Advanced search×

Drug Discovery Today

Print ISSN
Electronic ISSN
Impact factor
Usage rank
Article count
Free count
Free percentage
PDFs via platforms
CSA, Rcgp, Proquest, Sciencedirect from 1996, Gale, and Ingenta

  1. Breaking free from chemical spreadsheets

    Drug Discovery Today 20(9):1093 (2015) PMID 26050579

    • We think about compounds and data in terms of groups and relationships. • Chemoinformatics methods help to find important patterns in compound data. ...
  2. Contents page 2
    Author(s) unavailable

    Drug Discovery Today 20(9):iii (2015)

  3. Development of pyruvate dehydrogenase kinase inhibitors in medicinal chemistry with particular emphasis as anticancer agents

    Drug Discovery Today 20(9):1112 (2015) PMID 25842042

    Many cancer cells demonstrate a high rate of glucose consumption via glycolysis to provide intermediates for macromolecule biosynthesis. To accomplish this metabolic change, the expression of pyruvate dehydrogenase kinases (PDKs) is rapidly increased in cancer cells. Inhibition of PDKs could pro...
  4. Validating the anticancer potential of carbon nanotube-based therapeutics through cell line testing

    Drug Discovery Today 20(9):1049 (2015) PMID 25997997

    Recent years have witnessed the booming development of carbon nanotubes (CNTs) and their composites in biological and medicine. By virtue of their unique physicochemical properties, CNTs have emerged as potential tools in biomedical applications as a result of their development as safe, effectiv...
  5. Advances in measuring single-cell pharmacology in vivo

    Drug Discovery Today 20(9):1087 (2015) PMID 26024776 PMCID PMC4567932

    Measuring key pharmacokinetic and pharmacodynamic parameters in vivo at the single cell level is likely to enhance drug discovery and development. In this review, we summarize recent advances in this field and highlight current and future capabilities. Copyright © 2015 Elsevier Ltd. All rights ...
  6. Herbal drugs against cardiovascular disease: traditional medicine and modern development

    Drug Discovery Today 20(9):1074 (2015) PMID 25956424

    • Herbs have attracted attention as complementary/alternative treatments against CVDs. • Modern technology is crucial for revealing mechanisms of action of herbs a...
  7. Metal nanoparticles: a theranostic nanotool against cancer

    Drug Discovery Today 20(9):1143 (2015) PMID 26007605

    • Metal nanoparticles have been extensively explored for the management of various disease conditions including cancer. • Metal nanoparticles showed inherent antic...
  8. Patient-centered drug discovery as the means to improved R&D productivity

    Drug Discovery Today 20(9):1044 (2015) PMID 25908579

    • Current drug discovery approach is unsustainable as a result of high clinical attrition. • There is urgent need to improve understanding of disease biology. ...
  9. Implications of Akt2/Twist crosstalk on breast cancer metastatic outcome

    Drug Discovery Today 20(9):1152 (2015) PMID 26136161

    • Akt2, a pivotal player in a complex web of signaling pathways controlling cell growth, proliferation and survival. • Molecular mechanisms underlying cancer progr...
  10. Integrated risk assessment of suicidal ideation and behavior in drug development

    Drug Discovery Today 20(9):1135 (2015) PMID 26022402

    • We provide a brief outline of the clinical landscape and present labeling of compounds with suspected drug-induced suicidal intent and behavior (SIB). • The pres...