemistry & Cel... 45(3):583 (2013) PMID 23220175

    We used confocal microscopy do determine if DsRed-SNAP-25 microdomains, which define the final sites of exocytosis along with syntaxin-1, preferentially remain in contact with F-actin cortical structures labelled by lifeact-EGFP. A quantitative analysis showed that in cells over-expressing these con...
  10. Similarities and differences in the biogenesis, processing and lysosomal targeting between zebrafish and human pro-Cathepsin D: Functional i...

    The International Journal of Biochemistry & Cel... 45(2):273 (2013) PMID 23107604

    We have characterized the biogenetic pathways of zebrafish and human CD transgenically expressed in both human SH-SY5Y cells and zebrafish PAC2 cells. Differently from human CD, zebrafish CD was synthesized as a mono-glycosylated precursor (pro-CD) that was eventually processed into a single-chain m...